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Wyświetlanie 1-20 z 2670
Tytuł:
Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice.
Autorzy:
Keskin I; Department of Medical Biosciences, Pathology, Umeå University, 90185, Umeå, Sweden.
Ekhtiari Bidhendi E; Department of Clinical Sciences, Neurosciences, Umeå University, 90185, Umeå, Sweden.
Marklund M; Department of Medical Biosciences, Pathology, Umeå University, 90185, Umeå, Sweden.
Andersen PM; Department of Clinical Sciences, Neurosciences, Umeå University, 90185, Umeå, Sweden.
Brännström T; Department of Medical Biosciences, Pathology, Umeå University, 90185, Umeå, Sweden.
Marklund SL; Department of Medical Biosciences, Clinical Chemistry, Umeå University, 90185, Umeå, Sweden.
Nordström U; Department of Clinical Sciences, Neurosciences, Umeå University, 90185, Umeå, Sweden. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Jun 22; Vol. 9 (1), pp. 111. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Superoxide Dismutase-1*
Amyotrophic Lateral Sclerosis/*pathology
Protein Aggregation, Pathological/*pathology
Animals ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice.
Autorzy:
Lehmann M; Department of Clinical Science, Neurosciences, Umeå University, 901 87, Umeå, Sweden.
Marklund M; Department of Medical Biosciences, Pathology, Umeå University, 901 87, Umeå, Sweden.
Bolender AL; Department of Clinical Science, Neurosciences, Umeå University, 901 87, Umeå, Sweden.
Bidhendi EE; Department of Clinical Science, Neurosciences, Umeå University, 901 87, Umeå, Sweden.
Zetterström P; Department of Medical Biosciences, Clinical Chemistry, Umeå University, 901 87, Umeå, Sweden.
Andersen PM; Department of Clinical Science, Neurosciences, Umeå University, 901 87, Umeå, Sweden.
Brännström T; Department of Medical Biosciences, Pathology, Umeå University, 901 87, Umeå, Sweden.
Marklund SL; Department of Medical Biosciences, Clinical Chemistry, Umeå University, 901 87, Umeå, Sweden.
Gilthorpe JD; Department of Integrative Medical Biology, Umeå University, 901 87, Umeå, Sweden.
Nordström U; Department of Clinical Science, Neurosciences, Umeå University, 901 87, Umeå, Sweden. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2020 Sep 14; Vol. 8 (1), pp. 161. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis*
Antibodies, Monoclonal/*pharmacology
Protein Aggregation, Pathological/*metabolism
Protein Aggregation, Pathological/*pathology
Superoxide Dismutase-1/*metabolism
Animals ; Disease Models, Animal ; Disease Progression ; Humans ; Mice ; Mice, Transgenic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis.
Autorzy:
Paré B; Laval University Experimental Organogenesis Research Center/LOEX, Division of Regenerative Medicine, CHU de Québec Research Center - Enfant-Jésus Hospital, Québec, Canada.; Department of Surgery, Faculty of Medicine, Laval University, Québec, Canada.
Lehmann M; Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
Beaudin M; Neuroscience Division of the CHU de Québec and Department of Medicine of the Faculty of Medicine, Laval University, Québec, QC, Canada.
Nordström U; Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
Saikali S; Department of Medical Biology, Division of Anatomic Pathology and Neuropathology, CHU de Québec, Hôpital de l'Enfant-Jésus, Québec, Canada.
Julien JP; Department of Psychiatry and Neuroscience, Laval University, Québec City, Québec, Canada.; Centre de Recherche CERVO, Québec City, Québec, Canada.
Gilthorpe JD; Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
Marklund SL; Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.
Cashman NR; Department of Medicine (Neurology), Brain Research Center, University of British Columbia, Vancouver, BC, Canada.
Andersen PM; Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.
Forsberg K; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Dupré N; Neuroscience Division of the CHU de Québec and Department of Medicine of the Faculty of Medicine, Laval University, Québec, QC, Canada.
Gould P; Department of Medical Biology, Division of Anatomic Pathology and Neuropathology, CHU de Québec, Hôpital de l'Enfant-Jésus, Québec, Canada.
Brännström T; Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Gros-Louis F; Laval University Experimental Organogenesis Research Center/LOEX, Division of Regenerative Medicine, CHU de Québec Research Center - Enfant-Jésus Hospital, Québec, Canada. .; Department of Surgery, Faculty of Medicine, Laval University, Québec, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2018 Sep 21; Vol. 8 (1), pp. 14223. Date of Electronic Publication: 2018 Sep 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*metabolism
Superoxide Dismutase-1/*metabolism
Aged ; Animals ; Antibodies/metabolism ; Brain/metabolism ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Middle Aged ; Protein Folding ; Spinal Cord/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of exercise training associated with enalapril treatment on blood pressure variability and renal dysfunctions in an experimental model of arterial hypertension and postmenopause.
