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Tytuł:
ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population.
Autorzy:
Božina T; Department of Medical Chemistry, Biochemistry, and Clinical Chemistry, University of Zagreb School of Medicine, Zagreb, Croatia.
Ganoci L; Division of Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia.
Karačić E; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Šimičević L; Division of Pharmacogenomics and Therapy Individualization, Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia.
Vrkić-Kirhmajer M; Department of Cardiovascular Diseases Zagreb, University of Zagreb School of Medicine, University Hospital Centre Zagreb, Croatia.
Klarica-Domjanović I; Croatian Agency for Medicinal Products and Medical Devices, Zagreb, Croatia.
Križ T; Department of Ophthalmology, University Hospital Centre 'Sestre milosrdnice', Zagreb, Croatia.
Sertić Z; Department of Emergency Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.
Božina N; Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia.
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Źródło:
Annals of human biology [Ann Hum Biol] 2022 Dec; Vol. 49 (7-8), pp. 323-331. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics
Liver-Specific Organic Anion Transporter 1*/genetics
Neoplasm Proteins*/genetics
Polymorphism, Single Nucleotide*
Female ; Humans ; Alleles ; Croatia ; Gene Frequency ; Genotype ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Frequency of functional exonic single-nucleotide polymorphisms and haplotype distribution in the SLCO1B1 gene across genetic ancestry groups in the Qatari population.
Autorzy:
Dashti M; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Kuwait City, Kuwait.
Al-Matrouk A; Narcotic and Psychotropic Department, Ministry of Interior, Farwaniya, Kuwait.
Channanath A; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Kuwait City, Kuwait.
Al-Mulla F; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Kuwait City, Kuwait. .
Thanaraj TA; Genetics and Bioinformatics Department, Dasman Diabetes Institute, Kuwait City, Kuwait. .
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Źródło:
Scientific reports [Sci Rep] 2022 Sep 01; Vol. 12 (1), pp. 14858. Date of Electronic Publication: 2022 Sep 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Liver-Specific Organic Anion Transporter 1*/genetics
Organic Anion Transporters*/genetics
Polymorphism, Single Nucleotide*
Humans ; Exons/genetics ; Gene Frequency ; Genotype ; Haplotypes ; Qatar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model.
Autorzy:
Taylor ZL; Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, Ohio, USA.; Division of Research in Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Thompson LE; Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Bear H; Division of Research in Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Mizuno T; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Vinks AA; Division of Research in Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Ramsey LB; Division of Research in Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Nov; Vol. 14 (6), pp. 2267-2277. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Liver-Specific Organic Anion Transporter 1*
Mice, Knockout*
Pharmacogenomic Testing*
Antirheumatic Agents/*administration & dosage
Arthritis/*drug therapy
Methotrexate/*administration & dosage
Animals ; Antirheumatic Agents/pharmacology ; Collagen/drug effects ; Collagen/metabolism ; Genotype ; Humans ; Male ; Methotrexate/pharmacology ; Mice ; Pharmacogenetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Organic Anion Transporting Polypeptide 1B1 Is a Potential Reporter for Dual MR and Optical Imaging.
Autorzy:
Lee YH; Department of Medical Imaging, Taipei TzuChi General Hospital, Buddhist Tzu-Chi Medical Foundation, New Taipei City 23142, Taiwan.
Wu MR; Department of Medical Imaging, Taipei TzuChi General Hospital, Buddhist Tzu-Chi Medical Foundation, New Taipei City 23142, Taiwan.
Hsiao JK; Department of Medical Imaging, Taipei TzuChi General Hospital, Buddhist Tzu-Chi Medical Foundation, New Taipei City 23142, Taiwan.; School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 16; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 16.
Typ publikacji:
Journal Article
MeSH Terms:
Gadolinium DTPA/*chemistry
Liver-Specific Organic Anion Transporter 1/*metabolism
Meglumine/*analogs & derivatives
Optical Imaging/*methods
Organometallic Compounds/*chemistry
Genes, Reporter ; HEK293 Cells ; Humans ; Liver-Specific Organic Anion Transporter 1/chemistry ; Liver-Specific Organic Anion Transporter 1/genetics ; Magnetic Resonance Imaging ; Meglumine/chemistry ; Molecular Imaging ; Solute Carrier Organic Anion Transporter Family Member 1B3/chemistry ; Solute Carrier Organic Anion Transporter Family Member 1B3/genetics ; Solute Carrier Organic Anion Transporter Family Member 1B3/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma.
