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Tytuł:
Dual and Triple Incretin-Based Co-agonists: Novel Therapeutics for Obesity and Diabetes.
Autorzy:
Gutgesell RM; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Munich, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Nogueiras R; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), ISCIII, Madrid, Spain.; Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.
Tschöp MH; Helmholtz Munich, Neuherberg, Germany.; Division of Metabolic Diseases, Department of Medicine, Technical University of Munich, Munich, Germany.
Müller TD; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Munich, Neuherberg, Germany. .; German Center for Diabetes Research (DZD), Neuherberg, Germany. .; Walther-Straub Institute for Pharmacology and Toxicology, Ludwig-Maximilians University, Munich, Germany. .
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Źródło:
Diabetes therapy : research, treatment and education of diabetes and related disorders [Diabetes Ther] 2024 Apr 04. Date of Electronic Publication: 2024 Apr 04.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease.
Autorzy:
Sachs S; Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany.; Institute for Diabetes and Obesity, Division of Metabolic Diseases, Helmholtz Diabetes Center at Helmholtz Centre Munich, Munich, Germany.; Technische Universität München, 80333, Munich, Germany.
Götz A; Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany.; Institute for Diabetes and Obesity, Division of Metabolic Diseases, Helmholtz Diabetes Center at Helmholtz Centre Munich, Munich, Germany.
Finan B; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA.
Feuchtinger A; Research Unit Analytical Pathology, Helmholtz Center Munich, 85764, Neuherberg, Germany.
DiMarchi RD; Department of Chemistry, Indiana University, Bloomington, IN, USA.
Döring Y; Department of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Weber C; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Tschöp MH; Institute for Diabetes and Obesity, Division of Metabolic Diseases, Helmholtz Diabetes Center at Helmholtz Centre Munich, Munich, Germany.; Technische Universität München, 80333, Munich, Germany.; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.
Müller TD; Institute for Diabetes and Obesity, Division of Metabolic Diseases, Helmholtz Diabetes Center at Helmholtz Centre Munich, Munich, Germany. .; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany. .
Hofmann SM; Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany. .; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany. .; Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany. .
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Źródło:
Cardiovascular diabetology [Cardiovasc Diabetol] 2023 Aug 17; Vol. 22 (1), pp. 217. Date of Electronic Publication: 2023 Aug 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiovascular Diseases*
Diabetes Mellitus, Type 2*/drug therapy
Atherosclerosis*/drug therapy
Atherosclerosis*/genetics
Atherosclerosis*/prevention & control
Dyslipidemias*/drug therapy
Male ; Animals ; Mice ; Body Weight ; Weight Loss
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Placebo effects on nausea and motion sickness are resistant to experimentally-induced stress.
Autorzy:
Jacob C; Institute of Medical Psychology, Medical Faculty, LMU Munich, 80336, Munich, Germany.; Wessex Neurological Centre, University Hospital Southampton and Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.
Olliges E; Institute of Medical Psychology, Medical Faculty, LMU Munich, 80336, Munich, Germany.; Department of Psychosomatic Medicine and Psychotherapy, Klinik Barmelweid AG, 5017, Barmelweid, Switzerland.; Division of Health Promotion, Coburg University of Applied Sciences and Arts, Friedrich-Streib-Str. 2, 96450, Coburg, Germany.
Haile A; Institute of Medical Psychology, Medical Faculty, LMU Munich, 80336, Munich, Germany.
Hoffmann V; Institute of Medical Psychology, Medical Faculty, LMU Munich, 80336, Munich, Germany.
Jacobi B; Institute of Medical Psychology, Medical Faculty, LMU Munich, 80336, Munich, Germany.; Department of Psychiatry, University of Connecticut Health Center, H1010, Farmington, CT, 06030-1410, USA.
Steinkopf L; Institute of Medical Psychology, Medical Faculty, LMU Munich, 80336, Munich, Germany.
Lanz M; Institute of Medical Psychology, Medical Faculty, LMU Munich, 80336, Munich, Germany.
