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Tytuł:
Approaches to hepatitis C treatment and cure using NS5A inhibitors
Autorzy:
Kohler JJ
Nettles JH
Amblard F
Hurwitz SJ
Bassit L
Stanton RA
Ehteshami M
Schinazi RF
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Temat:
Infectious and parasitic diseases
RC109-216
Źródło:
Infection and Drug Resistance, Vol 2014, Iss default, Pp 41-56 (2014)
Opis pliku:
electronic resource
Relacje:
http://www.dovepress.com/approaches-to-hepatitis-c-treatment-and-cure-using-ns5a-inhibitors-a16015; https://doaj.org/toc/1178-6973
Dostęp URL:
https://doaj.org/article/54c0fd9d446e45e5a800e59a42184013  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Tytuł:
Synthesis of 4'-Substituted Carbocyclic Uracil Derivatives and Their Monophosphate Prodrugs as Potential Antiviral Agents.
Autorzy:
Biteau NG; Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
Amichai SA; Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
Azadi N; Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
De R; Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
Downs-Bowen J; Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
Lecher JC; Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
MacBrayer T; Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
Schinazi RF; Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
Amblard F; Laboratory of Biochemical Pharmacology, Center for ViroScience and Cure, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
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Źródło:
Viruses [Viruses] 2023 Feb 16; Vol. 15 (2). Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
COVID-19*
Influenza A virus*
Prodrugs*/pharmacology
Humans ; Antiviral Agents/pharmacology ; Hepatitis C Antibodies ; Influenza B virus ; Nucleosides ; SARS-CoV-2 ; Uracil
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Botanical inhibitors of SARS-CoV-2 viral entry: a phylogenetic perspective.
Autorzy:
Risener CJ; Molecular and Systems Pharmacology, Laney Graduate School, Emory University, Atlanta, GA, USA.; Center for the Study of Human Health, Emory University, Atlanta, GA, USA.
Woo S; Center for the Study of Human Health, Emory University, Atlanta, GA, USA.
Samarakoon T; Center for the Study of Human Health, Emory University, Atlanta, GA, USA.
Caputo M; Center for the Study of Human Health, Emory University, Atlanta, GA, USA.
Edwards E; Center for the Study of Human Health, Emory University, Atlanta, GA, USA.
Klepzig K; The Jones Center at Ichauway, Newton, GA, USA.
Applequist W; Missouri Botanical Garden, St. Louis, MO, USA.
Zandi K; Laboratory of Biochemical Pharmacology, Department of Pediatrics and Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Goh SL; Laboratory of Biochemical Pharmacology, Department of Pediatrics and Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Downs-Bowen JA; Laboratory of Biochemical Pharmacology, Department of Pediatrics and Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Schinazi RF; Laboratory of Biochemical Pharmacology, Department of Pediatrics and Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
Quave CL; Molecular and Systems Pharmacology, Laney Graduate School, Emory University, Atlanta, GA, USA. .; Center for the Study of Human Health, Emory University, Atlanta, GA, USA. .; Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 23; Vol. 13 (1), pp. 1244. Date of Electronic Publication: 2023 Jan 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Biological Products*
Humans ; Animals ; SARS-CoV-2 ; Phylogeny ; Virus Internalization ; Antiviral Agents ; Plant Extracts ; Protein Binding ; Mammals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis of Novel N -Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents.
Autorzy:
Amblard F; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
LeCher JC; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
De R; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Goh SL; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Li C; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Kasthuri M; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Biteau N; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Zhou L; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Tber Z; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Downs-Bowen J; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Zandi K; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Schinazi RF; Center for ViroScience/Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
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Źródło:
Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Sep 14; Vol. 15 (9). Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Assessment of a Computational Approach to Predict Drug Resistance Mutations for HIV, HBV and SARS-CoV-2.
Autorzy:
Patel D; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Dr., Atlanta, GA 30322, USA.
Ono SK; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Dr., Atlanta, GA 30322, USA.; Department of Gastroenterology, University of São Paulo School of Medicine, Av. Dr. Arnaldo, 455, São Paulo 05403-000, SP, Brazil.