Autorzy:
dos Santos Ferreira Silva, Michel Pablo (AUTHOR)
Ferreira, Maycon Junior (AUTHOR)
Shecaira, Tânia Plens (AUTHOR)
da Silva Dias, Danielle (AUTHOR)
Kimura, Débora Conte (AUTHOR)
Irigoyen, Maria Cláudia (AUTHOR)
Gomes, Guiomar Nascimento (AUTHOR)
De Angelis, Kátia (AUTHOR)
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Źródło:
PLoS ONE. 1/10/2024, Vol. 19 Issue 1, p1-16. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of oxidative stress-related genetic variants: "Explicating the role of reactive oxygen species influenced antioxidant gene polymorphism," a risk stratification of type 2 diabetes mellitus-associated nephropathy: a systematic review.
Autorzy:
Begum, Farhana (AUTHOR)
Lakshmanan, Karpagavel (AUTHOR)
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Źródło:
Egyptian Journal of Medical Human Genetics. 12/7/2023, Vol. 24 Issue 1, p1-9. 9p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comprehensive analysis to explain reduced or increased SOD1 enzymatic activity in ALS patients and their relatives.
Autorzy:
Keskin I; a Department of Pharmacology and Clinical Neurosciences , Umeå University , Umeå , Sweden.
Birve A; a Department of Pharmacology and Clinical Neurosciences , Umeå University , Umeå , Sweden.
Berdynski M; a Department of Pharmacology and Clinical Neurosciences , Umeå University , Umeå , Sweden.; b Department of Neurodegenerative Disorders , Mossakowski Medical Research Centre, Polish Academy of Sciences , Warsaw , Poland.
Hjertkvist K; c Department of Medical Biosciences, Clinical Chemistry , Umeå University , Umeå , Sweden , and.
Rofougaran R; a Department of Pharmacology and Clinical Neurosciences , Umeå University , Umeå , Sweden.
Nilsson TK; c Department of Medical Biosciences, Clinical Chemistry , Umeå University , Umeå , Sweden , and.
Glass JD; d Department of Neurology , Emory University School of Medicine , Atlanta , GA , USA.
Marklund SL; c Department of Medical Biosciences, Clinical Chemistry , Umeå University , Umeå , Sweden , and.
Andersen PM; a Department of Pharmacology and Clinical Neurosciences , Umeå University , Umeå , Sweden.
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Źródło:
Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2017 Aug; Vol. 18 (5-6), pp. 457-463. Date of Electronic Publication: 2017 Mar 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*blood
Amyotrophic Lateral Sclerosis/*genetics
Superoxide Dismutase-1/*blood
Superoxide Dismutase-1/*genetics
Aged ; Amyotrophic Lateral Sclerosis/diagnosis ; Cohort Studies ; Enzyme Activation/physiology ; Family ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A 50 bp deletion in the SOD1 promoter lowers enzyme expression but is not associated with ALS in Sweden.
Autorzy:
Ingre C; a Departments of Pharmacology and Clinical Neuroscience .; b Department of Clinical Neuroscience , Karolinska Institute , Stockholm , Sweden .
Wuolikainen A; c Chemistry , Umeå University , Umeå , and.
Marklund SL; d Medical Biosciences.
Birve A; a Departments of Pharmacology and Clinical Neuroscience .
Press R; b Department of Clinical Neuroscience , Karolinska Institute , Stockholm , Sweden .
Andersen PM; a Departments of Pharmacology and Clinical Neuroscience .
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Źródło:
Amyotrophic lateral sclerosis & frontotemporal degeneration [Amyotroph Lateral Scler Frontotemporal Degener] 2016 Jul-Aug; Vol. 17 (5-6), pp. 452-7. Date of Electronic Publication: 2016 Mar 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis*/enzymology
Amyotrophic Lateral Sclerosis*/epidemiology
Amyotrophic Lateral Sclerosis*/genetics
Polymorphism, Genetic/*genetics
Sequence Deletion/*genetics
Superoxide Dismutase-1/*genetics
Superoxide Dismutase-1/*metabolism
Adult ; Aged ; Analysis of Variance ; Cohort Studies ; Erythrocytes/enzymology ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Sweden/epidemiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The copper chelator ammonium tetrathiomolybdate inhibits the progression of experimental endometriosis in TNFR1-deficient mice.
Autorzy:
Conforti, Rocío Ayelem (AUTHOR)
Delsouc, María Belén (AUTHOR)
Zabala, Ana Sofia (AUTHOR)
Vallcaneras, Sandra Silvina (AUTHOR)
Casais, Marilina (AUTHOR)
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Źródło:
Scientific Reports. 6/26/2023, Vol. 13 Issue 1, p1-10. 10p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Valuable effects of lactobacillus and citicoline on steatohepatitis: role of Nrf2/HO-1 and gut microbiota.
