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Wyszukujesz frazę ""G2 Phase Cell Cycle Checkpoints"" wg kryterium: Wszystkie pola


Tytuł:
miR-17-5p drives G2/M-phase accumulation by directly targeting CCNG2 and is related to recurrence of head and neck squamous cell carcinoma.
Autorzy:
Huang Q; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Shen YJ; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Hsueh CY; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Guo Y; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Zhang YF; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Li JY; Department of Pediatric, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China.
Zhou L; Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. .
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Źródło:
BMC cancer [BMC Cancer] 2021 Oct 02; Vol. 21 (1), pp. 1074. Date of Electronic Publication: 2021 Oct 02.
Typ publikacji:
Journal Article
MeSH Terms:
G2 Phase Cell Cycle Checkpoints*
M Phase Cell Cycle Checkpoints*
Cyclin G2/*metabolism
Head and Neck Neoplasms/*metabolism
MicroRNAs/*metabolism
Neoplasm Recurrence, Local/*genetics
Squamous Cell Carcinoma of Head and Neck/*metabolism
3' Untranslated Regions/genetics ; Apoptosis/genetics ; Area Under Curve ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cyclin G2/genetics ; Down-Regulation ; Female ; Gene Silencing ; Head and Neck Neoplasms/genetics ; Humans ; Luciferases/metabolism ; Male ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Recurrence, Local/metabolism ; RNA, Messenger/metabolism ; Squamous Cell Carcinoma of Head and Neck/genetics ; Transfection ; Up-Regulation
Czasopismo naukowe
Tytuł:
Induction of G2/M Cell Cycle Arrest via p38/p21 -Dependent Signaling Pathway Activation by Bavachinin in Non-Small-Cell Lung Cancer Cells.
Autorzy:
Pai JT; Division of Hematology and Oncology, Tao-Yuan General Hospital, Ministry of Health and Welfare, Taoyuan City 33004, Taiwan.
Hsu MW; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Leu YL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.; Tissue Bank, Chang Gung Memorial Hospital, Linkou, Taoyuan City 33342, Taiwan.
Chang KT; Translational Medicine Center, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan City 33004, Taiwan.
Weng MS; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 25; Vol. 26 (17). Date of Electronic Publication: 2021 Aug 25.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cell Cycle Checkpoints/*drug effects
Flavonoids/*pharmacology
G2 Phase Cell Cycle Checkpoints/*drug effects
Lung Neoplasms/*drug therapy
Signal Transduction/*drug effects
A549 Cells ; Apoptosis/drug effects ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Cycle Checkpoints/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin B1 ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; G2 Phase Cell Cycle Checkpoints/genetics ; Humans ; Lung Neoplasms/genetics ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/genetics ; Signal Transduction/genetics ; p38 Mitogen-Activated Protein Kinases/genetics
Czasopismo naukowe
Tytuł:
Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle.
Autorzy:
Węgierek-Ciuk A; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Arabski M; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Ciepluch K; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Brzóska K; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
Lisowska H; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Czerwińska M; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
Stępkowski T; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.; Remedy International Research Agenda Unit, Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland.
Lis K; Holy Cross Cancer Center, Artwinskiego 3, 25-734 Kielce, Poland.
Lankoff A; Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.; Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 28; Vol. 22 (11). Date of Electronic Publication: 2021 May 28.
Typ publikacji:
Journal Article
MeSH Terms:
Berberine Alkaloids/*pharmacology
Cyclin-Dependent Kinase Inhibitor p21/*genetics
G2 Phase Cell Cycle Checkpoints/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Up-Regulation/*drug effects
A549 Cells ; Actin Cytoskeleton/drug effects ; Actin Cytoskeleton/radiation effects ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; G2 Phase Cell Cycle Checkpoints/radiation effects ; Humans ; Microscopy, Confocal ; Radiation, Ionizing ; Radiation-Sensitizing Agents/pharmacology
Czasopismo naukowe
Tytuł:
C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer.
Autorzy:
Ono H; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. .; Department of Surgery, College of Human Medicine, Michigan State University, Lansing, MI, USA. .
