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Tytuł :
YES1 as a Therapeutic Target for HER2-Positive Breast Cancer after Trastuzumab and Trastuzumab-Emtansine (T-DM1) Resistance Development.
Autorzy :
Fujihara M; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Shien T; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Shien K; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Suzawa K; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Takeda T; Departments of Pharmacy, Okayama University Hospital, Okayama 700-8558, Japan.
Zhu Y; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Mamori T; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Otani Y; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Yoshioka R; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Uno M; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Suzuki Y; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Abe Y; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Hatono M; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Tsukioki T; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Takahashi Y; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Kochi M; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Iwamoto T; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Taira N; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Doihara H; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
Toyooka S; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 26; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Ado-Trastuzumab Emtansine/*pharmacology
Breast Neoplasms/*therapy
Dasatinib/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Proto-Oncogene Proteins c-yes/*antagonists & inhibitors
RNA, Small Interfering/*genetics
Receptor, ErbB-2/*metabolism
Antineoplastic Agents, Immunological/pharmacology ; Apoptosis ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Female ; Humans ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-yes/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Differential effects of the Src family tyrosine kinases Yes and Fyn on lipopolysaccharide-induced lung injury in mice.
Autorzy :
Trittmann JK; Pulmonary Hypertension Group, Center for Perinatal Research, Abigail Wexner Research, Institute at Nationwide Children's Hospital, Columbus, Ohio.; Department of Pediatrics, The Ohio State University, Columbus, Ohio.
Jin Y; Pulmonary Hypertension Group, Center for Perinatal Research, Abigail Wexner Research, Institute at Nationwide Children's Hospital, Columbus, Ohio.; Department of Pediatrics, The Ohio State University, Columbus, Ohio.
Liu Y; Pulmonary Hypertension Group, Center for Perinatal Research, Abigail Wexner Research, Institute at Nationwide Children's Hospital, Columbus, Ohio.; Department of Pediatrics, The Ohio State University, Columbus, Ohio.
Nelin LD; Pulmonary Hypertension Group, Center for Perinatal Research, Abigail Wexner Research, Institute at Nationwide Children's Hospital, Columbus, Ohio.; Department of Pediatrics, The Ohio State University, Columbus, Ohio.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 Aug 01; Vol. 321 (2), pp. L392-L403. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Acute Lung Injury*/chemically induced
Acute Lung Injury*/enzymology
Acute Lung Injury*/genetics
Acute Lung Injury*/pathology
Proto-Oncogene Proteins c-fyn*/genetics
Proto-Oncogene Proteins c-fyn*/metabolism
Proto-Oncogene Proteins c-yes*/genetics
Proto-Oncogene Proteins c-yes*/metabolism
Lipopolysaccharides/*toxicity
Animals ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation.
Autorzy :
Zhao D; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Yin Z; Life Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Soellner MB; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Martin BR; Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Scorpion Therapeutics, Inc., 888 Boylston Street, Suite 1111, Boston, MA 02199, USA. Electronic address: .
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Źródło :
Cell chemical biology [Cell Chem Biol] 2021 Aug 19; Vol. 28 (8), pp. 1235-1241.e5. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Proto-Oncogene Proteins c-yes/*metabolism
YAP-Signaling Proteins/*metabolism
Animals ; Cells, Cultured ; Dogs ; Female ; Humans ; Male ; Phosphorylation ; Proto-Oncogene Proteins c-yes/genetics ; YAP-Signaling Proteins/genetics
Czasopismo naukowe
Tytuł :
EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis.
Autorzy :
Mao L; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.; Department of Gastrointestinal Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.
Yuan W; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.; Department of Gastrointestinal Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.; Department of Colorectal and Anus Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.
Cai K; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.
Lai C; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.; Department of Colorectal and Anus Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.
Huang C; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.; Department of Gastrointestinal Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.
Xu Y; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.
Zhong S; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.
Yang C; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.; Department of Gastrointestinal Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.
Wang R; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.; Department of Colorectal and Anus Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.
Zeng P; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.; Department of Gastrointestinal Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.
Huang H; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.; Department of Gastrointestinal Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.
Chen Z; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China.; Department of Colorectal and Anus Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China.; International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment & Standardization, Xiangya Hospital, CSU, Hunan, Changsha, China.
Chen Z; Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China. .; Department of Gastrointestinal Surgery, Xiangya Hospital, CSU, Hunan, Changsha, China. .; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, CSU, Hunan, Changsha, China. .; International Joint Research Center of Minimally Invasive Endoscopic Technology Equipment & Standardization, Xiangya Hospital, CSU, Hunan, Changsha, China. .
