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Tytuł:
A pivotal bridging study of lurbinectedin as second-line therapy in Chinese patients with small cell lung cancer.
Autorzy:
Cheng Y; Department of Oncology, Jilin Cancer Hospital, Changchun, 130000, China. .
Wu C; Department of Oncology, Jilin Cancer Hospital, Changchun, 130000, China.
Wu L; Department of Thoracic Oncology, Hunan Cancer Hospital, Changsha, 410013, China.
Zhao J; Department of Thoracic Oncology, Beijing Cancer Hospital, Beijing, 100142, China.
Zhao Y; Department of Oncology, Henan Cancer Hospital, Zhengzhou, 450003, China.
Chen L; Department of Oncology, Jilin Cancer Hospital, Changchun, 130000, China.
Xin Y; Department of Oncology, Jilin Cancer Hospital, Changchun, 130000, China.
Zhang L; Department of Oncology, Jilin Cancer Hospital, Changchun, 130000, China.
Pan P; Department of Respiratory Disease, Xiangya Hospital Central South University, Changsha, 410008, China.
Li X; Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Li J; Department of Oncology, Sichuan Cancer Hospital, Chengdu, 610041, China.
Dong X; Center of Oncology, Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Tang K; Clinical Research Center of Luye Pharma Group Ltd, Luye Life Sciences Group, Beijing, 100080, China.
Gao E; Clinical Research Center of Luye Pharma Group Ltd, Luye Life Sciences Group, Beijing, 100080, China.
Yu F; School of Pharmacy, Yantai University, Yantai, 264005, China.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 13; Vol. 14 (1), pp. 3598. Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Multicenter Study
MeSH Terms:
Anemia*/etiology
Carbolines*/adverse effects
Heterocyclic Compounds, 4 or More Rings*/adverse effects
Lung Neoplasms*/pathology
Neutropenia*/drug therapy
Small Cell Lung Carcinoma*/pathology
Thrombocytopenia*/etiology
Humans ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; China
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The results of determining the indicators of the morphological composition of the blood of animals and individual biochemical indicators using a potential drug with a mixture of two active compounds: 4-((5-(decylthio)-4-methyl-4H-1,2,4-triazole-3-yl)methyl)morpholine and 5-(2-fluorophenyl)-4-((4-bromophenyl)ylidene)amino-1,2,4-triazole-3-thiol in milk thistle seed oil
Autorzy:
M. V. Ohloblina
I V. Bushuieva
V. V. Parchenko
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Temat:
clinical studies
laboratory studies
4-((5-(decylthio)-4-methyl-4h-1
4-triazol-3-yl)methyl)morpholine
5-(2-fluorophenyl)-4-((4-bromophenyl)ylidene)amino-1
4-triazole-3-thiol
a mixture of active compounds
Pharmacy and materia medica
RS1-441
Źródło:
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, Vol 15, Iss 3, Pp 283-287 (2022)
Opis pliku:
electronic resource
Relacje:
http://pharmed.zsmu.edu.ua/article/view/263015/264365; https://doaj.org/toc/2306-8094; https://doaj.org/toc/2409-2932
Dostęp URL:
https://doaj.org/article/24d88432045e456c9bba596c81e68b5d  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Trabectedin and Lurbinectedin Modulate the Interplay between Cells in the Tumour Microenvironment-Progresses in Their Use in Combined Cancer Therapy.
Autorzy:
Povo-Retana A; Instituto de Investigaciones Biomédicas Alberto Sols-Morreale (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.
Landauro-Vera R; Instituto de Investigaciones Biomédicas Alberto Sols-Morreale (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.
Alvarez-Lucena C; Instituto de Investigaciones Biomédicas Alberto Sols-Morreale (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.
Cascante M; Department of Biochemistry and Molecular Biomedicine-Institute of Biomedicine (IBUB), Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.; Department of Material Science and Physical Chemistry, Research Institute of Theoretical and Computational Chemistry (IQTCUB), University of Barcelona, 08028 Barcelona, Spain.
