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Tytuł:
N-Type Ca Channel in Epileptic Syndromes and Epilepsy: A Systematic Review of Its Genetic Variants.
Autorzy:
Mayo S; Genetics and Inheritance Research Group, Instituto de Investigación Sanitaria Hospital 12 de Octubre, 28041 Madrid, Spain.; Department of Genetics, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Gómez-Manjón I; Genetics and Inheritance Research Group, Instituto de Investigación Sanitaria Hospital 12 de Octubre, 28041 Madrid, Spain.; Department of Genetics, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Marco-Hernández AV; Neuropediatric Unit, Hospital Universitario Doctor Peset, 46017 Valencia, Spain.; Translational Research in Genetics, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.
Fernández-Martínez FJ; Genetics and Inheritance Research Group, Instituto de Investigación Sanitaria Hospital 12 de Octubre, 28041 Madrid, Spain.; Department of Genetics, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Camacho A; Division of Pediatric Neurology, Department of Neurology, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Martínez F; Translational Research in Genetics, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.; Genomic Unit, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain.; Genetics Unit, Hospital Universitario y Politecnico La Fe, 46026 Valencia, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 23; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Calcium Channels, N-Type*
Epilepsy*/genetics
Epileptic Syndromes*
Humans ; Calcium/metabolism ; Neurons/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulation of N-type calcium channels by nociceptin receptors and its possible role in neurological disorders.
Autorzy:
Caminski ES; Graduate Program in Health Sciences, Laboratory of Research in Toxicology (LAPETOX), Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.
Antunes FTT; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Souza IA; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Dallegrave E; Graduate Program in Health Sciences, Laboratory of Research in Toxicology (LAPETOX), Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.
Zamponi GW; Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. .; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. .
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Źródło:
Molecular brain [Mol Brain] 2022 Nov 24; Vol. 15 (1), pp. 95. Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels, N-Type*
Nervous System Diseases*
Humans ; Analgesics, Opioid ; Calcium ; Nociceptin Receptor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The de novo CACNA1A pathogenic variant Y1384C associated with hemiplegic migraine, early onset cerebellar atrophy and developmental delay leads to a loss of Cav2.1 channel function.
Autorzy:
Gandini MA; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Souza IA; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Ferron L; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Innes AM; Department of Medical Genetics and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.
Zamponi GW; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. .
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Źródło:
Molecular brain [Mol Brain] 2021 Feb 08; Vol. 14 (1), pp. 27. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Calcium Channels, N-Type/*genetics
Cerebellum/*pathology
Developmental Disabilities/*genetics
Migraine with Aura/*genetics
Mutation/*genetics
Adolescent ; Adult ; Alternative Splicing/genetics ; Atrophy ; Biophysical Phenomena ; Calcium Channels, N-Type/chemistry ; Calcium Channels, N-Type/metabolism ; Cell Line ; Child, Preschool ; Developmental Disabilities/complications ; Female ; Humans ; Infant, Newborn ; Ion Channel Gating ; Male ; Migraine with Aura/complications ; Models, Molecular ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Protein Isoforms/genetics ; Protein Structure, Secondary ; Structural Homology, Protein
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain.
Autorzy:
Hasan MM; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia.
Ragnarsson L; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia.
Cardoso FC; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia.
Lewis RJ; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld, Australia.
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Źródło:
PloS one [PLoS One] 2021 Mar 05; Vol. 16 (3), pp. e0243645. Date of Electronic Publication: 2021 Mar 05 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels, N-Type/*genetics
NAV1.7 Voltage-Gated Sodium Channel/*genetics
Transfection/*methods
Action Potentials/drug effects ; Analgesics/pharmacology ; Animals ; CHO Cells ; Calcium Channels, N-Type/metabolism ; Cricetinae ; Cricetulus ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; Microscopy, Fluorescence ; NAV1.7 Voltage-Gated Sodium Channel/metabolism ; Pain/metabolism ; Pain/pathology ; Patch-Clamp Techniques
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison of effects of L/N-type and L-type calcium channel blockers on post-infarct cardiac remodelling in spontaneously hypertensive rats.
