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Wyświetlanie 1-20 z 27458
Tytuł:
Phosphorylation regulates tau's phase separation behavior and interactions with chromatin.
Autorzy:
Abasi LS; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
Elathram N; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
Movva M; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
Deep A; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Corbett KD; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Department of Molecular Biology, University of California San Diego, La Jolla, CA, 92093, USA.
Debelouchina GT; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA. .
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Źródło:
Communications biology [Commun Biol] 2024 Mar 01; Vol. 7 (1), pp. 251. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatin*/chemistry
Chromatin*/metabolism
tau Proteins*/chemistry
tau Proteins*/metabolism
Humans ; DNA/metabolism ; Heterochromatin ; Nucleosomes ; Phase Separation ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells.
Autorzy:
Padmanabhan P; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia. .
Kneynsberg A; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia.
Cruz E; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia.
Briner A; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia.
Götz J; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, 4072, Brisbane, Australia. .
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Źródło:
Molecular brain [Mol Brain] 2024 Feb 12; Vol. 17 (1), pp. 7. Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/metabolism
Alzheimer Disease*/pathology
Humans ; Phosphorylation ; Single Molecule Imaging ; Microtubules/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel Cre Recombinase Mouse Strain for Cell-Specific Deletion of Floxed Genes in Ribbon Synapse-Forming Retinal Neurons.
Autorzy:
Suiwal S; Institute of Anatomy and Cell Biology, Department of Neuroanatomy, Medical School, Saarland University, 66421 Homburg, Germany.
Wartenberg P; Institute of Clinical and Experimental Pharmacology, Center for Molecular Signaling (PZMS) and Center for Gender-Specific Biology and Medicine (CGBM), Medical School, Saarland University, 66421 Homburg, Germany.
Boehm U; Institute of Clinical and Experimental Pharmacology, Center for Molecular Signaling (PZMS) and Center for Gender-Specific Biology and Medicine (CGBM), Medical School, Saarland University, 66421 Homburg, Germany.
Schmitz F; Institute of Anatomy and Cell Biology, Department of Neuroanatomy, Medical School, Saarland University, 66421 Homburg, Germany.
Schwarz K; Institute of Anatomy and Cell Biology, Department of Neuroanatomy, Medical School, Saarland University, 66421 Homburg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 05; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/metabolism
Retinal Neurons*/metabolism
Mice ; Animals ; Mice, Transgenic ; Synapses/metabolism ; Integrases/genetics ; Integrases/metabolism ; Green Fluorescent Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tau induces inflammasome activation and microgliosis through acetylating NLRP3.
Autorzy:
Zhang, Lun (AUTHOR)
Gai, Yongkang (AUTHOR)
Liu, Yushuang (AUTHOR)
Meng, Dongli (AUTHOR)
Zeng, Yi (AUTHOR)
Luo, Yong (AUTHOR)
Zhang, Huiliang (AUTHOR)
Wang, Zhuoqun (AUTHOR)
Yang, Mengzhe (AUTHOR)
Li, Yunfan (AUTHOR)
Liu, Yi (AUTHOR)
Lai, Yiwen (AUTHOR)
Yang, Jiayu (AUTHOR)
Wu, Gang (AUTHOR)
Chen, Yu (AUTHOR)
Zhu, Jingtan (AUTHOR)
Liu, Shaojun (AUTHOR)
Yu, Tingting (AUTHOR)
Zeng, Ji (AUTHOR)
Wang, Jianzhi (AUTHOR)
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Źródło:
Clinical & Translational Medicine. Mar2024, Vol. 14 Issue 3, p1-28. 28p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Low-dose brain radiation: lowering hyperphosphorylated-tau without increasing DNA damage or oncogenic activation.
Autorzy:
Iacono D; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA. .; Department of Neurology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA. .; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA. .; Neuroscience Program, Department of Anatomy, Physiology and Genetics, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA. .; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA. .; Neurodegeneration Disorders Clinic, National Institute of Neurological Disorders and Stroke, NINDS, NIH, Bethesda, MD, USA. .
Murphy EK; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA.
Stimpson CD; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.; The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA.
Perl DP; DoD/USU Brain Tissue Repository and Neuropathology Program, Uniformed Services University (USU), Bethesda, MD, USA.; Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.
Day RM; Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University (USU), Bethesda, MD, USA.
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 30; Vol. 13 (1), pp. 21142. Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/metabolism
Alzheimer Disease*/metabolism
Animals ; Swine ; Brain/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; DNA Damage ; Amyloid beta-Peptides/metabolism ; Phosphorylation ; Mammals/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of Low Concentration of Nitroxides on SH-SY5Y Cells Transfected with the Tau Protein.