Kato T; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Murase Y; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Nakamura Y; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Ishikawa Y; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Watanabe S; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Akahoshi K; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Ogura T; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Ogawa K; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Ban D; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Kudo A; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Akiyama Y; Division of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tanaka S; Division of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Ito H; Department of Surgery, College of Human Medicine, Michigan State University, Lansing, MI, USA.
Tanabe M; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
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Źródło:
Scientific reports [Sci Rep] 2021 May 12; Vol. 11 (1), pp. 10078. Date of Electronic Publication: 2021 May 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
G2 Phase Cell Cycle Checkpoints*
Gene Expression Regulation, Neoplastic*
M Phase Cell Cycle Checkpoints*
Biomarkers, Tumor/*metabolism
Membrane Cofactor Protein/*metabolism
Aged ; Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Cycle ; Cell Proliferation ; Female ; Humans ; Male ; Mice ; Mice, Nude ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Prognosis ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Elevated TAB182 enhances the radioresistance of esophageal squamous cell carcinoma through G2-M checkpoint modulation.
Autorzy:
Cao Y; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, P.R. China.
Gao A; Suzhou Cancer Center Core Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, P.R. China.
Li X; Suzhou Cancer Center Core Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, P.R. China.
Min H; Suzhou Cancer Center Core Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, P.R. China.
He C; Suzhou Cancer Center Core Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, P.R. China.
Sun X; Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, P.R. China.
Ding WQ; Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
Zhou J; Suzhou Cancer Center Core Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, P.R. China.
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Źródło:
Cancer medicine [Cancer Med] 2021 May; Vol. 10 (9), pp. 3101-3112. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
G2 Phase Cell Cycle Checkpoints*
M Phase Cell Cycle Checkpoints*
Esophageal Neoplasms/*metabolism
Esophageal Squamous Cell Carcinoma/*metabolism
Radiation Tolerance/*physiology
Telomeric Repeat Binding Protein 1/*metabolism
Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Down-Regulation ; Esophageal Neoplasms/radiotherapy ; Esophageal Squamous Cell Carcinoma/radiotherapy ; Esophagus/metabolism ; Histones/analysis ; Humans ; LIM-Homeodomain Proteins/metabolism ; Molecular Targeted Therapy/methods ; Muscle Proteins/metabolism ; Postoperative Period ; Prognosis ; RNA, Small Interfering/metabolism ; Time Factors ; Transcription Factors/metabolism ; Treatment Failure
Czasopismo naukowe
Tytuł:
FRET-Based Sorting of Live Cells Reveals Shifted Balance between PLK1 and CDK1 Activities During Checkpoint Recovery.
Autorzy:
Lafranchi L; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Müllers E; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Rutishauser D; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.; Science for Life Laboratory, SE-171 65 Stockholm, Sweden.
Lindqvist A; Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
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Źródło:
Cells [Cells] 2020 Sep 19; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CDC2 Protein Kinase/*genetics
Cell Cycle Proteins/*genetics
Fibroblasts/*metabolism
G2 Phase Cell Cycle Checkpoints/*genetics
M Phase Cell Cycle Checkpoints/*genetics
Mitosis/*drug effects
Protein Serine-Threonine Kinases/*genetics
Proto-Oncogene Proteins/*genetics
ATPases Associated with Diverse Cellular Activities/genetics ; ATPases Associated with Diverse Cellular Activities/metabolism ; Aurora Kinase A/genetics ; Aurora Kinase A/metabolism ; CDC2 Protein Kinase/metabolism ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cyclin B1/genetics ; Cyclin B1/metabolism ; DNA Damage ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Flow Cytometry ; Fluorescence Resonance Energy Transfer ; G2 Phase Cell Cycle Checkpoints/drug effects ; Gene Expression Regulation ; Humans ; M Phase Cell Cycle Checkpoints/drug effects ; Phosphorylation ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Signal Transduction ; Tumor Suppressor p53-Binding Protein 1/genetics ; Tumor Suppressor p53-Binding Protein 1/metabolism ; Zinostatin/pharmacology ; Polo-Like Kinase 1
Czasopismo naukowe
Tytuł:
Biology of Glioblastoma Multiforme-Exploration of Mitotic Catastrophe as a Potential Treatment Modality.