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Źródło :
Oncogene [Oncogene] 2021 May; Vol. 40 (20), pp. 3610-3623. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Annexin A2/*metabolism
Proto-Oncogene Proteins c-yes/*metabolism
Receptor, EphA2/*metabolism
Stomach Neoplasms/*pathology
Animals ; Annexin A2/genetics ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Metastasis ; Phosphorylation ; Proto-Oncogene Proteins c-yes/genetics ; Receptor, EphA2/genetics ; Signal Transduction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Survival Rate ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation.
Autorzy :
Redin E; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; CIBERONC, ISCIII, Madrid, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.
Garmendia I; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.
Lozano T; Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Serrano D; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.
Senent Y; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Redrado M; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Villalba M; Department of Pathology, University Clinic of Navarra, Pamplona, Spain.
De Andrea CE; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.; Department of Pathology, University Clinic of Navarra, Pamplona, Spain.
Exposito F; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; CIBERONC, ISCIII, Madrid, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.
Ajona D; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; CIBERONC, ISCIII, Madrid, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.
Ortiz-Espinosa S; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.
Remirez A; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Bertolo C; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; CIBERONC, ISCIII, Madrid, Spain.
Sainz C; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Garcia-Pedrero J; CIBERONC, ISCIII, Madrid, Spain.; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, Oviedo, Spain.
Pio R; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; CIBERONC, ISCIII, Madrid, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.
Lasarte J; Immunology and Immunotherapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Agorreta J; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; CIBERONC, ISCIII, Madrid, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.
Montuenga LM; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.; CIBERONC, ISCIII, Madrid, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.
Calvo A; IDISNA and Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain .; CIBERONC, ISCIII, Madrid, Spain.; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain.
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Źródło :
Journal for immunotherapy of cancer [J Immunother Cancer] 2021 Mar; Vol. 9 (3).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cell Proliferation/*drug effects
Dasatinib/*pharmacology
Immune Checkpoint Inhibitors/*pharmacology
Lung Neoplasms/*drug therapy
Lymphocytes, Tumor-Infiltrating/*drug effects
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-yes/*antagonists & inhibitors
T-Lymphocytes, Regulatory/*drug effects
Animals ; Carcinoma, Non-Small-Cell Lung/enzymology ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Female ; Humans ; Lung Neoplasms/enzymology ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/enzymology ; Lymphocytes, Tumor-Infiltrating/immunology ; Mice ; Mice, 129 Strain ; Phenotype ; Programmed Cell Death 1 Receptor/metabolism ; Proto-Oncogene Proteins c-yes/metabolism ; Signal Transduction ; T-Lymphocytes, Regulatory/enzymology ; T-Lymphocytes, Regulatory/immunology ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
An RGDKGE-Containing Cryptic Collagen Fragment Regulates Phosphorylation of Large Tumor Suppressor Kinase-1 and Controls Ovarian Tumor Growth by a Yes-Associated Protein-Dependent Mechanism.
Autorzy :
Han X; Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, Maine.
Caron JM; Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, Maine.
Lary CW; Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, Maine.
Sathyanarayana P; Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, Maine.
Vary C; Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, Maine.
Brooks PC; Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, Maine. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2021 Mar; Vol. 191 (3), pp. 527-544. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Biomarkers, Tumor/*metabolism
Collagen/*metabolism
Ovarian Neoplasms/*pathology
Peptide Fragments/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Proto-Oncogene Proteins c-yes/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice, Inbred C57BL ; Mice, Nude ; Phosphorylation ; Protein Serine-Threonine Kinases/genetics ; Proto-Oncogene Proteins c-yes/genetics ; Signal Transduction ; Tumor Cells, Cultured ; Tumor Microenvironment ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Transcriptional co-activators YAP/TAZ: Potential therapeutic targets for metastatic breast cancer.
Autorzy :
Zhao W; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Wang M; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Cai M; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Zhang C; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Qiu Y; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Wang X; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Zhang T; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Zhou H; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Wang J; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Zhao W; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
Shao R; NHC Key Laboratory of Antibiotic Bioengineering, Laboratory of Oncology, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 110956. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Breast Neoplasms/*drug therapy
Protein Processing, Post-Translational/*drug effects
Proto-Oncogene Proteins c-yes/*metabolism
Trans-Activators/*metabolism
Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Humans ; Molecular Targeted Therapy ; Neoplasm Metastasis ; Protein Domains ; Proto-Oncogene Proteins c-yes/chemistry ; Signal Transduction ; Structure-Activity Relationship ; Trans-Activators/chemistry ; Transcriptional Coactivator with PDZ-Binding Motif Proteins
Czasopismo naukowe
Tytuł :
YES1 amplification confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive cancer.