Autorzy:
Bartosz G; Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, Poland.
Pieńkowska N; Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, Poland.
Kut K; Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, Poland.
Cieniek B; Institute of Materials Engineering, College of Natural Sciences, University of Rzeszów, 35-310 Rzeszów, Poland.
Stefaniuk I; Institute of Materials Engineering, College of Natural Sciences, University of Rzeszów, 35-310 Rzeszów, Poland.
Sadowska-Bartosz I; Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow University, 4 Zelwerowicza Street, 35-601 Rzeszow, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 23; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
tau Proteins*/genetics
Neuroblastoma*
Animals ; Humans ; Nitrogen Oxides/pharmacology ; Antioxidants/pharmacology ; Cyclic N-Oxides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CRISPR base editing-mediated correction of a tau mutation rescues cognitive decline in a mouse model of tauopathy.
Autorzy:
Gee, Min Sung (AUTHOR)
Kwon, Eunji (AUTHOR)
Song, Myeong-Hoon (AUTHOR)
Jeon, Seung Ho (AUTHOR)
Kim, Namkwon (AUTHOR)
Lee, Jong Kil (AUTHOR)
Koo, Taeyoung (AUTHOR)
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Źródło:
Translational Neurodegeneration. 4/12/2024, Vol. 13 Issue 1, p1-5. 5p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation‐induced synaptic damage and cognitive dysfunction via autophagy enhancement.
Autorzy:
Zhang, Tao (AUTHOR)
Tian, Yuan (AUTHOR)
Zheng, Xiaoqing (AUTHOR)
Li, Ruomeng (AUTHOR)
Hu, Li (AUTHOR)
Shui, Xindong (AUTHOR)
Mei, Yingxue (AUTHOR)
Wang, Quling (AUTHOR)
Zhang, Mi (AUTHOR)
Zheng, Xiuzhi (AUTHOR)
Wang, Long (AUTHOR)
Chen, Dongmei (AUTHOR)
Tao, Wucheng (AUTHOR)
Lee, Tae Ho (AUTHOR)
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Źródło:
CNS Neuroscience & Therapeutics. Mar2024, Vol. 30 Issue 3, p1-18. 18p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Total tau in cerebrospinal fluid detects treatment responders among spinal muscular atrophy types 1–3 patients treated with nusinersen.
Autorzy:
Šimić, Goran (AUTHOR)
Vukić, Vana (AUTHOR)
Babić, Marija (AUTHOR)
Banović, Maria (AUTHOR)
Berečić, Ivana (AUTHOR)
Španić, Ena (AUTHOR)
Zubčić, Klara (AUTHOR)
Golubić, Anja Tea (AUTHOR)
Barišić Kutija, Marija (AUTHOR)
Merkler Šorgić, Ana (AUTHOR)
Vogrinc, Željka (AUTHOR)
Lehman, Ivan (AUTHOR)
Hof, Patrick R. (AUTHOR)
Sertić, Jadranka (AUTHOR)
Barišić, Nina (AUTHOR)
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Źródło:
CNS Neuroscience & Therapeutics. Mar2024, Vol. 30 Issue 3, p1-11. 11p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice.
Autorzy:
Davidowitz EJ; Oligomerix, Inc., White Plains, NY, United States of America.; Oligomerix, Inc., Bronx, NY, United States of America.
Lopez P; Oligomerix, Inc., Bronx, NY, United States of America.
Jimenez H; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Adrien L; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Davies P; The Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Moe JG; Oligomerix, Inc., White Plains, NY, United States of America.; Oligomerix, Inc., Bronx, NY, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Aug 09; Vol. 18 (8), pp. e0286523. Date of Electronic Publication: 2023 Aug 09 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Neurodegenerative Diseases*
tau Proteins*/antagonists & inhibitors
tau Proteins*/metabolism
Tauopathies*/drug therapy
Tauopathies*/prevention & control
Tauopathies*/genetics
Animals ; Humans ; Mice ; Disease Models, Animal ; Mice, Transgenic ; Rhombencephalon/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models.
Autorzy:
Basheer, Neha (AUTHOR)
Buee, Luc (AUTHOR)
Brion, Jean-Pierre (AUTHOR)
Smolek, Tomas (AUTHOR)
Muhammadi, Muhammad Khalid (AUTHOR)
Hritz, Jozef (AUTHOR)
Hromadka, Tomas (AUTHOR)
Dewachter, Ilse (AUTHOR)
Wegmann, Susanne (AUTHOR)
Landrieu, Isabelle (AUTHOR)
Novak, Petr (AUTHOR)
Mudher, Amritpal (AUTHOR)
Zilka, Norbert (AUTHOR)
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Źródło:
Acta Neuropathologica Communications. 4/4/2024, Vol. 12 Issue 1, p1-31. 31p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neurodegeneration Biomarkers in Adult Spinal Muscular Atrophy (SMA) Patients Treated with Nusinersen.
