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Tytuł:
Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers.
Autorzy:
Choi B; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA. .; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA. .
San José Estépar R; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Godbole S; Anschutz Medical Campus, Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, USA.
Curtis JL; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Wang JM; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
San José Estépar R; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Rosas IO; Baylor College of Medicine, Houston, TX, USA.
Mayers JR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA.
Hobbs BD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Hersh CP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Ash SY; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.; Department of Critical Care, South Shore Hospital, South Weymouth, MA, USA.
Han MK; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Bowler RP; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Stringer KA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Washko GR; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Pulmonary-PBB-CA-3, Boston, MA, 02115, USA.; Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Labaki WW; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
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Źródło:
Respiratory research [Respir Res] 2023 Nov 04; Vol. 24 (1), pp. 265. Date of Electronic Publication: 2023 Nov 04.
Typ publikacji:
Journal Article
MeSH Terms:
Niacin*
Pulmonary Emphysema*/diagnostic imaging
Pulmonary Emphysema*/epidemiology
Emphysema*
Pulmonary Disease, Chronic Obstructive*/diagnostic imaging
Pulmonary Disease, Chronic Obstructive*/epidemiology
Humans ; Smokers ; Lung ; Niacinamide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prognostic value of severe acute respiratory syndrome coronavirus-2 viral load and antibodies in patients hospitalized with COVID-19.
Autorzy:
Bauer RN; Genentech, South San Francisco, California, USA.
Teterina A; F. Hoffmann-La Roche Ltd, Mississauga, Ontario, Canada.
Shivram H; Genentech, South San Francisco, California, USA.
McBride J; Genentech, South San Francisco, California, USA.
Rosenberger CM; Genentech, South San Francisco, California, USA.
Cai F; Genentech, South San Francisco, California, USA.
Bao M; Genentech, South San Francisco, California, USA.
Tsai L; Genentech, South San Francisco, California, USA.
Gordon O; Roche Products Ltd, Welwyn Garden City, UK.
Lee IT; Genentech, South San Francisco, California, USA.
Wallin JJ; Gilead Sciences, Foster City, California, USA.
Porter D; Gilead Sciences, Foster City, California, USA.
Juneja K; Gilead Sciences, Foster City, California, USA.
Camus G; Gilead Sciences, Foster City, California, USA.
Rosas IO; Baylor College of Medicine, Houston, Texas, USA.
Wildum S; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 Jun; Vol. 16 (6), pp. 1049-1062. Date of Electronic Publication: 2023 Mar 29.
Typ publikacji:
Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Humans ; SARS-CoV-2 ; Prognosis ; Viral Load ; Lung ; Antibodies, Viral
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Expert consensus on the management of systemic sclerosis-associated interstitial lung disease.
Autorzy:
Rahaghi FF; Respiratory Center, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL, 33331, USA. .
Hsu VM; Rutgers-RWJ Medical School, New Brunswick, NJ, USA.
Kaner RJ; Weill Cornell Medicine, New York, NY, USA.
Mayes MD; University of Texas, Houston, TX, USA.
Rosas IO; Brigham and Women's Hospital, Boston, MA, USA.
Saggar R; University of California Los Angeles, Los Angeles, CA, USA.
Steen VD; Georgetown University, Washington, D.C, USA.
Strek ME; University of Chicago, Chicago, IL, USA.
Bernstein EJ; Columbia University Irving Medical Center, New York, NY, USA.
Bhatt N; Ohio State University, Columbus, OH, USA.
Castelino FV; Harvard Medical School, Boston, MA, USA.
Chung L; Stanford University School of Medicine and Palo Alto VA Health Care System, Stanford, CA, USA.
Domsic RT; University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Flaherty KR; University of Michigan Scleroderma Clinic, Ann Arbor, MI, 48105, USA.
Gupta N; University of Cincinnati, Cincinnati, OH, USA.
Kahaleh B; University of Toledo Medical Center, Toledo, OH, USA.
Martinez FJ; Weill Cornell Medicine, New York, NY, USA.
Morrow LE; Creighton University, Omaha, NE, USA.
Moua T; Mayo Clinic, Rochester, MN, USA.
Patel N; Columbia University Irving Medical Center, New York, NY, USA.; Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA.
Shlobin OA; Inova Fairfax Hospital, Falls Church, VA, USA.
Southern BD; Cleveland Clinic, Cleveland, OH, USA.
Volkmann ER; University of California Los Angeles, Los Angeles, CA, USA.
Khanna D; University of Michigan Scleroderma Clinic, Ann Arbor, MI, 48105, USA. .
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Źródło:
Respiratory research [Respir Res] 2023 Jan 09; Vol. 24 (1), pp. 6. Date of Electronic Publication: 2023 Jan 09.