Wittmann M; Institute for Frontier Areas of Psychology and Mental Health, 79098, Freiburg, Germany.
Tschöp MH; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 81675, Munich, Germany.
Meissner K; Institute of Medical Psychology, Medical Faculty, LMU Munich, 80336, Munich, Germany. .; Division of Health Promotion, Coburg University of Applied Sciences and Arts, Friedrich-Streib-Str. 2, 96450, Coburg, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 19; Vol. 13 (1), pp. 9908. Date of Electronic Publication: 2023 Jun 19.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Motion Sickness*/drug therapy
Placebo Effect*
Female ; Humans ; Nausea/etiology ; Stomach
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.
Autorzy:
Baumann P; Research Unit Neurobiology of Diabetes, Helmholtz Zentrum München, Neuherberg, Germany.; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Neurobiology of Diabetes, TUM School of Medicine, Technical University of Munich, Munich, Germany.
Schriever SC; Research Unit Neurobiology of Diabetes, Helmholtz Zentrum München, Neuherberg, Germany.; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Kullmann S; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; Department of Internal Medicine IV, University Hospital of Tübingen, Tübingen, Germany.
Zimprich A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Chair of Developmental Genetics, c/o Helmholtz Zentrum München, Technische Universität München-Weihenstephan, Neuherberg, Germany.
Peter A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital of Tübingen, Tübingen, Germany.
Gailus-Durner V; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
Fuchs H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
Hrabe de Angelis M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Freising, Germany.
Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Chair of Developmental Genetics, c/o Helmholtz Zentrum München, Technische Universität München-Weihenstephan, Neuherberg, Germany.; German Center for Neurodegenerative Diseases (DZNE) Site Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-Universität München, Munich, Germany.
Tschöp MH; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Division of Metabolic Diseases, Technische Universität München, Munich, Germany.
Heni M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; Department of Internal Medicine IV, University Hospital of Tübingen, Tübingen, Germany.; Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital of Tübingen, Tübingen, Germany.
Hölter SM; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.; Chair of Developmental Genetics, c/o Helmholtz Zentrum München, Technische Universität München-Weihenstephan, Neuherberg, Germany.
Pfluger PT; Research Unit Neurobiology of Diabetes, Helmholtz Zentrum München, Neuherberg, Germany.; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Neurobiology of Diabetes, TUM School of Medicine, Technical University of Munich, Munich, Germany.
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Źródło:
Brain and behavior [Brain Behav] 2021 Jan; Vol. 11 (1), pp. e01928. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/genetics
Sucrose*
Dual-Specificity Phosphatases/*genetics
Animals ; Feeding Behavior ; Female ; Humans ; Mice ; Motivation ; Reward
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes.
Autorzy:
Schnell, Oliver (AUTHOR)
Barnard-Kelly, Katharine (AUTHOR)
Battelino, Tadej (AUTHOR)
Ceriello, Antonio (AUTHOR)
Larsson, Helena Elding (AUTHOR)
Fernández-Fernández, Beatriz (AUTHOR)
Forst, Thomas (AUTHOR)
Frias, Juan-Pablo (AUTHOR)
Gavin III, James R. (AUTHOR)
Giorgino, Francesco (AUTHOR)
Groop, Per-Henrik (AUTHOR)
Heerspink, Hiddo J. L. (AUTHOR)
Herzig, Stephan (AUTHOR)
Hummel, Michael (AUTHOR)
Huntley, George (AUTHOR)
Ibrahim, Mahmoud (AUTHOR)
Itzhak, Baruch (AUTHOR)
Jacob, Stephan (AUTHOR)
Ji, Linong (AUTHOR)
Kosiborod, Mikhail (AUTHOR)
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Źródło:
Cardiovascular Diabetology. 3/19/2024, Vol. 23 Issue 1, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation.
