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Tytuł:
Integrating glycolysis, citric acid cycle, pentose phosphate pathway, and fatty acid beta-oxidation into a single computational model.
Autorzy:
Kloska SM; Faculty of Medicine, Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum, 85-094, Bydgoszcz, Poland. .
Pałczyński K; Faculty of Telecommunications, Computer Science and Electrical Engineering, Bydgoszcz University of Science and Technology, 85-796, Bydgoszcz, Poland.
Marciniak T; Faculty of Telecommunications, Computer Science and Electrical Engineering, Bydgoszcz University of Science and Technology, 85-796, Bydgoszcz, Poland.
Talaśka T; Faculty of Telecommunications, Computer Science and Electrical Engineering, Bydgoszcz University of Science and Technology, 85-796, Bydgoszcz, Poland.
Wysocki BJ; Department of Biology, University of Nebraska at Omaha, Omaha, NE, 68182, USA.
Davis P; Department of Biology, University of Nebraska at Omaha, Omaha, NE, 68182, USA.
Wysocki TA; Faculty of Telecommunications, Computer Science and Electrical Engineering, Bydgoszcz University of Science and Technology, 85-796, Bydgoszcz, Poland.; Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Omaha, NE, 68182, USA.
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 02; Vol. 13 (1), pp. 14484. Date of Electronic Publication: 2023 Sep 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Citric Acid Cycle*
Pentose Phosphate Pathway*
Glycolysis ; Fatty Acids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.
Autorzy:
Sahu U; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Villa E; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Reczek CR; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Zhao Z; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
O'Hara BP; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Torno MD; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Mishra R; BioRankings, St. Louis, MO 63108, USA.
Shannon WD; BioRankings, St. Louis, MO 63108, USA.
Asara JM; Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Gao P; Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Shilatifard A; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Chandel NS; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Ben-Sahra I; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Mar 29; Vol. 383 (6690), pp. 1484-1492. Date of Electronic Publication: 2024 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Lipogenesis*
Pyrimidines*/metabolism
Pyruvates*/metabolism
Citric Acid Cycle*
Pyruvate Dehydrogenase Complex*/metabolism
Adenosine Triphosphate/metabolism ; Thiamine/metabolism ; Thiamine Pyrophosphate/metabolism ; Uridine Triphosphate/metabolism ; Oxidation-Reduction ; Protein Kinases/metabolism ; Humans ; HeLa Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tricarboxylic Acid Cycle Intermediates and Individual Ageing.
Autorzy:
Kurhaluk N; Department of Animal Physiology, Institute of Biology, Pomeranian University in Słupsk, Arciszewski St. 22 B, PL 76-200 Słupsk, Poland.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 22; Vol. 14 (3). Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Citric Acid Cycle*
Diabetes Mellitus, Type 2*/metabolism
Humans ; Animals ; Mice ; Epigenesis, Genetic ; Aging/metabolism ; Mitochondria/metabolism ; Caenorhabditis elegans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
FLVCR1a Controls Cellular Cholesterol Levels through the Regulation of Heme Biosynthesis and Tricarboxylic Acid Cycle Flux in Endothelial Cells.
Autorzy:
Manco M; Molecular Biotechnology Center 'Guido Tarone', Via Nizza 52, 10126 Torino, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Italy.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, VIB, 3000 Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
Ammirata G; Molecular Biotechnology Center 'Guido Tarone', Via Nizza 52, 10126 Torino, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Italy.
Petrillo S; Molecular Biotechnology Center 'Guido Tarone', Via Nizza 52, 10126 Torino, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Italy.
De Giorgio F; Molecular Biotechnology Center 'Guido Tarone', Via Nizza 52, 10126 Torino, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Italy.
Fontana S; Molecular Biotechnology Center 'Guido Tarone', Via Nizza 52, 10126 Torino, Italy.; Department of Oncology, University of Torino, Via Santena 5/bis, 10126 Torino, Italy.
Riganti C; Molecular Biotechnology Center 'Guido Tarone', Via Nizza 52, 10126 Torino, Italy.; Department of Oncology, University of Torino, Via Santena 5/bis, 10126 Torino, Italy.