Boscá L; Instituto de Investigaciones Biomédicas Alberto Sols-Morreale (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Jan 09; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Tumor Microenvironment*
Ovarian Neoplasms*
Carbolines*
Heterocyclic Compounds, 4 or More Rings*
Adult ; Female ; Humans ; Trabectedin ; Neoplasm Recurrence, Local
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SRT1720 induces SIRT1-independent cell death in adult T-cell leukemia/lymphoma.
Autorzy:
Kozako T; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Kato N; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Ohsugi T; Department of Laboratory Animal Science, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
Uchida YI; Division of Hematology and Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Yoshimitsu M; Division of Hematology and Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.; Department of Hematology and Immunology, Kagoshima University Hospital, Japan.
Ishitsuka K; Division of Hematology and Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.; Department of Hematology and Immunology, Kagoshima University Hospital, Japan.
Higaki Y; Faculty of Sports and Health Science, Fukuoka University, Japan.
Sato H; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Aikawa A; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Honda SI; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
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Źródło:
The FEBS journal [FEBS J] 2022 Jun; Vol. 289 (12), pp. 3477-3488. Date of Electronic Publication: 2022 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Heterocyclic Compounds, 4 or More Rings*/pharmacology
Leukemia-Lymphoma, Adult T-Cell*/drug therapy
Leukemia-Lymphoma, Adult T-Cell*/genetics
Leukemia-Lymphoma, Adult T-Cell*/metabolism
Animals ; Apoptosis ; Cell Death ; Humans ; Leukocytes, Mononuclear/metabolism ; Mice ; Sirtuin 1/genetics ; Sirtuin 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
NecroX-5 ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3-mediated epithelial-mesenchymal transition.
Autorzy:
Min L; Department of Pain Management, Wuhan First Hospital, Wuhan, China.
Shu-Li Z; Department of Pain Management, Wuhan First Hospital, Wuhan, China.
Feng Y; Department of Pain Management, Wuhan First Hospital, Wuhan, China.
Han H; Department of Pain Management, Wuhan First Hospital, Wuhan, China.
Shao-Jun L; Department of Pain Management, Wuhan First Hospital, Wuhan, China.
Sheng-Xiong T; Department of Pain Management, Wuhan First Hospital, Wuhan, China.
Jia-Yu T; Department of Pain Management, Wuhan First Hospital, Wuhan, China.
Xiang-Zhi F; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dan F; Department of Pain Management, Wuhan First Hospital, Wuhan, China. fengdan_.
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Źródło:
Respiratory research [Respir Res] 2022 May 20; Vol. 23 (1), pp. 128. Date of Electronic Publication: 2022 May 20.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*/drug effects
Heterocyclic Compounds, 4 or More Rings*/pharmacology
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/drug therapy
Pulmonary Fibrosis*/pathology
Sulfones*/pharmacology
Animals ; Bleomycin ; Mice ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nucleotide Analogues Bearing a C2' or C3'-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors.
Autorzy:
Manchoju A; Bio-Organic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Zelli R; Bio-Organic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Wang G; Bio-Organic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Eymard C; Bio-Organic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Oo A; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Nemer M; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Prévost M; Bio-Organic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Kim B; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA.; Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
Guindon Y; Bio-Organic Chemistry Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.; Department of Chemistry, Université de Montréal, Montréal, QC H3C 3J7, Canada.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 17; Vol. 27 (2). Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Journal Article
MeSH Terms:
Antiviral Agents/*pharmacology
Carbon/*chemistry
Heterocyclic Compounds, 4 or More Rings/*pharmacology
Nucleotides/*pharmacology
RNA-Dependent RNA Polymerase/*antagonists & inhibitors
SARS-CoV-2/*enzymology
Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Heterocyclic Compounds, 4 or More Rings/chemical synthesis ; Heterocyclic Compounds, 4 or More Rings/chemistry ; Nucleotides/chemical synthesis ; Nucleotides/chemistry ; SARS-CoV-2/drug effects ; Stereoisomerism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators.
Autorzy:
Chiaramonte N; Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Gabellini A; Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Angeli A; Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Bartolucci G; Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Braconi L; Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Dei S; Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Teodori E; Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Supuran CT; Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
Romanelli MN; Section of Pharmaceutical and Nutraceutical Sciences, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Via Ugo Schiff 6, 50019 Florence, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 15; Vol. 27 (2). Date of Electronic Publication: 2022 Jan 15.
