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Wyszukujesz frazę ""zinc finger nucleases"" wg kryterium: Temat


Tytuł:
Resolution of hepatic fibrosis after ZFN-mediated gene editing in the PiZ mouse model of human α1-antitrypsin deficiency.
Autorzy:
Li Y; Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA.
Guha C; Department of Radiation Oncology, Albert Einstein College of Medicine, New York, New York, USA.; Department of Pathology, Albert Einstein College of Medicine, New York, New York, USA.; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, New York, New York, USA.
Asp P; Department of Radiation Oncology, Albert Einstein College of Medicine, New York, New York, USA.; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, New York, New York, USA.
Wang X; Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA.
Tchaikovskya TL; Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA.; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, New York, New York, USA.
Kim K; Sangamo Therapeutics, Richmond, California, USA.
Mendel M; Sangamo Therapeutics, Richmond, California, USA.
Cost GJ; Sangamo Therapeutics, Richmond, California, USA.
Perlmutter DH; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Roy-Chowdhury N; Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA.; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, New York, New York, USA.; Department of Genetics, Albert Einstein College of Medicine, New York, New York, USA.
Fox IJ; Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Conway A; Sangamo Therapeutics, Richmond, California, USA.
Roy-Chowdhury J; Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA.; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, New York, New York, USA.; Department of Genetics, Albert Einstein College of Medicine, New York, New York, USA.
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Źródło:
Hepatology communications [Hepatol Commun] 2023 Feb 27; Vol. 7 (3), pp. e0070. Date of Electronic Publication: 2023 Feb 27 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Editing*
Zinc Finger Nucleases*
Humans ; Animals ; Mice ; Liver Cirrhosis/genetics ; Liver Cirrhosis/therapy ; Hepatocytes ; Disease Models, Animal ; Intracellular Signaling Peptides and Proteins
Czasopismo naukowe
Tytuł:
First-in-human in vivo genome editing via AAV-zinc-finger nucleases for mucopolysaccharidosis I/II and hemophilia B.
Autorzy:
Harmatz P; UCSF Benioff Children's Hospital Oakland, Oakland, CA 94609, USA. Electronic address: .
Prada CE; Division of Genetics, Birth Defects & Metabolism, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Department of Pediatrics, Feinberg School of Medicine of Northwestern University, Chicago, IL, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Burton BK; Division of Genetics, Birth Defects & Metabolism, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Department of Pediatrics, Feinberg School of Medicine of Northwestern University, Chicago, IL, USA.
Lau H; Department of Neurology, NYU School of Medicine, New York, NY, USA.
Kessler CM; Georgetown University, Washington, DC, USA.
Cao L; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Falaleeva M; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Villegas AG; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Zeitler J; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Meyer K; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Miller W; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Wong Po Foo C; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Vaidya S; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Swenson W; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Shiue LH; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Rouy D; Sangamo Therapeutics, Inc., Brisbane, CA, USA.
Muenzer J; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
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Źródło:
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2022 Dec 07; Vol. 30 (12), pp. 3587-3600. Date of Electronic Publication: 2022 Oct 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Zinc Finger Nucleases*
Humans
Czasopismo naukowe
Tytuł:
Filaggrin-deficient rats generated using zinc-finger nucleases spontaneously exhibit dry scaly skin.
Autorzy:
Nakashima C; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Dermatology, Faculty of Medicine, Kindai University Hospital, Osaka, Japan.
Doi H; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nakajima S; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Drug Discovery for Inflammatory Skin Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Mashimo T; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Oga T; Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ishida-Yamamoto A; Department of Dermatology, Asahikawa Medical University, Hokkaido, Japan.
Honda T; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Ishida Y; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Otsuka A; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Dermatology, Faculty of Medicine, Kindai University Hospital, Osaka, Japan; Translational Research Department for Skin and Brain Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: .
Kabashima K; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A∗STAR), Biopolis, Singapore. Electronic address: .
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Źródło:
Allergology international : official journal of the Japanese Society of Allergology [Allergol Int] 2022 Oct; Vol. 71 (4), pp. 545-547. Date of Electronic Publication: 2022 May 08.
Typ publikacji:
Letter
MeSH Terms:
Filaggrin Proteins*
Zinc Finger Nucleases*/metabolism
Animals ; Intermediate Filament Proteins/genetics ; Rats ; Skin/metabolism
Opinia redakcyjna
Tytuł:
Review of knockout technology approaches in bacterial drug resistance research.
Autorzy:
Tong C; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, China.
