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Tytuł:
Chronic replication stress invokes mitochondria dysfunction via impaired parkin activity.
Autorzy:
Kawabata T; Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan. .
Sekiya R; Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Goto S; Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Li TS; Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 03; Vol. 14 (1), pp. 7877. Date of Electronic Publication: 2024 Apr 03.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Mitochondrial Diseases*/metabolism
Humans ; Mitophagy/genetics ; Mitochondria/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
E3 ubiquitin ligase TaSDIR1-4A activates membrane-bound transcription factor TaWRKY29 to positively regulate drought resistance.
Autorzy:
Meng Y; State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling, China.
Lv Q; State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling, China.
Li L; State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling, China.
Wang B; State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling, China.
Chen L; State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling, China.
Yang W; State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling, China.
Lei Y; State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling, China.
Xie Y; State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling, China.
Li X; State Key Laboratory of Crop Stress Biology in Arid Areas and College of Agronomy, Northwest A&F University, Yangling, China.
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Źródło:
Plant biotechnology journal [Plant Biotechnol J] 2024 Apr; Vol. 22 (4), pp. 987-1000. Date of Electronic Publication: 2023 Nov 29.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Arabidopsis*/metabolism
Drought Resistance ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Abscisic Acid/metabolism ; Droughts ; Amino Acids/metabolism ; Stress, Physiological/genetics ; Gene Expression Regulation, Plant ; Plants, Genetically Modified/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PELI1: key players in the oncogenic characteristics of pancreatic Cancer.
Autorzy:
Fei X; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China.
Zhu C; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Liu P; Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Liu S; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China.; Department of Hepatobiliary Surgery, Baiyun Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Ren L; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China.
Lu R; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China.
Hou J; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China.
Gao Y; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China.
Wang X; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China. .; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China. .
Pan Y; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China. .; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Mar 25; Vol. 43 (1), pp. 91. Date of Electronic Publication: 2024 Mar 25.
Typ publikacji:
Journal Article
MeSH Terms:
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/metabolism
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Glycogen Synthase Kinase 3 beta/metabolism ; Mice, Nude ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Modulation of early gene expression responses to water deprivation stress by the E3 ubiquitin ligase ATL80: implications for retrograde signaling interplay.
Autorzy:
Méndez-Gómez M; Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Irapuato, Irapuato, 36824, Gto, México.
Sierra-Cacho D; Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Irapuato, Irapuato, 36824, Gto, México.
Jiménez-Morales E; Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Irapuato, Irapuato, 36824, Gto, México.
Guzmán P; Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Irapuato, Irapuato, 36824, Gto, México. .
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Źródło:
BMC plant biology [BMC Plant Biol] 2024 Mar 08; Vol. 24 (1), pp. 180. Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Water Deprivation*
Transcription Factors/genetics ; Dehydration ; Gene Expression ; Gene Expression Regulation, Plant ; Plant Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Survey on the Expression of the Ubiquitin Proteasome System Components HECT- and RBR-E3 Ubiquitin Ligases and E2 Ubiquitin-Conjugating and E1 Ubiquitin-Activating Enzymes during Human Brain Development.
Autorzy:
Magnati S; Centro Regionale Anti Doping-A. Bertinaria, Orbassano, 10043 Turin, Italy.; Politecnico di Torino, 10129, Turin, Italy.
Alladio E; Centro Regionale Anti Doping-A. Bertinaria, Orbassano, 10043 Turin, Italy.; Department of Chemistry, University of Turin, 10125 Turin, Italy.
Bracco E; Department of Oncology, University of Turin, 10043 Orbassano, Italy.; Istituto Nazionale Ricerca Metrologica, 10135 Turin, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 17; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Ubiquitin-Activating Enzymes*/metabolism
Humans ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitination ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; Brain/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide identification and transcriptome profiling expression analysis of the U-box E3 ubiquitin ligase gene family related to abiotic stress in maize (Zea mays L.).
Autorzy:
Liu Y; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China.; College of Life Sciences, Nanjing University, Nanjing, 210095, People's Republic of China.
Li C; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China.
Qin A; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China.
Deng W; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China.
Chen R; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China.
Yu H; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China.
Wang Y; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China.
Song J; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China. .; Jiangxi Provincial Key Laboratory of Conservation Biology, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China. .
Zeng L; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China. .