Autorzy:
Naseratun N; Department of Clinical Pharmacology, Division of Pathological Science, Kyoto Pharmaceutical University, Kyoto, Japan.
Kobara M; Department of Clinical Pharmacology, Division of Pathological Science, Kyoto Pharmaceutical University, Kyoto, Japan.
Watanabe Y; Department of Clinical Pharmacology, Division of Pathological Science, Kyoto Pharmaceutical University, Kyoto, Japan.
Toba H; Department of Clinical Pharmacology, Division of Pathological Science, Kyoto Pharmaceutical University, Kyoto, Japan.
Nakata T; Department of Clinical Pharmacology, Division of Pathological Science, Kyoto Pharmaceutical University, Kyoto, Japan.
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2020 Sep; Vol. 47 (9), pp. 1545-1553. Date of Electronic Publication: 2020 May 25.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amlodipine/*pharmacology
Antihypertensive Agents/*pharmacology
Calcium Channel Blockers/*pharmacology
Calcium Channels, L-Type/*drug effects
Calcium Channels, N-Type/*drug effects
Calcium Signaling/*drug effects
Dihydropyridines/*pharmacology
Heart Ventricles/*drug effects
Hypertension/*drug therapy
Myocardial Infarction/*drug therapy
Ventricular Function, Left/*drug effects
Ventricular Remodeling/*drug effects
Animals ; Blood Pressure/drug effects ; Calcium Channels, L-Type/metabolism ; Calcium Channels, N-Type/metabolism ; Disease Models, Animal ; Heart Ventricles/metabolism ; Heart Ventricles/physiopathology ; Hypertension/complications ; Hypertension/physiopathology ; Male ; Myocardial Infarction/complications ; Myocardial Infarction/metabolism ; Myocardial Infarction/physiopathology ; Norepinephrine/metabolism ; Rats, Inbred SHR ; Renin-Angiotensin System/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cav2.1 C-terminal fragments produced in Xenopus laevis oocytes do not modify the channel expression and functional properties.
Autorzy:
Ménard C; Institut des Biomolécules Max Mousseron (IBMM), Montpellier, France.; IBMM, Université de Montpellier, Montpellier, France.
Charnet P; Institut des Biomolécules Max Mousseron (IBMM), Montpellier, France.; IBMM, Université de Montpellier, Montpellier, France.
Rousset M; Institut des Biomolécules Max Mousseron (IBMM), Montpellier, France.; IBMM, Université de Montpellier, Montpellier, France.
Vignes M; Institut des Biomolécules Max Mousseron (IBMM), Montpellier, France.; IBMM, Université de Montpellier, Montpellier, France.
Cens T; Institut des Biomolécules Max Mousseron (IBMM), Montpellier, France.; IBMM, Université de Montpellier, Montpellier, France.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2020 May; Vol. 51 (9), pp. 1900-1913. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels, N-Type*/genetics
Oocytes*
Animals ; Mice ; Protein Isoforms/genetics ; Rats ; Xenopus laevis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional implications of Ca v 2.3 R-type voltage-gated calcium channels in the murine auditory system - novel vistas from brainstem-evoked response audiometry.
Autorzy:
Lundt A; Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
Soós J; Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
Seidel R; Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
Henseler C; Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
Müller R; Cognitive Neurophysiology, Department of Psychiatry and Psychotherapy and University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.
Raj Ginde V; Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
Imran Arshaad M; Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
Ehninger D; Molecular and Cellular Cognition, German Center for Neurodegenerative Diseases, (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE), Bonn, Germany.
Hescheler J; Institute of Neurophysiology, Faculty of Medicine, University of Cologne, Cologne, Germany.