Provero P; Department of Neurosciences 'Rita Levi Montalcini', University of Torino, Corso Massimo D'Azeglio 52, 10126 Torino, Italy.; Center for Omics Sciences, Ospedale San Raffaele IRCCS, Via Olgettina 60, 20132 Milan, Italy.
Fagoonee S; Molecular Biotechnology Center 'Guido Tarone', Via Nizza 52, 10126 Torino, Italy.; Institute of Biostructure and Bioimaging, CNR c/o Molecular Biotechnology Center 'Guido Tarone', 10126 Torino, Italy.
Altruda F; Molecular Biotechnology Center 'Guido Tarone', Via Nizza 52, 10126 Torino, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Italy.
Tolosano E; Molecular Biotechnology Center 'Guido Tarone', Via Nizza 52, 10126 Torino, Italy.; Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Italy.
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Źródło:
Biomolecules [Biomolecules] 2024 Jan 26; Vol. 14 (2). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*/metabolism
Citric Acid Cycle*
Mice ; Animals ; Membrane Transport Proteins/metabolism ; Cell Membrane/metabolism ; Mice, Knockout ; Heme/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi.
Autorzy:
Huang Z; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Wang Q; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Khan IA; Department of Agriculture, The University of Swabi, Khyber 29380, Pakistan.
Li Y; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Wang J; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Wang J; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
Liu X; Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.
Lin F; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.; Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.
Lu J; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Sep 17; Vol. 28 (18). Date of Electronic Publication: 2023 Sep 17.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Citric Acid Cycle*
Fungi*/metabolism
Acetyl Coenzyme A ; Carbon/metabolism ; Glyoxylates/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Natural Coumarin Shows Toxicity to Spodoptera litura by Inhibiting Detoxification Enzymes and Glycometabolism.
Autorzy:
Xia T; College of Life Sciences, Gannan Normal University, Ganzhou 341003, China.
Liu Y; College of Life Sciences, Gannan Normal University, Ganzhou 341003, China.
Lu Z; College of Life Sciences, Gannan Normal University, Ganzhou 341003, China.; National Navel Orange Engineering Research Center, Gannan Normal University, Ganzhou 341003, China.
Yu H; College of Life Sciences, Gannan Normal University, Ganzhou 341003, China.; National Navel Orange Engineering Research Center, Gannan Normal University, Ganzhou 341003, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 24; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylcholinesterase*
Citric Acid Cycle*
Animals ; Spodoptera ; Coumarins/toxicity ; ATP-Binding Cassette Transporters ; Larva ; Amino Acids
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration.
Autorzy:
Weh E; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Goswami M; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Chaudhury S; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Fernando R; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Miller N; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Hager H; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Sheskey S; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Sharma V; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Wubben TJ; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Besirli CG; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
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Źródło:
Cells [Cells] 2023 Aug 10; Vol. 12 (16). Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Retinal Rod Photoreceptor Cells*
Citric Acid Cycle*
Animals ; Mice ; Metabolomics ; Oxygen Consumption ; Retina ; Animals, Wild
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cell-Based Measurement of Mitochondrial Function in Human Airway Smooth Muscle Cells.
Autorzy:
Mahadev Bhat S; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Yap JQ; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Ramirez-Ramirez OA; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Delmotte P; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Sieck GC; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 15; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 15.
Typ publikacji:
Journal Article
MeSH Terms:
Mitochondria*/metabolism
Citric Acid Cycle*
Humans ; Myocytes, Smooth Muscle
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Optimal evaluation of energy yield and driving force in microbial metabolic pathway variants.
Autorzy:
Taha A; Department of Chemical Engineering, Research and Innovation Center on CO2 and H2 (RICH) Khalifa University, Abu Dhabi, United Arab Emirates.
Patón M; Department of Chemical Engineering, Research and Innovation Center on CO2 and H2 (RICH) Khalifa University, Abu Dhabi, United Arab Emirates.
Penas DR; Computational Biology Lab, MBG-CSIC (Spanish National Research Council), Pontevedra, Galicia, Spain.
Banga JR; Computational Biology Lab, MBG-CSIC (Spanish National Research Council), Pontevedra, Galicia, Spain.
