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Wyszukujesz frazę ""Amiloride"" wg kryterium: Temat


Tytuł:
Sodium Energetic Cycle in the Natronophilic Bacterium Thioalkalivibrio versutus .
Autorzy:
Muntyan MS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory, 119991 Moscow, Russia.
Viryasov MB; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory, 119991 Moscow, Russia.
Sorokin DY; Winogradsky Institute of Microbiology, Federal Research Centre of Biotechnology, Russian Academy of Sciences, 117312 Moscow, Russia.; Department of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands.
Skulachev VP; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory, 119991 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 10; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Ectothiorhodospiraceae/*metabolism
Sodium/*metabolism
Amiloride/metabolism ; Cell Membrane/metabolism ; Electron Transport Complex IV/metabolism ; Flagella/metabolism ; Lakes/microbiology
SCR Organism:
Thioalkalivibrio versutus
Czasopismo naukowe
Tytuł:
Amiloride Analogs as ASIC1a Inhibitors.
Autorzy:
Leng TD; Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA.
Si HF; Anhui Medical University, School of Pharmacy, Hefei, Anhui, China.
Li J; Anhui Medical University, School of Pharmacy, Hefei, Anhui, China.
Yang T; Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA.
Zhu M; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA.
Wang B; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA.
Simon RP; Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA.
Xiong ZG; Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2016 Jun; Vol. 22 (6), pp. 468-76. Date of Electronic Publication: 2016 Feb 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Acid Sensing Ion Channels/*physiology
Amiloride/*analogs & derivatives
Amiloride/*pharmacology
Amiloride/chemistry ; Amiloride/therapeutic use ; Animals ; Biophysics ; CHO Cells ; Cells, Cultured ; Cerebral Cortex/cytology ; Cricetinae ; Cricetulus ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Electric Stimulation ; Embryo, Mammalian ; Infarction, Middle Cerebral Artery/drug therapy ; Inhibitory Concentration 50 ; Male ; Membrane Potentials/drug effects ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Neurons/drug effects ; Patch-Clamp Techniques ; Transfection
Czasopismo naukowe
Tytuł:
Ion Selectivity in the ENaC/DEG Family: A Systematic Review with Supporting Analysis.
Autorzy:
Vallée C; Leverhulme Quantum Biology Doctoral Training Centre, University of Surrey, Guildford GU2 5XH, UK.; Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, UK.; School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.
Howlin B; Leverhulme Quantum Biology Doctoral Training Centre, University of Surrey, Guildford GU2 5XH, UK.; Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, UK.
Lewis R; Leverhulme Quantum Biology Doctoral Training Centre, University of Surrey, Guildford GU2 5XH, UK.; School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 12; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 12.
Typ publikacji:
Journal Article; Systematic Review
MeSH Terms:
Epithelial Sodium Channels/*metabolism
Amiloride/chemistry ; Amiloride/metabolism ; Animals ; Epithelial Sodium Channels/chemistry ; Epithelial Sodium Channels/genetics ; Humans ; Ion Transport ; Lithium/metabolism ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Protein Structure, Quaternary ; Sodium/metabolism
Czasopismo naukowe
Tytuł:
Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release.
Autorzy:
Zhou, Lin (AUTHOR)
Zhang, Tong (AUTHOR)
Shao, Wei (AUTHOR)
Lu, Ruohan (AUTHOR)
Wang, Lin (AUTHOR)
Liu, Haisheng (AUTHOR)
Jiang, Bin (AUTHOR)
Li, Shiqin (AUTHOR)
Zhuo, Huiqin (AUTHOR)
Wang, Suheng (AUTHOR)
Li, Qinxi (AUTHOR)
Huang, Caihua (AUTHOR)
Lin, Donghai (AUTHOR)
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Źródło:
Skeletal Muscle. 7/6/2021, Vol. 11 Issue 1, p1-16. 16p.
Czasopismo naukowe
Tytuł:
Rainbow Trout ( Oncorhynchus mykiss ) Na Exchangers tNhe3a and tNhe3b Display Unique Inhibitory Profiles Dissimilar from Mammalian NHE Isoforms.
