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Tytuł:
Huntington disease alters the actionable information in plasma extracellular vesicles.
Autorzy:
Neueder A; Department of Neurology, Ulm University Hospital, Ulm, Germany.
Nitzschner P; Department of Neurology, Ulm University Hospital, Ulm, Germany.
Wagner R; Department of Neurology, Ulm University Hospital, Ulm, Germany.
Hummel J; Department of Neurology, Ulm University Hospital, Ulm, Germany.
Hoschek F; Department of Neurology, Ulm University Hospital, Ulm, Germany.
Wagner M; Department of Neurology, Ulm University Hospital, Ulm, Germany.
Abdelmoez A; Department of Neurology, Ulm University Hospital, Ulm, Germany.; Department of Pharmaceutical Organic Chemistry, Assiut University, Assiut, Egypt.
von Einem B; Department of Neurology, Ulm University Hospital, Ulm, Germany.
Landwehrmeyer GB; Department of Neurology, Ulm University Hospital, Ulm, Germany.
Tabrizi SJ; UCL Huntington's disease Centre, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Orth M; Department of Neurology, Ulm University Hospital, Ulm, Germany.; Swiss Huntington Centre, Neurozentrum, Siloah AG, Gumligen, Switzerland.; University Hospital of Old Age Psychiatry and Psychotherapy, Bern University, Bern, Switzerland.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2024 Jan; Vol. 14 (1), pp. e1525.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Huntington Disease*/genetics
Extracellular Vesicles*
Humans
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
"Ten euros now" temporal discounting in Huntington disease.
Autorzy:
El Haj M; Nantes Université, Univ Angers, Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638), F-44000, Nantes, France. .; CHU Nantes, Clinical Gerontology Department, 41 rue Pierre et Marie Curie, 44093, Nantes, France. .; Institut Universitaire de France, Paris, France. .; Faculté de Psychologie, LPPL - Laboratoire de Psychologie des Pays de la Loire, Université Nantes, Chemin de la Censive du Tertre, BP 81227, 44312, Nantes Cedex 3, France. .
Caillaud M; University of Texas, Clinical Neuroscience Lab, 108 East Dean Keeton St., Austin, TX, 78712, USA.
Moustafa A; School of Psychology, Faculty of Society and Design, Bond University, Gold Coast, Queensland, Australia.; Department of Human Anatomy and Physiology, the Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.
Prundean A; Département de Neurologie, CHU Angers, Angers, France.
Scherer C; Département de Neurologie, CHU Angers, Angers, France.
Verny C; Département de Neurologie, CHU Angers, Angers, France.
Allain P; Département de Neurologie, CHU Angers, Angers, France.; Laboratoire de Psychologie des Pays de la Loire, LPPL EA 4638 SFR Confluences, UNIV Angers, Nantes Université, Maison de la recherche Germaine Tillion, 5 bis Boulevard Lavoisier, 49045, Angers Cedex 01, France.
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Źródło:
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2023 Aug; Vol. 44 (8), pp. 2763-2771. Date of Electronic Publication: 2023 Mar 24.
Typ publikacji:
Journal Article
MeSH Terms:
Delay Discounting*/physiology
Huntington Disease*
Humans ; Reward ; Decision Making ; Motivation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Comprehensive Bioinformatics Approach to Identify Molecular Signatures and Key Pathways for the Huntington Disease.
Autorzy:
Meem, Tahera Mahnaz (AUTHOR)
Khan, Umama (AUTHOR)
Mredul, Md Bazlur Rahman (AUTHOR)
Awal, Md Abdul (AUTHOR)
Rahman, Md Habibur (AUTHOR)
Khan, Md Salauddin (AUTHOR)
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Źródło:
Bioinformatics & Biology Insights. 11/27/2023, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome.
Autorzy:
Dalene Skarping K; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.; Department of Clinical Genetics and Pathology, Office for Medical Service, 221 85, Lund, Sweden.; Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Arning L; Department of Human Genetics, Faculty of Medicine, Ruhr University Bochum, Universitätsstr. 150, 44801, Bochum, Germany.
Petersén Å; Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Nguyen HP; Department of Human Genetics, Faculty of Medicine, Ruhr University Bochum, Universitätsstr. 150, 44801, Bochum, Germany. .
Gebre-Medhin S; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden. .; Department of Clinical Genetics and Pathology, Office for Medical Service, 221 85, Lund, Sweden. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 21; Vol. 14 (1), pp. 4300. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms, Hereditary Nonpolyposis*/genetics
Huntington Disease*/genetics
Huntington Disease*/pathology
Humans ; Trinucleotide Repeat Expansion ; Alleles ; DNA Mismatch Repair/genetics ; Huntingtin Protein/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Health state utility estimates for value assessments of novel treatments in Huntington's disease: a systematic literature review.
