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Tytuł:
Bioinformatics-driven discovery of novel EGFR kinase inhibitors as anti-cancer therapeutics: In silico screening and in vitro evaluation.
Autorzy:
Radwan AA; Department of Pharmaceutics, Kayyli Chair for Pharmaceutical Industries, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.; Department King Faisal Specialized Hospital and Research Center, Cell Therapy & Immunobiology, Riyadh, Saudi Arabia.
Alanazi F; Department of Pharmaceutics, Kayyli Chair for Pharmaceutical Industries, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Al-Dhfyan A; Department King Faisal Specialized Hospital and Research Center, Cell Therapy & Immunobiology, Riyadh, Saudi Arabia.
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Źródło:
PloS one [PLoS One] 2024 Apr 16; Vol. 19 (4), pp. e0298326. Date of Electronic Publication: 2024 Apr 16 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/metabolism
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/metabolism
Humans ; ErbB Receptors/metabolism ; Ligands ; Protein Kinase Inhibitors/therapeutic use ; Mutation ; Computational Biology ; Drug Resistance, Neoplasm/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison of early patient-reported outcomes between uniportal thoracoscopic segmentectomy and wedge resection for peripheral small-sized non-small-cell lung cancer.
Autorzy:
Zhao Y; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
Liu W; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
Gao X; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
Zhang K; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Graduate School, Chengdu Medical college, Chengdu, 610041, Sichuan, China.
Dai W; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
Wei X; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
Zheng H; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
Lei C; School of Public Health, Chongqing Medical University, Chongqing, 400016, China.
Yu H; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China.
Shi Q; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.; School of Public Health, Chongqing Medical University, Chongqing, 400016, China.; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China.
Li Q; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China.
Xie T; Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, 610041, Sichuan, China. .
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Źródło:
Journal of cardiothoracic surgery [J Cardiothorac Surg] 2024 Apr 15; Vol. 19 (1), pp. 215. Date of Electronic Publication: 2024 Apr 15.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/surgery
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/surgery
Lung Neoplasms*/pathology
Humans ; Aftercare ; Neoplasm Staging ; Patient Discharge ; Pneumonectomy/methods ; Prospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anti-EGFR ScFv functionalized exosomes delivering LPCAT1 specific siRNAs for inhibition of lung cancer brain metastases.
Autorzy:
Jiang J; Department of Health Service, Base of Health Service, Air Force Medical University, Xi'an, China.; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.
Lu Y; Department of Respiratory and Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China. .
Chu J; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Air Force Medical University, Xi'an, China.
Zhang X; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Air Force Medical University, Xi'an, China.
Xu C; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.
Liu S; Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China.
Wan Z; Department of Hematology, Tangdu Hospital, Air Force Medical University, Xi'an, China.
Wang J; Basic Medicine School, Air Force Medical University, Xi'an, China.
Zhang L; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Air Force Medical University, Xi'an, China.
Liu K; Department of Health Service, Base of Health Service, Air Force Medical University, Xi'an, China.
Liu Z; Department of Health Service, Base of Health Service, Air Force Medical University, Xi'an, China.
Yang A; State Key Laboratory of Cancer Biology, Department of Immunology, Air Force Medical University, Xi'an, Shaanxi, 710032, China.
Ren X; Department of Respiratory and Critical Care Medicine, Shenzhen General Hospital, Shenzhen University, Shenzhen, China.
Zhang R; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Air Force Medical University, Xi'an, China. .; State Key Laboratory of Cancer Biology, Department of Immunology, Air Force Medical University, Xi'an, Shaanxi, 710032, China. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2024 Apr 08; Vol. 22 (1), pp. 159. Date of Electronic Publication: 2024 Apr 08.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Neoplasms*/therapy
Lung Neoplasms*/metabolism
Carcinoma, Non-Small-Cell Lung*/therapy
Carcinoma, Non-Small-Cell Lung*/metabolism
Exosomes*/metabolism
Brain Neoplasms*/therapy
Brain Neoplasms*/pathology
Animals ; Humans ; RNA, Small Interfering/pharmacology ; HEK293 Cells ; Cell Line, Tumor ; ErbB Receptors/genetics ; ErbB Receptors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Circ_0001786 facilitates gefitinib resistance and malignant progression in non-small cell lung cancer via miR-34b-5p/SRSF1.