Typ publikacji:
Journal Article
MeSH Terms:
Carbonic Anhydrase I/*metabolism
Heterocyclic Compounds, 4 or More Rings/*chemistry
Heterocyclic Compounds, 4 or More Rings/*pharmacology
Histamine/*chemistry
Histamine/*pharmacology
Carbonic Anhydrase I/drug effects ; Carbonic Anhydrase II/drug effects ; Carbonic Anhydrase II/metabolism ; Carbonic Anhydrase V/drug effects ; Carbonic Anhydrase V/metabolism ; Carbonic Anhydrases/drug effects ; Carbonic Anhydrases/metabolism ; Heterocyclic Compounds, 4 or More Rings/chemical synthesis ; Histamine/analogs & derivatives ; Histamine/chemical synthesis ; Humans ; Imidazoles/chemistry ; Protein Isoforms/drug effects ; Protein Isoforms/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Afidopyropen, a novel insecticide originating from microbial secondary extracts.
Autorzy:
Horikoshi R; Agricultural and Veterinary Research Labs., Agricultural and Veterinary Division, Meiji Seika Pharma Co., Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama, 222-8567, Japan. .
Goto K; Agricultural and Veterinary Research Labs., Agricultural and Veterinary Division, Meiji Seika Pharma Co., Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama, 222-8567, Japan.
Mitomi M; Agricultural and Veterinary Research Labs., Agricultural and Veterinary Division, Meiji Seika Pharma Co., Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama, 222-8567, Japan.
Oyama K; Agricultural and Veterinary Research Labs., Agricultural and Veterinary Division, Meiji Seika Pharma Co., Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama, 222-8567, Japan.
Hirose T; Graduate School of Infection Control Sciences, Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Sunazuka T; Graduate School of Infection Control Sciences, Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
Ōmura S; Graduate School of Infection Control Sciences, Ōmura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan.
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 18; Vol. 12 (1), pp. 2827. Date of Electronic Publication: 2022 Feb 18.
Typ publikacji:
Journal Article
MeSH Terms:
Heterocyclic Compounds, 4 or More Rings/*chemistry
Insecticides/*chemistry
Lactones/*chemistry
Penicillium/*metabolism
Pyridines/*metabolism
Sesquiterpenes/*metabolism
Animals ; Aphids/drug effects ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Insecticides/pharmacology ; Japan ; Lactones/pharmacology ; Penicillium/chemistry ; Pyridines/chemistry ; Sesquiterpenes/chemistry
SCR Organism:
Penicillium coprobium
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimal dose for the efficacy of asenapine in patients with schizophrenia: Real-world data.
Autorzy:
Takekita Y; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
Hiraoka S; Medical Affairs Department, Meiji Seika Pharma Co., Ltd., Tokyo, Japan.
Iwama Y; Regulatory & Datascience Department, Pharmaceutical Research & Development Division, Meiji Seika Pharma Co., Ltd., Tokyo, Japan.
Matsui D; Safety Vigilance & Management Department, Reliability & Quality Assurance Division, Meiji Seika Pharma Co., Ltd., Tokyo, Japan.
Aoki N; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.; School of Psychiatry, University of New South Wales, Randwick, New South Wales, Australia.; Black Dog Institute, Randwick, New South Wales, Australia.
Ogata H; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
Funatsuki T; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
Shimizu T; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
Murase Y; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
Koshikawa Y; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
Kato M; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
Kinoshita T; Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
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Źródło:
Neuropsychopharmacology reports [Neuropsychopharmacol Rep] 2024 Mar; Vol. 44 (1), pp. 234-239. Date of Electronic Publication: 2023 Nov 05.
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Schizophrenia*/drug therapy
Antipsychotic Agents*/adverse effects
Dibenzocycloheptenes*
Humans ; Treatment Outcome ; Heterocyclic Compounds, 4 or More Rings/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparative efficacy and safety of Sofosbuvir/Velpatasvir and Danoprevir for the treatment of chronic hepatitis C: the real-world data in China.