Autorzy:
El-Baz, Ahmed M. (AUTHOR)
El-Ganiny, Amira M. (AUTHOR)
Hellal, Doaa (AUTHOR)
Anwer, Hala M. (AUTHOR)
El-Aziz, Hend A. Abd (AUTHOR)
Tharwat, Ibrahim E. (AUTHOR)
El-Adawy, Mohamed A. (AUTHOR)
Helal, Shehab El-Din M. (AUTHOR)
Mohamed, Menna Tallah A. (AUTHOR)
Azb, Tassnim M. (AUTHOR)
Elshafaey, Hanya M. (AUTHOR)
Shalata, AbdulRahman A. (AUTHOR)
Elmeligi, Sahar M. (AUTHOR)
Abdelbary, Noran H. (AUTHOR)
El-kott, Attalla F. (AUTHOR)
Al-Saeed, Fatimah A. (AUTHOR)
Salem, Eman T. (AUTHOR)
El-Sokkary, Mohamed M. Adel (AUTHOR)
Shata, Ahmed (AUTHOR)
Shabaan, Ahmed A. (AUTHOR)
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Źródło:
AMB Express. 6/8/2023, Vol. 13 Issue 1, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Protein kinetics of superoxide dismutase‐1 in familial and sporadic amyotrophic lateral sclerosis.
Autorzy:
Ly, Cindy V. (AUTHOR)
Ireland, Margaret D. (AUTHOR)
Self, Wade K. (AUTHOR)
Bollinger, James (AUTHOR)
Jockel‐Balsarotti, Jennifer (AUTHOR)
Herzog, Hillary (AUTHOR)
Allred, Peggy (AUTHOR)
Miller, Leah (AUTHOR)
Doyle, Michael (AUTHOR)
Anez‐Bruzual, Isabel (AUTHOR)
Trikamji, Bhavesh (AUTHOR)
Hyman, Ted (AUTHOR)
Kung, Tyler (AUTHOR)
Nicholson, Katherine (AUTHOR)
Bucelli, Robert C. (AUTHOR)
Patterson, Bruce W. (AUTHOR)
Bateman, Randall J. (AUTHOR)
Miller, Timothy M. (AUTHOR)
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Źródło:
Annals of Clinical & Translational Neurology. Jun2023, Vol. 10 Issue 6, p1012-1024. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients.
Autorzy:
Keskin I; Department of Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden.
Forsgren E; Department of Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden.
Lange DJ; Department of Neurology, Hospital for Special Surgery and Weill Cornell Medical Center, New York, NY, United States of America.
Weber M; Neuromusucular Diseases Unit/ALS Clinic, Kantonsspital St.Gallen, St. Gallen, Switzerland.
Birve A; Department of Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden.
Synofzik M; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Research Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany.
Gilthorpe JD; Department of Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden.
Andersen PM; Department of Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden.
Marklund SL; Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.
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Źródło:
PloS one [PLoS One] 2016 Feb 26; Vol. 11 (2), pp. e0150133. Date of Electronic Publication: 2016 Feb 26 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Protein Folding*
Amyotrophic Lateral Sclerosis/*metabolism
Fibroblasts/*enzymology
Superoxide Dismutase/*metabolism
Adenine/analogs & derivatives ; Adenine/pharmacology ; Age of Onset ; Aging/metabolism ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Autophagy/drug effects ; Autophagy/physiology ; Bortezomib/pharmacology ; C9orf72 Protein ; Case-Control Studies ; Cells, Cultured ; DNA Repeat Expansion ; Electron Transport Complex I/antagonists & inhibitors ; Endoplasmic Reticulum Stress ; Enzyme-Linked Immunosorbent Assay ; Fibroblasts/pathology ; Genotype ; Humans ; Mutation ; Protease Inhibitors/pharmacology ; Proteasome Endopeptidase Complex/metabolism ; Protein Aggregation, Pathological ; Proteins/genetics ; Proteolysis ; Rotenone/pharmacology ; Solubility ; Superoxide Dismutase/genetics ; Superoxide Dismutase-1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase.
Autorzy:
Tokuda E; Department of Medical Biosciences, Umeå University, Building 6 M, 2nd Floor, Umeå, SE 901 85, Sweden.; Present Address: Department of Chemistry, Keio University, 3-14-1, Hiyoshi, Yokohama, 223-0061, Kanagawa, Japan.
Brännström T; Department of Medical Biosciences, Umeå University, Building 6 M, 2nd Floor, Umeå, SE 901 85, Sweden.
Andersen PM; Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, SE 901 85, Sweden.
Marklund SL; Department of Medical Biosciences, Umeå University, Building 6 M, 2nd Floor, Umeå, SE 901 85, Sweden. stefan.marklund@medbio.umu.se.
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2016 Jan 25; Vol. 4, pp. 6. Date of Electronic Publication: 2016 Jan 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amyotrophic Lateral Sclerosis/*genetics
Amyotrophic Lateral Sclerosis/*pathology
Autophagy/*genetics
Mutation/*genetics
Spinal Cord/*pathology
Superoxide Dismutase/*genetics
Adult ; Aged ; Aged, 80 and over ; Animals ; Apoptosis Regulatory Proteins/deficiency ; Apoptosis Regulatory Proteins/genetics ; Beclin-1 ; C9orf72 Protein ; Disease Models, Animal ; Female ; Gene Expression Regulation/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Phenotype ; Proteasome Endopeptidase Complex/metabolism ; Protein Aggregation, Pathological/genetics ; Proteins/genetics ; Spinal Cord/metabolism ; Ubiquitinated Proteins/genetics ; Ubiquitinated Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 2670

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