Bassit L; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Dr., Atlanta, GA 30322, USA.
Verma K; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Dr., Atlanta, GA 30322, USA.
Amblard F; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Dr., Atlanta, GA 30322, USA.
Schinazi RF; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Dr., Atlanta, GA 30322, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Aug 24; Vol. 27 (17). Date of Electronic Publication: 2022 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*
HIV Infections*/drug therapy
Antiviral Agents/chemistry ; Drug Resistance, Viral/genetics ; Hepatitis B virus/genetics ; Humans ; Mutation ; SARS-CoV-2/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In silico design of a novel nucleotide antiviral agent by free energy perturbation.
Autorzy:
Patel D; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Cox BD; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Kasthuri M; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Mengshetti S; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Bassit L; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Verma K; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Ollinger-Russell O; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Amblard F; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2022 Jun; Vol. 99 (6), pp. 801-815. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Hepatitis C*/drug therapy
Prodrugs*/pharmacology
Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Hepacivirus ; Humans ; Nucleosides/pharmacology ; Nucleotides/pharmacology ; RNA-Dependent RNA Polymerase ; Uridine ; Viral Nonstructural Proteins ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lethal mutagenesis as an antiviral strategy.
Autorzy:
Swanstrom R; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Schinazi RF; Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Feb 04; Vol. 375 (6580), pp. 497-498. Date of Electronic Publication: 2022 Feb 03.
Typ publikacji:
Journal Article
MeSH Terms:
Mutagenesis*
Antiviral Agents/*pharmacology
Cytidine/*analogs & derivatives
Hydroxylamines/*pharmacology
RNA Viruses/*drug effects
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; COVID-19/virology ; Cytidine/adverse effects ; Cytidine/metabolism ; Cytidine/pharmacology ; Cytidine/therapeutic use ; Cytidine/toxicity ; DNA/biosynthesis ; Evolution, Molecular ; Genome, Viral ; Humans ; Hydroxylamines/adverse effects ; Hydroxylamines/metabolism ; Hydroxylamines/therapeutic use ; Mutagenicity Tests ; Phosphorylation ; RNA Virus Infections/drug therapy ; RNA Virus Infections/virology ; RNA Viruses/genetics ; RNA, Viral/biosynthesis ; RNA, Viral/genetics ; Ribonucleosides/metabolism ; SARS-CoV-2/genetics ; COVID-19 Drug Treatment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy Inhibition.
Autorzy:
Bestion E; Genoscience Pharma, 13006 Marseille, France.; Institut de Recherche Pour le Développement, Aix-Marseille University, Assitance Publique-Hopitaux de Marseille, Microbe, Phylogeny and Infection, 13005 Marseille, France.; Institut Hospitalo-Universitaire Méditerranée Infection, Aix-Marseille University, 13005 Marseille, France.
Zandi K; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Belouzard S; Lille University, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille (CIIL), INSERM U 1019-UMR 9017-UMR 8204, 59019 Lille, France.
Andreani J; Institut de Recherche Pour le Développement, Aix-Marseille University, Assitance Publique-Hopitaux de Marseille, Microbe, Phylogeny and Infection, 13005 Marseille, France.; Institut Hospitalo-Universitaire Méditerranée Infection, Aix-Marseille University, 13005 Marseille, France.
Lepidi H; Department of Pathology, La Timone Hospital, Aix-Marseille Université, 13005 Marseille, France.
Novello M; Genoscience Pharma, 13006 Marseille, France.
Rouquairol C; Genoscience Pharma, 13006 Marseille, France.
Baudoin JP; Institut de Recherche Pour le Développement, Aix-Marseille University, Assitance Publique-Hopitaux de Marseille, Microbe, Phylogeny and Infection, 13005 Marseille, France.; Institut Hospitalo-Universitaire Méditerranée Infection, Aix-Marseille University, 13005 Marseille, France.