Autorzy:
Zhou Y; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road , 510630, Guangzhou City, Guangdong Province, China.
Liang M; Department of Infectious disease, The First people's hospital of Foshan, Foshan City, Guangdong Province, China.
Li Y; Department of General Practice, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, Guangdong Province, China.
Chen X; Department of Infectious Diseases, Yangjiang Public Health Hospital, Yangjiang City, Guangdong Province, China.
Yang J; Clinical Medicine Department of Southwest Medical University, Luzhou City, Sichuan Province, China.
Bai H; Department of Infectious disease, The First people's hospital of Foshan, Foshan City, Guangdong Province, China.
Long Y; Department of Infectious Diseases, The Eighth Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province, China.
Zhang X; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road , 510630, Guangzhou City, Guangdong Province, China.
Lin C; Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road , 510630, Guangzhou City, Guangdong Province, China. .
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Źródło:
BMC gastroenterology [BMC Gastroenterol] 2024 Feb 14; Vol. 24 (1), pp. 73. Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Benzimidazoles*
Benzopyrans*
Carbamates*
Cyclopropanes*
Drug Combinations*
Hepatitis C*/drug therapy
Hepatitis C, Chronic*/genetics
Isoindoles*
Lactams, Macrocyclic*
Proline*/analogs & derivatives
Sulfonamides*
Humans ; Antiviral Agents/adverse effects ; China ; Genotype ; Hepacivirus/genetics ; Heterocyclic Compounds, 4 or More Rings/adverse effects ; Liver Cirrhosis/drug therapy ; Retrospective Studies ; Ribavirin/adverse effects ; Sofosbuvir/adverse effects ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of single-administration of D-sorbitol pretreatment on the bitterness and continued willingness to take asenapine: a randomized, single-blind, placebo-controlled, crossover trial.
Autorzy:
Wada S; Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan.
Iwamoto K; Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan. .
Okumura H; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan.
Hida H; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan.
Hiraoka S; Medical Affairs Department, Meiji Seika Pharma Co., Ltd, 2-4-16Chuo-Ku, KyobashiTokyo, 104-8002, Japan.
Kamei A; Medical Affairs Department, Meiji Seika Pharma Co., Ltd, 2-4-16Chuo-Ku, KyobashiTokyo, 104-8002, Japan.
Mori D; Brain and Mind Research Center, Nagoya University, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan.
Yamada K; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8560, Japan.
Ando M; Department of Advanced Medicine, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan.
Ozaki N; Pathophysiology of Mental Disorders, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan.
Ikeda M; Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan.
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Źródło:
BMC psychiatry [BMC Psychiatry] 2024 Jan 30; Vol. 24 (1), pp. 81. Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Antipsychotic Agents*/adverse effects
Dibenzocycloheptenes*
Adult ; Humans ; Taste ; Single-Blind Method ; Cross-Over Studies ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protective Role of a Donepezil-Huprine Hybrid against the β-Amyloid (1-42) Effect on Human Erythrocytes.
Autorzy:
Zambrano P; Facultad de Ciencias Químicas, Universidad de Concepción, Concepción 4030000, Chile.
Suwalsky M; Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción 4030000, Chile.
Jemiola-Rzeminska M; Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Gallardo-Nelson MJ; School of Medicine, University of Atacama, Copiapó 1530000, Chile.
Strzalka K; Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Muñoz-Torrero D; Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food, Sciences, University of Barcelona (UB), E-08028 Barcelona, Spain.; Institute of Biomedicine (IBUB), University of Barcelona (UB), E-08028 Barcelona, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 03; Vol. 22 (17). Date of Electronic Publication: 2021 Sep 03.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid beta-Peptides*/chemistry
Amyloid beta-Peptides*/toxicity
Erythrocyte Membrane*/chemistry
Erythrocyte Membrane*/metabolism
Erythrocyte Membrane*/ultrastructure
Heterocyclic Compounds, 4 or More Rings*/chemistry
Heterocyclic Compounds, 4 or More Rings*/pharmacology
Models, Molecular*
Peptide Fragments*/chemistry
Peptide Fragments*/toxicity
Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Thiophene-Fused 1,4-Diazapentalene: A Stable C=N-Containing π-Conjugated System with Restored Antiaromaticity.