Autorzy:
Blair S; Department of Biology, Winthrop University, Rock Hill, SC 29733, USA.; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Li X; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Dutta D; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Chamot D; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Fliegel L; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Goss G; Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 23; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Oncorhynchus mykiss*
Fish Proteins/*metabolism
Sodium Channel Blockers/*pharmacology
Sodium-Hydrogen Exchanger 3/*metabolism
Amiloride/analogs & derivatives ; Amiloride/pharmacology ; Animals ; CHO Cells ; Cloning, Molecular ; Cricetulus ; Fish Proteins/antagonists & inhibitors ; Fish Proteins/genetics ; Gene Expression ; Gills/physiology ; Indoles/pharmacology ; Mammals ; Organ Specificity ; Sodium-Hydrogen Exchanger 3/antagonists & inhibitors ; Sodium-Hydrogen Exchanger 3/genetics ; Transfection
Czasopismo naukowe
Tytuł:
Contribution of Syndecans to the Cellular Entry of SARS-CoV-2.
Autorzy:
Hudák A; Pharmacoidea Ltd., H-6726 Szeged, Hungary.
Letoha A; Department of Medicine, Albert Szent-Györgyi Clinical Center, Faculty of Medicine, University of Szeged, H-6725 Szeged, Hungary.
Szilák L; Pharmacoidea Ltd., H-6726 Szeged, Hungary.; Szilak Laboratories, Bioinformatics and Molecule-Design, H-6723 Szeged, Hungary.
Letoha T; Pharmacoidea Ltd., H-6726 Szeged, Hungary.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 19; Vol. 22 (10). Date of Electronic Publication: 2021 May 19.
Typ publikacji:
Journal Article
MeSH Terms:
Virus Internalization*
COVID-19/*metabolism
Receptors, Coronavirus/*metabolism
SARS-CoV-2/*pathogenicity
Spike Glycoprotein, Coronavirus/*metabolism
Syndecans/*metabolism
Amiloride/pharmacology ; Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; COVID-19/virology ; Cell Line ; Cell Survival/drug effects ; Epithelial Sodium Channel Blockers/pharmacology ; Humans ; Peptides/pharmacology ; Protein Domains ; SARS-CoV-2/metabolism ; Syndecan-4/antagonists & inhibitors ; Syndecan-4/metabolism ; Syndecans/antagonists & inhibitors
Czasopismo naukowe
Tytuł:
Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage.
Autorzy:
Aredia F; Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100, Pavia, Italy.; Dipartimento di Biologia e Biotecnologie 'L. Spallanzani', Università di Pavia, Via Ferrata 9, 27100, Pavia, Italy.
Czaplinski S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstrasse 3a, 60528, Frankfurt, Germany.
Fulda S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstrasse 3a, 60528, Frankfurt, Germany.
Scovassi AI; Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100, Pavia, Italy. .
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Źródło:
BMC cancer [BMC Cancer] 2016 Nov 05; Vol. 16 (1), pp. 851. Date of Electronic Publication: 2016 Nov 05.
Typ publikacji:
Journal Article
MeSH Terms:
Amiloride/*analogs & derivatives
Antineoplastic Agents/*pharmacology
Mitochondria/*drug effects
Reactive Oxygen Species/*metabolism
Sodium-Hydrogen Exchangers/*antagonists & inhibitors
Amiloride/pharmacology ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Shape/drug effects ; DNA Damage ; Drug Screening Assays, Antitumor ; HCT116 Cells ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly Adenosine Diphosphate Ribose/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł:
Is amiloride a promising cardiovascular medication to persist in the COVID-19 crisis?
Autorzy:
Adil MS; Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA.
Narayanan SP; Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA.
Somanath PR; Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA.