Autorzy:
Vitovcova B; Department of Medical Biology and Genetics, Charles University Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
Skarkova V; Department of Medical Biology and Genetics, Charles University Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
Rudolf K; Department of Medical Biology and Genetics, Charles University Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
Rudolf E; Department of Medical Biology and Genetics, Charles University Faculty of Medicine in Hradec Kralove, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 27; Vol. 21 (15). Date of Electronic Publication: 2020 Jul 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Brain Neoplasms*/metabolism
Brain Neoplasms*/mortality
Brain Neoplasms*/pathology
Brain Neoplasms*/therapy
G2 Phase Cell Cycle Checkpoints*
Glioblastoma*/metabolism
Glioblastoma*/mortality
Glioblastoma*/therapy
M Phase Cell Cycle Checkpoints*
Mitosis*
Humans
Czasopismo naukowe
Tytuł:
G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer.
Autorzy:
Oshi M; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Takahashi H; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Tokumaru Y; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Surgical Oncology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.
Yan L; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Rashid OM; Department of Surgery, Holy Cross Hospital, Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale, FL 33308, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Matsuyama R; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Endo I; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Takabe K; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.; Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.; Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14263, USA.; Department of Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.; Department of Breast Surgery and Oncology, Tokyo Medical University, Tokyo 160-8402, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 22; Vol. 21 (8). Date of Electronic Publication: 2020 Apr 22.
Typ publikacji:
Journal Article
MeSH Terms:
Biomarkers, Tumor*
G2 Phase Cell Cycle Checkpoints*/genetics
Signal Transduction*
Breast Neoplasms/*metabolism
Breast Neoplasms/*pathology
Receptors, Estrogen/*metabolism
Breast Neoplasms/etiology ; Breast Neoplasms/mortality ; Cell Proliferation ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł:
ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α.
Autorzy:
Lee D; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea.
Hokinson D; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea.
Park S; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea.
Elvira R; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea.
Kusuma F; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea.
Lee JM; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea.
Yun M; Department of Bioindustry and Bioresource Engineering, College of Life Sciences, Sejong University, Seoul 02447, Korea.
Lee SG; KHU-KIST Department of Converging Science & Technology, Department of Science in Korean Medicine, and Bionanocomposite Research Center, Kyung Hee Univerisity, 26 Kyungheedae-ro, Seoul 02447, Korea.
Han J; Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 13; Vol. 20 (24). Date of Electronic Publication: 2019 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Division*
Endoplasmic Reticulum Stress*
G2 Phase Cell Cycle Checkpoints*
Signal Transduction*
Cell Cycle Proteins/*metabolism
Eukaryotic Initiation Factor-2/*metabolism
Cell Cycle Proteins/genetics ; Cyclin B1/genetics ; Cyclin B1/metabolism ; Databases, Genetic ; Eukaryotic Initiation Factor-2/genetics ; Humans ; Phosphorylation
Czasopismo naukowe
Tytuł:
Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer.
Autorzy:
Kim K; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Kwon O; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Ryu TY; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Jung CR; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Kim J; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Min JK; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Kim DS; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Son MY; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Cho HS; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2019 Aug; Vol. 20 (2), pp. 1569-1574. Date of Electronic Publication: 2019 Jun 26.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
Butyric Acid/*pharmacology
G2 Phase Cell Cycle Checkpoints/*drug effects
Propionates/*pharmacology
Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/agonists ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; G2 Phase Cell Cycle Checkpoints/genetics ; Gastrointestinal Microbiome/physiology ; Humans ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Signal Transduction ; Survivin/antagonists & inhibitors ; Survivin/genetics ; Survivin/metabolism
Czasopismo naukowe
Tytuł:
Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G 2 -phase.