Sachinidis A; Institute of Neurophysiology, Faculty of Medicine, University of Cologne, Cologne, Germany.
Broich K; Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
Wormuth C; Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
Papazoglou A; Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
Weiergräber M; Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Bonn, Germany.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2020 Apr; Vol. 51 (7), pp. 1583-1604. Date of Electronic Publication: 2019 Nov 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Audiometry, Evoked Response*
Auditory Threshold*
Calcium Channels, N-Type*
Evoked Potentials, Auditory, Brain Stem*
Acoustic Stimulation ; Animals ; Brain Stem ; Calcium Channels ; Female ; Male ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors.
Autorzy:
Gandini MA; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Souza IA; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Raval D; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Xu J; Department of Neurology and the Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Pan YX; Department of Neurology and the Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Zamponi GW; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. .
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Źródło:
Molecular brain [Mol Brain] 2019 Nov 27; Vol. 12 (1), pp. 98. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alternative Splicing/*genetics
Calcium Channels, N-Type/*genetics
Exons/*genetics
Receptors, Opioid, mu/*genetics
Animals ; Calcium Channels, N-Type/metabolism ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology ; GTP-Binding Proteins/metabolism ; Ion Channel Gating/genetics ; Mice ; Protein-Tyrosine Kinases/metabolism ; Rats ; Receptors, Opioid, mu/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli.
Autorzy:
Bunda A; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
LaCarubba B; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Bertolino M; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Akiki M; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Bath K; Department of Cognitive, Linguistic and Psychological Sciences, Brown University, 190 Thayer Street, Providence, RI, 02912, USA.
Lopez-Soto J; Robert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, 185 Meeting Street, Providence, RI, 02912, USA.
Lipscombe D; Robert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, 185 Meeting Street, Providence, RI, 02912, USA.
Andrade A; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA. .
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Źródło:
Molecular brain [Mol Brain] 2019 Oct 21; Vol. 12 (1), pp. 81. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Behavior, Animal*
Alternative Splicing/*genetics
Calcium Channels, N-Type/*genetics
Synaptic Transmission/*genetics
Animals ; Brain/metabolism ; Calcium Channels, N-Type/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Female ; Gene Expression Regulation ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Physical Stimulation ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Synapses/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Attenuation of renal fibrosis after unilateral ureteral obstruction in mice lacking the N-type calcium channel.
Autorzy:
Mishima K; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Nakasatomi M; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Takahashi S; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Ikeuchi H; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Sakairi T; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Kaneko Y; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Hiromura K; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Nojima Y; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Maeshima A; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
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Źródło:
PloS one [PLoS One] 2019 Oct 09; Vol. 14 (10), pp. e0223496. Date of Electronic Publication: 2019 Oct 09 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels, N-Type/*deficiency
Kidney Diseases/*metabolism
Actins/genetics ; Actins/metabolism ; Animals ; Calcium Channels, N-Type/genetics ; Cell Hypoxia ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Fibrosis ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/etiology ; Kidney Diseases/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Tyrosine 3-Monooxygenase/genetics ; Tyrosine 3-Monooxygenase/metabolism ; Ureteral Obstruction/complications
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Presynaptic Calcium Channels.
Autorzy:
Mochida S; Department of Physiology, Tokyo Medical University, Tokyo 160-8402, Japan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 May 06; Vol. 20 (9). Date of Electronic Publication: 2019 May 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Calcium Channels, N-Type/*metabolism
Presynaptic Terminals/*metabolism
Animals ; Calcium Channels, N-Type/genetics ; Calcium-Binding Proteins/metabolism ; Humans ; Presynaptic Terminals/physiology ; Synaptic Potentials
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Drosophila CaV2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca2+ store release pathway.
Autorzy:
Brusich DJ; Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Spring AM; Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.; Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, United States of America.
James TD; Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, United States of America.
Yeates CJ; Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, United States of America.