Autorzy:
Usuba J; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Institute for Advanced Study, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan.; Department of Chemistry, Graduate School of Science, Nagoya University, Furom, Chikusa, Nagoya, 464-8602, Japan.
Fukazawa A; Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Institute for Advanced Study, Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Nov 22; Vol. 27 (65), pp. 16061. Date of Electronic Publication: 2021 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Heterocyclic Compounds, 4 or More Rings*
Thiophenes*
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Deinduction of P-glycoprotein resulting in delayed viral response during hepatitis C treatment.
Autorzy:
Stark JE; Department of Pharmacy, Veterans Health Care System of the Ozarks, Fayetteville, AR, USA.
Cole JL; Department of Pharmacy, Veterans Health Care System of the Ozarks, Fayetteville, AR, USA.
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Źródło:
Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2021 Oct; Vol. 46 (5), pp. 1465-1468. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji:
Case Reports
MeSH Terms:
ATP Binding Cassette Transporter, Subfamily B, Member 1/*drug effects
Anti-Retroviral Agents/*therapeutic use
Carbamates/*therapeutic use
Carbamazepine/*pharmacology
Hepatitis C, Chronic/*drug therapy
Heterocyclic Compounds, 4 or More Rings/*therapeutic use
Ribavirin/*therapeutic use
Sofosbuvir/*therapeutic use
Anti-Retroviral Agents/administration & dosage ; Carbamates/administration & dosage ; Cell Membrane/drug effects ; Drug Combinations ; Drug Interactions ; Heterocyclic Compounds, 4 or More Rings/administration & dosage ; Humans ; Male ; Middle Aged ; Ribavirin/administration & dosage ; Sofosbuvir/administration & dosage
Raport
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Tytuł:
Estimating the net value of treating hepatitis C virus using sofosbuvir-velpatasvir in India.
Autorzy:
Bloom DE; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Khoury A; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Srinivasan V; Stanford Graduate School of Business, Stanford, California, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Jul 22; Vol. 16 (7), pp. e0252764. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cost of Illness*
Antiviral Agents/*economics
Carbamates/*economics
Hepatitis C/*economics
Heterocyclic Compounds, 4 or More Rings/*economics
Sofosbuvir/*economics
Adolescent ; Adult ; Aged ; Antiviral Agents/therapeutic use ; Carbamates/therapeutic use ; Disability Evaluation ; Drugs, Generic ; Female ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Humans ; India ; International Normalized Ratio ; Liver Cirrhosis/etiology ; Male ; Middle Aged ; Quality of Life ; Sofosbuvir/therapeutic use ; Young Adult
Czasopismo naukowe
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Tytuł:
Pancracine, a Montanine-Type Amaryllidaceae Alkaloid, Inhibits Proliferation of A549 Lung Adenocarcinoma Cells and Induces Apoptotic Cell Death in MOLT-4 Leukemic Cells.
Autorzy:
Koutová D; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
Havelek R; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
Peterová E; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
Muthná D; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
Královec K; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.
Breiterová K; ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Cahlíková L; ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Řezáčová M; Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 500 03 Hradec Kralove, Czech Republic.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 29; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 29.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma of Lung/*pathology
Cell Proliferation/*drug effects
Heterocyclic Compounds, 4 or More Rings/*pharmacology
Leukemia/*pathology
Lung Neoplasms/*pathology
A549 Cells ; Alkaloids/isolation & purification ; Alkaloids/pharmacology ; Amaryllidaceae/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Hep G2 Cells ; Heterocyclic Compounds, 4 or More Rings/isolation & purification ; Humans ; MCF-7 Cells
Czasopismo naukowe
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Tytuł:
Cell mechanical properties of human breast carcinoma cells depend on temperature.
Autorzy:
Aermes C; Biological Physics Division, Faculty of Physics and Earth Science, Peter Debye Institute of Soft Matter Physics, University of Leipzig, Linnéstr. 5, 04103, Leipzig, Germany.
