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Tytuł:
Phenotype and imaging features associated with APP duplications.
Autorzy:
Grangeon L; Department of Neurology and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France. .; Department of Neurology, Rouen University Hospital, Rouen Cedex, 76031, France. .
Charbonnier C; Department of Genetics and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Zarea A; Department of Neurology and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Rousseau S; Department of Genetics and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Rovelet-Lecrux A; Department of Genetics and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Bendetowicz D; Neurology Department, Sorbonne Université, Paris Brain Institute - ICM, Inserm, CNRS and APHP, Hôpital de la Pitié-Salpétrière APHP, Paris, France.
Lemaitre M; Geriatric department, Seclin-Carvin Hospital, Seclin, France.
Malrain C; Department of Neurology, Rennes Hospital, Rennes, France.
Quillard-Muraine M; Laboratoire de biochimie, Rouen University Hospital and University of Rouen, Rouen, France.
Cassinari K; Department of Genetics and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Maltete D; Department of Neurology and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Pariente J; Neurology Department, Toulouse University Hospital and Toulouse NeuroImaging Center (ToNIC) INSERM-Univeristy of Toulouse Paul Sabatier, Toulouse, France.
Moreaud O; Department of Neurology, Grenoble Hospital, Grenoble, France.
Magnin E; Department of Neurology, Besancon Hospital, Besancon, France.
Cretin B; Department of Neurology, Hautepierre Hospital, Strasbourg, France.
Mackowiak MA; Univ. Lille, CHU Lille, CNRMAJ, 59000, Lille, France.
Sillaire AR; Univ. Lille, CHU Lille, CNRMAJ, 59000, Lille, France.
Vercelletto M; Department of Neurology, Nantes University Hospital, Nantes, France.
Dionet E; Department of Neurology, Clermont-Ferrand Hospital, Clermont-Ferrand, France.
Felician O; APHM, Service de Neurologie et Neuropsychologie, CHU Timone, Marseille, France.; Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
Rod-Olivieri P; Neurology Department, Hôpital Saint Anne APHP, Paris, France.
Thomas-Antérion C; Department of Neurology, Lyon University Hospital, Lyon, France.
Godeneche G; Department of Neurology, La Rochelle Hospital, La Rochelle, France.
Sauvée M; Department of Neurology, Grenoble Hospital, Grenoble, France.
Cartz-Piver L; Centre Mémoire Ressources et Recherche (CMRR), Limoges University Hospital, Limoges, France.
Le Ber I; Neurology Department, Sorbonne Université, Paris Brain Institute - ICM, Inserm, CNRS and APHP, Hôpital de la Pitié-Salpétrière APHP, Paris, France.
Chauvire V; Department of Neurology, Angers University Hospital, Angers, France.
Jonveaux T; Department of Neurology, Nancy University Hospital, Nancy, France.
Balageas AC; CHRU Tours, Centre Mémoire Ressources et Recherche (CMRR), Tours, France.
Laquerriere A; Department of Neuropathology, F 76000, Normandy Center for Genomic and Personalized Medicine, Normandie Univ, UNIROUEN, Inserm U1245 and Rouen University Hospital, Rouen, France.
Duyckaerts C; Sorbonne Unviersité, INSERM, CNRS U1127, ICM and Laboratoire de Neuropathologie R. Escourolle, Hospital Pitie-Salpêtrière, Paris, France.
Vital A; Department of Pathology, University Hospital, Bordeaux, France.
de Paula AM; Department of Pathology, La Timone University Hospital, Marseille, France.
Meyronet D; Department of Pathology, Hopital Civil University Hospital, Lyon, France.
Guyant-Marechal L; Department of Genetics and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Hannequin D; Department of Neurology and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Tournier-Lasserve E; AP-HP, Groupe Hospitalier Saint-Louis Lariboisière-Fernand-Widal, Service de Génétique Moléculaire Neurovasculaire, INSERM UMR 1141, NeuroDiderot, Université de Paris, Paris, France.
Campion D; Department of Genetics and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Nicolas G; Department of Genetics and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
Wallon D; Department of Neurology and CNR-MAJ, Univ Rouen Normandie, U1245 and CHU Rouen, 76000, Rouen, France.
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Corporate Authors:
CNR-MAJ collaborators
Źródło:
Alzheimer's research & therapy [Alzheimers Res Ther] 2023 May 11; Vol. 15 (1), pp. 93. Date of Electronic Publication: 2023 May 11.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/diagnostic imaging
Alzheimer Disease*/genetics
Alzheimer Disease*/complications
Cerebral Amyloid Angiopathy*/diagnostic imaging
Cerebral Amyloid Angiopathy*/genetics
Cerebral Amyloid Angiopathy*/complications
Humans ; Amyloid/genetics ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/genetics ; Cerebral Hemorrhage/pathology ; Magnetic Resonance Imaging ; Phenotype ; Retrospective Studies
Czasopismo naukowe
Tytuł:
Ultrafast Excited-State Decay Mechanisms of 6-Thioguanine Followed by Sub-20 fs UV Transient Absorption Spectroscopy.