Helms TH; Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Frank CA; Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.; Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, United States of America.; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2018 Aug 06; Vol. 14 (8), pp. e1007577. Date of Electronic Publication: 2018 Aug 06 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium/*metabolism
Calcium Channels, N-Type/*genetics
Cerebellar Ataxia/*genetics
Drosophila melanogaster/*genetics
Migraine Disorders/*genetics
Synapses/*physiology
Amino Acid Sequence ; Animals ; Calcium Channels, N-Type/metabolism ; Cerebellar Ataxia/metabolism ; Drosophila melanogaster/metabolism ; Humans ; Migraine Disorders/metabolism ; Mutation ; Neuromuscular Junction/physiology ; Neurons/physiology ; Phenotype ; Synaptic Transmission ; Transgenes
SCR Disease Name:
Hemiplegic migraine, familial type 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Environmental Enrichment Enhances Ca v 2.1 Channel-Mediated Presynaptic Plasticity in Hypoxic-Ischemic Encephalopathy.
Autorzy:
Song SY; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Graduate Program of NanoScience and Technology, Yonsei University, Seoul 03722, Korea.
Pyo S; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea.
Choi S; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Department of Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Oh HS; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Department of Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Seo JH; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Yu JH; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Baek A; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Department of Rehabilitation Medicine, Yonsei University Wonju College of Medicine, Wonju 26493, Korea.
Shin YK; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Lee HY; Department of Medicine, the Graduate School of Yonsei University, Seoul 03722, Korea.; TBI Rehabilitation Center, National Traffic Injury Rehabilitation Hospital, Gyeonggi-do, Yangpyeong 12564, Korea.; Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul University College of Medicine, Seoul 03080, Korea.; National Traffic Injury Rehabilitation Research Institute, National Traffic Injury Rehabilitation Hospital, Yangpyeong 12564, Korea.
Choi JY; Department of Rehabilitation Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon 35015, Korea.
Cho SR; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Graduate Program of NanoScience and Technology, Yonsei University, Seoul 03722, Korea.; Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea.; Rehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Seoul 03722, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 26; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 26.
Typ publikacji:
Journal Article
MeSH Terms:
Environment*
Neuronal Plasticity*
Perception*
Calcium Channels, N-Type/*metabolism
Hypoxia-Ischemia, Brain/*metabolism
Animals ; Cerebral Cortex/metabolism ; Cognition ; Hippocampus/metabolism ; Hypoxia-Ischemia, Brain/physiopathology ; Hypoxia-Ischemia, Brain/therapy ; Locomotion ; Male ; Mice ; Mice, Inbred ICR ; Spatial Learning
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.
Autorzy:
Ohno S; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yokoi H; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Mori K; Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kasahara M; Institute for Clinical and Translational Science, Nara Medical University Hospital, Kashihara, Japan.
Kuwahara K; Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Fujikura J; Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Naito M; Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kuwabara T; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Imamaki H; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ishii A; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Saleem MA; Children's Renal Unit, Bristol Royal Hospital for Children, University of Bristol, Bristol, UK.
Numata T; Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engineering, Kyoto, Japan.; Department of Physiology, Fukuoka University Graduate School of Medical Sciences, Fukuoka, Japan.
Mori Y; Department of Synthetic Chemistry and Biological Chemistry, Kyoto University Graduate School of Engineering, Kyoto, Japan.
Nakao K; Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yanagita M; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Mukoyama M; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.; Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
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Źródło:
Scientific reports [Sci Rep] 2016 Jun 07; Vol. 6, pp. 27192. Date of Electronic Publication: 2016 Jun 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood Glucose/*metabolism
Blood Pressure/*drug effects
Calcium Channels, N-Type/*genetics
Diabetic Nephropathies/*drug therapy
omega-Conotoxins/*administration & dosage
Animals ; Blood Glucose/drug effects ; Calcium Channels, N-Type/drug effects ; Calcium Channels, N-Type/metabolism ; Cells, Cultured ; Diabetes Mellitus, Experimental ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/physiopathology ; Disease Models, Animal ; Gene Knockout Techniques ; Kidney Tubules, Distal/cytology ; Kidney Tubules, Distal/metabolism ; Mice ; Podocytes/cytology ; Podocytes/metabolism ; omega-Conotoxins/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α 2 δ-1 subunit.
