Nanopore sequencing identifies a higher frequency and expanded spectrum of mitochondrial DNA deletion mutations in human aging.
Autorzy:
Vandiver AR; Division of Dermatology, Department of Medicine, UCLA, Los Angeles, California, USA.; Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA. Hoang AN; Division of Geriatrics, Department of Medicine, UCLA, Los Angeles, California, USA. Herbst A; US Geological Survey National Wildlife Health Center, Madison, Wisconsin, USA. Lee CC; Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA.; Division of Geriatrics, Department of Medicine, UCLA, Los Angeles, California, USA. AikenJM; Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada. McKenzie D; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada. Teitell MA; Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.; Department of Bioengineering, California NanoSystems Institute, Broad Center for Regenerative Medicine and Stem Cell Research, University of California at Los Angeles, Los Angeles, California, USA.; Department of Pediatrics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Timp W; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Wanagat J; Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA.; Division of Geriatrics, Department of Medicine, UCLA, Los Angeles, California, USA.
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Źródło:
Aging cell [Aging Cell] 2023 Jun; Vol. 22 (6), pp. e13842. Date of Electronic Publication: 2023 May 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
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