Rodríguez J; Department of Chemical Engineering, Research and Innovation Center on CO2 and H2 (RICH) Khalifa University, Abu Dhabi, United Arab Emirates.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2023 Jul 06; Vol. 19 (7), pp. e1011264. Date of Electronic Publication: 2023 Jul 06 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Metabolic Networks and Pathways*
Citric Acid Cycle*
Energy Metabolism ; Fermentation ; Thermodynamics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon.
Autorzy:
Skalidis I; Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3a, 06120, Halle/Saale, Germany.; Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3, 06120, Halle/Saale, Germany.
Kyrilis FL; Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3a, 06120, Halle/Saale, Germany.; Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3, 06120, Halle/Saale, Germany.
Tüting C; Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3a, 06120, Halle/Saale, Germany.
Hamdi F; Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3a, 06120, Halle/Saale, Germany.
Träger TK; Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3a, 06120, Halle/Saale, Germany.; Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3, 06120, Halle/Saale, Germany.
Belapure J; Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3a, 06120, Halle/Saale, Germany.
Hause G; Biozentrum, Martin Luther University Halle-Wittenberg, Weinbergweg 22, 06120, Halle/Saale, Germany.
Fratini M; Department of Plant Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120, Halle/Saale, Germany.
O'Reilly FJ; Center for Structural Biology, Center for Cancer Research, National Cancer Institute (NCI), Frederick, MD, 21702-1201, USA.
Heilmann I; Department of Plant Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120, Halle/Saale, Germany.
Rappsilber J; Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355, Berlin, Germany.; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3BF, Scotland, United Kingdom.
Kastritis PL; Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3a, 06120, Halle/Saale, Germany. .; Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 3, 06120, Halle/Saale, Germany. .; Biozentrum, Martin Luther University Halle-Wittenberg, Weinbergweg 22, 06120, Halle/Saale, Germany. .; Institute of Chemical Biology, National Hellenic Research Foundation, Athens, 11635, Greece. .
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Źródło:
Communications biology [Commun Biol] 2023 May 22; Vol. 6 (1), pp. 552. Date of Electronic Publication: 2023 May 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ketoglutarate Dehydrogenase Complex*/chemistry
Ketoglutarate Dehydrogenase Complex*/metabolism
Citric Acid Cycle*
Acyl Coenzyme A/metabolism ; Cytoplasm
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of pyruvate metabolism and citric acid cycle patterns predicts response to immunotherapeutic and ferroptosis in gastric cancer.
Autorzy:
Wang, Xu (AUTHOR)
Xu, Bing (AUTHOR)
Du, Jing (AUTHOR)
Xia, Jun (AUTHOR)
Lei, Guojie (AUTHOR)
Zhou, Chaoting (AUTHOR)
Hu, Jiayu (AUTHOR)
Zhang, Yinhao (AUTHOR)
Chen, Sufeng (AUTHOR)
Shao, Fangchun (AUTHOR)
Yang, Jiyun (AUTHOR)
Li, Yanchun (AUTHOR)
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Źródło:
Cancer Cell International. 10/13/2022, Vol. 22 Issue 1, p1-20. 20p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Citric Acid Cycle Metabolites Predict Infarct Size in Pigs Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning.
Autorzy:
Consegal M; Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Núñez N; Unit of High Technology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Barba I; Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Faculty of Medicine, University of Vic-Central University of Catalonia (UVicUCC), Can Baumann. Ctra. de Roda, 70, 08500 Vic, Spain.
Benito B; Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Ruiz-Meana M; Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Inserte J; Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Ferreira-González I; Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Rodríguez-Sinovas A; Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.; Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 16; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 16.
Typ publikacji:
Journal Article
MeSH Terms:
Citric Acid Cycle*
Coronary Occlusion/*metabolism
Enzyme Inhibitors/*therapeutic use
Ischemic Preconditioning/*methods
Myocardial Infarction/*metabolism
Succinate Dehydrogenase/*antagonists & inhibitors
Animals ; Biomarkers/blood ; Biomarkers/metabolism ; Coronary Occlusion/pathology ; Coronary Occlusion/therapy ; Dicarboxylic Acids/blood ; Dicarboxylic Acids/metabolism ; Enzyme Inhibitors/pharmacology ; Heart/drug effects ; Myocardial Infarction/pathology ; Myocardial Infarction/therapy ; Myocardium/metabolism ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material.