Autorzy:
Ng, Mei Ying (AUTHOR)
Song, Zhi Jian (AUTHOR)
Venkatesan, Gopalakrishnan (AUTHOR)
Rodriguez-Cuenca, Sergio (AUTHOR)
West, James A. (AUTHOR)
Yang, Shili (AUTHOR)
Tan, Choon Hong (AUTHOR)
Ho, Paul Chi-Lui (AUTHOR)
Griffin, Julian L. (AUTHOR)
Vidal-Puig, Antonio (AUTHOR)
Bassetto, Marcella (AUTHOR)
Hagen, Thilo (AUTHOR)
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Źródło:
Scientific Reports. 3/4/2024, Vol. 14 Issue 1, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
New insight of chemical constituents in Persea americana fruit against obesity via integrated pharmacology.
Autorzy:
Cha, Min‐Gi (AUTHOR)
Lee, Su‐Been (AUTHOR)
Yoon, Sang‐Jun (AUTHOR)
Lee, Sang Youn (AUTHOR)
Gupta, Haripriya (AUTHOR)
Ganesan, Raja (AUTHOR)
Sharma, Satya Priya (AUTHOR)
Won, Sung‐Min (AUTHOR)
Jeong, Jin‐Ju (AUTHOR)
Kim, Dong Joon (AUTHOR)
Oh, Ki‐Kwang (AUTHOR)
Suk, Ki‐Tae (AUTHOR)
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Źródło:
CTS: Clinical & Translational Science. Mar2024, Vol. 17 Issue 3, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reduction of prevalence of patients meeting the criteria for metabolic syndrome with tirzepatide: a post hoc analysis from the SURPASS Clinical Trial Program.
Autorzy:
Nicholls, Stephen J. (AUTHOR)
Tofé, Santiago (AUTHOR)
le Roux, Carel W. (AUTHOR)
D'Alessio, David A. (AUTHOR)
Wiese, Russell J. (AUTHOR)
Pavo, Imre (AUTHOR)
Brown, Katelyn (AUTHOR)
Weerakkody, Govinda J. (AUTHOR)
Zeytinoglu, Meltem (AUTHOR)
Romera, Irene C. (AUTHOR)
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Źródło:
Cardiovascular Diabetology. 2/10/2024, Vol. 23 Issue 1, p1-15. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Facile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect.
Autorzy:
Hsu, Ching-Yun (AUTHOR)
Liao, Chia-Chih (AUTHOR)
Lin, Zih-Chan (AUTHOR)
Alalaiwe, Ahmed (AUTHOR)
Hwang, Erica (AUTHOR)
Lin, Tzu-Wei (AUTHOR)
Fang, Jia-You (AUTHOR)
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Źródło:
Journal of Nanobiotechnology. 2/6/2024, Vol. 22 Issue 1, p1-17. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model.
Autorzy:
Horska, Katerina (AUTHOR)
Skrede, Silje (AUTHOR)
Kucera, Jan (AUTHOR)
Kuzminova, Gabriela (AUTHOR)
Suchy, Pavel (AUTHOR)
Micale, Vincenzo (AUTHOR)
Ruda‐Kucerova, Jana (AUTHOR)
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Źródło:
CNS Neuroscience & Therapeutics. Feb2024, Vol. 30 Issue 2, p1-13. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dusp8 affects hippocampal size and behavior in mice and humans.
Autorzy:
Baumann P; Research Unit Neurobiology of Diabetes, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Institute for Diabetes and Obesity, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.
Schriever SC; Research Unit Neurobiology of Diabetes, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Institute for Diabetes and Obesity, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.
Kullmann S; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, 72076, Tübingen, Germany.; Department of Internal Medicine IV, University Hospital of Tübingen, 72076, Tübingen, Germany.
Zimprich A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Institute of Developmental Genetics, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Chair of Developmental Genetics, Technische Universität München-Weihenstephan, c/o Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Feuchtinger A; Research Unit Analytical Pathology, Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Amarie O; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Peter A; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, 72076, Tübingen, Germany.; Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital of Tübingen, 72076, Tübingen, Germany.
Walch A; Research Unit Analytical Pathology, Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Gailus-Durner V; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Fuchs H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Hrabě de Angelis M; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, 85354, Freising, Germany.
Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Chair of Developmental Genetics, Technische Universität München-Weihenstephan, c/o Helmholtz Zentrum München, 85764, Neuherberg, Germany.; German Center for Neurodegenerative Diseases (DZNE) Site Munich, 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
Tschöp MH; Institute for Diabetes and Obesity, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.; Division of Metabolic Diseases, Technische Universität München, 80333, Munich, Germany.
Heni M; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.; Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen, 72076, Tübingen, Germany.; Department of Internal Medicine IV, University Hospital of Tübingen, 72076, Tübingen, Germany.
Hölter SM; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Institute of Developmental Genetics, Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Chair of Developmental Genetics, Technische Universität München-Weihenstephan, c/o Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Pfluger PT; Research Unit Neurobiology of Diabetes, Helmholtz Zentrum München, 85764, Neuherberg, Germany. .; Institute for Diabetes and Obesity, Helmholtz Zentrum München, 85764, Neuherberg, Germany. .; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany. .; Neurobiology of Diabetes, TUM School of Medicine, Technische Universität München, 80333, Munich, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2019 Dec 20; Vol. 9 (1), pp. 19483. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dual-Specificity Phosphatases/*metabolism
Hippocampus/*metabolism
Adult ; Animals ; Apoptosis/genetics ; Apoptosis/physiology ; Cell Proliferation/genetics ; Cell Proliferation/physiology ; Dual-Specificity Phosphatases/genetics ; Female ; Humans ; Male ; Maze Learning ; Mice ; Mice, Knockout ; Neurogenesis/genetics ; Neurogenesis/physiology ; Phosphorylation/genetics ; Phosphorylation/physiology ; Young Adult ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease.
Autorzy:
Niu L; Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Geyer PE; Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Wewer Albrechtsen NJ; Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Gluud LL; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Gastrounit, Medical Division, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
Santos A; Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Doll S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Treit PV; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Holst JJ; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Knop FK; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.
Vilsbøll T; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.
Junker A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.
Sachs S; Helmholtz Diabetes Center at Helmholtz Centre Munich & Division of Metabolic Diseases, Institute for Diabetes and Obesity, Technische Universität München, Munich, Germany.
Stemmer K; Helmholtz Diabetes Center at Helmholtz Centre Munich & Division of Metabolic Diseases, Institute for Diabetes and Obesity, Technische Universität München, Munich, Germany.
Müller TD; Helmholtz Diabetes Center at Helmholtz Centre Munich & Division of Metabolic Diseases, Institute for Diabetes and Obesity, Technische Universität München, Munich, Germany.
Tschöp MH; Helmholtz Diabetes Center at Helmholtz Centre Munich & Division of Metabolic Diseases, Institute for Diabetes and Obesity, Technische Universität München, Munich, Germany.
Hofmann SM; Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, München, Germany.
Mann M; Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark .; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
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Źródło:
Molecular systems biology [Mol Syst Biol] 2019 Mar 01; Vol. 15 (3), pp. e8793. Date of Electronic Publication: 2019 Mar 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proteome*
Proteomics*
Biomarkers/*blood
Liver Cirrhosis/*blood
Non-alcoholic Fatty Liver Disease/*blood
Animals ; Cohort Studies ; Female ; Gene Expression Profiling ; Humans ; Liver/metabolism ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Male ; Mass Spectrometry ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.
Autorzy:
Nikolakopoulou P; Department of Medicine, Technische Universität Dresden, Dresden, Germany.
Chatzigeorgiou A; Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Dresden, Germany.
Kourtzelis I; Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Dresden, Germany.
Toutouna L; Department of Medicine, Technische Universität Dresden, Dresden, Germany.
Masjkur J; Department of Medicine, Technische Universität Dresden, Dresden, Germany.
Arps-Forker C; Department of Medicine, Technische Universität Dresden, Dresden, Germany.
Poser SW; Department of Medicine, Technische Universität Dresden, Dresden, Germany.