Liang Y; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, China.
Zhang Z; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, China.
Wang S; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, China.
Zheng X; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, China.
Liu Q; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, China.
Song B; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, China.
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Źródło:
PeerJ [PeerJ] 2023 Aug 17; Vol. 11, pp. e15790. Date of Electronic Publication: 2023 Aug 17 (Print Publication: 2023).
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Craniocerebral Trauma*
Drug Resistance, Bacterial/genetics ; Gene Knockout Techniques ; Genes, Bacterial ; Technology ; Transcription Activator-Like Effector Nucleases ; Zinc Finger Nucleases ; Animals
Czasopismo naukowe
Tytuł:
Genome centric engineering using ZFNs, TALENs and CRISPR-Cas9 systems for trait improvement and disease control in Animals.
Autorzy:
Wani AK; School of Bioengineering and Biosciences, Lovely Professional University, Punjab, 144411, India.
Akhtar N; School of Bioengineering and Biosciences, Lovely Professional University, Punjab, 144411, India.
Singh R; School of Bioengineering and Biosciences, Lovely Professional University, Punjab, 144411, India.
Prakash A; Department of Biochemistry and Biophysics, University of North Carolina, 120 Mason Farm Road, CB# 7260, 3093 Genetic Medicine, Chapel Hill, NC, 27599-2760, USA.
Raza SHA; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Cavalu S; Faculty of Medicine and Pharmacy, University of Oradea, P -ta 1Decembrie 10, 410073, Oradea, Romania.
Chopra C; School of Bioengineering and Biosciences, Lovely Professional University, Punjab, 144411, India.
Madkour M; Animal Production Department, National Research Centre, Dokki, Giza, 12622, Egypt.
Elolimy A; Animal Production Department, National Research Centre, Dokki, Giza, 12622, Egypt.
Hashem NM; Department of Animal and Fish Production, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, 21545, Egypt. .
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Źródło:
Veterinary research communications [Vet Res Commun] 2023 Jan; Vol. 47 (1), pp. 1-16. Date of Electronic Publication: 2022 Jul 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
CRISPR-Cas Systems*/genetics
Transcription Activator-Like Effector Nucleases*/genetics
Animals ; Zinc Finger Nucleases/genetics ; Gene Editing/veterinary ; Gene Editing/methods ; Mammals/genetics ; Livestock/genetics
Czasopismo naukowe
Tytuł:
CRISPR-Cas9 Technology for the Creation of Biological Avatars Capable of Modeling and Treating Pathologies: From Discovery to the Latest Improvements.
Autorzy:
Nasrallah A; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
Sulpice E; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
Kobaisi F; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
Gidrol X; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
Rachidi W; Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France.
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Źródło:
Cells [Cells] 2022 Nov 15; Vol. 11 (22). Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
CRISPR-Cas Systems*/genetics
Gene Editing*
Humans ; Zinc Finger Nucleases ; Transcription Activator-Like Effector Nucleases/genetics ; Technology
Czasopismo naukowe
Tytuł:
Application of CRISPR-Mediated Gene Editing for Crop Improvement.
Autorzy:
Negi C; Department of Genetics-Plant Breeding and Biotechnology, Dr. Khem Singh Gill Akal College of Agriculture, Eternal University, Baru Sahib, Himachal Pradesh, 173101, India.
Vasistha NK; Department of Genetics-Plant Breeding and Biotechnology, Dr. Khem Singh Gill Akal College of Agriculture, Eternal University, Baru Sahib, Himachal Pradesh, 173101, India.
Singh D; Government Model College, Jhabua, Madhya Pradesh, 457661, India.
Vyas P; Department of Genetics-Plant Breeding and Biotechnology, Dr. Khem Singh Gill Akal College of Agriculture, Eternal University, Baru Sahib, Himachal Pradesh, 173101, India. .
Dhaliwal HS; Department of Genetics-Plant Breeding and Biotechnology, Dr. Khem Singh Gill Akal College of Agriculture, Eternal University, Baru Sahib, Himachal Pradesh, 173101, India.
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Źródło:
Molecular biotechnology [Mol Biotechnol] 2022 Nov; Vol. 64 (11), pp. 1198-1217. Date of Electronic Publication: 2022 Jun 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
CRISPR-Associated Proteins*/genetics
Gene Editing*/methods
CRISPR-Cas Systems/genetics ; Crops, Agricultural/genetics ; Genome, Plant/genetics ; Plant Breeding/methods ; RNA ; Transcription Activator-Like Effectors/genetics ; Zinc Finger Nucleases/genetics
Czasopismo naukowe
Tytuł:
A review on CRISPR/Cas-based epigenetic regulation in plants.