Autorzy :
Wang L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Wang Q; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Xu P; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Fu L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Li Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Fu H; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
Quan H; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China. .
Lou L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China. .
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Źródło :
British journal of cancer [Br J Cancer] 2020 Sep; Vol. 123 (6), pp. 1000-1011. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Amplification*
Ado-Trastuzumab Emtansine/*therapeutic use
Breast Neoplasms/*drug therapy
Proto-Oncogene Proteins c-yes/*genetics
Receptor, ErbB-2/*analysis
Ado-Trastuzumab Emtansine/pharmacokinetics ; Animals ; Breast Neoplasms/chemistry ; Breast Neoplasms/genetics ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Female ; Mice ; Mice, Inbred BALB C ; Proto-Oncogene Proteins c-yes/antagonists & inhibitors ; Receptor, ErbB-2/antagonists & inhibitors ; src-Family Kinases/physiology
Czasopismo naukowe
Tytuł :
MicroRNA-140 inhibit prostate cancer cell invasion and migration by targeting YES proto-oncogene 1.
Autorzy :
Zhao S; Department of Urology, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jie C; Department of Gynaecology and Obstetrics, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xu P; Department of Urology and Urodynamics Center, First Affiliated Hospital of Zhengzhou University, China.
Diao Y; Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, People's Republic of China.
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Źródło :
Journal of cellular biochemistry [J Cell Biochem] 2020 Jan; Vol. 121 (1), pp. 482-488. Date of Electronic Publication: 2019 Jul 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
MicroRNAs/*genetics
Prostatic Neoplasms/*pathology
Proto-Oncogene Proteins c-yes/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Cell Cycle ; Cell Proliferation ; Humans ; Male ; Neoplasm Invasiveness ; Prognosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-yes/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Long non-coding TUG1 accelerates prostate cancer progression through regulating miR-128-3p/YES1 axis.
Autorzy :
Hao SD; Department of Urology, Zhejiang Integrated Traditional and Western Medicine Hospital/Hangzhou Red Cross Hospital, Hangzhou, China. .
Ma JX
Liu Y
Liu PJ
Qin Y
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Źródło :
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2020 Jan; Vol. 24 (2), pp. 619-632.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
MicroRNAs/*biosynthesis
Prostatic Neoplasms/*metabolism
Prostatic Neoplasms/*pathology
Proto-Oncogene Proteins c-yes/*biosynthesis
RNA, Long Noncoding/*biosynthesis
Animals ; Cell Line, Tumor ; Gene Knockdown Techniques/methods ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; Prostatic Neoplasms/genetics ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-yes/antagonists & inhibitors ; Proto-Oncogene Proteins c-yes/genetics ; RNA, Long Noncoding/antagonists & inhibitors ; RNA, Long Noncoding/genetics ; Tumor Burden/physiology
Czasopismo naukowe
Tytuł :
To Scar or Not to Scar.
Autorzy :
Clark RAF; From the Departments of Dermatology and Biomedical Engineering, State University of New York at Stony Brook Health Sciences Center, Stony Brook, NY.
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Źródło :
The New England journal of medicine [N Engl J Med] 2021 Jul 29; Vol. 385 (5), pp. 469-471.
Typ publikacji :
Journal Article
MeSH Terms :
Cicatrix/*physiopathology
Homeodomain Proteins/*genetics
Proto-Oncogene Proteins c-yes/*physiology
Wound Healing/*physiology
Animals ; Cicatrix/pathology ; Cicatrix/prevention & control ; Collagen/physiology ; Fibroblasts/physiology ; Homeodomain Proteins/metabolism ; Humans ; Hyaluronoglucosaminidase/metabolism ; Mice ; Mice, Knockout ; Models, Animal ; Signal Transduction ; Verteporfin/therapeutic use
Czasopismo naukowe
Tytuł :
MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells.