Autorzy:
Ouyang K; Department of Medical Oncology, Huizhou Municipal Central Hospital of Guangdong Province, NO.41 North Eling Road, Huizhou, 516000, Guangdong Province, China.
Xie D; Department of Medical Oncology, Huizhou Municipal Central Hospital of Guangdong Province, NO.41 North Eling Road, Huizhou, 516000, Guangdong Province, China.
Liao H; Department of Medical Oncology, Huizhou Municipal Central Hospital of Guangdong Province, NO.41 North Eling Road, Huizhou, 516000, Guangdong Province, China.
He Y; Department of Medical Oncology, Huizhou Municipal Central Hospital of Guangdong Province, NO.41 North Eling Road, Huizhou, 516000, Guangdong Province, China.
Xiong H; Department of Medical Oncology, Huizhou Municipal Central Hospital of Guangdong Province, NO.41 North Eling Road, Huizhou, 516000, Guangdong Province, China. .
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Źródło:
Journal of cardiothoracic surgery [J Cardiothorac Surg] 2024 Apr 05; Vol. 19 (1), pp. 178. Date of Electronic Publication: 2024 Apr 05.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
MicroRNAs*/genetics
Humans ; Gefitinib/pharmacology ; Apoptosis ; Cell Proliferation ; Cell Line, Tumor ; Serine-Arginine Splicing Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
LTK mutations responsible for resistance to lorlatinib in non-small cell lung cancer harboring CLIP1-LTK fusion.
Autorzy:
Mori S; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan.
Izumi H; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan.
Araki M; Graduate School of Medicine, Kyoto University, Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.
Liu J; Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, 277-8577, Japan.
Tanaka Y; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan.
Kagawa Y; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan.
Sagae Y; Graduate School of Medicine, Kyoto University, Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.
Ma B; RIKEN Center for Computational Science, Kobe, Hyogo, 650-0047, Japan.
Isaka Y; RIKEN Center for Computational Science, Kobe, Hyogo, 650-0047, Japan.
Sasakura Y; RIKEN Center for Computational Science, Kobe, Hyogo, 650-0047, Japan.
Kumagai S; Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, 277-8577, Japan.
Sakae Y; Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, 277-8577, Japan.
Tanaka K; Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, 277-8577, Japan.
Shibata Y; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan.
Udagawa H; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan.
Matsumoto S; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan.
Yoh K; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan.
Okuno Y; Graduate School of Medicine, Kyoto University, Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.
Goto K; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577, Japan.
Kobayashi SS; Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, 277-8577, Japan. .; Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, 277-8561, Japan. .; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. .
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Źródło:
Communications biology [Commun Biol] 2024 Apr 04; Vol. 7 (1), pp. 412. Date of Electronic Publication: 2024 Apr 04.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Aminopyridines*
Lactams*
Pyrazoles*
Humans ; Anaplastic Lymphoma Kinase/genetics ; Anaplastic Lymphoma Kinase/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Lactams, Macrocyclic/pharmacology ; Lactams, Macrocyclic/therapeutic use ; Mutation ; Cytoskeletal Proteins/genetics ; Receptor Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mobocertinib in Patients with EGFR Exon 20 Insertion-Positive Non-Small Cell Lung Cancer (MOON): An International Real-World Safety and Efficacy Analysis.
Autorzy:
Illini O; Department of Respiratory and Critical Care Medicine, Klinik Floridsdorf, Vienna Healthcare Group, Bruenner Straße 68, A-1210 Vienna, Austria.; Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, A-1210 Vienna, Austria.
Saalfeld FC; Clinic for Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.; National Center for Tumor Diseases, 01307 Dresden, Germany.; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.
Christopoulos P; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Thoraxklinik and Translational Lung Research Center (TLRC), member of the German Center for Lung Research (DZL), Heidelberg University Hospital, 69126 Heidelberg, Germany.
Duruisseaux M; Respiratory Department and Early Phase, Louis Pradel Hospital, Hospices Civils de Lyon Cancer Institute, 69002 Lyon, France.; Oncopharmacology Laboratory, Cancer Research Center of Lyon, Unité Mixte de Recherche (UMR), Institut National de la Santé et de la Recherche Médicale (INSERM), 1052 Centre National de la Recherche Scientifique (CNRS), 5286 Lyon, France.; Université Claude Bernard, Université de Lyon, 69622 Villeurbanne cedex, France.