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Źródło:
Drug discoveries & therapeutics [Drug Discov Ther] 2020 Nov 04; Vol. 14 (5), pp. 256-258. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Amiloride/*pharmacology
Antiviral Agents/*pharmacology
Betacoronavirus/*drug effects
Coronavirus Infections/*drug therapy
Epithelial Sodium Channel Blockers/*pharmacology
Pneumonia, Viral/*drug therapy
Respiratory Mucosa/*drug effects
Virus Internalization/*drug effects
A549 Cells ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/pathogenicity ; COVID-19 ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/enzymology ; Coronavirus Infections/enzymology ; Coronavirus Infections/virology ; Down-Regulation ; Host-Pathogen Interactions ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/virology ; Receptors, Virus/metabolism ; Respiratory Mucosa/enzymology ; Respiratory Mucosa/virology ; SARS-CoV-2 ; COVID-19 Drug Treatment
Czasopismo naukowe
Tytuł:
The importance of the epithelial sodium channel in determining salt sensitivity in people of African origin.
Autorzy:
Jones E; Division of Nephrology and Hypertension, University of Cape Town, Cape Town, South Africa.
Rayner B; Division of Nephrology and Hypertension, University of Cape Town, Cape Town, South Africa. .; E13 Groote Schuur Hospital, Observatory, Cape Town, 7925, South Africa. .
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Źródło:
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2021 Feb; Vol. 36 (2), pp. 237-243. Date of Electronic Publication: 2020 Jan 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hypertension*/diagnosis
Hypertension*/drug therapy
Aldosterone ; Amiloride ; Blood Pressure ; Epithelial Sodium Channels ; Humans ; Sodium/metabolism ; Sodium Chloride, Dietary/adverse effects
Czasopismo naukowe
Tytuł:
Evaluating the clinical and mechanistic effects of eplerenone and amiloride monotherapy, and combination therapy with cinacalcet, in primary hyperparathyroidism: A placebo‐controlled randomized trial.
Autorzy:
Parksook, Wasita W. (AUTHOR)
Heydarpour, Mahyar (AUTHOR)
Brown, Jenifer M. (AUTHOR)
Turchin, Alexander (AUTHOR)
Mannstadt, Michael (AUTHOR)
Vaidya, Anand (AUTHOR)
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Źródło:
Clinical Endocrinology. Apr2023, Vol. 98 Issue 4, p516-526. 11p.
Czasopismo naukowe
Tytuł:
NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia.
Autorzy:
Coote KJ; Novartis Institutes for BioMedical Research, Horsham, UK.
Paisley D; Novartis Institutes for BioMedical Research, Horsham, UK.
Czarnecki S; Novartis Institutes for BioMedical Research, Horsham, UK.
Tweed M; Novartis Institutes for BioMedical Research, Horsham, UK.
Watson H; Novartis Institutes for BioMedical Research, Horsham, UK.
Young A; Novartis Institutes for BioMedical Research, Horsham, UK.
Sugar R; Novartis Institutes for BioMedical Research, Horsham, UK.
Vyas M; Novartis Institutes for BioMedical Research, Horsham, UK.
Smith NJ; Novartis Institutes for BioMedical Research, Horsham, UK.
Baettig U; Novartis Institutes for BioMedical Research, Horsham, UK.
Groot-Kormelink PJ; Novartis Institutes for BioMedical Research, Horsham, UK.
Gosling M; Novartis Institutes for BioMedical Research, Horsham, UK.
Lock R; Novartis Institutes for BioMedical Research, Horsham, UK.
Ethell B; Novartis Institutes for BioMedical Research, Horsham, UK.
Williams G; Novartis Institutes for BioMedical Research, Horsham, UK.
Schumacher A; Genomics Institute of the Novartis Foundation, San Diego, CA, USA.
Harris J; Genomics Institute of the Novartis Foundation, San Diego, CA, USA.
Abraham WM; Department of Research, Mount Sinai Medical Center, Miami, FL, USA.
Sabater J; Department of Research, Mount Sinai Medical Center, Miami, FL, USA.
Poll CT; Retroscreen Virology Ltd, London, UK.
Faller T; Novartis Institutes for BioMedical Research, Horsham, UK.
Collingwood SP; Novartis Institutes for BioMedical Research, Horsham, UK.