Autorzy:
Sawant R; Sage Therapeutics, Inc, 215 First Street, Cambridge, MA, 02142, USA. .
Paret K; Health Economics, RTI Health Solutions, 3040 East Cornwallis Road, Research Triangle Park, Research Triangle Park, NC, USA.
Petrillo J; Sage Therapeutics, Inc, 215 First Street, Cambridge, MA, 02142, USA.
Koenig A; Sage Therapeutics, Inc, 215 First Street, Cambridge, MA, 02142, USA.
Wolowacz S; Health Economics, RTI Health Solutions, The Pavilion, Towers Business Park, Wilmslow Road, Didsbury, Manchester, UK.
Ronquest N; Health Economics, RTI Health Solutions, 3040 East Cornwallis Road, Research Triangle Park, Research Triangle Park, NC, USA.
Rickards H; Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, 32-34 Colmore Circus Queensway, Birmingham, UK.
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Źródło:
Health and quality of life outcomes [Health Qual Life Outcomes] 2024 Apr 16; Vol. 22 (1), pp. 33. Date of Electronic Publication: 2024 Apr 16.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Huntington Disease*/therapy
Neurodegenerative Diseases*
Humans ; Quality of Life ; Quality-Adjusted Life Years ; Cost-Benefit Analysis ; Surveys and Questionnaires ; Health Status
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dietary fasting and time-restricted eating in Huntington's disease: therapeutic potential and underlying mechanisms.
Autorzy:
Wells RG; Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA. .
Neilson LE; Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.; Neurology and PADRECC VA Portland Health Care System, Portland, OR, 97239, USA.
McHill AW; Sleep, Chronobiology and Health Laboratory, School of Nursing, Oregon Health & Science University, Portland, OR, 97239, USA.; Oregon Institute of Occupational Health Sciences, Oregon Health & Sciences University, Portland, OR, 97239, USA.
Hiller AL; Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.; Neurology and PADRECC VA Portland Health Care System, Portland, OR, 97239, USA.
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2024 Apr 02; Vol. 13 (1), pp. 17. Date of Electronic Publication: 2024 Apr 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Huntington Disease*/genetics
Huntington Disease*/therapy
Huntington Disease*/metabolism
Neurodegenerative Diseases*
Animals ; Humans ; Fasting ; Oxidative Stress
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Huntington's Disease: Complex Pathogenesis and Therapeutic Strategies.
Autorzy:
Tong H; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Yang T; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Xu S; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Li X; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Liu L; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Zhou G; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Yang S; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Yin S; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Li XJ; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Li S; Guangdong Key Laboratory of Non-Human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 29; Vol. 25 (7). Date of Electronic Publication: 2024 Mar 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Huntington Disease*/genetics
Huntington Disease*/therapy
Humans ; Genetic Therapy ; Mutant Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The polyglutamine domain is the primary driver of seeding in huntingtin aggregation.
Autorzy:
Skeens A; The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America.
Siriwardhana C; The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America.
Massinople SE; The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America.
Wunder MM; The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America.
Ellis ZL; The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America.
Keith KM; The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America.
Girman T; The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America.
Frey SL; The Department of Chemistry, Gettysburg College, Gettysburg, Pennsylvania, United States of America.
Legleiter J; The C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, United States of America.; Rockefeller Neurosciences Institutes, West Virginia University, Morgantown, West Virginia, United States of America.; Department of Neuroscience, West Virginia University, Morgantown, West Virginia, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Mar 14; Vol. 19 (3), pp. e0298323. Date of Electronic Publication: 2024 Mar 14 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Neurodegenerative Diseases*
Huntington Disease*/genetics
Huntington Disease*/metabolism
Peptides*
Animals ; Humans ; Huntingtin Protein/genetics ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Amyloid/metabolism ; Lipids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Intravenous MSC-Treatment Improves Impaired Brain Functions in the R6/2 Mouse Model of Huntington's Disease via Recovered Hepatic Pathological Changes.
Autorzy:
Yu-Taeger L; Department of Human Genetics, Ruhr University of Bochum, D-44801 Bochum, Germany.; Institute of Medical Genetics and Applied Genomics, University of Tuebingen, D-72076 Tuebingen, Germany.