Hayn A; Biological Physics Division, Faculty of Physics and Earth Science, Peter Debye Institute of Soft Matter Physics, University of Leipzig, Linnéstr. 5, 04103, Leipzig, Germany.
Fischer T; Biological Physics Division, Faculty of Physics and Earth Science, Peter Debye Institute of Soft Matter Physics, University of Leipzig, Linnéstr. 5, 04103, Leipzig, Germany.
Mierke CT; Biological Physics Division, Faculty of Physics and Earth Science, Peter Debye Institute of Soft Matter Physics, University of Leipzig, Linnéstr. 5, 04103, Leipzig, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2021 May 24; Vol. 11 (1), pp. 10771. Date of Electronic Publication: 2021 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Actins/*metabolism
Breast Neoplasms/*metabolism
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Demecolcine/*pharmacology
Fibronectins/*chemistry
Heterocyclic Compounds, 4 or More Rings/*pharmacology
Thiazolidines/*pharmacology
Biomechanical Phenomena ; Breast Neoplasms/drug therapy ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Cell Line, Tumor ; Demecolcine/chemistry ; Female ; Heterocyclic Compounds, 4 or More Rings/chemistry ; Humans ; MCF-7 Cells ; Magnetic Iron Oxide Nanoparticles/chemistry ; Microtubules/drug effects ; Temperature ; Thiazolidines/chemistry
Czasopismo naukowe
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Tytuł:
Osteogenic Activities of Trifolirhizin as a Bioactive Compound for the Differentiation of Osteogenic Cells.
Autorzy:
Yun HM; Department of Oral and Maxillofacial Pathology, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of Korea.
Cho MH; Korea Basic Science Institute (KBSI), Seoul 02841, Republic of Korea.
Jeong H; Korea Basic Science Institute (KBSI), Seoul 02841, Republic of Korea.
Kim SH; National Development Institute for Korean Medicine, Gyeongsan 38540, Republic of Korea.
Jeong YH; National Development Institute for Korean Medicine, Gyeongsan 38540, Republic of Korea.
Park KR; Korea Basic Science Institute (KBSI), Gwangju 61751, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 04; Vol. 24 (23). Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Journal Article
MeSH Terms:
Osteogenesis*
Glucosides*/pharmacology
Cell Differentiation ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Bone Morphogenetic Proteins/metabolism ; Flavonoids/pharmacology ; Flavonoids/metabolism ; Osteoblasts/metabolism
Czasopismo naukowe
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Tytuł:
Transgenerational effect of Afidopyropen on Bemisia tabaci Gennadius (Homoptera: Aleyrodidae).
Autorzy:
Shafi MS; Institute of Plant Protection, MNS University of Agriculture, Multan, Pakistan.
Iqbal N; Institute of Plant Protection, MNS University of Agriculture, Multan, Pakistan. .
Naqqash MN; Institute of Plant Protection, MNS University of Agriculture, Multan, Pakistan. .
Saeed S; Institute of Plant Protection, MNS University of Agriculture, Multan, Pakistan.
Usman M; Department of Agronomy, MNS University of Agriculture, Multan, Pakistan.
Abid AD; Department of Plant Protection, Ministry of National Food Security & Research, Karachi, Pakistan.
Shahzad MS; Department of Plant Protection, Ministry of National Food Security & Research, Karachi, Pakistan.
Riaz H; Institute of Plant Protection, MNS University of Agriculture, Multan, Pakistan.
Bashir MA; Department of Plant Protection, Faculty of Agricultural Sciences, Ghazi University, Dera Ghazi Khan, Punjab, Pakistan.; College of Plant Protection, South West University, Chongqing, China.
Alajmi RA; Department of Zoology, Faculty of Science, King Saud University, 11451, Riyadh, Saudi Arabia.
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 15; Vol. 13 (1), pp. 19988. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Hemiptera*
Insecticides*/pharmacology
Male ; Female ; Animals ; Humans ; Insecta ; Heterocyclic Compounds, 4 or More Rings/pharmacology
Czasopismo naukowe
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Wyświetlanie 1-20 z 56889

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