Vikström A; Department of Pulmonary Medicine, University Hospital Linköping, 58185 Linköping, Sweden.
Peled N; The Hemsely Cancer Center, Shaare Zedek Medical Center, Jerusalem 9103102, Israel.
Demedts I; Department of Pulmonary Diseases, AZ Delta, Deltalaan 1, 8800 Roeselare, Belgium.
Dudnik E; Head, Thoracic Oncology Service, Assuta Medical Centers, Tel-Aviv 6329302, Israel.; Faculty of Health Sciences, Ben-Gurion Unversity of the Negev, Be'er Sheva 84105, Israel.
Eisert A; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine and Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50937 Cologne, Germany.
Hashemi SMS; Department of Pulmonary Medicine, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, 1081 Amsterdam, The Netherlands.
Janzic U; Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.; Medical Oncology Unit, University Clinic Golnik, 4204 Golnik, Slovenia.
Kian W; The Hemsely Cancer Center, Shaare Zedek Medical Center, Jerusalem 9103102, Israel.; Institute of Oncology, Assuta Ashdod University Hospital, Ashdod 7747629, Israel.
Mohorcic K; Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Mohammed S; Kent Oncology Centre, Maidstone and Tunbridge Wells NHS Trust, Kent TN24QJ, UK.
Silvoniemi M; Department of Pulmonary Diseases, Turku University Hospital, University of Turku, 20014 Turku, Finland.
Rothschild SI; Center for Oncology & Hematology and Comprehensive Cancer Center, Cantonal Hospital Baden, 5404 Baden, Switzerland.
Schulz C; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department of Internal Medicine II, University Hospital, 93053 Regensburg, Germany.
Wesseler C; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department of Pneumology, Asklepios Tumorzentrum Hamburg, Klinikum Harburg, 21075 Hamburg, Germany.
Addeo A; Oncology Department, University Hospital Geneva, 1205 Geneva, Switzerland.
Armster K; Department of Pneumology, Universitätsklinikum Krems, 3500 Krems an der Donau, Austria.
Itchins M; Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.; Northern Clinical School, University of Sydney, St Leonards, NSW 2065, Australia.
Ivanović M; Department of Oncology, University Medical Centre Maribor, 2000 Maribor, Slovenia.
Kauffmann-Guerrero D; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Division of Respiratory Medicine and Thoracic Oncology, Department of Medicine V, Thoracic Oncology Center Munich, University Hospital, University of Munich (LMU), 81377 Munich, Germany.
Koivunen J; Department of Oncology and Radiotherapy, Oulu University Hospital, 90014 Oulu, Finland.; Cancer and Translational Medicine Research Unit, University of Oulu, 90014 Oulu, Finland.; Medical Research Center Oulu, 90014 Oulu, Finland.
Kuon J; Department Thoracic Oncology, SLK Fachklinik Löwenstein, 74245 Löwenstein, Germany.
Pavlakis N; Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.; Northern Clinical School, University of Sydney, St Leonards, NSW 2065, Australia.
Piet B; Department of Respiratory Medicine, Radboudumc, 6225 GA Nijmegen, The Netherlands.
Sebastian M; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department of Medicine, Hematology/Oncology, University Hospital, University of Frankfurt, 60596 Frankfurt am Main, Germany.
Velthaus-Rusik JL; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Wannesson L; Istituto Oncologico della Svizzera Italiana, 6500 Bellinzona, Switzerland.
Wiesweg M; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; West German Cancer Center, Department of Medical Oncology, University Duisburg-Essen, 45147 Essen, Germany.
Wurm R; Division of Pulmonology, Department of Internal Medicine, LKH-Universitätsklinikum, Medical University of Graz, 8036 Graz, Austria.
Albers-Leischner C; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Aust DE; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department for Pathology, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.
Janning M; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, 68167 Mannheim, Germany.; Department of Personalized Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.; Division of Personalized Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; German Center for Lung Research (DZL), 69120 Heidelberg, Germany.
Fabikan H; Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, A-1210 Vienna, Austria.
Herold S; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department for Pathology, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.
Klimova A; Core Unit for Data Management and Analytics, National Center for Tumor Diseases, 01307 Dresden, Germany.
Loges S; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, 68167 Mannheim, Germany.; Department of Personalized Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.; Division of Personalized Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; German Center for Lung Research (DZL), 69120 Heidelberg, Germany.