Autorzy :
Zhang G; Department of Breast Surgery, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
Wang J; Department of Medical Insurance Management, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
Zheng R; Department of Breast Surgery, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
Song B; Department of Medical Insurance Management, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
Huang L; Department of Breast Surgery, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
Liu Y; Department of Breast Surgery, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
Hao Y; Department of Breast Surgery, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
Bai X; Department of Breast Surgery, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
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Źródło :
Technology in cancer research & treatment [Technol Cancer Res Treat] 2020 Jan-Dec; Vol. 19, pp. 1533033820927011.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adaptor Proteins, Signal Transducing/*metabolism
Biomarkers, Tumor/*metabolism
MicroRNAs/*genetics
Proto-Oncogene Proteins c-yes/*metabolism
Transcription Factors/*metabolism
Triple Negative Breast Neoplasms/*pathology
Adaptor Proteins, Signal Transducing/genetics ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Female ; Humans ; Middle Aged ; Phosphorylation ; Prognosis ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-yes/genetics ; Transcription Factors/genetics ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/surgery ; Tumor Cells, Cultured ; YAP-Signaling Proteins
Czasopismo naukowe
Tytuł :
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring.
Autorzy :
Mascharak S; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
desJardins-Park HE; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Davitt MF; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Griffin M; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Borrelli MR; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Moore AL; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Chen K; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Duoto B; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Chinta M; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Foster DS; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Shen AH; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Januszyk M; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kwon SH; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wernig G; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Wan DC; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lorenz HP; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Gurtner GC; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. .
Longaker MT; Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. .; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Apr 23; Vol. 372 (6540).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Regeneration*
Wound Healing*
Cicatrix/*pathology
Fibroblasts/*physiology
Homeodomain Proteins/*genetics
Homeodomain Proteins/*metabolism
Skin/*injuries
Animals ; Cicatrix/prevention & control ; Fibroblasts/transplantation ; Gene Expression Regulation ; Gene Knockout Techniques ; Mechanotransduction, Cellular ; Mice ; Mice, Transgenic ; Proto-Oncogene Proteins c-yes/antagonists & inhibitors ; Proto-Oncogene Proteins c-yes/genetics ; Proto-Oncogene Proteins c-yes/metabolism ; Signal Transduction ; Stress, Mechanical ; Transcriptional Activation ; Transcriptome ; Verteporfin/pharmacology
Czasopismo naukowe
Tytuł :
Suppression of IL-17A-induced CCL20 production by cytokine inducible SH2-containing protein 1 in epidermal keratinocytes.
Autorzy :
Tohyama M; Department of Dermatology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan; Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan. Electronic address: .
Matsumoto A; Department of Infection and Host Defenses, Ehime University Graduate School of Medicine, Ehime, Japan.
Tsuda T; Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.
Dai X; Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.
Shiraishi K; Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.
Sayama K; Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.
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Źródło :
Journal of dermatological science [J Dermatol Sci] 2021 Mar; Vol. 101 (3), pp. 202-209. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Chemokine CCL20/*metabolism
Dermatitis, Atopic/*immunology
Epidermis/*pathology
Suppressor of Cytokine Signaling 1 Protein/*metabolism
Cells, Cultured ; Dermatitis, Atopic/pathology ; Epidermis/immunology ; Gene Expression Regulation/immunology ; Gene Knockdown Techniques ; Humans ; Interleukin-17/metabolism ; Keratinocytes/immunology ; Keratinocytes/pathology ; Phosphorylation/genetics ; Phosphorylation/immunology ; Primary Cell Culture ; Proto-Oncogene Proteins c-yes/genetics ; Proto-Oncogene Proteins c-yes/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Th2 Cells/immunology ; Th2 Cells/metabolism
Czasopismo naukowe
Tytuł :
YES1 Drives Lung Cancer Growth and Progression and Predicts Sensitivity to Dasatinib.
Autorzy :
Garmendia I; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Department of Pathology, Anatomy, and Physiology, School of Medicine and.
Pajares MJ; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Department of Pathology, Anatomy, and Physiology, School of Medicine and.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Navarra Health Research Institute, Pamplona, Spain.
Hermida-Prado F; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo, Spain.
Ajona D; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Navarra Health Research Institute, Pamplona, Spain.
Bértolo C; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.
Sainz C; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.
Lavín A; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.
Remírez AB; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.
Valencia K; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.
Moreno H; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.
Ferrer I; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Lung Cancer Clinical Research Unit and Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.
Behrens C; Department of Translational Molecular Pathology and.; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cuadrado M; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas, University of Salamanca, Salamanca, Spain.