Danahay H; Novartis Institutes for BioMedical Research, Horsham, UK.; School of Life Sciences, University of Sussex, Brighton, UK.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2015 Jun; Vol. 172 (11), pp. 2814-26. Date of Electronic Publication: 2015 Apr 23.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amiloride/*analogs & derivatives
Amiloride/*pharmacology
Epithelial Cells/*drug effects
Epithelial Sodium Channel Blockers/*pharmacology
Hyperkalemia/*chemically induced
Mucociliary Clearance/*drug effects
Phenyl Ethers/*pharmacology
Piperidines/*pharmacology
Administration, Inhalation ; Amiloride/adverse effects ; Animals ; Epithelial Sodium Channel Blockers/adverse effects ; Guanidines ; Guinea Pigs ; In Vitro Techniques ; Phenyl Ethers/adverse effects ; Piperidines/adverse effects ; Pyrazines ; Rats ; Respiratory Mucosa/cytology ; Sheep
Czasopismo naukowe
Tytuł:
Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
Autorzy:
Hrvat, Antonio
Schmidt, Mathias
Wagner, Bernd
Zwanziger, DeniseAff2, Aff3
Kimmig, Rainer
Volbracht, Lothar
Brandau, SvenAff1, Aff5, IDs13046023027988_cor7
Mallmann-Gottschalk, NinaAff1, Aff6
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Źródło:
Journal of Experimental & Clinical Cancer Research. 42(1)
Czasopismo naukowe
Tytuł:
Controlling epithelial sodium channels with light using photoswitchable amilorides.
Autorzy:
Schönberger M; Department of Chemistry and Center for Integrated Protein Science, Ludwig Maximilians-Universität München, Butenandtstraße 5-13 (F4.086), 81377 Munich, Germany.
Althaus M; Institute of Animal Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, 35392 Giessen, Germany.
Fronius M; 1] Institute of Animal Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, 35392 Giessen, Germany [2] Department of Physiology, University of Otago, PO Box 913, Dunedin 9054, New Zealand.
Clauss W; Institute of Animal Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26, 35392 Giessen, Germany.
Trauner D; Department of Chemistry and Center for Integrated Protein Science, Ludwig Maximilians-Universität München, Butenandtstraße 5-13 (F4.086), 81377 Munich, Germany.
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Źródło:
Nature chemistry [Nat Chem] 2014 Aug; Vol. 6 (8), pp. 712-9. Date of Electronic Publication: 2014 Jul 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Light*
Amiloride/*analogs & derivatives
Amiloride/*chemistry
Azo Compounds/*chemistry
Epithelial Sodium Channels/*metabolism
Sodium Channel Blockers/*chemistry
Amiloride/chemical synthesis ; Amiloride/pharmacology ; Animals ; Azo Compounds/chemical synthesis ; Azo Compounds/pharmacology ; Cell Line ; Crystallography, X-Ray ; Epithelial Sodium Channels/chemistry ; HEK293 Cells ; Humans ; Molecular Conformation ; Oocytes/drug effects ; Oocytes/physiology ; Protein Isoforms/chemistry ; Protein Isoforms/metabolism ; Sodium Channel Blockers/chemical synthesis ; Sodium Channel Blockers/pharmacology ; Xenopus/growth & development
Czasopismo naukowe
Tytuł:
Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.
Autorzy:
Bohnert BN; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany.
Daiminger S; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Wörn M; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Sure F; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany.
Staudner T; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany.
Ilyaskin AV; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany.
Batbouta F; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Janessa A; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Schneider JC; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Essigke D; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Kanse S; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Haerteis S; Institute of Anatomy, University of Regensburg, Regensburg, Germany.
Korbmacher C; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany.
Artunc F; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany.
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Źródło:
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2019 Dec; Vol. 227 (4), pp. e13286. Date of Electronic Publication: 2019 May 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial Sodium Channels/*metabolism
Sodium/*metabolism
Urokinase-Type Plasminogen Activator/*metabolism
Amiloride/administration & dosage ; Amiloride/pharmacology ; Animals ; Dose-Response Relationship, Drug ; Epithelial Sodium Channel Blockers/administration & dosage ; Epithelial Sodium Channel Blockers/pharmacology ; Epithelial Sodium Channels/genetics ; Gene Expression Regulation/drug effects ; Ion Channel Gating ; Mice ; Mice, Knockout ; Nephrotic Syndrome ; Oocytes ; Urokinase-Type Plasminogen Activator/genetics ; Xenopus laevis
Czasopismo naukowe

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