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Źródło:
BMC genomics [BMC Genomics] 2024 Feb 01; Vol. 25 (1), pp. 132. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Zea mays*/metabolism
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Phylogeny ; Gene Expression Profiling ; Stress, Physiological/genetics ; Ubiquitins/genetics ; Gene Expression Regulation, Plant ; Plant Proteins/metabolism ; Multigene Family
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Autorzy:
Mercer JAM; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
DeCarlo SJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Roy Burman SS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Sreekanth V; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Nelson AT; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Hunkeler M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Chen PJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Donovan KA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Kokkonda P; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Tiwari PK; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Shoba VM; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Deb A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Mar 15; Vol. 383 (6688), pp. eadk4422. Date of Electronic Publication: 2024 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Proteolysis*
Ubiquitin-Protein Ligases*/chemistry
Degrons*/genetics
Zinc Fingers*/genetics
Directed Molecular Evolution*/methods
Cryoelectron Microscopy ; Thalidomide/chemistry ; Ubiquitination ; Proteolysis Targeting Chimera ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GRAF1 Acts as a Downstream Mediator of Parkin to Regulate Mitophagy in Cardiomyocytes.
Autorzy:
Zhu Q; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Combs ME; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Bowles DE; Division of Surgical Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Gross RT; Division of Surgical Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Mendiola Pla M; Division of Surgical Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Mack CP; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
Taylor JM; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
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Źródło:
Cells [Cells] 2024 Mar 04; Vol. 13 (5). Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
GTPase-Activating Proteins*/metabolism
Mitophagy*/physiology
Myocytes, Cardiac*/metabolism
Phosphatidylinositol Phosphates*
Ubiquitin-Protein Ligases*/metabolism
Animals ; Humans ; Mice ; Actins ; Protein Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity.
Autorzy:
Rizvi Z; CSIR-Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Reddy GS; CSIR-Centre for Cellular and Molecular Biology, Hyderabad-500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, UP, India.
Gorde SM; CSIR-Centre for Cellular and Molecular Biology, Hyderabad-500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, UP, India.
Pundir P; CSIR-Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Das D; CSIR-Centre for Cellular and Molecular Biology, Hyderabad-500007, India.
Sijwali PS; CSIR-Centre for Cellular and Molecular Biology, Hyderabad-500007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, UP, India.
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Źródło:
PLoS pathogens [PLoS Pathog] 2024 Feb 28; Vol. 20 (2), pp. e1012045. Date of Electronic Publication: 2024 Feb 28 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Plasmodium falciparum*/genetics
Plasmodium falciparum*/metabolism
Ubiquitin-Protein Ligases*/metabolism
Humans ; Cell Division ; Cullin Proteins/metabolism ; Ubiquitin/metabolism ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cloflucarban Illuminates Specificity and Context-Dependent Activation of the PINK1-Parkin Pathway by Mitochondrial Complex Inhibition.
Autorzy:
Ramirez AT; Department of Biochemistry, Jennie Smoly Caruthers Biotechnology Building, University of Colorado-Boulder, 3415 Colorado Ave, Boulder, CO 80303, USA.
Liu Z; Department of Biochemistry, Jennie Smoly Caruthers Biotechnology Building, University of Colorado-Boulder, 3415 Colorado Ave, Boulder, CO 80303, USA.
Xu Q; Department of Biochemistry, Jennie Smoly Caruthers Biotechnology Building, University of Colorado-Boulder, 3415 Colorado Ave, Boulder, CO 80303, USA.
Nowosadtko S; Department of Biochemistry, Jennie Smoly Caruthers Biotechnology Building, University of Colorado-Boulder, 3415 Colorado Ave, Boulder, CO 80303, USA.
Liu X; Department of Biochemistry, Jennie Smoly Caruthers Biotechnology Building, University of Colorado-Boulder, 3415 Colorado Ave, Boulder, CO 80303, USA.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 20; Vol. 14 (3). Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Kinases*/metabolism
Ubiquitin-Protein Ligases*/metabolism
Carbanilides*
Humans ; Reproducibility of Results ; Mitochondria/metabolism ; Albumins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
E3 Ubiquitin Ligase PUB23 in Kiwifruit Interacts with Trihelix Transcription Factor GT1 and Negatively Regulates Immune Responses against Pseudomonas syringae pv. actinidiae .
Autorzy:
Wang T; Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.
Wang G; Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.
Zhang J; Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.
Xuan J; Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 05; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquitin-Protein Ligases*/genetics
Actinidia*/microbiology
Pseudomonas syringae/physiology ; Transcription Factors/genetics ; Gene Expression Regulation ; Immunity ; Plant Diseases/genetics ; Plant Diseases/microbiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Expression and regulatory network of E3 ubiquitin ligase NEDD4 family in cancers.