Autorzy:
Kadurin I; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
Rothwell SW; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
Lana B; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
Nieto-Rostro M; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
Dolphin AC; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
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Źródło:
Scientific reports [Sci Rep] 2017 Mar 03; Vol. 7, pp. 43802. Date of Electronic Publication: 2017 Mar 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels, N-Type/*metabolism
Cell Membrane/*metabolism
LDL-Receptor Related Protein-Associated Protein/*metabolism
Low Density Lipoprotein Receptor-Related Protein-1/*metabolism
Amines/metabolism ; Animals ; Calcium Channels, N-Type/genetics ; Cell Line ; Cyclohexanecarboxylic Acids/metabolism ; Gabapentin ; Humans ; LDL-Receptor Related Protein-Associated Protein/genetics ; Low Density Lipoprotein Receptor-Related Protein-1/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Mutation ; Protein Binding ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Protein Transport ; Radioligand Assay ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CACNA1B (Ca v 2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
Autorzy:
Zhou X; Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China; Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Wang W; Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Zhang S; Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Wang X; Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Tang Z; Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Gu J; Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China; Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Li J; Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China; Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Huang J; Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
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Źródło:
Disease markers [Dis Markers] 2017; Vol. 2017, pp. 6136401. Date of Electronic Publication: 2017 Jan 03.
Typ publikacji:
Journal Article
MeSH Terms:
Biomarkers, Tumor/*metabolism
Calcium Channels, N-Type/*metabolism
Carcinoma, Non-Small-Cell Lung/*metabolism
Lung Neoplasms/*metabolism
Biomarkers, Tumor/genetics ; Calcium Channels, N-Type/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Deep Learning-Assisted High-Throughput Analysis of Freeze-Fracture Replica Images Applied to Glutamate Receptors and Calcium Channels at Hippocampal Synapses.
Autorzy:
Kleindienst D; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
Montanaro J; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
Bhandari P; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
Case MJ; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
Fukazawa Y; Department of Histological and Physiological Sciences, Faculty of Medical Science, University of Fukui, Yoshida, Fukui 910-1193, Japan.
Shigemoto R; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 14; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
Calcium Channels, N-Type/*metabolism
Hippocampus/*metabolism
Receptors, AMPA/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Synapses/*metabolism
Animals ; Deep Learning ; Dendrites/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron/methods ; Neuronal Plasticity/physiology ; Signal Transduction/physiology ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protein Kinase CK2 Controls Ca V 2.1-Dependent Calcium Currents and Insulin Release in Pancreatic β-Cells.
Autorzy:
Scheuer R; Department of Medical Biochemistry and Molecular Biology, Saarland University, Kirrberger Str., bldg. 44, D-66424 Homburg, Germany.
Philipp SE; Department of Experimental and Clinical Pharmacology and Toxicology, Saarland University Kirrberger Str., bldg. 45-46, D-66424 Homburg, Germany.
Becker A; Department of Experimental and Clinical Pharmacology and Toxicology, Saarland University Kirrberger Str., bldg. 45-46, D-66424 Homburg, Germany.
Nalbach L; Institute for Clinical & Experimental Surgery, Saarland University Kirrberger Str., bldg. 65, D-66424 Homburg, Germany.
Ampofo E; Institute for Clinical & Experimental Surgery, Saarland University Kirrberger Str., bldg. 65, D-66424 Homburg, Germany.
Montenarh M; Department of Medical Biochemistry and Molecular Biology, Saarland University, Kirrberger Str., bldg. 44, D-66424 Homburg, Germany.