Autorzy:
Mladenov E; Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, 45122, Essen, Germany.
Fan X; Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, 45122, Essen, Germany.
Dueva R; Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, 45122, Essen, Germany.
Soni A; Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, 45122, Essen, Germany.
Iliakis G; Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, 45122, Essen, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2019 Jun 04; Vol. 9 (1), pp. 8255. Date of Electronic Publication: 2019 Jun 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Radiation, Ionizing*
Ataxia Telangiectasia Mutated Proteins/*genetics
DNA-Activated Protein Kinase/*genetics
G2 Phase Cell Cycle Checkpoints/*radiation effects
Cell Cycle/genetics ; Cell Cycle/radiation effects ; Cell Division/genetics ; Cell Division/radiation effects ; Checkpoint Kinase 1/genetics ; DNA Breaks, Double-Stranded/radiation effects ; DNA Damage/genetics ; DNA Damage/radiation effects ; DNA End-Joining Repair/radiation effects ; DNA-Binding Proteins/genetics ; G2 Phase Cell Cycle Checkpoints/genetics ; Humans ; Phosphorylation/radiation effects ; Signal Transduction/radiation effects
Czasopismo naukowe
Tytuł:
DLIC1, but not DLIC2, is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells.
Autorzy:
Even I; Division of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.; Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Reidenbach S; Division of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.
Schlechter T; Division of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.
Berns N; Department for Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Herold R; Division of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.
Roth W; Clinical Cooperation Unit Molecular Tumor Pathology, German Cancer Research Center, Heidelberg, Germany.
Krunic D; Light Microscopy Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Riechmann V; Department for Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Hofmann I; Division of Vascular Oncology and Metastasis, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.; Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
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Źródło:
The FEBS journal [FEBS J] 2019 Feb; Vol. 286 (4), pp. 803-820. Date of Electronic Publication: 2019 Feb 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement*
Cell Proliferation*
G2 Phase Cell Cycle Checkpoints*
Colon/*pathology
Colonic Neoplasms/*pathology
Cytoplasmic Dyneins/*metabolism
Animals ; Apoptosis ; Case-Control Studies ; Cells, Cultured ; Colon/metabolism ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Cytoplasmic Dyneins/genetics ; Drosophila ; Gene Expression Regulation, Neoplastic ; Humans ; Up-Regulation
Czasopismo naukowe
Tytuł:
ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells.
Autorzy:
Neilsen BK; Eppley Institute, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Frodyma DE; Eppley Institute, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
McCall JL; Eppley Institute, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Fisher KW; Eppley Institute, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Lewis RE; Eppley Institute, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Jan 10; Vol. 14 (1), pp. e0209224. Date of Electronic Publication: 2019 Jan 10 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Cycle Proteins/*metabolism
Colonic Neoplasms/*metabolism
Colonic Neoplasms/*pathology
G2 Phase Cell Cycle Checkpoints/*physiology
Intracellular Signaling Peptides and Proteins/*metabolism
CDC2 Protein Kinase/metabolism ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Proliferation ; Checkpoint Kinase 1/antagonists & inhibitors ; Checkpoint Kinase 1/metabolism ; Colonic Neoplasms/genetics ; DNA Damage ; G2 Phase Cell Cycle Checkpoints/genetics ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Histones/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/genetics ; MAP Kinase Signaling System ; Nuclear Proteins/antagonists & inhibitors ; Protein-Tyrosine Kinases/antagonists & inhibitors ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł:
The Tuberin and Cyclin B1 complex functions as a novel G2/M sensor of serum conditions and Akt signaling.
Autorzy:
Fidalgo da Silva E; Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada.
Botsford S; Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada.
Dare-Shih J; Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada.
Hanna MA; Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada.
Porter LA; Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada.
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Źródło:
PloS one [PLoS One] 2019 Jan 10; Vol. 14 (1), pp. e0210612. Date of Electronic Publication: 2019 Jan 10 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
G2 Phase Cell Cycle Checkpoints*
M Phase Cell Cycle Checkpoints*
Signal Transduction*
Cyclin B1/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Tuberous Sclerosis Complex 2 Protein/*metabolism
HEK293 Cells ; Humans ; Mitosis ; Protein Interaction Maps ; Serum/metabolism
Czasopismo naukowe
Tytuł:
Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation.