Autorzy:
Teles-Ferreira DC; Instituto Federal de Minas Gerais, Campus Ouro Preto, Ouro Preto 35400-000, MG, Brazil.
Manzoni C; Istituto di Fotonica e Nanotecnologie-Consiglio Nazionale delle Ricerche (IFN-CNR), Piazza Leonardo da Vinci 32, I-20133 Milano, Italy.
Martínez-Fernández L; Departamento de Química, Facultad de Ciencias and Institute for Advanced Research in Chemistry (IADCHEM), Campus de Excelencia UAM-CSIC, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Cerullo G; Istituto di Fotonica e Nanotecnologie-Consiglio Nazionale delle Ricerche (IFN-CNR), Piazza Leonardo da Vinci 32, I-20133 Milano, Italy.; Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milano, Italy.
de Paula AM; Departamento de Física, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Borrego-Varillas R; Istituto di Fotonica e Nanotecnologie-Consiglio Nazionale delle Ricerche (IFN-CNR), Piazza Leonardo da Vinci 32, I-20133 Milano, Italy.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Feb 10; Vol. 27 (4). Date of Electronic Publication: 2022 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Thioguanine/*chemistry
Spectrophotometry, Ultraviolet
Czasopismo naukowe
Tytuł:
Poor physical fitness is associated with impaired memory, executive function, and depression in institutionalized older adults: a cross-sectional study.
Autorzy:
Monteiro-Junior RS; Programa de Pós-Graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
Oliveira TR; Instituto de Neurociência do Exercício, Hospital Aroldo Tourinho, Montes Claros, MG, Brazil.
Leão LL; Programa de Pós-Graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
Baldo MP; Programa de Pós-Graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
de Paula AM; Programa de Pós-Graduação em Ciências da Saúde, Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
Laks J; Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Pokaż więcej
Źródło:
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) [Braz J Psychiatry] 2022 Jan-Feb; Vol. 44 (1), pp. 41-45.
Typ publikacji:
Journal Article
MeSH Terms:
Depression*
Executive Function*
Aged ; Cognition ; Cross-Sectional Studies ; Female ; Humans ; Male ; Physical Fitness
Czasopismo naukowe
Tytuł:
Canine mammary cancer tumour behaviour and patient survival time are associated with collagen fibre characteristics.
Autorzy:
Garcia APV; Laboratório de Patologia Comparada, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Reis LA; Departamento de Física, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Nunes FC; Laboratório de Patologia Comparada, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Longford FGJ; University of Southampton, Southampton, SO17 1BJ, UK.
Frey JG; University of Southampton, Southampton, SO17 1BJ, UK.
de Paula AM; Departamento de Física, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. .
Cassali GD; Laboratório de Patologia Comparada, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. .
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 11; Vol. 11 (1), pp. 5668. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Collagen/*metabolism
Mammary Neoplasms, Animal/*pathology
Animals ; Disease Progression ; Dogs ; Female ; Imaging, Three-Dimensional ; Linear Models ; Mammary Neoplasms, Animal/diagnostic imaging ; Prognosis ; Statistics as Topic ; Survival Rate
Czasopismo naukowe
Tytuł:
Efficacy and toxicity of photon, proton, and carbon ion radiotherapy in the treatment of intracranial solitary fibrous tumor/hemangiopericytoma.
Autorzy:
Ton, Mike (AUTHOR) .de
Deng, Maximilian (AUTHOR)
Meixner, Eva (AUTHOR)
Eichkorn, Tanja (AUTHOR)
Krämer, Anna (AUTHOR)
Seidensaal, Katharina (AUTHOR)
Hörner-Rieber, Juliane (AUTHOR)
Lischalk, Jonathan (AUTHOR)
Herfarth, Klaus (AUTHOR)
Debus, Jürgen (AUTHOR)
König, Laila (AUTHOR)
Pokaż więcej
Źródło:
Radiation Oncology. 3/29/2024, Vol. 19 Issue 1, p1-12. 12p.
Czasopismo naukowe
Tytuł:
A Unified Experimental/Theoretical Description of the Ultrafast Photophysics of Single and Double Thionated Uracils.
Autorzy:
Teles-Ferreira DC; Departamento de Física, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil.; Electrical Engineering Department, Federal Institute of Minas Gerais, Formiga, MG, Brazil.
Conti I; Dipartimento di Chimica Industriale, Università degli Studi di Bologna, Viale del Risorgimento 4, 40136, Bologna, Italy.
