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Tytuł:
Genome-wide DNA methylation patterns reveal clinically relevant predictive and prognostic subtypes in human osteosarcoma.
Autorzy:
Lietz CE; Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Newman ET; Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Kelly AD; Foundation Medicine, Cambridge, MA, USA.
Xiang DH; Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Zhang Z; Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Luscko CA; Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Lozano-Calderon SA; Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Ebb DH; Division of Pediatric Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Raskin KA; Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Cote GM; Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Choy E; Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Nielsen GP; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Haibe-Kains B; Department of Medical Biophysics, Princess Margaret Cancer Centre, University of Toronto, Toronto, M5G 2M9, ON, Canada.
Aryee MJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Spentzos D; Department of Orthopaedic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. .
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Źródło:
Communications biology [Commun Biol] 2022 Mar 08; Vol. 5 (1), pp. 213. Date of Electronic Publication: 2022 Mar 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Bone Neoplasms*/genetics
Bone Neoplasms*/pathology
Osteosarcoma*/genetics
Osteosarcoma*/pathology
DNA ; DNA Methylation ; Humans ; Prognosis
Czasopismo naukowe
Tytuł:
Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report.
Autorzy:
Lessing AJ; Neurofibromatosis Northeast, Burlington, Massachusetts, USA.
Cote GM; Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
DeLaney TF; Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Plotkin SR; Department of Neurology and Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Raskin KA; Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Lessing JN; Division of Hospital Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
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Źródło:
Case reports in oncology [Case Rep Oncol] 2021 Sep 20; Vol. 14 (3), pp. 1342-1346. Date of Electronic Publication: 2021 Sep 20 (Print Publication: 2021).
Typ publikacji:
Case Reports
Raport
Tytuł:
Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution.
Autorzy:
Miao R; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Choy E; Department of Medical Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA.
Raskin KA; Harvard Medical School, Boston, MA 02115, USA.; Department of Orthopedic Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Schwab JH; Harvard Medical School, Boston, MA 02115, USA.; Department of Orthopedic Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Nielsen GP; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
Deshpande V; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
Chebib I; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
DeLaney TF; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA.
Hornicek FJ; Harvard Medical School, Boston, MA 02115, USA.; Department of Orthopedic Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Orthopedic Surgery, University of California Los Angeles, Santa Monica, CA 90404, USA.
Cote GM; Department of Medical Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA.
Chen YE; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA.
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Źródło:
Sarcoma [Sarcoma] 2019 Dec 13; Vol. 2019, pp. 9069272. Date of Electronic Publication: 2019 Dec 13 (Print Publication: 2019).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016).
Autorzy:
Widemann BC; National Cancer Institute, Center for Cancer Research, Pediatric Oncology Branch, 10 Center Drive, Building 10, Room 1-3752, Bethesda, MD 20892, USA.
Lu Y; SARC Statistics, Weill Cornell Medicine Healthcare and Policy Research, 402 East 67th Street, New York, NY 10065, USA.
Reinke D; SARC, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48105, USA.
Okuno SH; Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA.
Meyer CF; Johns Hopkins Hospital, 1650 Orleans St., CRB1/Room G89, Baltimore, MD 21231, USA.
Cote GM; Massachusetts General Hospital Cancer Center, Harvard Medical School, 10 North Grove Street, POB-2, Boston, MA 02114, USA.
Chugh R; University of Michigan, 1500 E. Medical Center Dr, SPC 5912, Ann Arbor, MI 48109, USA.
Milhem MM; University of Iowa, 200 Hawkins Drive, C32 GH, Iowa, IA 52242, USA.
Hirbe AC; Washington University of St. Louis, 660 S, Euclid Ave, St. Louis, MO 63110, USA.
Kim A; Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010, USA.
Turpin B; Cincinnati Children's Hospital, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
Pressey JG; Cincinnati Children's Hospital Medical Center, University of Alabama, 1600 7th Avenue South, Lowder 512, Birmingham, AL 35233, USA.
Dombi E; National Cancer Institute, Center for Cancer Research, Pediatric Oncology Branch, 10 Center Drive, Building 10, Room 1-3752, Bethesda, MD 20892, USA.
Jayaprakash N; National Cancer Institute, Center for Cancer Research, Pediatric Oncology Branch, 10 Center Drive, Building 10, Room 1-3752, Bethesda, MD 20892, USA.
Helman LJ; National Cancer Institute, Center for Cancer Research, Pediatric Oncology Branch, 10 Center Drive, Building 10, Room 1-3752, Bethesda, MD 20892, USA.
Onwudiwe N; SARC, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48105, USA.
Cichowski K; Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Perentesis JP; Cincinnati Children's Hospital, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
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Źródło:
Sarcoma [Sarcoma] 2019 Jul 24; Vol. 2019, pp. 7656747. Date of Electronic Publication: 2019 Jul 24 (Print Publication: 2019).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Myxoid Liposarcoma: Treatment Outcomes from Chemotherapy and Radiation Therapy.