Rozman J; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Rathkolb B; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University Munich, Feodor-Lynen Str. 25, 81377, Munich, Germany.
Aguilar-Pimentel JA; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Wolf E; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University Munich, Feodor-Lynen Str. 25, 81377, Munich, Germany.
Klingenspor M; Chair of Molecular Nutritional Medicine, Technical University Munich, EKFZ - Else Kröner Fresenius Center for Nutritional Medicine, Gregor-Mendel-Str. 2, 85350, Freising-Weihenstephan, Germany.; ZIEL - Institute for Food and Health, Technical University Munich, Gregor-Mendel-Str. 2, 85350, Freising-Weihenstephan, Germany.
Ollert M; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.; Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis, University of Southern Denmark, Odense, Denmark.
Schmidt-Weber C; Center of Allergy & Environment (ZAUM), Technische Universität München, and Helmholtz Zentrum München, Ingolstädter Landstr.1, 85764, Neuherberg, Germany.
Fuchs H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Gailus-Durner V; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.
Hrabe de Angelis M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Alte Akademie 8, 85354, Freising, Germany.
Tsata V; DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universität Dresden, Dresden, Germany.
Monasor LS; Department of Medicine, Technische Universität Dresden, Dresden, Germany.
Troullinaki M; Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Dresden, Germany.
Witt A; Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Dresden, Germany.
Anastasiou V; DZD/Paul Langerhans Institute Dresden of Helmholtz Centre Munich, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Chrousos G; First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, Athens, Greece.; Aghia Sophia Children's Hospital, Athens, Greece.
Yi CX; Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Helmholtz Diabetes Center (HDC) & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, 85764, Neuherberg, Germany.
García-Cáceres C; Helmholtz Diabetes Center (HDC) & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, 85764, Neuherberg, Germany.
Tschöp MH; Helmholtz Diabetes Center (HDC) & German Center for Diabetes Research (DZD), Helmholtz Zentrum München, 85764, Neuherberg, Germany.; Division of Metabolic Diseases, Technische Universität München, 80333, Munich, Germany.
Bornstein SR; Department of Medicine, Technische Universität Dresden, Dresden, Germany.
Androutsellis-Theotokis A; Department of Medicine, Technische Universität Dresden, Dresden, Germany. .; DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universität Dresden, Dresden, Germany. .; Division of Cancer and Stem Cells, University of Nottingham, Nottingham, NG7 2RD, UK. .
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Corporate Authors:
German Mouse Clinic Consortium
Źródło:
Scientific reports [Sci Rep] 2018 Jul 27; Vol. 8 (1), pp. 11335. Date of Electronic Publication: 2018 Jul 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet, High-Fat*
Aging/*metabolism
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Brain/*metabolism
Insulin-Secreting Cells/*metabolism
Insulin-Secreting Cells/*pathology
Metformin/*administration & dosage
Nerve Tissue Proteins/*metabolism
Streptozocin/*toxicity
Animals ; Basic Helix-Loop-Helix Transcription Factors/deficiency ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Gene Expression Regulation/drug effects ; Insulin-Secreting Cells/drug effects ; Male ; Mice, Inbred C57BL ; Nerve Tissue Proteins/deficiency ; Nerve Tissue Proteins/genetics ; Phenotype ; Repressor Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
JianPi-QingHua formula attenuates nonalcoholic fatty liver disease by regulating the AMPK/SIRT1/NF-κB pathway in high-fat-diet-fed C57BL/6 mice.
Autorzy:
Tian, Jing (AUTHOR)
Cai, Mengjie (AUTHOR)
Jin, Shenyi (AUTHOR)
Chen, Qingguang (AUTHOR)
Xu, Jiahui (AUTHOR)
Guo, Qiuyue (AUTHOR)
Yan, Zihui (AUTHOR)
Han, Xu (AUTHOR)
Lu, Hao (AUTHOR)
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Źródło:
Pharmaceutical Biology. Dec2023, Vol. 61 Issue 1, p647-656. 10p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 1307

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