Autorzy:
Cao L; Department of Anus and Intestine Surgery, the First Affiliated Hospital of China Medical University, 155# North Nanjing Street, Heping District, Shenyang City, 110001, Liaoning Province, China.
Li H; Department of Clinical Laboratory, The First Hospital of China Medical University, Shenyang, China.
Liu X; Department of Anus and Intestine Surgery, the First Affiliated Hospital of China Medical University, 155# North Nanjing Street, Heping District, Shenyang City, 110001, Liaoning Province, China.
Wang Y; Department of Anus and Intestine Surgery, the First Affiliated Hospital of China Medical University, 155# North Nanjing Street, Heping District, Shenyang City, 110001, Liaoning Province, China.
Zheng B; Department of Anus and Intestine Surgery, the First Affiliated Hospital of China Medical University, 155# North Nanjing Street, Heping District, Shenyang City, 110001, Liaoning Province, China.
Xing C; Department of Anus and Intestine Surgery, the First Affiliated Hospital of China Medical University, 155# North Nanjing Street, Heping District, Shenyang City, 110001, Liaoning Province, China. .
Zhang N; Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China. .
Liu J; Department of Anus and Intestine Surgery, the First Affiliated Hospital of China Medical University, 155# North Nanjing Street, Heping District, Shenyang City, 110001, Liaoning Province, China. .
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Źródło:
BMC cancer [BMC Cancer] 2023 Jun 08; Vol. 23 (1), pp. 526. Date of Electronic Publication: 2023 Jun 08.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Neoplasms*/genetics
Humans ; Ubiquitination ; Endosomal Sorting Complexes Required for Transport/genetics ; Endosomal Sorting Complexes Required for Transport/metabolism ; Nedd4 Ubiquitin Protein Ligases/genetics ; Nedd4 Ubiquitin Protein Ligases/metabolism ; Nerve Tissue Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
E3 Ubiquitin Ligase Uhrf2 Knockout Reveals a Critical Role in Social Behavior and Synaptic Plasticity in the Hippocampus.
Autorzy:
Zhuang Y; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Li C; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Zhao F; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Yan Y; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Pan H; National Health Commission (NHC) Key Laboratory of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai 200032, China.
Zhan J; National Health Commission (NHC) Key Laboratory of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai 200032, China.
Behnisch T; State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 26; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Hippocampus*/metabolism
Neuronal Plasticity*/genetics
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Animals ; Mice ; Memory Disorders/metabolism ; Mice, Knockout ; Social Behavior ; Ubiquitin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeted Protein Degradation Systems: Controlling Protein Stability Using E3 Ubiquitin Ligases in Eukaryotic Species.
Autorzy:
Ogawa Y; Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan.
Ueda TP; Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan.
Obara K; Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan.
Nishimura K; Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan.
Kamura T; Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan.
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Źródło:
Cells [Cells] 2024 Jan 17; Vol. 13 (2). Date of Electronic Publication: 2024 Jan 17.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Proteasome Endopeptidase Complex*
Ubiquitin-Protein Ligases*
Proteolysis ; Cytoplasm ; Protein Stability
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Autorzy:
Xu L; Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, NSW, 2308, Australia.
Xiang W; Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Yang J; Department of Pathology, Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen, 361015, China.
Gao J; Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Wang X; Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Meng L; Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China.
Ye K; Translational Research Institute, Henan Provincial and Zhengzhou City Key Laboratory of Non-Coding RNA and Cancer Metabolism, Henan International Join Laboratory of Non-Coding RNA and Metabolism in Cancer, Henan Provincial People's Hospital, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450053, Henan, China.
Zhao XH; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, NSW, 2308, Australia.
Zhang XD; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, NSW, 2308, Australia. .; Translational Research Institute, Henan Provincial and Zhengzhou City Key Laboratory of Non-Coding RNA and Cancer Metabolism, Henan International Join Laboratory of Non-Coding RNA and Metabolism in Cancer, Henan Provincial People's Hospital, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450053, Henan, China. .
Jin L; Translational Research Institute, Henan Provincial and Zhengzhou City Key Laboratory of Non-Coding RNA and Cancer Metabolism, Henan International Join Laboratory of Non-Coding RNA and Metabolism in Cancer, Henan Provincial People's Hospital, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450053, Henan, China. .; School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, 2308, Australia. .
Ye Y; Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, Anhui, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Jan 11; Vol. 43 (1), pp. 17. Date of Electronic Publication: 2024 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Stomach Neoplasms*/genetics
Ubiquitin-Protein Ligases*
Humans ; Inositol Polyphosphate 5-Phosphatases ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Signal Transduction ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma by promoting vimentin degradation.