Götz C; Department of Medical Biochemistry and Molecular Biology, Saarland University, Kirrberger Str., bldg. 44, D-66424 Homburg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jun 30; Vol. 21 (13). Date of Electronic Publication: 2020 Jun 30.
Typ publikacji:
Journal Article
MeSH Terms:
Calcium Channels, N-Type/*metabolism
Casein Kinase II/*metabolism
Insulin/*metabolism
Insulin-Secreting Cells/*enzymology
Animals ; Calcium/metabolism ; Cell Line ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
"Slow" Voltage-Dependent Inactivation of CaV2.2 Calcium Channels Is Modulated by the PKC Activator Phorbol 12-Myristate 13-Acetate (PMA).
Autorzy:
Zhu L; Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee, United States of America.
McDavid S; Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee, United States of America.
Currie KP; Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee, United States of America.
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Źródło:
PloS one [PLoS One] 2015 Jul 29; Vol. 10 (7), pp. e0134117. Date of Electronic Publication: 2015 Jul 29 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium Channels, N-Type/*metabolism
Protein Kinase C/*metabolism
Tetradecanoylphorbol Acetate/*pharmacology
Animals ; Calcium Channel Blockers/pharmacology ; Calcium Channels, N-Type/chemistry ; Calcium Channels, N-Type/genetics ; Calcium Signaling/drug effects ; Cattle ; Cells, Cultured ; Chromaffin Cells/drug effects ; Chromaffin Cells/metabolism ; Enzyme Activation/drug effects ; Guanosine Diphosphate/analogs & derivatives ; Guanosine Diphosphate/metabolism ; HEK293 Cells ; Humans ; Kinetics ; Patch-Clamp Techniques ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Thionucleotides/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.
Autorzy:
Benleulmi-Chaachoua A; Inserm, U1016, Institut Cochin, Paris, France.; CNRS UMR 8104, Paris, France.; Sorbonne Paris Cité, Université Paris Descartes, Paris, France.
Chen L; Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Sokolina K; Donnelly Centre, Department of Biochemistry, Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Wong V; Donnelly Centre, Department of Biochemistry, Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Jurisica I; Princess Margaret Cancer Centre, University Health Network and TECHNA Institute for the Advancement of Technology for Health, Toronto, ON, Canada.
Emerit MB; Sorbonne Paris Cité, Université Paris Descartes, Paris, France.; Centre de Psychiatrie et Neurosciences, INSERM U894, Paris, France.
Darmon M; Sorbonne Paris Cité, Université Paris Descartes, Paris, France.; Centre de Psychiatrie et Neurosciences, INSERM U894, Paris, France.
Espin A; Inserm, U1016, Institut Cochin, Paris, France.; CNRS UMR 8104, Paris, France.; Sorbonne Paris Cité, Université Paris Descartes, Paris, France.
Stagljar I; Donnelly Centre, Department of Biochemistry, Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Tafelmeyer P; Hybrigenics Services, Paris, France.
Zamponi GW; Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Delagrange P; IDR SERVIER, Croissy/Seine, France.
Maurice P; Inserm, U1016, Institut Cochin, Paris, France.; CNRS UMR 8104, Paris, France.; Sorbonne Paris Cité, Université Paris Descartes, Paris, France.
Jockers R; Inserm, U1016, Institut Cochin, Paris, France.; CNRS UMR 8104, Paris, France.; Sorbonne Paris Cité, Université Paris Descartes, Paris, France.
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Źródło:
Journal of pineal research [J Pineal Res] 2016 Jan; Vol. 60 (1), pp. 95-108. Date of Electronic Publication: 2015 Nov 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*metabolism
Calcium Channels, N-Type/*metabolism
Nerve Tissue Proteins/*metabolism
Presynaptic Terminals/*metabolism
Receptor, Melatonin, MT1/*metabolism
Calcium Channels, N-Type/genetics ; HEK293 Cells ; Humans ; Nerve Tissue Proteins/genetics ; Receptor, Melatonin, MT1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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