El-Ayoubi A; Department of Human Genetics, Ruhr University of Bochum, D-44801 Bochum, Germany.; Institute of Medical Genetics and Applied Genomics, University of Tuebingen, D-72076 Tuebingen, Germany.
Qi P; Department of Human Genetics, Ruhr University of Bochum, D-44801 Bochum, Germany.; Institute of Medical Genetics and Applied Genomics, University of Tuebingen, D-72076 Tuebingen, Germany.
Danielyan L; Department of Clinical Pharmacology, University Hospital of Tuebingen, D-72076 Tuebingen, Germany.; Departments of Biochemistry and Clinical Pharmacology, and Neuroscience Laboratory, Yerevan State Medical University, Yerevan 0025, Armenia.
Nguyen HHP; Department of Human Genetics, Ruhr University of Bochum, D-44801 Bochum, Germany.; Department of Medical Chemistry, Yerevan State Medical University, Yerevan 0025, Armenia.
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Źródło:
Cells [Cells] 2024 Mar 07; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/metabolism
Mice ; Humans ; Animals ; Mice, Transgenic ; Disease Models, Animal ; Brain/metabolism ; Liver/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington's disease.
Autorzy:
Vasilkovska T; Bio-Imaging Lab, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium. .; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium. .
Salajeghe S; Bio-Imaging Lab, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.
Vanreusel V; Bio-Imaging Lab, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.
Van Audekerke J; Bio-Imaging Lab, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Verschuuren M; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium.; Laboratory of Cell Biology and Histology, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.; Antwerp Centre for Advanced Microscopy, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.
Hirschler L; C.J. Gorter MRI Center, Leiden University Medical Center, Leiden, the Netherlands.
Warnking J; Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, Grenoble, France.
Pintelon I; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium.; Laboratory of Cell Biology and Histology, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.; Antwerp Centre for Advanced Microscopy, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.
Pustina D; CHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc, Princeton, NJ, USA.
Cachope R; CHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc, Princeton, NJ, USA.
Mrzljak L; CHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc, Princeton, NJ, USA.; Present Address: Takeda Pharmaceuticals, Cambridge, MA, USA.
Muñoz-Sanjuan I; CHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc, Princeton, NJ, USA.; Present Address: Cajal Neuroscience Inc, Seattle, WA, USA.
Barbier EL; Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, Grenoble, France.
De Vos WH; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium.; Laboratory of Cell Biology and Histology, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.; Antwerp Centre for Advanced Microscopy, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.
Van der Linden A; Bio-Imaging Lab, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Verhoye M; Bio-Imaging Lab, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium.; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium.
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Źródło:
Journal of biomedical science [J Biomed Sci] 2024 Apr 16; Vol. 31 (1), pp. 37. Date of Electronic Publication: 2024 Apr 16.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/genetics
Humans ; Mice ; Animals ; Infant ; Cross-Sectional Studies ; Hypercapnia ; Brain ; Disease Models, Animal ; Perfusion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Associations of inflammatory cytokines and cortisol with nonmotor features of Huntington's disease.
Autorzy:
Bilal H; School of Psychological Sciences, and Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.
McDonald SJ; Department of Neuroscience, Central Clinical School, Monash University, Prahran, Victoria, Australia.
Stout JC; School of Psychological Sciences, and Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.
Harding IH; Department of Neuroscience, Central Clinical School, Monash University, Prahran, Victoria, Australia.; Monash Biomedical Imaging, Monash University, Clayton, Victoria, Australia.
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Źródło:
Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2024 Apr; Vol. 11 (4), pp. 989-999. Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/diagnosis
Neurodegenerative Diseases*
Adult ; Humans ; Cytokines ; Hydrocortisone ; Interleukin-10 ; Tumor Necrosis Factor-alpha ; Interleukin-6 ; Inflammation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration.
Autorzy:
Creus-Muncunill J; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Haure-Mirande JV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Mattei D; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Bons J; Buck Institute for Research on Aging, Novato, CA, USA.
Ramirez AV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Hamilton BW; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Corwin C; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Chowdhury S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
Schilling B; Buck Institute for Research on Aging, Novato, CA, USA.
Ellerby LM; Buck Institute for Research on Aging, Novato, CA, USA.
Ehrlich ME; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Mar 08; Vol. 21 (1), pp. 66. Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/metabolism
Mice ; Animals ; Humans ; Microglia/metabolism ; Gliosis/genetics ; Gliosis/metabolism ; Proteomics ; Corpus Striatum/metabolism ; Disease Models, Animal ; Mice, Transgenic ; Membrane Proteins/metabolism ; Adaptor Proteins, Signal Transducing/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identifying and verifying Huntington's disease subtypes: Clinical features, neuroimaging, and cytokine changes.