Sharapova Y; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; DKFZ-Hector Cancer Institute at the University Medical Center Mannheim, 68167 Mannheim, Germany.; Department of Personalized Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.; Division of Personalized Medical Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; German Center for Lung Research (DZL), 69120 Heidelberg, Germany.
Schütz M; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department for Pathology, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.
Weinlinger C; Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, A-1210 Vienna, Austria.
Valipour A; Department of Respiratory and Critical Care Medicine, Klinik Floridsdorf, Vienna Healthcare Group, Bruenner Straße 68, A-1210 Vienna, Austria.; Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, A-1210 Vienna, Austria.
Overbeck TR; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen University, 37075 Göttingen, Germany.
Griesinger F; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.; Department of Hematology and Oncology, Pius University Hospital, University Medicine Oldenburg, 26121 Oldenburg, Germany.
Jakopovic M; Department for Respiratory Diseases Jordanovac, University Hospital Center Zagreb, 10000 Zagreb, Croatia.; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Hochmair MJ; Department of Respiratory and Critical Care Medicine, Klinik Floridsdorf, Vienna Healthcare Group, Bruenner Straße 68, A-1210 Vienna, Austria.; Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, A-1210 Vienna, Austria.
Wermke M; Clinic for Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.; National Center for Tumor Diseases, 01307 Dresden, Germany.; National Network Genomic Medicine Lung Cancer (nNGM), 50937 Cologne, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 03; Vol. 25 (7). Date of Electronic Publication: 2024 Apr 03.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Aniline Compounds*
Indoles*
Pyrimidines*
Male ; Humans ; Female ; Aged ; ErbB Receptors/genetics ; Exons
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mesothelin promotes brain metastasis of non-small cell lung cancer by activating MET.
Autorzy:
Xia S; Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China.
Duan W; Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China.
Xu M; Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China.
Li M; Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China.
Tang M; Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China.
Wei S; Department of Oncology, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Lin M; Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China.
Li E; Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China. .
Liu W; Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China. .; Department of Scientific Research Center, The Second Hospital, Dalian Medical University, Dalian, China. .
Wang Q; Department of Respiratory Medicine, The Second Hospital, Dalian Medical University, Dalian, China. .; Department of Scientific Research Center, The Second Hospital, Dalian Medical University, Dalian, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Apr 03; Vol. 43 (1), pp. 103. Date of Electronic Publication: 2024 Apr 03.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/pathology
Brain Neoplasms*/pathology
Benzamides*
Imidazoles*
Triazines*
Humans ; Animals ; Mice ; Mesothelin ; GPI-Linked Proteins/metabolism ; Crizotinib ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.
Autorzy:
Lv M; Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China.
Li X; Department of Epidemiology, School of Public Health of China Medical University, Shenyang, China.
Yin Z; Department of Epidemiology, School of Public Health of China Medical University, Shenyang, China.
Yang H; Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China.
Zhou B; Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China.
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Źródło:
PloS one [PLoS One] 2024 Apr 02; Vol. 19 (4), pp. e0294227. Date of Electronic Publication: 2024 Apr 02 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/diagnosis
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/diagnosis
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Epstein-Barr Virus Infections*
Humans ; Herpesvirus 4, Human/metabolism ; Signal Transduction ; Neoplasm Proteins/genetics ; GTPase-Activating Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correlation of distribution characteristics and dynamic changes of gut microbiota with the efficacy of immunotherapy in EGFR-mutated non-small cell lung cancer.
Autorzy:
Luo WC; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Mei SQ; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Huang ZJ; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Chen ZH; Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Zhang YC; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Yang MY; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Liu JQ; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Xu JY; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Yang XR; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Zhong RW; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Tang LB; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Yin LX; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Deng Y; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Peng YL; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Lu C; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Chen BL; Xiamen Treatgut Biotechnology Co., Ltd, Xiamen, China.
Ke DX; Xiamen Treatgut Medical Laboratory Co., Ltd, Xiamen, China.
Tu HY; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Yang JJ; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Xu CR; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Wu YL; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Zhou Q; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Apr 02; Vol. 22 (1), pp. 326. Date of Electronic Publication: 2024 Apr 02.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/therapy
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/therapy
Lung Neoplasms*/drug therapy
Gastrointestinal Microbiome*
Humans ; Immunotherapy ; ErbB Receptors/genetics ; Anti-Bacterial Agents/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells.