Autorzy:
Jogam P; Department of Biotechnology, Kakatiya University, Warangal, Telangana 506009, India. Electronic address: .
Sandhya D; Department of Biotechnology, Kakatiya University, Warangal, Telangana 506009, India.
Alok A; Department of Plant Pathology, University of Minnesota, Saint Paul, MN 55108, USA.
Peddaboina V; Department of Microbiology, Kakatiya University, Warangal, Telangana 506009, India.
Allini VR; Department of Biotechnology, Kakatiya University, Warangal, Telangana 506009, India.
Zhang B; Department of Biology, East Carolina University, Greenville, NC 27858, USA. Electronic address: .
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Źródło:
International journal of biological macromolecules [Int J Biol Macromol] 2022 Oct 31; Vol. 219, pp. 1261-1271. Date of Electronic Publication: 2022 Aug 31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
CRISPR-Cas Systems*/genetics
Gene Editing*
CRISPR-Associated Protein 9 ; Crops, Agricultural/genetics ; Epigenesis, Genetic/genetics ; RNA, Untranslated ; Transcription Activator-Like Effector Nucleases/genetics ; Zinc Finger Nucleases/genetics
Czasopismo naukowe
Tytuł:
New perspectives in gene therapy for inherited disorders.
Autorzy:
Cicalese MP; San Raffaele Telethon Institute for Gene Therapy (TIGET), San Raffaele Scientific Institute Milan, Milan, Italy.; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Aiuti A; San Raffaele Telethon Institute for Gene Therapy (TIGET), San Raffaele Scientific Institute Milan, Milan, Italy.; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
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Źródło:
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2020 Feb; Vol. 31 Suppl 24, pp. 5-7.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Diseases, Inborn/*therapy
Genetic Therapy/*methods
Heredodegenerative Disorders, Nervous System/*therapy
Immune System Diseases/*therapy
Zinc Finger Nucleases/*metabolism
Animals ; CRISPR-Cas Systems ; Gene Editing ; Genetic Diseases, Inborn/genetics ; Genetic Therapy/trends ; Genetic Vectors ; Heredodegenerative Disorders, Nervous System/genetics ; Humans ; Immune System Diseases/genetics ; Zinc Finger Nucleases/genetics
Czasopismo naukowe
Tytuł:
Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets.
Autorzy:
Conway A; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA. Electronic address: .
Mendel M; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
Kim K; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
McGovern K; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
Boyko A; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
Zhang L; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
Miller JC; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
DeKelver RC; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
Paschon DE; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
Mui BL; Acuitas Therapeutics, 6190 Agronomy Rd., Suite 402, Vancouver, BC, Canada.
Lin PJC; Acuitas Therapeutics, 6190 Agronomy Rd., Suite 402, Vancouver, BC, Canada.
Tam YK; Acuitas Therapeutics, 6190 Agronomy Rd., Suite 402, Vancouver, BC, Canada.
Barbosa C; Acuitas Therapeutics, 6190 Agronomy Rd., Suite 402, Vancouver, BC, Canada.
Redelmeier T; Acuitas Therapeutics, 6190 Agronomy Rd., Suite 402, Vancouver, BC, Canada.
Holmes MC; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
Lee G; Sangamo Therapeutics, 501 Canal Blvd., Suite A, Richmond, CA 94804, USA.
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Źródło:
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2019 Apr 10; Vol. 27 (4), pp. 866-877. Date of Electronic Publication: 2019 Mar 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Delivery Systems/*methods
Gene Editing/*methods
Nanoparticles/*administration & dosage
RNA, Messenger/*administration & dosage
Zinc Finger Nucleases/*administration & dosage
Animals ; Cells, Cultured ; Dependovirus/genetics ; Female ; Gene Knockout Techniques ; Genetic Vectors ; Hepatocytes/metabolism ; Introns/genetics ; Lipids/chemistry ; Male ; Mice ; Mice, Inbred C57BL ; Prealbumin/genetics ; Proprotein Convertase 9/genetics ; RNA, Messenger/genetics ; Transgenes/genetics ; Zinc Finger Nucleases/pharmacology
Czasopismo naukowe
Tytuł:
Zinc finger nuclease-mediated targeting of multiple transgenes to an endogenous soybean genomic locus via non-homologous end joining.