Typ publikacji:
Journal Article
MeSH Terms:
Lung Diseases, Interstitial*/diagnosis
Lung Diseases, Interstitial*/drug therapy
Lung Diseases, Interstitial*/etiology
Scleroderma, Systemic*/complications
Scleroderma, Systemic*/diagnosis
Scleroderma, Systemic*/therapy
Humans ; Consensus ; Immunosuppressive Agents/therapeutic use ; Lung ; Mycophenolic Acid/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF.
Autorzy:
Wang L; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Zhao W; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Xia C; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Li Z; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Zhao W; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Xu K; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Wang N; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Lian H; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
Rosas IO; Division of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Yu G; State Key Laboratory Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan Center for Outstanding Overseas Scientists of Pulmonary Fibrosis, College of Life Science, Henan Normal University, Xinxiang 453007, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 11; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 11.
Typ publikacji:
Journal Article
MeSH Terms:
Idiopathic Pulmonary Fibrosis*/metabolism
Humans ; Fibrosis ; Lung/pathology ; Extracellular Matrix/metabolism ; Fibroblasts/metabolism ; Repressor Proteins/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Cell Cycle Proteins/metabolism ; Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dysregulated myosin in Hermansky-Pudlak syndrome lung fibroblasts is associated with increased cell motility.
Autorzy:
Imani J; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Bodine SPM; Medical Genetics Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
Lamattina AM; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Ma DD; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Shrestha S; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Maynard DM; Medical Genetics Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
Bishop K; Zebrafish Core Facility, NHGRI, NIH, Bethesda, MD, 20892, USA.
Nwokeji A; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Malicdan MCV; NIH Undiagnosed Diseases Program, Common Fund, Office of the Director, NIH, Bethesda, MD, 20892, USA.
Testa LC; Medical Genetics Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
Sood R; Zebrafish Core Facility, NHGRI, NIH, Bethesda, MD, 20892, USA.
Stump B; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Rosas IO; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Perrella MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Handin R; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Young LR; Division of Pulmonary and Sleep Medicine, The Children's Hospital of Philadelphia, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Gochuico BR; Medical Genetics Branch, NHGRI, NIH, Bethesda, MD, 20892, USA.
El-Chemaly S; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. .
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Źródło:
Respiratory research [Respir Res] 2022 Jun 23; Vol. 23 (1), pp. 167. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:
Journal Article
MeSH Terms:
Hermanski-Pudlak Syndrome*/genetics
Albinism ; Animals ; Cell Movement ; Fibroblasts/metabolism ; Hemorrhagic Disorders ; Humans ; Losartan/metabolism ; Lung/metabolism ; Nonmuscle Myosin Type IIB/metabolism ; Receptors, Angiotensin ; Zebrafish
SCR Disease Name:
Albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection.
Autorzy:
Yang CX; Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, BC V6T 1Z4, Canada.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Tomchaney M; Asthma and Airway Disease Research Center, College of Medicine, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Landecho MF; Department of Internal Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
Zamacona BR; Department of Internal Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
Marin Oto M; Department of Internal Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
Zulueta J; Mount-Sinai Hospital, New York, NY 10029, USA.
Malo J; Department of Surgery, University of Arizona, Tucson, AZ 85719, USA.
Knoper S; Department of Surgery, University of Arizona, Tucson, AZ 85719, USA.
Contoli M; Pulmonary Division, University of Ferrara, 44121 Ferrara, Italy.
Papi A; Pulmonary Division, University of Ferrara, 44121 Ferrara, Italy.
Vasilescu DM; Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, BC V6T 1Z4, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Sauler M; Department of Medicine, Yale University, New Haven, CT 06520, USA.
Straub C; Nanostring Technologies, Seattle, WA 98109, USA.
Tan C; Nanostring Technologies, Seattle, WA 98109, USA.
Martinez FD; Asthma and Airway Disease Research Center, College of Medicine, University of Arizona College of Medicine, Tucson, AZ 85719, USA.
Bhattacharya D; Department of Immunobiology, University of Arizona, Tucson, AZ 85719, USA.
Rosas IO; Department of Medicine and Center for Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Kheradmand F; Department of Medicine and Center for Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
Hackett TL; Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, BC V6T 1Z4, Canada.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Polverino F; Department of Medicine and Center for Translational Research, Baylor College of Medicine, Houston, TX 77030, USA.
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Źródło:
Cells [Cells] 2022 Jun 07; Vol. 11 (12). Date of Electronic Publication: 2022 Jun 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
COVID-19*
Pulmonary Disease, Chronic Obstructive*/metabolism
Humans ; Lung/metabolism ; Proteomics ; SARS-CoV-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS-CoV-2 infection.