Autorzy:
Gong EY; Unidad de Investigación, Hospital Universitario de Canarias, Ofra s/n, La Cuesta, La Laguna, 38320, Tenerife, Spain.; Nano-Bio Resources Center, Sookmyung Women's University, Chungpa-Dong 2-Ka, Yongsan-ku, Seoul, 04310, Republic of Korea.
Hernández B; Unidad de Investigación, Hospital Universitario de Canarias, Ofra s/n, La Cuesta, La Laguna, 38320, Tenerife, Spain.
Nielsen JH; Unidad de Investigación, Hospital Universitario de Canarias, Ofra s/n, La Cuesta, La Laguna, 38320, Tenerife, Spain.
Smits VAJ; Unidad de Investigación, Hospital Universitario de Canarias, Ofra s/n, La Cuesta, La Laguna, 38320, Tenerife, Spain.
Freire R; Unidad de Investigación, Hospital Universitario de Canarias, Ofra s/n, La Cuesta, La Laguna, 38320, Tenerife, Spain.
Gillespie DA; Instituto de Tecnologías Biomédicas, Centro de Investigaciones Biomédicas de Canarias, Facultad de Medicina, Campus Ciencias de la Salud, Universidad de La Laguna, La Laguna, 38071, Tenerife, Spain. .
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Źródło:
Scientific reports [Sci Rep] 2018 Dec 03; Vol. 8 (1), pp. 17536. Date of Electronic Publication: 2018 Dec 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
G2 Phase Cell Cycle Checkpoints*
Proteolysis*
Checkpoint Kinase 1/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Amino Acid Motifs ; Cell Line, Transformed ; Checkpoint Kinase 1/genetics ; Humans ; Mutation ; Phosphorylation ; Proteasome Endopeptidase Complex/genetics ; Protein Domains
Czasopismo naukowe
Tytuł:
Defining the regulatory role of programmed cell death 4 in laryngeal squamous cell carcinoma.
Autorzy:
Xu YT; a Department of Otolaryngology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, P.R. China.
Chen RQ; b Central Laboratory, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, P.R. China.
Lin GB; a Department of Otolaryngology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, P.R. China.
Fang XL; a Department of Otolaryngology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, P.R. China.
Yu SJ; a Department of Otolaryngology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, P.R. China.
Liang XH; c Clinical Laboratory, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, P.R. China.
Zhang R; a Department of Otolaryngology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, P.R. China.
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Źródło:
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2018 Oct; Vol. 96 (5), pp. 522-538. Date of Electronic Publication: 2018 Mar 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
G2 Phase Cell Cycle Checkpoints*
Apoptosis Regulatory Proteins/*metabolism
Carcinoma, Squamous Cell/*metabolism
Laryngeal Neoplasms/*metabolism
Neoplasm Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Apoptosis Regulatory Proteins/genetics ; Cadherins/biosynthesis ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/pathology ; Neoplasm Metastasis ; Neoplasm Proteins/genetics ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21.
Autorzy:
Chen SM; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Lin TK; Department of Neurosurgery, School of Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan.
Tseng YY; Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
Tu CH; Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Lui TN; Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Huang SF; Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Hsieh LL; Department of Public Health, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Li YY; Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida.
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Źródło:
Cancer medicine [Cancer Med] 2018 Aug; Vol. 7 (8), pp. 3988-4003. Date of Electronic Publication: 2018 Jul 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Apoptosis Regulatory Proteins/*antagonists & inhibitors
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
G2 Phase Cell Cycle Checkpoints/*drug effects
Medulloblastoma/*metabolism
Apoptosis/genetics ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Biomarkers ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinases/metabolism ; Dose-Response Relationship, Drug ; G2 Phase Cell Cycle Checkpoints/genetics ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Medulloblastoma/genetics ; Protein Processing, Post-Translational
Czasopismo naukowe
Tytuł:
Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest.