Autorzy:
Cao LX; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yin JH; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Du G; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Department of Neurology, The Third People's Hospital of Longgang District, Shenzhen, China.
Yang Q; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Huang Y; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Pharmacology Department, School of Biomedical Sciences, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.
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Źródło:
Brain and behavior [Brain Behav] 2024 Mar; Vol. 14 (3), pp. e3469.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/diagnostic imaging
Chorea*
Humans ; Magnetic Resonance Imaging ; Neuroimaging ; Biomarkers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Disentangling the neurobiological bases of temporal impulsivity in Huntington's disease.
Autorzy:
Pardina-Torner H; Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
De Paepe AE; Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Garcia-Gorro C; Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Rodriguez-Dechicha N; Hestia Duran i Reynals, Hospital Duran i Reynals, Hospitalet de Llobregat, Barcelona, Spain.; Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.
Vaquer I; Hestia Duran i Reynals, Hospital Duran i Reynals, Hospitalet de Llobregat, Barcelona, Spain.; Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.
Calopa M; Movement Disorders Unit, Neurology Service, Hospital Universitari de Bellvitge, Barcelona, Spain.; ICREA (Catalan Institute for Research and Advanced Studies), Barcelona, Spain.
Ruiz-Idiago J; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.; Hospital Mare de Deu de la Mercè, Barcelona, Spain.
Mareca C; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.; Hospital Mare de Deu de la Mercè, Barcelona, Spain.
de Diego-Balaguer R; Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.; Department of Cognition, Development and Education Psychology, Universitat de Barcelona, Barcelona, Spain.; Institute of Neurosciences, Universitat de Barcelona, Barcelona, Spain.; ICREA (Catalan Institute for Research and Advanced Studies), Barcelona, Spain.
Camara E; Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
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Źródło:
Brain and behavior [Brain Behav] 2024 Mar; Vol. 14 (3), pp. e3335.
Typ publikacji:
Journal Article
MeSH Terms:
Diffusion Tensor Imaging*
Huntington Disease*/diagnostic imaging
Humans ; Quality of Life ; Impulsive Behavior ; Individuality
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
Autorzy:
Gaudet ID; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Xu H; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Gordon E; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Cannestro GA; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Lu ML; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Wei J; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, 33431, USA. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Feb 28; Vol. 21 (1), pp. 59. Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/genetics
Nitrosative Stress*
Animals ; Humans ; Mice ; Amino Acid Transport Systems, Basic/metabolism ; Arginine ; Cell Line ; Inflammation ; Neuroinflammatory Diseases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Retinal dysfunction in Huntington's disease mouse models concurs with local gliosis and microglia activation.
Autorzy:
Cano-Cano F; Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Unidad de Investigación, Hospital Universitario Puerta del Mar, Av. Ana de Viya 21, 11009, Cádiz, Spain.
Martín-Loro F; Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Unidad de Investigación, Hospital Universitario Puerta del Mar, Av. Ana de Viya 21, 11009, Cádiz, Spain.
Gallardo-Orihuela A; Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Unidad de Investigación, Hospital Universitario Puerta del Mar, Av. Ana de Viya 21, 11009, Cádiz, Spain.
González-Montelongo MDC; Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Unidad de Investigación, Hospital Universitario Puerta del Mar, Av. Ana de Viya 21, 11009, Cádiz, Spain.
Ortuño-Miquel S; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Unidad de Bioinformática, Hospital General Universitario Dr. Balmis, 03010, Alicante, Spain.
Hervás-Corpión I; Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Unidad de Investigación, Hospital Universitario Puerta del Mar, Av. Ana de Viya 21, 11009, Cádiz, Spain.; Programa de Tumores Sólidos, Centro de Investigación Médica Aplicada (CIMA), Departamento de Pediatría, Clínica Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008, Pamplona, Spain.
de la Villa P; Departamento de Biología de Sistemas, Universidad de Alcalá de Henares, 28871, Alcalá de Henares, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034, Madrid, Spain.
Ramón-Marco L; Laboratorio de Investigación, Diagnostics Building, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario Dr. Balmis, Av. Pintor Baeza 12, 03010, Alicante, Spain.
Navarro-Calvo J; Laboratorio de Investigación, Diagnostics Building, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario Dr. Balmis, Av. Pintor Baeza 12, 03010, Alicante, Spain.
Gómez-Jaramillo L; Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Unidad de Investigación, Hospital Universitario Puerta del Mar, Av. Ana de Viya 21, 11009, Cádiz, Spain.