Autorzy:
Andrés-Benito, Pol (AUTHOR)
Vázquez-Costa, Juan Francisco (AUTHOR)
Ñungo Garzón, Nancy Carolina (AUTHOR)
Colomina, María J. (AUTHOR)
Marco, Carla (AUTHOR)
González, Laura (AUTHOR)
Terrafeta, Cristina (AUTHOR)
Domínguez, Raúl (AUTHOR)
Ferrer, Isidro (AUTHOR)
Povedano, Mónica (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 7, p3810. 18p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Chronic Effects of a Single Low-Intensity Blast Exposure on Phosphoproteome Networks and Cognitive Function Influenced by Mutant Tau Overexpression.
Autorzy:
Jackson, Marcus (AUTHOR)
Chen, Shanyan (AUTHOR)
Nguyen, Thao Thi (AUTHOR)
Siedhoff, Heather R. (AUTHOR)
Balderrama, Ashley (AUTHOR)
Zuckerman, Amitai (AUTHOR)
Li, Runting (AUTHOR)
Greenlief, C. Michael (AUTHOR)
Cole, Gregory (AUTHOR)
Frautschy, Sally A. (AUTHOR)
Cui, Jiankun (AUTHOR)
Gu, Zezong (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3338. 28p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Trans - and Cis -Phosphorylated Tau Protein: New Pieces of the Puzzle in the Development of Neurofibrillary Tangles in Post-Ischemic Brain Neurodegeneration of the Alzheimer's Disease-like Type.
Autorzy:
Pluta, Ryszard (AUTHOR)
Czuczwar, Stanisław J. (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3091. 12p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tau and Aβ42 in lavage fluid of pneumonia patients are associated with end-organ dysfunction: A prospective exploratory study.
Autorzy:
Renema, Phoibe (AUTHOR)
Pittet, Jean-Francois (AUTHOR)
Brandon, Angela P. (AUTHOR)
Leal Jr., Sixto M. (AUTHOR)
Gu, Steven (AUTHOR)
Promer, Grace (AUTHOR)
Hackney, Andrew (AUTHOR)
Braswell, Phillip (AUTHOR)
Pickering, Andrew (AUTHOR)
Rafield, Grace (AUTHOR)
Voth, Sarah (AUTHOR)
Balczon, Ron (AUTHOR)
Lin, Mike T. (AUTHOR)
Morrow, K. Adam (AUTHOR)
Bell, Jessica (AUTHOR)
Audia, Jonathon P. (AUTHOR)
Alvarez, Diego (AUTHOR)
Stevens, Troy (AUTHOR)
Wagener, Brant M. (AUTHOR)
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Źródło:
PLoS ONE. 2/23/2024, Vol. 19 Issue 2, p1-18. 18p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization.
Autorzy:
De Leiris, Nicolas (AUTHOR)
Perret, Pascale (AUTHOR)
Lombardi, Charlotte (AUTHOR)
Gözel, Bülent (AUTHOR)
Chierici, Sabine (AUTHOR)
Millet, Philippe (AUTHOR)
Debiossat, Marlène (AUTHOR)
Bacot, Sandrine (AUTHOR)
Tournier, Benjamin B. (AUTHOR)
Chames, Patrick (AUTHOR)
Lenormand, Jean-Luc (AUTHOR)
Ghezzi, Catherine (AUTHOR)
Fagret, Daniel (AUTHOR)
Moulin, Marcelle (AUTHOR)
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Źródło:
Journal of Translational Medicine. 2/16/2024, Vol. 22 Issue 1, p1-14. 14p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study.
Autorzy:
Wu, Jie (AUTHOR)
Xiao, Zhenxu (AUTHOR)
Wang, Mengjing (AUTHOR)
Wu, Wanqing (AUTHOR)
Ma, Xiaoxi (AUTHOR)
Liang, Xiaoniu (AUTHOR)
Zheng, Li (AUTHOR)
Ding, Saineng (AUTHOR)
Luo, Jianfeng (AUTHOR)
Cao, Yang (AUTHOR)
Hong, Zhen (AUTHOR)
Chen, Jing (AUTHOR)
Zhao, Qianhua (AUTHOR)
Ding, Ding (AUTHOR)
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Źródło:
Alzheimer's Research & Therapy. 2/12/2024, Vol. 16, p1-12. 12p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 27458

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