Autorzy:
Bonawitz ND; Dow AgroSciences LLC, Indianapolis, IN, USA.
Ainley WM; Dow AgroSciences LLC, Indianapolis, IN, USA.
Itaya A; Agriculture and Agri-Food Canada, Ottawa, ON, Canada.
Chennareddy SR; Dow AgroSciences LLC, Indianapolis, IN, USA.
Cicak T; Dow AgroSciences LLC, Indianapolis, IN, USA.
Effinger K; Dow AgroSciences LLC, Indianapolis, IN, USA.
Jiang K; Dow AgroSciences LLC, Indianapolis, IN, USA.
Mall TK; Dow AgroSciences LLC, Indianapolis, IN, USA.
Marri PR; Dow AgroSciences LLC, Indianapolis, IN, USA.
Samuel JP; Dow AgroSciences LLC, Indianapolis, IN, USA.
Sardesai N; Dow AgroSciences LLC, Indianapolis, IN, USA.
Simpson M; Dow AgroSciences LLC, Indianapolis, IN, USA.
Folkerts O; Dow AgroSciences LLC, Indianapolis, IN, USA.
Sarria R; Dow AgroSciences LLC, Indianapolis, IN, USA.
Webb SR; Dow AgroSciences LLC, Indianapolis, IN, USA.
Gonzalez DO; Dow AgroSciences LLC, Indianapolis, IN, USA.
Simmonds DH; Agriculture and Agri-Food Canada, Ottawa, ON, Canada.
Pareddy DR; Dow AgroSciences LLC, Indianapolis, IN, USA.
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Źródło:
Plant biotechnology journal [Plant Biotechnol J] 2019 Apr; Vol. 17 (4), pp. 750-761. Date of Electronic Publication: 2018 Oct 15.
Typ publikacji:
Journal Article
MeSH Terms:
DNA End-Joining Repair*
Gene Editing*
Gene Targeting*
Glycine max/*genetics
Zinc Finger Nucleases/*metabolism
DNA Breaks, Double-Stranded ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Somatic Embryogenesis Techniques ; Plants, Genetically Modified ; Recombinational DNA Repair ; Glycine max/embryology ; Glycine max/enzymology ; Transformation, Genetic ; Transgenes ; Zinc Finger Nucleases/genetics
Czasopismo naukowe
Tytuł:
New Advances in Using Virus-like Particles and Related Technologies for Eukaryotic Genome Editing Delivery.
Autorzy:
Lyu P; School of Physical Education, Hangzhou Normal University, Hangzhou 311121, China.
Lu B; Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 06; Vol. 23 (15). Date of Electronic Publication: 2022 Aug 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
CRISPR-Cas Systems*/genetics
Gene Editing*/methods
Animals ; Endonucleases/metabolism ; Eukaryota/genetics ; Zinc Finger Nucleases/genetics
Czasopismo naukowe
Tytuł:
Gene knockout in cellular immunotherapy: Application and limitations.
Autorzy:
Zhang X; School of Medicine, Nankai University, Tianjin, China.
Jin X; Department of Hematology, Tianjin First Central Hospital, Tianjin, China.
Sun R; School of Medicine, Nankai University, Tianjin, China.
Zhang M; First Central Clinical College, Tianjin Medical University, Tianjin, China.
Lu W; Department of Hematology, Tianjin First Central Hospital, Tianjin, China. Electronic address: .
Zhao M; School of Medicine, Nankai University, Tianjin, China; Department of Hematology, Tianjin First Central Hospital, Tianjin, China. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2022 Aug 01; Vol. 540, pp. 215736. Date of Electronic Publication: 2022 May 13.
Typ publikacji:
Journal Article; Review
MeSH Terms:
CRISPR-Cas Systems*
Gene Editing*
Gene Knockout Techniques ; Humans ; Immunotherapy, Adoptive ; Zinc Finger Nucleases/genetics
Czasopismo naukowe
Tytuł:
Genetic Kidney Diseases (GKDs) Modeling Using Genome Editing Technologies.
Autorzy:
Gómez-García F; Laboratorio de Nefroloxía (No. 11), Grupo de Xenética e Bioloxía do Desenvolvemento das Enfermidades Renais, Instituto de Investigación Sanitaria de Santiago (IDIS), Complexo Hospitalario de Santiago de Compostela (CHUS), 15706 Santiago de Compostela, Spain.; Grupo de Medicina Xenómica, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), 15706 Santiago de Compostela, Spain.