Autorzy:
Wen J; Department of GCP, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Zhao M; School of Pharmacy, Nanchang University, Nanchang 330006, China.
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Źródło:
Disease markers [Dis Markers] 2021 Sep 26; Vol. 2021, pp. 9711179. Date of Electronic Publication: 2021 Sep 26 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Mutation*
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Liver-Specific Organic Anion Transporter 1/*metabolism
Sorafenib/*pharmacokinetics
Sorafenib/*pharmacology
Animals ; Antineoplastic Agents ; Apoptosis ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver-Specific Organic Anion Transporter 1/genetics ; Male ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prevalence of dyslipidemia and gene polymorphisms of ABCB1 and SLCO1B1 in Han, Uygur, Kazak, Hui, Tatar, Kirgiz, and Sibe populations with coronary heart disease in Xinjiang, China.
Autorzy:
Wang T; Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.; Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.
Sun L; Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.; Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.
Xu L; Internal Medicine-Cardiovascular Department, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.
Zhao T; Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.
Feng J; Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.
Yu L; Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.
Wu J; Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China. .; Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China. .
Li H; Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2021 Sep 25; Vol. 20 (1), pp. 116. Date of Electronic Publication: 2021 Sep 25.
Typ publikacji:
Journal Article
MeSH Terms:
Coronary Disease/*blood
Coronary Disease/*genetics
Dyslipidemias/*blood
Dyslipidemias/*genetics
Liver-Specific Organic Anion Transporter 1/*genetics
ATP Binding Cassette Transporter, Subfamily B/blood ; ATP Binding Cassette Transporter, Subfamily B/genetics ; Aged ; Alleles ; Apolipoproteins/blood ; China/epidemiology ; China/ethnology ; Ethnicity ; Female ; Genotype ; Humans ; Liver-Specific Organic Anion Transporter 1/blood ; Male ; Middle Aged ; Models, Statistical ; Polymorphism, Genetic ; Prevalence ; Retrospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics.
Autorzy:
Ambrus C; SOLVO Biotechnology, Irinyi József street 4-20, 1117, Budapest, Hungary.; Doctoral School of Molecular Medicine, Semmelweis University, Tűzoltó u. 37-47, 1094, Budapest, Hungary.
Bakos É; Institute of Enzymology, ELKH Research Centre for Natural Sciences, Magyar Tudósok krt. 2, 1117, Budapest, Hungary.
Sarkadi B; Institute of Enzymology, ELKH Research Centre for Natural Sciences, Magyar Tudósok krt. 2, 1117, Budapest, Hungary.; Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó u. 37-47, 1094, Budapest, Hungary.
Özvegy-Laczka C; Institute of Enzymology, ELKH Research Centre for Natural Sciences, Magyar Tudósok krt. 2, 1117, Budapest, Hungary.
Telbisz Á; Institute of Enzymology, ELKH Research Centre for Natural Sciences, Magyar Tudósok krt. 2, 1117, Budapest, Hungary. .
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Źródło:
Scientific reports [Sci Rep] 2021 Sep 08; Vol. 11 (1), pp. 17810. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
ATP Binding Cassette Transporter, Subfamily B, Member 11/*metabolism
Antiviral Agents/*pharmacology
Liver/*drug effects
Liver-Specific Organic Anion Transporter 1/*metabolism
Organic Cation Transport Proteins/*metabolism
ATP Binding Cassette Transporter, Subfamily B, Member 11/antagonists & inhibitors ; Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/chemistry ; Adenosine Monophosphate/metabolism ; Adenosine Monophosphate/pharmacology ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/chemistry ; Alanine/metabolism ; Alanine/pharmacology ; Alanine/therapeutic use ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/therapeutic use ; Comorbidity ; Drug Repositioning ; Humans ; Liver/metabolism ; Liver/pathology ; Liver-Specific Organic Anion Transporter 1/antagonists & inhibitors ; Lopinavir/chemistry ; Lopinavir/metabolism ; Lopinavir/pharmacology ; Lopinavir/therapeutic use ; Multidrug Resistance-Associated Protein 2 ; Organic Cation Transport Proteins/antagonists & inhibitors ; Ritonavir/chemistry ; Ritonavir/metabolism ; Ritonavir/pharmacology ; Ritonavir/therapeutic use ; SARS-CoV-2/isolation & purification ; Substrate Specificity ; COVID-19 Drug Treatment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Regulatory guidelines do not accurately predict tolvaptan and metabolite interactions at BCRP, OATP1B1, and OAT3 transporters.