Rachid M; Genoscience Pharma, 13006 Marseille, France.
La Scola B; Institut de Recherche Pour le Développement, Aix-Marseille University, Assitance Publique-Hopitaux de Marseille, Microbe, Phylogeny and Infection, 13005 Marseille, France.; Institut Hospitalo-Universitaire Méditerranée Infection, Aix-Marseille University, 13005 Marseille, France.
Mege JL; Institut de Recherche Pour le Développement, Aix-Marseille University, Assitance Publique-Hopitaux de Marseille, Microbe, Phylogeny and Infection, 13005 Marseille, France.; Institut Hospitalo-Universitaire Méditerranée Infection, Aix-Marseille University, 13005 Marseille, France.
Dubuisson J; Lille University, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Centre d'Infection et d'Immunité de Lille (CIIL), INSERM U 1019-UMR 9017-UMR 8204, 59019 Lille, France.
Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Mezouar S; Genoscience Pharma, 13006 Marseille, France.; Institut de Recherche Pour le Développement, Aix-Marseille University, Assitance Publique-Hopitaux de Marseille, Microbe, Phylogeny and Infection, 13005 Marseille, France.; Institut Hospitalo-Universitaire Méditerranée Infection, Aix-Marseille University, 13005 Marseille, France.
Halfon P; Genoscience Pharma, 13006 Marseille, France.
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Źródło:
Viruses [Viruses] 2022 Jan 12; Vol. 14 (1). Date of Electronic Publication: 2022 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19 Drug Treatment*
Antiviral Agents/*pharmacology
Autophagy/*drug effects
SARS-CoV-2/*drug effects
Animals ; Antiviral Agents/therapeutic use ; Autophagosomes/metabolism ; COVID-19/pathology ; COVID-19/virology ; Cell Line ; Disease Models, Animal ; Humans ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Lysosomes/metabolism ; Mice ; SARS-CoV-2/physiology ; Viral Load/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens.
Autorzy:
Immergluck K
Gonzalez MD
Frediani JK
Levy JM
Figueroa J
Wood A
Rogers BB
O'Neal J
Elias-Marcellin R
Suessmith A
Sullivan J
Schinazi RF
Babiker A
Piantadosi A
Vos MB
Martin GS
Lam WA
Waggoner JJ
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Źródło:
Emerging infectious diseases [Emerg Infect Dis] 2021 Nov; Vol. 27 (11), pp. 2887-2891. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
COVID-19*
SARS-CoV-2*
Diagnostic Tests, Routine ; Humans ; Nasopharynx ; RNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration.
Autorzy:
Frediani JK; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia.; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.
Levy JM; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia.
Rao A; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Bassit L; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Laboratory of Biochemical Pharmacology, Emory University, Atlanta, Georgia.
Figueroa J; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Vos MB; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.; Children's Healthcare of Atlanta, Atlanta, Georgia.
Wood A; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Jerris R; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.
Van Leung-Pineda; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.
Gonzalez MD; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.
Rogers BB; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.
Mavigner M; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Schinazi RF; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Schoof N; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Waggoner JJ; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.; Rollins School of Public Health, Emory University, Atlanta, Georgia.
Kempker RR; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Rebolledo PA; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.; Rollins School of Public Health, Emory University, Atlanta, Georgia.
O'Neal JW; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Stone C; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Children's Healthcare of Atlanta, Atlanta, Georgia.
Chahroudi A; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.; Children's Healthcare of Atlanta, Atlanta, Georgia.
Morris CR; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.; Children's Healthcare of Atlanta, Atlanta, Georgia.
Suessmith A; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Sullivan J; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Farmer S; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Georgia Institute of Technology, Atlanta, Georgia.
Foster A; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Georgia Institute of Technology, Atlanta, Georgia.
Roback JD; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.
Ramachandra T; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Washington C; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Le K; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.
Cordero MC; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Esper A; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Nehl EJ; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Rollins School of Public Health, Emory University, Atlanta, Georgia.
Wang YF; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.