Martínez-Pulleiro R; Laboratorio de Nefroloxía (No. 11), Grupo de Xenética e Bioloxía do Desenvolvemento das Enfermidades Renais, Instituto de Investigación Sanitaria de Santiago (IDIS), Complexo Hospitalario de Santiago de Compostela (CHUS), 15706 Santiago de Compostela, Spain.; Grupo de Medicina Xenómica, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), 15706 Santiago de Compostela, Spain.
Carrera N; Laboratorio de Nefroloxía (No. 11), Grupo de Xenética e Bioloxía do Desenvolvemento das Enfermidades Renais, Instituto de Investigación Sanitaria de Santiago (IDIS), Complexo Hospitalario de Santiago de Compostela (CHUS), 15706 Santiago de Compostela, Spain.
Allegue C; Grupo de Medicina Xenómica, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), 15706 Santiago de Compostela, Spain.
Garcia-Gonzalez MA; Laboratorio de Nefroloxía (No. 11), Grupo de Xenética e Bioloxía do Desenvolvemento das Enfermidades Renais, Instituto de Investigación Sanitaria de Santiago (IDIS), Complexo Hospitalario de Santiago de Compostela (CHUS), 15706 Santiago de Compostela, Spain.; Fundación Pública Galega de Medicina Xenómica-SERGAS, Complexo Hospitalario de Santiago de Compostela (CHUS), 15706 Santiago de Compostela, Spain.
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Źródło:
Cells [Cells] 2022 May 06; Vol. 11 (9). Date of Electronic Publication: 2022 May 06.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Editing*/methods
Kidney Diseases*/genetics
Kidney Diseases*/therapy
Animals ; CRISPR-Cas Systems/genetics ; Endonucleases/genetics ; Female ; Humans ; Male ; Zinc Finger Nucleases
Czasopismo naukowe
Tytuł:
Diversifying the structure of zinc finger nucleases for high-precision genome editing.
Autorzy:
Paschon DE; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Lussier S; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Wangzor T; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Xia DF; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Li PW; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Hinkley SJ; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Scarlott NA; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Lam SC; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Waite AJ; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Truong LN; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Gandhi N; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Kadam BN; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Patil DP; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Shivak DA; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Lee GK; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Holmes MC; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Zhang L; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Miller JC; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA.
Rebar EJ; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Suite A100, Richmond, California, 94804, USA. .
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Źródło:
Nature communications [Nat Commun] 2019 Mar 08; Vol. 10 (1), pp. 1133. Date of Electronic Publication: 2019 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Genome, Human*
Deoxyribonucleases, Type II Site-Specific/*genetics
Gene Editing/*methods
Protein Engineering/*methods
Zinc Finger Nucleases/*genetics
Base Pairing ; Base Sequence ; DNA-Directed RNA Polymerases/genetics ; DNA-Directed RNA Polymerases/metabolism ; Deoxyribonucleases, Type II Site-Specific/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Genetic Loci ; Genomic Library ; Humans ; INDEL Mutation ; K562 Cells ; Peptide Library ; Plasmids/chemistry ; Plasmids/metabolism ; Transformation, Genetic ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Zinc Finger Nucleases/metabolism
Czasopismo naukowe
Tytuł:
ZFN-Mediated In Vivo Genome Editing Corrects Murine Hurler Syndrome.
Autorzy:
Ou L; Gene Therapy Center, University of Minnesota, Minneapolis, MN, USA.
DeKelver RC; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
Rohde M; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
Tom S; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
Radeke R; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
St Martin SJ; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
Santiago Y; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
Sproul S; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
Przybilla MJ; Center for Genome Engineering, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
Koniar BL; Research Animal Resources, University of Minnesota, Minneapolis, MN, USA.
Podetz-Pedersen KM; Center for Genome Engineering, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
Laoharawee K; Center for Genome Engineering, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
Cooksley RD; Gene Therapy Center, University of Minnesota, Minneapolis, MN, USA.
Meyer KE; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
Holmes MC; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
McIvor RS; Center for Genome Engineering, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.
Wechsler T; Sangamo Therapeutics, Inc., 501 Canal Boulevard, Richmond, CA, USA.
Whitley CB; Gene Therapy Center, University of Minnesota, Minneapolis, MN, USA. Electronic address: .