Autorzy:
Zhou J; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.; Shanghai Respiratory Research Institute, Shanghai, China.
Chang M; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.; Shanghai Respiratory Research Institute, Shanghai, China.
Li J; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.; Shanghai Respiratory Research Institute, Shanghai, China.
Fang T; Department of Oncology, Shengli Oilfield Central Hospital, Shandong Province, China. .
Hu J; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. .; Shanghai Respiratory Research Institute, Shanghai, China. .
Bai C; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. .; Shanghai Respiratory Research Institute, Shanghai, China. .; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China. .
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Źródło:
Respiratory research [Respir Res] 2018 May 21; Vol. 19 (1), pp. 96. Date of Electronic Publication: 2018 May 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Knockdown Techniques*
Annexin A5/*deficiency
Antineoplastic Agents/*pharmacology
G2 Phase Cell Cycle Checkpoints/*physiology
M Phase Cell Cycle Checkpoints/*physiology
Quinazolines/*pharmacology
Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenocarcinoma of Lung ; Animals ; Annexin A5/biosynthesis ; Annexin A5/genetics ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/physiology ; G2 Phase Cell Cycle Checkpoints/drug effects ; Gefitinib ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; M Phase Cell Cycle Checkpoints/drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude
Czasopismo naukowe
Tytuł:
Kaempferol Induces G2/M Cell Cycle Arrest via Checkpoint Kinase 2 and Promotes Apoptosis via Death Receptors in Human Ovarian Carcinoma A2780/CP70 Cells.
Autorzy:
Gao Y; Tea Research Institute Chinese Academy of Agricultural Sciences, Ministry of Agriculture, Hangzhou 310008, China. .
Yin J; Tea Research Institute Chinese Academy of Agricultural Sciences, Ministry of Agriculture, Hangzhou 310008, China. .
Rankin GO; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. .
Chen YC; College of Science, Technology and Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2018 May 05; Vol. 23 (5). Date of Electronic Publication: 2018 May 05.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents, Phytogenic/*pharmacology
Checkpoint Kinase 2/*genetics
Epithelial Cells/*drug effects
G2 Phase Cell Cycle Checkpoints/*drug effects
Kaempferols/*pharmacology
Receptors, Death Domain/*genetics
Apoptosis/drug effects ; Apoptosis/genetics ; CDC2 Protein Kinase/genetics ; CDC2 Protein Kinase/metabolism ; Caspase 8/genetics ; Caspase 8/metabolism ; Cell Line, Tumor ; Checkpoint Kinase 2/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Fas-Associated Death Domain Protein/genetics ; Fas-Associated Death Domain Protein/metabolism ; Female ; G2 Phase Cell Cycle Checkpoints/genetics ; Humans ; Ovary/drug effects ; Ovary/metabolism ; Ovary/pathology ; Receptors, Death Domain/metabolism ; Signal Transduction ; cdc25 Phosphatases/genetics ; cdc25 Phosphatases/metabolism
Czasopismo naukowe
Tytuł:
Janerin Induces Cell Cycle Arrest at the G2/M Phase and Promotes Apoptosis Involving the MAPK Pathway in THP-1, Leukemic Cell Line.
Autorzy:
Ahmed MZ; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Nasr FA; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Qamar W; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Noman OM; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Khan JM; Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Al-Mishari AA; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alqahtani AS; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Dec 13; Vol. 26 (24). Date of Electronic Publication: 2021 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic*/chemistry
Antineoplastic Agents, Phytogenic*/pharmacology
Leukemia*/drug therapy
Leukemia*/metabolism
Sesquiterpenes*/chemistry
Sesquiterpenes*/pharmacology
Apoptosis/*drug effects
G2 Phase Cell Cycle Checkpoints/*drug effects
M Phase Cell Cycle Checkpoints/*drug effects
MAP Kinase Signaling System/*drug effects
Humans ; THP-1 Cells
Czasopismo naukowe

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