Autorzy:
Lv S; The Fifth Affiliated Hospital,Guangdong Province & NMPA & State Key Laboratory,School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Pan Q; The Fifth Affiliated Hospital,Guangdong Province & NMPA & State Key Laboratory,School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Lu W; The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People's Hospital), Heyuan, 517000, China.
Zhang W; The Fifth Affiliated Hospital,Guangdong Province & NMPA & State Key Laboratory,School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Wang N; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Huang L; The Fifth Affiliated Hospital,Guangdong Province & NMPA & State Key Laboratory,School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Li L; The Fifth Affiliated Hospital,Guangdong Province & NMPA & State Key Laboratory,School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Liu J; The Fifth Affiliated Hospital,Guangdong Province & NMPA & State Key Laboratory,School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Ma J; Medicine and Health Science College, Guangzhou Huashang College, Guangzhou, People's Republic of China.
Li Z; The Fifth Affiliated Hospital,Guangdong Province & NMPA & State Key Laboratory,School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Huang Y; The Fifth Affiliated Hospital,Guangdong Province & NMPA & State Key Laboratory,School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Deng Q; GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China. .
Lei X; The Fifth Affiliated Hospital,Guangdong Province & NMPA & State Key Laboratory,School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 01; Vol. 14 (1), pp. 7654. Date of Electronic Publication: 2024 Apr 01.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/metabolism
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Ferroptosis*
Humans ; ErbB Receptors/metabolism ; Apoptosis ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Protein Kinase Inhibitors/pharmacology ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prognosis of non-small cell lung cancer with postoperative regional lymph node recurrence.
Autorzy:
Ohtaki Y; Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery, Integrative Center of General Surgery, Gunma University Hospital, Maebashi, Japan.
Nagashima T; Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery, Integrative Center of General Surgery, Gunma University Hospital, Maebashi, Japan.
Okano N; Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Kubo N; Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Ohtaka T; Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Sunaga N; Division of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine, Gunma University Hospital, Maebashi, Japan.
Sakurai R; Division of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine, Gunma University Hospital, Maebashi, Japan.
Miura Y; Division of Allergy and Respiratory Medicine, Integrative Center of Internal Medicine, Gunma University Hospital, Maebashi, Japan.
Nakazawa S; Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery, Integrative Center of General Surgery, Gunma University Hospital, Maebashi, Japan.
Kawatani N; Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery, Integrative Center of General Surgery, Gunma University Hospital, Maebashi, Japan.
Yazawa T; Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery, Integrative Center of General Surgery, Gunma University Hospital, Maebashi, Japan.
Yoshikawa R; Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery, Integrative Center of General Surgery, Gunma University Hospital, Maebashi, Japan.
Narusawa E; Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery, Integrative Center of General Surgery, Gunma University Hospital, Maebashi, Japan.
Shirabe K; Department of General Surgical Science, Gunma University Graduate School of Medicine, Division of General Thoracic Surgery, Integrative Center of General Surgery, Gunma University Hospital, Maebashi, Japan.
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Źródło:
Thoracic cancer [Thorac Cancer] 2024 Apr; Vol. 15 (11), pp. 859-866. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/surgery
Lung Neoplasms*/genetics
Lung Neoplasms*/surgery
Humans ; Retrospective Studies ; Protein-Tyrosine Kinases ; Neoplasm Recurrence, Local/pathology ; Proto-Oncogene Proteins ; Prognosis ; Lymph Nodes/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Quantitative modeling of tumor dynamics and development of drug resistance in non-small cell lung cancer patients treated with erlotinib.
Autorzy:
Yin A; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
Veerman GDM; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
van Hasselt JGC; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Steendam CMJ; Department of Pulmonary Diseases, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.; Department of Pulmonary Diseases, Catharina Hospital, Eindhoven, The Netherlands.
Dubbink HJ; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
Friberg LE; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Dingemans AC; Department of Pulmonary Diseases, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Mathijssen RHJ; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Moes DJAR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Apr; Vol. 13 (4), pp. 612-623. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Humans ; Erlotinib Hydrochloride/therapeutic use ; Erlotinib Hydrochloride/pharmacokinetics ; ErbB Receptors/genetics ; Drug Resistance, Neoplasm/genetics ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Co-Expression Network Analysis Unveiled lncRNA-mRNA Links Correlated to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance and/or Intermediate Epithelial-to-Mesenchymal Transition Phenotypes in a Human Non-Small Cell Lung Cancer Cellular Model System.