Tyburski EA; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia.; Georgia Institute of Technology, Atlanta, Georgia.
Martin GS; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia. .; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia. .
Lam WA; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, Georgia. .; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia. .; Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia. .; Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 16; Vol. 11 (1), pp. 14604. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
COVID-19 Serological Testing*
Point-of-Care Systems*
Self-Testing*
COVID-19/*diagnosis
Humans ; Limit of Detection ; SARS-CoV-2 ; Sensitivity and Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-( E )-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs.
Autorzy:
Abuduaini T; Institute of Organic and Analytical Chemistry, CNRS UMR 7311, Universite d'Orléans, F-45067 Orléans, France.
Roy V; Institute of Organic and Analytical Chemistry, CNRS UMR 7311, Universite d'Orléans, F-45067 Orléans, France.
Marlet J; Inserm U1259, Université de Tours, 37032 Tours, France.
Gaudy-Graffin C; Inserm U1259, Université de Tours, 37032 Tours, France.
Brand D; Inserm U1259, Université de Tours, 37032 Tours, France.
Baronti C; Unité des Virus Émergents (UVE: Aix-Marseille Univ, IRD 190, Inserm 1207, IHU Méditerranée Infection), 13000 Marseille, France.
Touret F; Unité des Virus Émergents (UVE: Aix-Marseille Univ, IRD 190, Inserm 1207, IHU Méditerranée Infection), 13000 Marseille, France.
Coutard B; Unité des Virus Émergents (UVE: Aix-Marseille Univ, IRD 190, Inserm 1207, IHU Méditerranée Infection), 13000 Marseille, France.
McBrayer TR; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA 30222, USA.
Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA 30222, USA.
Agrofoglio LA; Institute of Organic and Analytical Chemistry, CNRS UMR 7311, Universite d'Orléans, F-45067 Orléans, France.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 09; Vol. 26 (5). Date of Electronic Publication: 2021 Mar 09.
Typ publikacji:
Journal Article
MeSH Terms:
Antiviral Agents/*chemical synthesis
Antiviral Agents/*pharmacology
Azo Compounds/*chemistry
Nucleosides/*chemistry
Organophosphonates/*chemistry
Prodrugs/*chemical synthesis
Prodrugs/*pharmacology
Alkenes/chemistry ; Animals ; Cell Line, Tumor ; Chlorocebus aethiops ; HIV-1/drug effects ; Hepatitis B virus/drug effects ; Humans ; Magnetic Resonance Spectroscopy ; Methylation ; SARS-CoV-2/drug effects ; Structure-Activity Relationship ; Triazoles/chemistry ; Vero Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Studies on the Efficacy, Potential Cardiotoxicity and Monkey Pharmacokinetics of GLP-26 as a Potent Hepatitis B Virus Capsid Assembly Modulator.
Autorzy:
Hurwitz SJ; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
McBrearty N; Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
Arzumanyan A; Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
Bichenkov E; Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
Tao S; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Bassit L; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Chen Z; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Kohler JJ; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Amblard F; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
Feitelson MA; Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA 30322, USA.
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Źródło:
Viruses [Viruses] 2021 Jan 15; Vol. 13 (1). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Capsid/*drug effects
Capsid/*metabolism
Cardiotoxins/*pharmacokinetics
Hepatitis B virus/*drug effects
Hepatitis B virus/*physiology
Sulfonylurea Compounds/*pharmacokinetics
Virus Assembly/*drug effects
Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hepatitis B/drug therapy ; Hepatitis B/virology ; Humans ; Macaca fascicularis ; Male ; Mice ; Myocytes, Cardiac/drug effects ; Sulfonylurea Compounds/adverse effects ; Sulfonylurea Compounds/chemistry ; Viral Load
Czasopismo naukowe
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Tytuł:
Antibody Profiles According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020.