Autorzy:
Shoaf SE; Quantitative Pharmacology, Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA.
Bricmont P; Global Clinical Management, Otsuka Pharmaceutical Development & Commercialization, Inc, Rockville, Maryland, USA.
Repella Gordon J; Global Clinical Management, Otsuka Pharmaceutical Development & Commercialization, Inc, Rockville, Maryland, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Jul; Vol. 14 (4), pp. 1535-1542. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
Drug Approval/*statistics & numerical data
Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Organic Anion Transporters, Sodium-Independent/*antagonists & inhibitors
Tolvaptan/*pharmacology
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Adult ; Clinical Trials as Topic/standards ; Cross-Over Studies ; Drug Interactions ; Female ; Furosemide/pharmacology ; Furosemide/therapeutic use ; Guidelines as Topic ; HEK293 Cells ; Half-Life ; Humans ; Liver-Specific Organic Anion Transporter 1/metabolism ; Male ; Neoplasm Proteins/metabolism ; Organic Anion Transporters, Sodium-Independent/metabolism ; Rosuvastatin Calcium/pharmacology ; Rosuvastatin Calcium/therapeutic use ; Tolvaptan/metabolism ; Tolvaptan/therapeutic use ; United States ; United States Food and Drug Administration/standards ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Relationship of hemoglobin level and plasma coproporphyrin-I concentrations as an endogenous probe for phenotyping OATP1B.
Autorzy:
Suzuki Y; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Kiyose, Japan.
Sasamoto Y; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Kiyose, Japan.
Koyama T; Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yoshijima C; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Kiyose, Japan.
Oda A; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Kiyose, Japan.
Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Momozawa Y; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Uehara R; Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ohno K; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Kiyose, Japan.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Jul; Vol. 14 (4), pp. 1403-1411. Date of Electronic Publication: 2021 May 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Coproporphyrins/*blood
Hemoglobins/*analysis
Liver-Specific Organic Anion Transporter 1/*genetics
Adult ; Aged ; Alleles ; Biomarkers/blood ; Cohort Studies ; Coproporphyrins/metabolism ; Female ; Genome-Wide Association Study ; Heme/analysis ; Heme/biosynthesis ; Humans ; Liver-Specific Organic Anion Transporter 1/metabolism ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Precision Medicine/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Substantially Increased Plasma Coproporphyrin-I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population.
Autorzy:
Suzuki Y; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Tokyo, Japan.
Sasamoto Y; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Tokyo, Japan.
Koyama T; Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yoshijima C; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Tokyo, Japan.
Nakatochi M; Department of Nursing, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Momozawa Y; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Uehara R; Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ohno K; Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Tokyo, Japan.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Jan; Vol. 14 (1), pp. 382-388. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji:
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Pharmacological/*blood
Coproporphyrins/*blood
Liver-Specific Organic Anion Transporter 1/*genetics
Adult ; Aged ; Alleles ; Biomarkers, Pharmacological/metabolism ; Coproporphyrins/metabolism ; Dose-Response Relationship, Drug ; Drug Interactions ; Feasibility Studies ; Female ; Genotyping Techniques ; Humans ; Japan ; Liver-Specific Organic Anion Transporter 1/metabolism ; Male ; Middle Aged ; Pharmacogenomic Variants
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Coproporphyrin I Can Serve as an Endogenous Biomarker for OATP1B1 Inhibition: Assessment Using a Glecaprevir/Pibrentasvir Clinical Study.