Arroba AI; Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Unidad de Investigación, Hospital Universitario Puerta del Mar, Av. Ana de Viya 21, 11009, Cádiz, Spain. .
Valor LM; Laboratorio de Investigación, Diagnostics Building, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario Dr. Balmis, Av. Pintor Baeza 12, 03010, Alicante, Spain. valor_.; Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), 03202, Elche, Spain. valor_.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 20; Vol. 14 (1), pp. 4176. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/pathology
Mice ; Animals ; Humans ; Mice, Transgenic ; Gliosis/genetics ; Gliosis/pathology ; Microglia/metabolism ; Neuroinflammatory Diseases ; Disease Models, Animal ; Corpus Striatum/metabolism ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deregulated Transcriptome as a Platform for Adrenal Huntington's Disease-Related Pathology.
Autorzy:
Olechnowicz A; Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.; Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Blatkiewicz M; Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Jopek K; Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Isalan M; Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK.; Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK.
Mielcarek M; Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK.; Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK.
Rucinski M; Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 11; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/metabolism
Mice ; Animals ; Mice, Transgenic ; Transcriptome ; Disease Models, Animal ; Gene Expression Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Post-mortem 7T MR imaging and neuropathology in middle stage juvenile-onset Huntington disease: A case report.
Autorzy:
Bakels HS; Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
van Duinen SG; Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands.
de Bresser J; Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
van Roon-Mom WMC; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
van der Weerd L; Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
de Bot ST; Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
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Źródło:
Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2023 Feb; Vol. 49 (1), pp. e12858. Date of Electronic Publication: 2022 Nov 13.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Huntington Disease*/pathology
Humans ; Magnetic Resonance Imaging/methods ; Atrophy ; Autopsy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing.
Autorzy:
Makeeva VS; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10 Akad. Lavrentiev Ave., 630090 Novosibirsk, Russia.
Dyrkheeva NS; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 8 Akad. Lavrentiev Ave., 630090 Novosibirsk, Russia.
Lavrik OI; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 8 Akad. Lavrentiev Ave., 630090 Novosibirsk, Russia.
Zakian SM; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10 Akad. Lavrentiev Ave., 630090 Novosibirsk, Russia.
Malakhova AA; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 10 Akad. Lavrentiev Ave., 630090 Novosibirsk, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 27; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Huntington Disease*/drug therapy
Huntington Disease*/genetics
Huntington Disease*/metabolism
Neurodegenerative Diseases*
Humans ; Drug Repositioning ; Drug Development ; Huntingtin Protein/genetics ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Uncovering the Genetic and Molecular Features of Huntington's Disease in Northern Colombia.
Autorzy:
Ahmad M; Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Life Science Research Center, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
Ríos-Anillo MR; Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Life Science Research Center, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Médica Residente de Neurología, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
Acosta-López JE; Life Science Research Center, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Facultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
Cervantes-Henríquez ML; Life Science Research Center, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Facultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
Martínez-Banfi M; Life Science Research Center, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Facultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
Pineda-Alhucema W; Life Science Research Center, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Facultad de Ciencias Jurídicas y Sociales, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
Puentes-Rozo P; Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Life Science Research Center, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Grupo de Neurociencias del Caribe, Universidad del Atlántico, Barranquilla 080001, Colombia.
Sánchez-Barros C; Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Life Science Research Center, Universidad Simón Bolívar, Barranquilla 080002, Colombia.; Departamento de Neurofisiología Clínica Palma de Mallorca, Hospital Juaneda Miramar, Islas Baleares, 07011 Palma, Spain.
Pinzón A; Bioinformatics and Systems Biology Laboratory, Institute for Genetics, Universidad Nacional de Colombia, Bogota 111321, Colombia.
Patel HR; National Centre for Indigenous Genomics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
Vélez JI; Department of Industrial Engineering, Universidad del Norte, Barranquilla 081007, Colombia.
Villarreal-Camacho JL; Programa de Medicina, Facultad de Ciencias de la Salud, Universidad Libre Seccional Barranquilla, Barranquilla 081007, Colombia.
Pineda DA; Grupo de Investigación en Neuropsicología y Conducta, Universidad de San Buenaventura, Medellin 050010, Colombia.; Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin 050010, Colombia.
Arcos-Burgos M; Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellin 050010, Colombia.
Sánchez-Rojas M; Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 10; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/genetics
Huntington Disease*/diagnosis
Adult ; Female ; Humans ; Colombia ; Alleles ; DNA ; Pedigree ; Huntingtin Protein/genetics ; Trinucleotide Repeat Expansion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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