Borrego-Varillas R; IFN-CNR, Department of Physics, Politecnico di Milano, P.za L. da Vinci 32, 20133, Milano, Italy.
Nenov A; Dipartimento di Chimica Industriale, Università degli Studi di Bologna, Viale del Risorgimento 4, 40136, Bologna, Italy.
Van Stokkum IHM; Department of Physics and Astronomy, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1081, 1081HV, Amsterdam, The Netherlands.
Ganzer L; IFN-CNR, Department of Physics, Politecnico di Milano, P.za L. da Vinci 32, 20133, Milano, Italy.
Manzoni C; IFN-CNR, Department of Physics, Politecnico di Milano, P.za L. da Vinci 32, 20133, Milano, Italy.
de Paula AM; Departamento de Física, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil.
Cerullo G; IFN-CNR, Department of Physics, Politecnico di Milano, P.za L. da Vinci 32, 20133, Milano, Italy.
Garavelli M; Dipartimento di Chimica Industriale, Università degli Studi di Bologna, Viale del Risorgimento 4, 40136, Bologna, Italy.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Jan 02; Vol. 26 (1), pp. 336-343. Date of Electronic Publication: 2019 Dec 10.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Potassium humate and cobalt enhance peanut tolerance to water stress through regulation of proline, antioxidants, and maintenance of nutrient homeostasis.
Autorzy:
Elshamly, Ayman M. S. (AUTHOR)
Parrey, Zubair Ahmad (AUTHOR)
Gaafar, Abdel-Rhman Z. (AUTHOR)
Siddiqui, Manzer H. (AUTHOR)
Hussain, Saddam (AUTHOR)
Pokaż więcej
Źródło:
Scientific Reports. 1/18/2024, Vol. 13 Issue 1, p1-23. 23p.
Czasopismo naukowe
Tytuł:
Endocannabinoid and psychological responses to acute resistance exercise in trained and untrained adults.
Autorzy:
Sirotiak, Zoe (AUTHOR)
Gallagher, Brandon T. (AUTHOR)
Smith-Hernandez, Courtney A. (AUTHOR)
Showman, Lucas J. (AUTHOR)
Hillard, Cecilia J. (AUTHOR)
Brellenthin, Angelique G. (AUTHOR)
Pokaż więcej
Źródło:
PLoS ONE. 12/1/2023, Vol. 18 Issue 12, p1-12. 12p.
Czasopismo naukowe
Tytuł:
Proteomic interrogation of the meninges reveals the molecular identities of structural components and regional distinctions along the CNS axis.
Autorzy:
Santorella, Elise (AUTHOR)
Balsbaugh, Jeremy L. (AUTHOR)
Ge, Shujun (AUTHOR)
Saboori, Parisa (AUTHOR)
Baker, David (AUTHOR)
Pachter, Joel S. (AUTHOR)
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Źródło:
Fluids & Barriers of the CNS. 10/19/2023, Vol. 20 Issue 1, p1-21. 21p.
Czasopismo naukowe
Tytuł:
بررسی تراکم ماست سلها و عروق ریز خونی و ارتباط آنها در ژانت سل گرانولوماي محیطی حفره دهان.
Autorzy:
حمیده کده
شیرین سراوانی
مهسا محمدپور
Pokaż więcej
Alternatywny tytuł:
Correlation between Mast Cell Counts and Microvessel Density in Peripheral Giant Cell Granuloma of the Oral Cavity.
Źródło:
Journal of Mazandaran University of Medical Sciences (JMUMS). Aug2023, Vol. 33 Issue 223, p48-56. 9p.
Czasopismo naukowe
Tytuł:
Angiotensin Converting Enzyme Regulates Cell Proliferation and Migration.
Autorzy:
Alvarenga EC; Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.; Department of Natural Sciences, Federal University of São João del Rei, São João Del Rey, MG, Brazil.
Fonseca MC; Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Carvalho CC; Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Florentino RM; Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
França A; Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Matias E; Department of Physics, Federal University of Ceará, Fortaleza, CE, Brazil.
Guimarães PB; Department of Biophysics, Federal University of São Paulo, São Paulo, SP, Brazil.
Batista C; Department of Biophysics, Federal University of São Paulo, São Paulo, SP, Brazil.
Freire V; Department of Physics, Federal University of Ceará, Fortaleza, CE, Brazil.
Carmona AK; Department of Biophysics, Federal University of São Paulo, São Paulo, SP, Brazil.