Autorzy:
Kalluri HV; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.
Kikuchi R; Drug Metabolism and Pharmacokinetics, AbbVie Inc., North Chicago, Illinois, USA.
Coppola S; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.
Schmidt J; Drug Metabolism and Pharmacokinetics, AbbVie Inc., North Chicago, Illinois, USA.
Mohamed MF; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.
Bow DAJ; Drug Metabolism and Pharmacokinetics, AbbVie Inc., North Chicago, Illinois, USA.
Salem AH; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2021 Jan; Vol. 14 (1), pp. 373-381. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzimidazoles/*pharmacokinetics
Biomarkers, Pharmacological/*blood
Coproporphyrins/*blood
Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors
Pyrrolidines/*pharmacokinetics
Quinoxalines/*pharmacokinetics
Sulfonamides/*pharmacokinetics
Adult ; Area Under Curve ; Benzimidazoles/administration & dosage ; Biological Availability ; Biomarkers, Pharmacological/metabolism ; Coproporphyrins/metabolism ; Cross-Over Studies ; Drug Combinations ; Drug Interactions ; Drug Monitoring/methods ; Female ; Healthy Volunteers ; Humans ; Liver-Specific Organic Anion Transporter 1/metabolism ; Male ; Middle Aged ; Prospective Studies ; Pyrrolidines/administration & dosage ; Quinoxalines/administration & dosage ; Sulfonamides/administration & dosage ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population.
Autorzy:
Wu H; Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Engineering and Technology Research Center for Clinical Molecular Diagnostics and Antibody Therapeutics, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Engineering and Technology Research Center for Molecular Diagnostics of Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.
Huang Q; Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Engineering and Technology Research Center for Clinical Molecular Diagnostics and Antibody Therapeutics, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Engineering and Technology Research Center for Molecular Diagnostics of Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.
Yu Z; Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Engineering and Technology Research Center for Clinical Molecular Diagnostics and Antibody Therapeutics, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Engineering and Technology Research Center for Molecular Diagnostics of Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.
Wu H; Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Engineering and Technology Research Center for Clinical Molecular Diagnostics and Antibody Therapeutics, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.; Guangdong Provincial Engineering and Technology Research Center for Molecular Diagnostics of Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China.
Zhong Z; Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China. .; Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China. .; Guangdong Provincial Engineering and Technology Research Center for Clinical Molecular Diagnostics and Antibody Therapeutics, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China. .; Guangdong Provincial Engineering and Technology Research Center for Molecular Diagnostics of Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China. .; Center for Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P. R. China. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2020 Sep 05; Vol. 19 (1), pp. 202. Date of Electronic Publication: 2020 Sep 05.
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Predisposition to Disease*
Polymorphism, Single Nucleotide*
Apolipoproteins E/*genetics
Cerebral Infarction/*genetics
Liver-Specific Organic Anion Transporter 1/*genetics
Aged ; Alleles ; Apolipoprotein A-I/blood ; Apolipoprotein A-I/genetics ; Apolipoprotein B-100/blood ; Apolipoprotein B-100/genetics ; Apolipoproteins E/blood ; Case-Control Studies ; Cerebral Infarction/blood ; Cerebral Infarction/ethnology ; Cerebral Infarction/pathology ; China ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Ethnicity ; Female ; Gene Expression ; Gene Frequency ; Haplotypes ; Humans ; Hypertension/physiopathology ; Liver-Specific Organic Anion Transporter 1/blood ; Male ; Middle Aged ; Protein Isoforms/blood ; Protein Isoforms/genetics ; Risk Factors ; Smoking/physiopathology ; Triglycerides/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Physiologically-Based Pharmacokinetic Model-Informed Drug Development for Fenebrutinib: Understanding Complex Drug-Drug Interactions.
Autorzy:
Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Ma F; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Jones NS; Department of Clinical Science, Genentech, Inc., South San Francisco, California, USA.
Yoshida K; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Chiang PC; Department of Pharmaceutical Science, Genentech, Inc., South San Francisco, California, USA.