Paz-Ares L; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Lung Cancer Clinical Research Unit and Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.; Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain.; Medical School, Universidad Complutense, Madrid, Spain.
Bustelo XR; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas, University of Salamanca, Salamanca, Spain.
Gil-Bazo I; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Navarra Health Research Institute, Pamplona, Spain.; Medical Oncology Department, Clínica Universidad de Navarra, Pamplona, Spain.
Alameda D; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.
Lecanda F; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Department of Pathology, Anatomy, and Physiology, School of Medicine and.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Navarra Health Research Institute, Pamplona, Spain.
Calvo A; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Department of Pathology, Anatomy, and Physiology, School of Medicine and.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Navarra Health Research Institute, Pamplona, Spain.
Felip E; Oncology Department, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain; and.
Sánchez-Céspedes M; Cancer Epigenetics and Biology Program, Genes and Cancer Group, Bellvitge Biomedical Research Institute, Hospitalet de Llobregat, Barcelona, Spain.
Wistuba II; Department of Translational Molecular Pathology and.; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Granda-Diaz R; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo, Spain.
Rodrigo JP; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo, Spain.
García-Pedrero JM; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo, Spain.
Pio R; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Navarra Health Research Institute, Pamplona, Spain.
Montuenga LM; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Department of Pathology, Anatomy, and Physiology, School of Medicine and.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Navarra Health Research Institute, Pamplona, Spain.
Agorreta J; Program in Solid Tumors, Center for Applied Medical Research, Pamplona, Spain.; Department of Pathology, Anatomy, and Physiology, School of Medicine and.; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.; Navarra Health Research Institute, Pamplona, Spain.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Oct 01; Vol. 200 (7), pp. 888-899.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*genetics
Cell Proliferation/*genetics
Dasatinib/*pharmacology
Lung Neoplasms/*genetics
Proto-Oncogene Proteins c-yes/*genetics
A549 Cells ; Animals ; Antineoplastic Agents/therapeutic use ; CRISPR-Cas Systems ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dasatinib/therapeutic use ; Gene Amplification ; Gene Knockdown Techniques ; Gene Knockout Techniques ; Humans ; Lung Neoplasms/drug therapy ; Mice ; Prognosis ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-yes/antagonists & inhibitors ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Yes-associated protein expression in germ cells is dispensable for spermatogenesis in mice.
Autorzy :
Abou Nader N; Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.
Levasseur A; Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.
Zhang X; Department of Obstetrics and Gynecology, Division of Reproductive Biology, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Boerboom D; Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.
Nagano MC; Department of Obstetrics and Gynecology, Division of Reproductive Biology, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Boyer A; Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada.
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Źródło :
Genesis (New York, N.Y. : 2000) [Genesis] 2019 Oct; Vol. 57 (10), pp. e23330. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Proto-Oncogene Proteins c-yes/*physiology
Spermatogenesis/*physiology
Animals ; Cells, Cultured ; DEAD-box RNA Helicases/genetics ; Female ; Gene Expression Regulation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Proto-Oncogene Proteins c-yes/genetics ; Spermatogenesis/genetics ; Spermatogonia/cytology ; Spermatogonia/physiology
Raport
Tytuł :
MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1.
Autorzy :
Yang S; Department of Cardiology, Linyi Central Hospital, Linyi, Shandong, China.
Li H; Department of Cardiology, Linyi Central Hospital, Linyi, Shandong, China.
Chen L; Department of Cardiology, Shandong Provincial Hospital, Jinan, Shandong, China.
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Źródło :
Journal of cellular biochemistry [J Cell Biochem] 2019 Mar; Vol. 120 (3), pp. 3813-3821. Date of Electronic Publication: 2018 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*genetics
MicroRNAs/*genetics
Mitochondria/*genetics
Myocardial Infarction/*genetics
Myocardial Reperfusion Injury/*genetics
Proto-Oncogene Proteins c-yes/*genetics
Animals ; Antagomirs/genetics ; Antagomirs/metabolism ; Disease Models, Animal ; Dynamins/genetics ; Dynamins/metabolism ; Gene Expression Regulation ; Genes, Reporter ; Luciferases/genetics ; Luciferases/metabolism ; Mice ; MicroRNAs/agonists ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Dynamics/genetics ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Myocardial Infarction/etiology ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Reperfusion Injury/complications ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oligoribonucleotides/genetics ; Oligoribonucleotides/metabolism ; Proto-Oncogene Proteins c-yes/metabolism ; Signal Transduction
Czasopismo naukowe

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