Autorzy:
Fustaino V; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Campus Adriano Buzzati Traverso, Via E. Ramarini 32, 00015 Monterotondo (Roma), Italy.
Papoff G; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Campus Adriano Buzzati Traverso, Via E. Ramarini 32, 00015 Monterotondo (Roma), Italy.
Ruberti F; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Campus Adriano Buzzati Traverso, Via E. Ramarini 32, 00015 Monterotondo (Roma), Italy.
Ruberti G; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Campus Adriano Buzzati Traverso, Via E. Ramarini 32, 00015 Monterotondo (Roma), Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 29; Vol. 25 (7). Date of Electronic Publication: 2024 Mar 29.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
RNA, Long Noncoding*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Humans ; Tyrosine Kinase Inhibitors ; ErbB Receptors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Immune checkpoint inhibitor plus chemotherapy as first-line treatment for non-small cell lung cancer with malignant pleural effusion: a retrospective multicenter study.
Autorzy:
Wei Q; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Deng T; Pulmonary and Critical Care Medicine, Guang 'an People's Hospital, Guang 'an, China.
Wu J; Respiratory and Critical Care Medicine, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, China.
Zeng H; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Qi C; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Tan S; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zhang Y; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Huang Q; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Pu X; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.; Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xu W; Respiratory and Critical Care Medicine, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, China.
Li W; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Tian P; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. .; Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China. .
Li Y; Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Center/Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. .; Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China. .
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Źródło:
BMC cancer [BMC Cancer] 2024 Mar 28; Vol. 24 (1), pp. 393. Date of Electronic Publication: 2024 Mar 28.
Typ publikacji:
Multicenter Study; Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/complications
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/complications
Lung Neoplasms*/drug therapy
Pleural Effusion, Malignant*/drug therapy
Pleural Effusion, Malignant*/pathology
Humans ; Male ; Middle Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Immune Checkpoint Inhibitors/adverse effects ; Retrospective Studies ; Female
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation.
Autorzy:
Florio A; Biomarker Discovery Laboratory, Center for Individualized Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Johnson S; Biomarker Discovery Laboratory, Center for Individualized Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Salvatori R; Biomarker Discovery Laboratory, Center for Individualized Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Vasmatzis G; Biomarker Discovery Laboratory, Center for Individualized Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. .; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 27; Vol. 14 (1), pp. 7303. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
MicroRNAs*/metabolism
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Antineoplastic Agents*/pharmacology
Adenocarcinoma of Lung*/drug therapy
Adenocarcinoma of Lung*/genetics
Humans ; Erlotinib Hydrochloride/pharmacology ; Erlotinib Hydrochloride/therapeutic use ; Feedback ; ErbB Receptors/metabolism ; Cell Line, Tumor ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Drug Resistance, Neoplasm ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC.
Autorzy:
Polcaro G; Oncology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Liguori L; Oncology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.; Oncology Unit, Department of Medicine, Surgery and Dentistry, University of Naples 'Federico II', Naples, 80131, Italy.
Manzo V; Clinical Pharmacology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.; University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy.
Chianese A; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy.
Donadio G; Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Caputo A; University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy.; Pathology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Scognamiglio G; Pathology Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, 80131, Italy.
Dell'Annunziata F; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy.
Langella M; Hematology and Transplant Unit, University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy.
Corbi G; Department of Translational Medical Sciences, University of Naples 'Federico II', Naples, 80131, Italy.
Ottaiano A; Division of Innovative Therapies for Abdominal Metastases, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, 80131, Italy.
Cascella M; Unit of Anesthesiology, Intensive Care Medicine, and Pain Medicine, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Perri F; Medical and Experimental Head and Neck Oncology Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, 80131, Italy.
De Marco M; Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Col JD; Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Nassa G; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Giurato G; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Zeppa P; University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy.; Pathology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Filippelli A; Clinical Pharmacology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.; University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy.
Franci G; University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy.; Clinical Microbiology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Piaz FD; University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy.; Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy.
Conti V; Clinical Pharmacology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy. .; University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy. .
Pepe S; Oncology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy. .; University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy. .
Sabbatino F; Oncology Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081, Italy. .; University Hospital 'San Giovanni di Dio e Ruggi d'Aragona', Salerno, 84131, Italy. .