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Źródło:
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2019 Jan 02; Vol. 27 (1), pp. 178-187. Date of Electronic Publication: 2018 Nov 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Editing/*methods
Genetic Therapy/*methods
Mucopolysaccharidosis I/*therapy
Zinc Finger Nucleases/*metabolism
Animals ; Disease Models, Animal ; Enzyme Replacement Therapy ; Female ; Glycosaminoglycans/metabolism ; Iduronidase/metabolism ; Lysosomal Storage Diseases/drug therapy ; Lysosomal Storage Diseases/metabolism ; Lysosomal Storage Diseases/therapy ; Male ; Mice ; Mucopolysaccharidosis I/drug therapy ; Mucopolysaccharidosis I/metabolism ; Zinc Finger Nucleases/genetics
Czasopismo naukowe
Tytuł:
Making ends meet: targeted integration of DNA fragments by genome editing.
Autorzy:
Yamamoto Y; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University Division of Biology and Medicine, Sidney Frank Hall room 260, 185 Meeting Street, Providence, RI, 02912, USA.
Gerbi SA; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University Division of Biology and Medicine, Sidney Frank Hall room 260, 185 Meeting Street, Providence, RI, 02912, USA. Susan_.
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Źródło:
Chromosoma [Chromosoma] 2018 Dec; Vol. 127 (4), pp. 405-420. Date of Electronic Publication: 2018 Jul 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:
CRISPR-Cas Systems*
DNA Repair*
Gene Editing/*methods
Transcription Activator-Like Effector Nucleases/*genetics
Zinc Finger Nucleases/*genetics
Animals ; Chromosomes ; DNA ; DNA Breaks, Double-Stranded ; DNA End-Joining Repair ; Genome ; Humans ; Plasmids/genetics ; RNA, Guide, CRISPR-Cas Systems ; Recombination, Genetic ; Zinc Finger Nucleases/metabolism
Czasopismo naukowe
Tytuł:
Recent Advances in the Production of Genome-Edited Rats.
Autorzy:
Sato M; Department of Genome Medicine, National Center for Child Health and Development, Tokyo 157-8535, Japan.
Nakamura S; Division of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
Inada E; Department of Pediatric Dentistry, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.
Takabayashi S; Laboratory Animal Facilities & Services, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 25; Vol. 23 (5). Date of Electronic Publication: 2022 Feb 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
CRISPR-Cas Systems*/genetics
Nucleic Acids*
Animals ; Female ; Gene Editing/methods ; Genome/genetics ; Humans ; Rats ; Transcription Activator-Like Effector Nucleases/genetics ; Zinc Finger Nucleases/genetics
Czasopismo naukowe
Tytuł:
Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size.
Autorzy:
Shaltz S; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Jinks-Robertson S; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: .
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Źródło:
DNA repair [DNA Repair (Amst)] 2021 Dec; Vol. 108, pp. 103228. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae*/metabolism
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
DNA End-Joining Repair ; DNA Repair ; Mutagens/metabolism ; Zinc Finger Nucleases/genetics ; Zinc Finger Nucleases/metabolism
Czasopismo naukowe
Tytuł:
Recent Advances in CRISPR/Cas9-Based Genome Editing Tools for Cardiac Diseases.
Autorzy:
Schreurs J; Department of Molecular Genetics, Faculty of Health, Medicine and Life Sciences, Faculty of Science and Engineering, Maastricht University, ER 6229 Maastricht, The Netherlands.
Sacchetto C; Department of Molecular Genetics, Faculty of Health, Medicine and Life Sciences, Faculty of Science and Engineering, Maastricht University, ER 6229 Maastricht, The Netherlands.
Colpaert RMW; Department of Molecular Genetics, Faculty of Health, Medicine and Life Sciences, Faculty of Science and Engineering, Maastricht University, ER 6229 Maastricht, The Netherlands.
Vitiello L; Department of Biology, University of Padova, 35131 Padova, Italy.
Rampazzo A; Department of Biology, University of Padova, 35131 Padova, Italy.
Calore M; Department of Molecular Genetics, Faculty of Health, Medicine and Life Sciences, Faculty of Science and Engineering, Maastricht University, ER 6229 Maastricht, The Netherlands.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 12; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
CRISPR-Cas Systems/*genetics
Gene Editing/*methods
Heart Diseases/*genetics
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Animals ; Heart Diseases/pathology ; Humans ; Models, Biological ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; RNA, Guide, CRISPR-Cas Systems/metabolism ; Zinc Finger Nucleases/genetics ; Zinc Finger Nucleases/metabolism
Czasopismo naukowe

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