Pesquero JB; Department of Biophysics, Federal University of São Paulo, São Paulo, SP, Brazil.
de Paula AM; Department of Physics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Foureaux G; Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.; Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Leite MF; Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Pokaż więcej
Źródło:
PloS one [PLoS One] 2016 Dec 19; Vol. 11 (12), pp. e0165371. Date of Electronic Publication: 2016 Dec 19 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Angiotensin II/*metabolism
Cell Nucleus/*metabolism
Melanoma/*enzymology
Peptidyl-Dipeptidase A/*metabolism
Phospholipase C beta/*metabolism
Vinculin/*metabolism
Animals ; CHO Cells ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Computer Simulation ; Cricetulus ; Humans ; Lisinopril/pharmacology ; Melanoma/genetics ; Melanoma/metabolism ; Peptidyl-Dipeptidase A/genetics ; Protein Transport
Czasopismo naukowe
Tytuł:
Muscle magnetic resonance characterization of STIM1 tubular aggregate myopathy using unsupervised learning.
Autorzy:
Lupi, Amalia (AUTHOR)
Spolaor, Simone (AUTHOR)
Favero, Alessandro (AUTHOR)
Bello, Luca (AUTHOR)
Stramare, Roberto (AUTHOR)
Pegoraro, Elena (AUTHOR)
Nobile, Marco Salvatore (AUTHOR)
Pokaż więcej
Źródło:
PLoS ONE. 5/8/2023, Vol. 17 Issue 5, p1-11. 11p.
Czasopismo naukowe
Tytuł:
COVID‐19 as a trigger of Guillain‐Barré syndrome: A review of the molecular mechanism.
Autorzy:
Malekpour, Mahdi (AUTHOR)
Khanmohammadi, Shaghayegh (AUTHOR)
Meybodi, Mohammad Javad Entezari (AUTHOR)
Shekouh, Dorsa (AUTHOR)
Rahmanian, Mohammad Reza (AUTHOR)
Kardeh, Sina (AUTHOR)
Azarpira, Negar (AUTHOR)
Pokaż więcej
Źródło:
Immunity, Inflammation & Disease. May2023, Vol. 11 Issue 5, p1-14. 14p.
Czasopismo naukowe
Tytuł:
Protein expression of MMP-2 and MT1-MMP in actinic keratosis, squamous cell carcinoma of the skin, and basal cell carcinoma.
Autorzy:
de Oliveira Poswar F; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
de Carvalho Fraga CA; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
Gomes ES; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
Farias LC; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
Souza LW; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
Santos SH; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Gomez RS; Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
de-Paula AM; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
Guimarães AL; Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil .
Pokaż więcej
Źródło:
International journal of surgical pathology [Int J Surg Pathol] 2015 Feb; Vol. 23 (1), pp. 20-5. Date of Electronic Publication: 2014 Jun 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Basal Cell/*metabolism
Carcinoma, Squamous Cell/*metabolism
Keratosis, Actinic/*metabolism
Matrix Metalloproteinase 14/*metabolism
Matrix Metalloproteinase 2/*metabolism
Skin Neoplasms/*metabolism
Aged ; Aged, 80 and over ; Carcinoma, Basal Cell/pathology ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Keratosis, Actinic/pathology ; Male ; Middle Aged ; Neoplasm Grading ; Skin Neoplasms/pathology
Czasopismo naukowe
Tytuł:
Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet.
Autorzy:
Andrade JM; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais, Brazil.
Frade AC
Guimarães JB
Freitas KM
Lopes MT
Guimarães AL
de Paula AM
Coimbra CC
Santos SH
Pokaż więcej
Źródło:
European journal of nutrition [Eur J Nutr] 2014 Oct; Vol. 53 (7), pp. 1503-10. Date of Electronic Publication: 2014 Jan 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adipose Tissue, Brown/*drug effects
Energy Metabolism/*drug effects
Sirtuin 1/*metabolism
Stilbenes/*pharmacology
Thermogenesis/*drug effects
Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/drug effects ; Adipose Tissue, White/metabolism ; Animals ; Bone Morphogenetic Protein 7/genetics ; Bone Morphogenetic Protein 7/metabolism ; Diet ; Ion Channels/genetics ; Ion Channels/metabolism ; Male ; Mice ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Resveratrol ; Sirtuin 1/genetics ; Uncoupling Protein 1
Czasopismo naukowe
Tytuł:
The added values of F-FDG PET/CT in differentiating cancer recurrence and osteoradionecrosis of mandible in patients with treated oral squamous cell carcinoma.
Autorzy:
Cheng, Nai-Ming (AUTHOR)
Lin, Chien-Yu (AUTHOR)
Liao, Chun-Ta (AUTHOR)
Tsan, Din-Li (AUTHOR)
Ng, Shu-Hang (AUTHOR)
Yen, Tzu-Chen (AUTHOR)
Pokaż więcej
Źródło:
EJNMMI Research. 4/3/2023, Vol. 13 Issue 1, p1-9. 9p.
Czasopismo naukowe

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