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Źródło:
Molecular cancer [Mol Cancer] 2024 Mar 25; Vol. 23 (1), pp. 63. Date of Electronic Publication: 2024 Mar 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
B7-H1 Antigen*/genetics
B7-H1 Antigen*/metabolism
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/metabolism
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/metabolism
Humans ; Biomarkers ; CCAAT-Enhancer-Binding Protein-beta/genetics ; CCAAT-Enhancer-Binding Protein-beta/metabolism ; NFI Transcription Factors/metabolism ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Six-Gene Signature for Differential Diagnosis and Therapeutic Decisions in Non-Small-Cell Lung Cancer-A Validation Study.
Autorzy:
Charkiewicz R; Center of Experimental Medicine, Medical University of Bialystok, 15-369 Bialystok, Poland.; Department of Clinical Molecular Biology, Medical University of Bialystok, 15-269 Bialystok, Poland.
Sulewska A; Department of Clinical Molecular Biology, Medical University of Bialystok, 15-269 Bialystok, Poland.
Karabowicz P; Biobank, Medical University of Bialystok, 15-269 Bialystok, Poland.
Lapuc G; Department of Thoracic Surgery, Medical University of Bialystok, 15-269 Bialystok, Poland.
Charkiewicz A; Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, 15-089 Bialystok, Poland.
Kraska M; Department of Clinical Molecular Biology, Medical University of Bialystok, 15-269 Bialystok, Poland.; Department of Medical Pathomorphology, Medical University of Bialystok, 15-269 Bialystok, Poland.
Pancewicz J; Department of Histology and Embryology, Medical University of Bialystok, 15-269 Bialystok, Poland.
Lukasik M; Department of Histology and Embryology, Medical University of Bialystok, 15-269 Bialystok, Poland.
Kozlowski M; Department of Thoracic Surgery, Medical University of Bialystok, 15-269 Bialystok, Poland.
Stec R; Department of Oncology, Medical University of Warsaw, 02-091 Warsaw, Poland.
Ziembicka D; Department of Public Health, Medical University of Bialystok, 15-295 Bialystok, Poland.
Piszcz W; Department of Clinical Molecular Biology, Medical University of Bialystok, 15-269 Bialystok, Poland.
Miltyk W; Department of Analysis and Bioanalysis of Medicines, Medical University of Bialystok, 15-089 Bialystok, Poland.
Niklinska W; Department of Histology and Embryology, Medical University of Bialystok, 15-269 Bialystok, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 23; Vol. 25 (7). Date of Electronic Publication: 2024 Mar 23.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/diagnosis
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/therapy
Lung Neoplasms*/diagnosis
Lung Neoplasms*/genetics
Lung Neoplasms*/therapy
Adenocarcinoma*
Carcinoma, Squamous Cell*/diagnosis
Carcinoma, Squamous Cell*/genetics
Carcinoma, Squamous Cell*/therapy
Small Cell Lung Carcinoma*
Humans ; Diagnosis, Differential
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An epidermal growth factor receptor compound mutation of L858R with S768I in advanced non-small-cell lung cancer: a case report.
Autorzy:
Boukansa S; Laboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco. .; Laboratory of Anatomic Pathology and Molecular Pathology, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco. .
Mouhrach I; Unit of Medical Genetics and Oncogenetics, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
El Agy F; Laboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco.; Laboratory of Anatomic Pathology and Molecular Pathology, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Bouguenouch L; Unit of Medical Genetics and Oncogenetics, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Serraj M; Department of Pneumology, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Amara B; Department of Pneumology, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Ouadnouni Y; Department of Thoracic Surgery, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Smahi M; Department of Thoracic Surgery, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Alami B; Department of Radiology, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Mellas N; Department of Oncology, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Benbrahim Z; Department of Oncology, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
El Fatemi H; Laboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco.; Laboratory of Anatomic Pathology and Molecular Pathology, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
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Źródło:
Journal of medical case reports [J Med Case Rep] 2024 Mar 18; Vol. 18 (1), pp. 118. Date of Electronic Publication: 2024 Mar 18.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Humans ; Middle Aged ; Clinical Decision-Making ; ErbB Receptors/genetics ; ErbB Receptors/therapeutic use ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Tyrosine Kinase Inhibitors ; Uncertainty ; Male
Czasopismo naukowe
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