Autorzy:
Hu WT
Howell JC
Ozturk T
Benameur K
Bassit LC
Ramonell R
Cashman KS
Pirmohammed S
Roback JD
Marconi VC
Yang I
Mac VV
Smith D
Sanz I
Wharton W
Lee FE
Schinazi RF
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Źródło:
Emerging infectious diseases [Emerg Infect Dis] 2020 Dec; Vol. 26 (12), pp. 2974-2978. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Severity of Illness Index*
COVID-19/*immunology
Immunoglobulin G/*immunology
Immunoglobulin M/*immunology
Adult ; Aged ; Aged, 80 and over ; COVID-19/physiopathology ; Case-Control Studies ; Disease Progression ; Female ; Georgia ; Humans ; Male ; Middle Aged ; Pandemics ; Prospective Studies ; SARS-CoV-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance.
Autorzy:
Bertoletti N; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066, USA.
Chan AH; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066, USA.
Schinazi RF; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520-8066, USA.; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Anderson KS; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Oct 21; Vol. 25 (20). Date of Electronic Publication: 2020 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-HIV Agents/*pharmacology
Drug Resistance, Viral/*drug effects
HIV Infections/*drug therapy
HIV Reverse Transcriptase/*drug effects
HIV-1/*drug effects
Reverse Transcriptase Inhibitors/*pharmacology
Anti-HIV Agents/chemistry ; Catalysis ; Crystallography, X-Ray ; Emtricitabine/chemistry ; Emtricitabine/pharmacology ; Humans ; Models, Molecular ; Nucleotides/chemistry ; Nucleotides/pharmacology ; Reverse Transcriptase Inhibitors/chemistry ; Stavudine/chemistry ; Stavudine/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020.
Autorzy:
Benameur K
Agarwal A
Auld SC
Butters MP
Webster AS
Ozturk T
Howell JC
Bassit LC
Velasquez A
Schinazi RF
Mullins ME
Hu WT
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Źródło:
Emerging infectious diseases [Emerg Infect Dis] 2020 Sep; Vol. 26 (9), pp. 2016-2021. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji:
Case Reports; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Betacoronavirus*
Brain Diseases/*virology
Coronavirus Infections/*complications
Cytokines/*cerebrospinal fluid
Encephalitis, Viral/*virology
Pneumonia, Viral/*complications
Adult ; Brain Diseases/cerebrospinal fluid ; COVID-19 ; Coronavirus Infections/cerebrospinal fluid ; Coronavirus Infections/virology ; Encephalitis, Viral/cerebrospinal fluid ; Fatal Outcome ; Female ; Georgia ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/cerebrospinal fluid ; Pneumonia, Viral/virology ; SARS-CoV-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Direct-Acting Antivirals Remain Cost-Effective Treatments for Chronic Hepatitis C in Australia Despite Changes to the Treated Population and the Availability of Retreatment: The Glecaprevir/Pibrentasvir (Maviret) Example.
Autorzy:
Warren, Emma (AUTHOR)
Castles, Belinda J. C. (AUTHOR)
Sharratt, Gillian C. (AUTHOR)
Arteaga, Aitor (AUTHOR)
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Źródło:
Infectious Diseases & Therapy. Mar2024, Vol. 13 Issue 3, p549-564. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Scale-up of Direct-Acting Antiviral Treatment in Prisons Is Both Cost-effective and Key to Hepatitis C Virus Elimination.
Autorzy:
Shih, Sophy T F (AUTHOR)
Stone, Jack (AUTHOR)
Martin, Natasha K (AUTHOR)
Hajarizadeh, Behzad (AUTHOR)
Cunningham, Evan B (AUTHOR)
Kwon, Jisoo A (AUTHOR)
McGrath, Colette (AUTHOR)
Grant, Luke (AUTHOR)
Grebely, Jason (AUTHOR)
Dore, Gregory J (AUTHOR)
Lloyd, Andrew R (AUTHOR)
Vickerman, Peter (AUTHOR)
Chambers, Georgina M (AUTHOR)
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Źródło:
Open Forum Infectious Diseases. Feb2024, Vol. 11 Issue 2, p1-9. 9p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 2534

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