Durk MR; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Wright MR; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Jin JY; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Chinn LW; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2020 Jun; Vol. 9 (6), pp. 332-341. Date of Electronic Publication: 2020 May 29.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Biological*
ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
Cytochrome P-450 CYP3A/*metabolism
Cytochrome P-450 CYP3A Inhibitors/*pharmacokinetics
Intestines/*drug effects
Liver/*drug effects
Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Piperazines/*pharmacokinetics
Pyridones/*pharmacokinetics
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Animals ; Biotransformation ; Clinical Trials, Phase I as Topic ; Computer Simulation ; Cytochrome P-450 CYP3A Inhibitors/adverse effects ; Cytochrome P-450 CYP3A Inhibitors/chemistry ; Dogs ; Drug Compounding ; Drug Development ; Drug Interactions ; Excipients/chemistry ; Humans ; Liver/metabolism ; Liver-Specific Organic Anion Transporter 1/metabolism ; Madin Darby Canine Kidney Cells ; Neoplasm Proteins/metabolism ; Piperazines/adverse effects ; Piperazines/chemistry ; Pyridones/adverse effects ; Pyridones/chemistry ; Retrospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Alternative Splicing of the SLCO1B1 Gene: An Exploratory Analysis of Isoform Diversity in Pediatric Liver.
Autorzy:
van Groen BD; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Bi C; Division of Clinical Pharmacology, Toxicology, & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Gaedigk R; Division of Clinical Pharmacology, Toxicology, & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Staggs VS; Health Services and Outcomes Research, Children's Mercy Kansas City, School of Medicine, University of Missouri-Kansas, Kansas City, Missouri, USA.
Tibboel D; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
de Wildt SN; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Pharmacology and Toxicology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Leeder JS; Division of Clinical Pharmacology, Toxicology, & Therapeutic Innovation, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2020 May; Vol. 13 (3), pp. 509-519. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Alternative Splicing*
Gene Expression Regulation, Developmental*
Liver/*metabolism
Liver-Specific Organic Anion Transporter 1/*genetics
Aborted Fetus ; Adolescent ; Age Factors ; Child ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Liver-Specific Organic Anion Transporter 1/metabolism ; Netherlands ; Organic Anion Transporters/genetics ; Organic Anion Transporters/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA-Seq ; Solute Carrier Proteins/genetics ; Solute Carrier Proteins/metabolism ; Stillbirth
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reused palm oil from frying pork or potato induced expression of cytochrome P450s and the SLCO1B1 transporter in HepG2 cells.
Autorzy:
Chatuphonprasert W; Faculty of Medicine, Mahasarakham University, Maha Sarakham, Thailand.
Nawaratt N; Research Group for Pharmaceutical Activities of Natural Products using Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Jarukamjorn K; Research Group for Pharmaceutical Activities of Natural Products using Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand.
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Źródło:
Journal of food biochemistry [J Food Biochem] 2020 May; Vol. 44 (5), pp. e13178. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cytochrome P-450 Enzyme System*/genetics
Liver-Specific Organic Anion Transporter 1*
Palm Oil*
Pork Meat*
Solanum tuberosum*
Animals ; Hep G2 Cells ; Humans ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.
Autorzy:
Wagner JB; Ward Family Heart Center, Children's Mercy, Kansas City, Missouri, USA.; Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Abdel-Rahman S; Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Gaedigk A; Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Gaedigk R; Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Raghuveer G; Ward Family Heart Center, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Staggs VS; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Health Services & Outcomes Research, Children's Mercy, Kansas City, Missouri, USA.
Van Haandel L; Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Leeder JS; Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2020 May; Vol. 13 (3), pp. 628-637. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji:
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypercholesterolemia/*drug therapy
Liver-Specific Organic Anion Transporter 1/*genetics
Rosuvastatin Calcium/*pharmacokinetics
Adolescent ; Child ; Female ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/genetics ; Liver-Specific Organic Anion Transporter 1/metabolism ; Male ; Pharmacogenomic Variants ; Polymorphism, Single Nucleotide ; Rosuvastatin Calcium/administration & dosage ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Scutellarin inhibition of the rosuvastatin uptake in rat hepatocytes and the competition for organic anion transporting polypeptide 1B1 in HEK293T cells.