Autorzy:
Zhou SQ; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.; Otorhinolaryngology Head and Neck Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Feng P; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
Ye ML; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
Huang SY; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
He SW; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
Zhu XH; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
Chen J; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
Zhang Q; Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, People's Republic of China. .
Li YQ; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Jan 09; Vol. 43 (1), pp. 14. Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquitin-Protein Ligases*/genetics
Nasopharyngeal Neoplasms*/genetics
Humans ; Nasopharyngeal Carcinoma/genetics ; Vimentin/genetics ; Epithelial-Mesenchymal Transition
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proliferation, migration and phenotypic transformation of VSMC induced via Hcy related to up-expression of WWP2 and p-STAT3.
Autorzy:
Wang X; Department of Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.; Key Laboratory of Metabolic Cardiovascular Diseases Research of National Health Commission, Ningxia Key Laboratory of Vascular Injury and Repair Research, Yinchuan, Ningxia, P.R. China.
Gui N; Department of Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.
Ma X; Key Laboratory of Metabolic Cardiovascular Diseases Research of National Health Commission, Ningxia Key Laboratory of Vascular Injury and Repair Research, Yinchuan, Ningxia, P.R. China.
Zeng Y; Key Laboratory of Metabolic Cardiovascular Diseases Research of National Health Commission, Ningxia Key Laboratory of Vascular Injury and Repair Research, Yinchuan, Ningxia, P.R. China.
Mo T; Department of Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.
Zhang M; Department of Pathophysiology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia, P.R. China.; Key Laboratory of Metabolic Cardiovascular Diseases Research of National Health Commission, Ningxia Key Laboratory of Vascular Injury and Repair Research, Yinchuan, Ningxia, P.R. China.
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Źródło:
PloS one [PLoS One] 2024 Jan 02; Vol. 19 (1), pp. e0296359. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Muscle, Smooth, Vascular*/metabolism
Muscle, Smooth, Vascular*/pathology
Atherosclerosis*/metabolism
Atherosclerosis*/pathology
Homocystine*/metabolism
Ubiquitin-Protein Ligases*/metabolism
Male ; Animals ; Mice ; STAT3 Transcription Factor/metabolism ; Apolipoproteins E/metabolism ; Signal Transduction ; Aorta/cytology ; Cell Movement ; Sirtuin 1/metabolism ; Phosphorylation ; Histone Demethylases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Centriolin interacts with HectD1 in a cell cycle dependent manner.
Autorzy:
Salas J; DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN, USA.
Garcia A; DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN, USA.
Zora V; DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN, USA.
Dornbush S; DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN, USA.
Mousa-Ibrahim F; DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN, USA.
Fogg H; DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN, USA.
Gromley Z; DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN, USA.
Gromley A; DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN, USA. .
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Źródło:
BMC research notes [BMC Res Notes] 2023 Dec 19; Vol. 16 (1), pp. 375. Date of Electronic Publication: 2023 Dec 19.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquitin-Protein Ligases*/genetics
Animals ; Cell Cycle
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition.
Autorzy:
Kimani SW; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada.
Perveen S; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Szewezyk M; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Zeng H; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Dong A; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Li F; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Ghiabi P; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Li Y; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Chau I; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Santhakumar V; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada. .
Vedadi M; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada. .; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. .
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Źródło:
Communications biology [Commun Biol] 2023 Dec 16; Vol. 6 (1), pp. 1272. Date of Electronic Publication: 2023 Dec 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Ubiquitin-Protein Ligases*/chemistry
Neoplasms*
Humans ; Protein Binding ; Molecular Conformation ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove.
Autorzy:
Cheng P; National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.
Hou Y; National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.
Bian M; National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.
Fang X; National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.
Liu Y; National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.
Rao Y; National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.
Cao S; National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.
Liu Y; National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China.
Zhang S; College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, China.
Chen Y; College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, 430070, China. .
Dong X; Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, 430071, China. .; State Key Laboratory of Biocatalysis and Enzyme Engineering, College of Life Sciences, Hubei University, Wuhan, 430074, China. .
Liu Z; National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, China. .
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Źródło:
Communications biology [Commun Biol] 2023 Dec 12; Vol. 6 (1), pp. 1260. Date of Electronic Publication: 2023 Dec 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ubiquitin-Protein Ligases*/metabolism
Ubiquitin*/metabolism
Ubiquitination ; Mitochondrial Membranes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 15735

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