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Wyświetlanie 1-20 z 2309
Tytuł:
A polo-like kinase inhibitor identified by computational repositioning attenuates pulmonary fibrosis.
Autorzy:
Imakura T; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Sato S; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Koyama K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Ogawa H; Department of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Niimura T; Department of Clinical Pharmacology and Therapeutics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Murakami K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Yamashita Y; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Haji K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Naito N; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Kagawa K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Kawano H; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Zamami Y; Department of Clinical Pharmacology and Therapeutics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.; Department of Pharmacy, Okayama University Hospital, Okayama, Japan.
Ishizawa K; Department of Clinical Pharmacology and Therapeutics, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Nishioka Y; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. .
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Źródło:
Respiratory research [Respir Res] 2023 Jun 02; Vol. 24 (1), pp. 148. Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Repositioning*
Idiopathic Pulmonary Fibrosis*/metabolism
Mice ; Animals ; Thiophenes/therapeutic use ; Benzimidazoles/metabolism ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use ; Lung/metabolism ; Fibroblasts/metabolism ; Bleomycin/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The lymphocyte-specific protein tyrosine kinase-specific inhibitor A-770041 attenuates lung fibrosis via the suppression of TGF-β production in regulatory T-cells.
Autorzy:
Kagawa K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Sato S; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Koyama K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Imakura T; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Murakami K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Yamashita Y; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Naito N; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Ogawa H; Department of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Kawano H; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Nishioka Y; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
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Źródło:
PloS one [PLoS One] 2022 Oct 27; Vol. 17 (10), pp. e0275987. Date of Electronic Publication: 2022 Oct 27 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/drug therapy
Pulmonary Fibrosis*/metabolism
Mice ; Animals ; T-Lymphocytes, Regulatory ; Transforming Growth Factor beta1/metabolism ; Bleomycin ; Transforming Growth Factor beta/metabolism ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prominent gamma band activity during visual motion perception in early-stage Alzheimer's disease.
Autorzy:
Naito N; Department of Psychiatry & Behavioral Science, Kanazawa University, Kanazawa, Japan.
Hirosawa T; Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan.
Tsubomoto M; Department of Psychiatry & Behavioral Science, Kanazawa University, Kanazawa, Japan.
Miyagishi Y; Department of Psychiatry & Behavioral Science, Kanazawa University, Kanazawa, Japan.
Kikuchi M; Department of Psychiatry & Behavioral Science, Kanazawa University, Kanazawa, Japan.; Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan.
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Źródło:
PloS one [PLoS One] 2022 Apr 18; Vol. 17 (4), pp. e0266693. Date of Electronic Publication: 2022 Apr 18 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/diagnosis
Motion Perception*
Humans ; Magnetoencephalography ; Neural Pathways ; Visual Perception
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Miniaturized centrifugal ventricular assist device for bridge to decision: Preclinical chronic study in a bovine model.
Autorzy:
Shimamura J; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.; Department of Cardiac Surgery, University of Tokyo, Tokyo, Japan.
Mizuno T; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Takewa Y; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Tsukiya T; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Naito N; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.; Department of Cardiac Surgery, University of Tokyo, Tokyo, Japan.
Akiyama D; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.; Department of Cardiac Surgery, University of Tokyo, Tokyo, Japan.
Iizuka K; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Katagiri N; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Nishimura T; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.; Department of Cardiac Surgery, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
Ono M; Department of Cardiac Surgery, University of Tokyo, Tokyo, Japan.
Tatsumi E; Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
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Źródło:
Artificial organs [Artif Organs] 2019 Sep; Vol. 43 (9), pp. 821-827. Date of Electronic Publication: 2019 Apr 25.
Typ publikacji:
Journal Article
MeSH Terms:
Heart-Assist Devices*/adverse effects
Hemodynamics*
Animals ; Anticoagulants/therapeutic use ; Cattle ; Disease Models, Animal ; Equipment Design ; Extracorporeal Circulation/instrumentation ; Heart Failure/physiopathology ; Heart Failure/surgery ; Hemorrhage/etiology ; Humans ; Hydrodynamics ; Male ; Thrombosis/etiology ; Thrombosis/prevention & control
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 2309

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