Autorzy:
Liu J; Clinical Pharmacology Institute, Nanchang University, Nanchang, Jiangxi, 330031, China. .; School of Pharmacy, JiangXi Medical College, Shangrao, Jiangxi, 334000, China. .
Guo Y; School of Pharmacy, JiangXi Medical College, Shangrao, Jiangxi, 334000, China.
Liu K; School of Pharmacy, JiangXi Medical College, Shangrao, Jiangxi, 334000, China.
Ye X; School of Pharmacy, JiangXi Medical College, Shangrao, Jiangxi, 334000, China.
Wang F; School of Pharmacy, JiangXi Medical College, Shangrao, Jiangxi, 334000, China.
Xu Y; School of Pharmacy, JiangXi Medical College, Shangrao, Jiangxi, 334000, China.
Xia C; Clinical Pharmacology Institute, Nanchang University, Nanchang, Jiangxi, 330031, China. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jan 28; Vol. 10 (1), pp. 1308. Date of Electronic Publication: 2020 Jan 28.
Typ publikacji:
Journal Article
MeSH Terms:
Anions/*metabolism
Apigenin/*pharmacology
Glucuronates/*pharmacology
Hepatocytes/*drug effects
Hepatocytes/*metabolism
Liver-Specific Organic Anion Transporter 1/*metabolism
Rosuvastatin Calcium/*metabolism
Animals ; Biomarkers ; Cell Line, Tumor ; Gene Expression ; Humans ; Liver/drug effects ; Liver/metabolism ; Liver-Specific Organic Anion Transporter 1/genetics ; Male ; Mass Spectrometry ; Rats ; Rosuvastatin Calcium/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Variability in In Vitro OATP1B1/1B3 Inhibition Data: Impact of Incubation Conditions on Variability and Subsequent Drug Interaction Predictions.
Autorzy:
McFeely SJ; Department of Pharmaceutics, UW Drug Interaction Solutions, University of Washington, Seattle, Washington, USA.
Ritchie TK; Department of Pharmaceutics, UW Drug Interaction Solutions, University of Washington, Seattle, Washington, USA.
Ragueneau-Majlessi I; Department of Pharmaceutics, UW Drug Interaction Solutions, University of Washington, Seattle, Washington, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2020 Jan; Vol. 13 (1), pp. 47-52. Date of Electronic Publication: 2019 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Evaluation, Preclinical/*methods
Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors
Solute Carrier Organic Anion Transporter Family Member 1B3/*antagonists & inhibitors
Cell Culture Techniques/methods ; Cell Culture Techniques/standards ; Cyclosporine/pharmacology ; Datasets as Topic ; Drug Evaluation, Preclinical/standards ; Drug Interactions ; Gemfibrozil/pharmacology ; Guidelines as Topic ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Liver-Specific Organic Anion Transporter 1/metabolism ; Reproducibility of Results ; Rifampin/pharmacology ; Solute Carrier Organic Anion Transporter Family Member 1B3/metabolism ; United States ; United States Food and Drug Administration/standards
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
microRNA-206 modulates the hepatic expression of the organic anion-transporting polypeptide 1B1.
Autorzy:
El Saadany T; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
van Rosmalen B; Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Gai Z; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.; Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China.
Hiller C; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Verheij J; Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Stieger B; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
van Gulik T; Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Visentin M; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Kullak-Ublick GA; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.; Mechanistic Safety, CMO & Patient Safety, Global Drug Development, Novartis Pharma, Basel, Switzerland.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2019 Dec; Vol. 39 (12), pp. 2350-2359. Date of Electronic Publication: 2019 Sep 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Estrone/*analogs & derivatives
Liver/*metabolism
Liver-Specific Organic Anion Transporter 1/*metabolism
MicroRNAs/*metabolism
Animals ; CHO Cells ; Cell Line, Tumor ; Computer Simulation ; Cricetulus ; Estrone/metabolism ; Female ; Humans ; Liver-Specific Organic Anion Transporter 1/genetics ; Male ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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