Autorzy:
Alba GA; Division of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USA.
Samokhin AO; Division of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Wang RS; Division of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Wertheim BM; Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Haley KJ; Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital Boston Massachusetts USA.
Padera RF; Department of Pathology Brigham and Women's Hospital Boston Massachusetts USA.
Vargas SO; Department of Pathology Boston Children's Hospital Boston Massachusetts USA.
Rosas IO; Division of Pulmonary and Critical Care Medicine Baylor College of Medicine Houston Texas USA.
Hariri LP; Division of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USA.; Department of Pathology Massachusetts General Hospital Boston Massachusetts USA.
Shih A; Department of Pathology Massachusetts General Hospital Boston Massachusetts USA.
Thompson BT; Division of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts USA.
Mitchell RN; Department of Pathology Brigham and Women's Hospital Boston Massachusetts USA.
Maron BA; Division of Cardiovascular Medicine Brigham and Women's Hospital Boston Massachusetts USA.
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Źródło:
Pulmonary circulation [Pulm Circ] 2022 May 11; Vol. 12 (2), pp. e12071. Date of Electronic Publication: 2022 May 11 (Print Publication: 2022).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Autorzy:
Tsoyi K; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA. .
Esposito AJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sun B; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bowen RG; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Xiong K; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Poli F; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Cardenas R; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Chu SG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Liang X; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Ryter SW; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Beeton C; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA.
Doyle TJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Robertson MJ; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Celada LJ; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
Romero F; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
El-Chemaly SY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Perrella MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ho IC; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rosas IO; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 18; Vol. 12 (1), pp. 2847. Date of Electronic Publication: 2022 Feb 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Arthritis, Rheumatoid/*genetics
Lung Injury/*genetics
Protein-Arginine Deiminase Type 2/*genetics
Pulmonary Fibrosis/*genetics
Syndecan-2/*genetics
Animals ; Anti-Citrullinated Protein Antibodies/genetics ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology ; Bleomycin/toxicity ; Citrullination/genetics ; Fibroblasts/metabolism ; Gene Expression Regulation/genetics ; Humans ; Lung/metabolism ; Lung/pathology ; Lung Injury/chemically induced ; Lung Injury/complications ; Lung Injury/pathology ; Mice ; Mice, Transgenic ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/pathology ; Receptor-Like Protein Tyrosine Phosphatases, Class 3 ; Sp1 Transcription Factor/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation.
Autorzy:
Han J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; School of Life Sciences, Beijing University of Chinese Medicine, China.
Shi Y; School of Life Sciences, Beijing University of Chinese Medicine, China.
Willis G; Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, MA, USA.
Imani J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kwon MY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Li G; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ayaub E; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ghanta S; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ng J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Hwang N; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Tsoyi K; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
El-Chemaly S; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kourembanas S; Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, MA, USA.
Mitsialis SA; Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, MA, USA.
Rosas IO; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Liu X; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Perrella MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
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Źródło:
The FEBS journal [FEBS J] 2022 Jan; Vol. 289 (2), pp. 417-435. Date of Electronic Publication: 2021 Aug 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Extracellular Vesicles/*genetics
Inflammation/*genetics
Sepsis/*genetics
Syndecan-2/*genetics
Animals ; Cell Polarity/genetics ; Cell Polarity/immunology ; Disease Models, Animal ; Extracellular Vesicles/immunology ; Extracellular Vesicles/microbiology ; Gene Expression Regulation, Developmental/genetics ; Gene Silencing ; Humans ; Immunity/genetics ; Inflammation/microbiology ; Inflammation/pathology ; Inflammation/therapy ; Macrophages/immunology ; Macrophages/microbiology ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/metabolism ; Mice ; Neutrophils/immunology ; Neutrophils/microbiology ; Paracrine Communication/genetics ; Phagocytosis/genetics ; Sepsis/microbiology ; Sepsis/pathology ; Sepsis/therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The lung microbiome in end-stage Lymphangioleiomyomatosis.
Autorzy:
Ng J; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Pacheco-Rodriguez G; Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Begley L; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Huang YJ; Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA.
Poli S; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.; Department of Internal Medicine, Mount Sinai Medical Center, Miami, FL, USA.
Perrella MA; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Rosas IO; Department of Medicine, Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA.
Moss J; Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
El-Chemaly S; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. .
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Źródło:
Respiratory research [Respir Res] 2021 Oct 26; Vol. 22 (1), pp. 277. Date of Electronic Publication: 2021 Oct 26.