Autorzy:
Roosterman D; Independent Scholar, 48291 Telgte, Germany.
Cottrell GS; School of Pharmacy, University of Reading, Reading RG6 6AP, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 09; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Citric Acid Cycle*
Citrate (si)-Synthase/*metabolism
Pyruvate Carboxylase/*metabolism
Animals ; Exercise ; Humans ; L-Lactate Dehydrogenase/metabolism ; Monocarboxylic Acid Transporters/metabolism ; Oxidative Phosphorylation ; Protons ; Symporters/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Potential clinical applications of alpha‑ketoglutaric acid in diseases (Review).
Autorzy:
Meng X; Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.
Liu H; Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.
Peng L; Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.
He W; Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.
Li S; Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2022 May; Vol. 25 (5). Date of Electronic Publication: 2022 Mar 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Citric Acid Cycle*/physiology
Ketoglutaric Acids*/metabolism
Energy Metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Copper induces cell death by targeting lipoylated TCA cycle proteins.
Autorzy:
Tsvetkov P; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Coy S; Laboratory of Systems Pharmacology, Department of Systems Biology, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Petrova B; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Boston Children's Hospital, Boston, MA USA.
Dreishpoon M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Verma A; Laboratory of Systems Pharmacology, Department of Systems Biology, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Abdusamad M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Rossen J; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Joesch-Cohen L; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Humeidi R; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Spangler RD; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Eaton JK; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Frenkel E; Whitehead Institute and Massachusetts Institute of Technology, Cambridge, MA, USA.
Kocak M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Corsello SM; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.
Lutsenko S; Department of Physiology, Johns Hopkins Medical Institutes, Baltimore, MD, USA.
Kanarek N; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Boston Children's Hospital, Boston, MA USA.
Santagata S; Laboratory of Systems Pharmacology, Department of Systems Biology, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Dana Farber Cancer Institute, Boston, MA, USA.
Golub TR; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA.; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Mar 18; Vol. 375 (6586), pp. 1254-1261. Date of Electronic Publication: 2022 Mar 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Citric Acid Cycle*
Regulated Cell Death*
Copper/*metabolism
Copper/*toxicity
Animals ; Cell Respiration ; Dihydrolipoyllysine-Residue Acetyltransferase/metabolism ; Hepatolenticular Degeneration/metabolism ; Homeostasis ; Humans ; Hydrazines/toxicity ; Ionophores/toxicity ; Iron-Sulfur Proteins/metabolism ; Lipoylation ; Metabolic Networks and Pathways ; Mice ; Mitochondria/metabolism
Czasopismo naukowe
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Tytuł:
Analysis of steady-state carbon tracer experiments using akaike information criteria.
Autorzy:
Alger JR; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. .; NeuroSpectroScopics LLC, Sherman Oaks, CA, USA. .; Department of Neurology, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. .; Hura Imaging Inc, Calabasas, CA, USA. .
Minhajuddin A; Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dean Sherry A; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Chemistry, University of Texas at Dallas, Richardson, TX, USA.
Malloy CR; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Veterans Affairs North Texas Healthcare System, Dallas, TX, USA.
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Źródło:
Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2021 Jun 19; Vol. 17 (7), pp. 61. Date of Electronic Publication: 2021 Jun 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Carbon*
Citric Acid Cycle*
Carbon Isotopes ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset.
Autorzy:
Jeong J; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Lee J; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Kim JH; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Lim C; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
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Źródło:
PLoS genetics [PLoS Genet] 2021 Oct 29; Vol. 17 (10), pp. e1009871. Date of Electronic Publication: 2021 Oct 29 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Citric Acid Cycle/*physiology
Glutamic Acid/*metabolism
Seizures/*metabolism
Animals ; Citric Acid/metabolism ; Citric Acid Cycle/genetics ; Dicarboxylic Acid Transporters/genetics ; Dicarboxylic Acid Transporters/metabolism ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Glutamic Acid/genetics ; Male ; Metabolic Networks and Pathways/genetics ; Metabolic Networks and Pathways/physiology ; Mutation/genetics ; Neurons/metabolism ; Seizures/genetics ; Symporters/genetics ; Symporters/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 33515

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