Autorzy:
Chowdhry V; Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Goldberg S; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
DeLaney TF; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Cote GM; Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Chebib I; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
Kim J; Department of Orthopedic Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Lozano-Calderón SA; Department of Orthopedic Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
De Amorim Bernstein K; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
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Źródło:
Sarcoma [Sarcoma] 2018 Nov 01; Vol. 2018, pp. 8029157. Date of Electronic Publication: 2018 Nov 01 (Print Publication: 2018).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents.
Autorzy:
Khalil, Ahmed F. (AUTHOR)
El-Moselhy, Tarek F. (AUTHOR)
El-Bastawissy, Eman A. (AUTHOR)
Abdelhady, Rasha (AUTHOR)
Younis, Nancy S. (AUTHOR)
El-Hamamsy, Mervat H. (AUTHOR)
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Źródło:
Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-22. 22p.
Czasopismo naukowe
Tytuł:
IDH mutations in G2-3 conventional central bone chondrosarcoma: a mono institutional experience.
Autorzy:
Setola, Elisabetta (AUTHOR)
Benini, S. (AUTHOR)
Righi, A. (AUTHOR)
Gamberi, G. (AUTHOR)
Carretta, E. (AUTHOR)
Ferrari, C. (AUTHOR)
Avnet, S. (AUTHOR)
Palmerini, E. (AUTHOR)
Magagnoli, G. (AUTHOR)
Gambarotti, M. (AUTHOR)
Lollini, P. L. (AUTHOR)
Cesari, M. (AUTHOR)
Cocchi, S. (AUTHOR)
Paioli, A. (AUTHOR)
Longhi, A. (AUTHOR)
Scotlandi, K. (AUTHOR)
Laginestra, M. A. (AUTHOR)
Donati, D. M. (AUTHOR)
Baldini, N. (AUTHOR)
Ibrahim, T. (AUTHOR)
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Źródło:
BMC Cancer. 9/26/2023, Vol. 23 Issue 1, p1-12. 12p.
Czasopismo naukowe
Tytuł:
Primary cardiac sarcomas: A clinicopathologic study in a single institution with 25 years of experience with an emphasis on MDM2 expression and adjuvant therapy for prognosis.
Autorzy:
Cho, Haeyon (AUTHOR)
Song, In‐Hye (AUTHOR)
Jo, Uiree (AUTHOR)
Jeong, Ji‐Seon (AUTHOR)
Koo, Hyun Jung (AUTHOR)
Yang, Dong Hyun (AUTHOR)
Jung, Sung‐Ho (AUTHOR)
Song, Joon Seon (AUTHOR)
Cho, Kyung‐Ja (AUTHOR)
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Źródło:
Cancer Medicine. Aug2023, Vol. 12 Issue 16, p16815-16828. 14p.
Czasopismo naukowe
Tytuł:
Isovalerylspiramycin I inhibits proliferation, migration and invasion of osteosarcoma cells by targeting Topoisomerase 1 and suppressing the ataxia telangiectasia and Rad3-related/checkpoint kinase 1 pathway.
Autorzy:
Jinrong Liang
Peng Zhang
Kunyan He
Yawen Zhang
Xiaomin Ding
Qian Li
Wang Zhou
Haiyan Hu
Jianjun Zhang
Yan Zhou
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Źródło:
Clinical & Translational Discovery. Aug2023, Vol. 3 Issue 4, p1-14. 14p.
Czasopismo naukowe
Tytuł:
Rewiring innate and adaptive immunity with TLR9 agonist to treat osteosarcoma.
Autorzy:
Cascini, Caterina (AUTHOR)
Ratti, Chiara (AUTHOR)
Botti, Laura (AUTHOR)
Parma, Beatrice (AUTHOR)
Cancila, Valeria (AUTHOR)
Salvaggio, Adriana (AUTHOR)
Meazza, Cristina (AUTHOR)
Tripodo, Claudio (AUTHOR)
Colombo, Mario P. (AUTHOR)
Chiodoni, Claudia (AUTHOR)
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Źródło:
Journal of Experimental & Clinical Cancer Research (17569966). 6/26/2023, Vol. 42 Issue 1, p1-16. 16p.
Czasopismo naukowe
Tytuł:
Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro.
Autorzy:
Shen JK; Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, United States.
Cote GM; Division of Hematology and Oncology, Massachusetts General Hospital, Boston, United States.
Gao Y; Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, United States.
Choy E; Division of Hematology and Oncology, Massachusetts General Hospital, Boston, United States.
Mankin HJ; Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, United States.
Hornicek FJ; Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, United States.
Duan Z; Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, United States.
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Źródło:
Scientific reports [Sci Rep] 2016 Apr 29; Vol. 6, pp. 25239. Date of Electronic Publication: 2016 Apr 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Movement*
Cell Proliferation*
Protein Processing, Post-Translational*
Enhancer of Zeste Homolog 2 Protein/*metabolism
Histones/*metabolism
Lysine/*metabolism
Sarcoma, Synovial/*pathology
Cell Line, Tumor ; Gene Knockdown Techniques ; Humans ; Methylation
Czasopismo naukowe

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