Typ publikacji:
Comparative Study; Letter
MeSH Terms:
Microbiota*
Lung/*microbiology
Lymphangioleiomyomatosis/*microbiology
Pulmonary Disease, Chronic Obstructive/*microbiology
Respiratory Tract Infections/*microbiology
Disease Progression ; Dysbiosis ; Humans ; Lung Diseases, Fungal/diagnosis ; Lung Diseases, Fungal/microbiology ; Lymphangioleiomyomatosis/diagnosis ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Respiratory Tract Infections/diagnosis ; Ribotyping
Raport
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Tytuł:
Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice.
Autorzy:
Han J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Li G; Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Hou M; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Ng J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Kwon MY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Xiong K; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Liang X; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, 77024, USA.
Taglauer E; Department of Pediatrics, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Shi Y; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Mitsialis SA; Department of Pediatrics, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Kourembanas S; Department of Pediatrics, Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
El-Chemaly S; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Lederer JA; Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Rosas IO; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, 77024, USA.
Perrella MA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Liu X; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. .; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2021 Aug 30; Vol. 12 (1), pp. 487. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Acute Lung Injury*/chemically induced
Acute Lung Injury*/therapy
Trophoblasts*
Alveolar Epithelial Cells ; Animals ; Bronchoalveolar Lavage Fluid ; Lipopolysaccharides ; Lung ; Mice ; Mice, Inbred C57BL ; Stem Cells
Czasopismo naukowe
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Tytuł:
Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung.
Autorzy:
Cuevas-Mora K; Department of Medicine, Division of Pulmonary, Allergy and Critical Care and the Center for Translational Medicine, The Jane & Leonard Korman Respiratory Institute, Philadelphia, PA, USA.
Roque W; Department of Medicine, Rutgers - New Jersey Medical School, 185 S Orange Ave, Newark, NJ, 07103, USA.
Shaghaghi H; Department of Medicine, Division of Pulmonary, Allergy and Critical Care and the Center for Translational Medicine, The Jane & Leonard Korman Respiratory Institute, Philadelphia, PA, USA.
Gochuico BR; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Rosas IO; Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA.
Summer R; Department of Medicine, Division of Pulmonary, Allergy and Critical Care and the Center for Translational Medicine, The Jane & Leonard Korman Respiratory Institute, Philadelphia, PA, USA. .
Romero F; Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA. .
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Źródło:
Respiratory research [Respir Res] 2021 Feb 08; Vol. 22 (1), pp. 49. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Adaptor Protein Complex 3/*genetics
Adaptor Protein Complex beta Subunits/*genetics
Homeostasis/*physiology
Lung/*physiopathology
Mitochondria/*physiology
Pulmonary Alveoli/*physiopathology
Respiratory Mucosa/*physiopathology
Animals ; Hermanski-Pudlak Syndrome/genetics ; Hermanski-Pudlak Syndrome/pathology ; Hermanski-Pudlak Syndrome/physiopathology ; Lung/pathology ; Mice ; Mice, Inbred C57BL ; Pulmonary Alveoli/pathology ; Respiratory Mucosa/pathology
SCR Disease Name:
Hermansky Pudlak syndrome 2
Czasopismo naukowe
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Tytuł:
NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence.
Autorzy:
Wan, Ruyan (AUTHOR)
Long, Siqi (AUTHOR)
Ma, Shuaichen (AUTHOR)
Yan, Peishuo (AUTHOR)
Li, Zhongzheng (AUTHOR)
Xu, Kai (AUTHOR)
Lian, Hui (AUTHOR)
Li, Wenwen (AUTHOR)
Duan, Yudi (AUTHOR)
Zhu, Miaomiao (AUTHOR)
Wang, Lan (AUTHOR)
Yu, Guoying (AUTHOR)
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Źródło:
Respiratory Research. 4/2/2024, Vol. 25 Issue 1, p1-19. 19p.
Czasopismo naukowe
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Tytuł:
The novel molecular mechanism of pulmonary fibrosis: insight into lipid metabolism from reanalysis of single-cell RNA-seq databases.
Autorzy:
Shi, Xiangguang (AUTHOR)
Chen, Yahui (AUTHOR)
Shi, Mengkun (AUTHOR)
Gao, Fei (AUTHOR)
Huang, Lihao (AUTHOR)
Wang, Wei (AUTHOR)
Wei, Dong (AUTHOR)
Shi, Chenyi (AUTHOR)
Yu, Yuexin (AUTHOR)
Xia, Xueyi (AUTHOR)
Song, Nana (AUTHOR)
Chen, Xiaofeng (AUTHOR)
Distler, Jörg H. W. (AUTHOR)
Lu, Chenqi (AUTHOR)
Chen, Jingyu (AUTHOR)
Wang, Jiucun (AUTHOR)
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Źródło:
Lipids in Health & Disease. 4/3/2024, Vol. 23 Issue 1, p1-19. 19p.
Czasopismo naukowe
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