Temat: "Amino Acid Chloromethyl Ketones" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Cytotoxicity of the Sesquiterpene Lactone Spiciformin and Its Acetyl Derivative against the Human Leukemia Cell Lines U-937 and HL-60.
Autorzy:: Saavedra E; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Estévez-Sarmiento F; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Said M; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Eiroa JL; Departamento de Química, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain.
Rubio S; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Quintana J; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Estévez F; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Apr 16; Vol. 21 (8). Date of Electronic Publication: 2020 Apr 16.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Sesquiterpenes/*chemistry
Amino Acid Chloromethyl Ketones/pharmacology ; Antineoplastic Agents/chemistry ; Caspases/chemistry ; Caspases/metabolism ; Cell Line, Tumor ; HL-60 Cells ; Humans ; Lactones/chemistry ; Leukemia, Promyelocytic, Acute/metabolism ; Leukemia, Promyelocytic, Acute/pathology ; Membrane Potential, Mitochondrial/drug effects ; Mitogen-Activated Protein Kinases/metabolism ; Phosphorylation/drug effects ; Poly(ADP-ribose) Polymerases/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Reactive Oxygen Species/metabolism ; Sesquiterpenes/pharmacology ; Signal Transduction/drug effects

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 2.

Tytuł:: Arenobufagin Induces Apoptotic Cell Death in Human Non-Small-Cell Lung Cancer Cells via the Noxa-Related Pathway.
Autorzy:: Ma L; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Zhu Y; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Fang S; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Long H; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Liu X; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Liu Z; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2017 Sep 11; Vol. 22 (9). Date of Electronic Publication: 2017 Sep 11.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Bufanolides/*chemistry
Bufanolides/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*genetics
A549 Cells ; Amino Acid Chloromethyl Ketones/pharmacology ; Amphibian Venoms/chemistry ; Antineoplastic Agents/isolation & purification ; Apoptosis/genetics ; Bufanolides/isolation & purification ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 9/genetics ; Caspase 9/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Medicine, Chinese Traditional ; Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Signal Transduction ; Tumor Suppressor Protein p53/agonists ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 3.

Tytuł:: Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells.
Autorzy:: Min KJ; Department of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu 704-701, Korea. .
Nam JO; Department of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea. .
Kwon TK; Department of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu 704-701, Korea. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2017 Aug 02; Vol. 22 (8). Date of Electronic Publication: 2017 Aug 02.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Flavonoids/*pharmacology
Receptors, TNF-Related Apoptosis-Inducing Ligand/*metabolism
Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Apoptosis ; Carcinoma ; Caspase Inhibitors/pharmacology ; Cell Line, Tumor ; Down-Regulation ; Flavonols ; Humans ; Kidney Neoplasms ; Mice ; Poly(ADP-ribose) Polymerases/metabolism ; Reactive Oxygen Species/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; Transcription, Genetic ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 4.

Tytuł:: Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells.
Autorzy:: Chiu LY; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Hu ME; Department of Anatomy, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Yang TY; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Hsin IL; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Ko JL; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Oncology and Chest Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Tsai KJ; School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Sheu GT; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Oncology and Chest Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2015 May 06; Vol. 10 (5), pp. e0125774. Date of Electronic Publication: 2015 May 06 (Print Publication: 2015).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*therapeutic use
Apoptosis/*drug effects
Autophagy/*drug effects
Carcinoma, Non-Small-Cell Lung/*drug therapy
Fungal Proteins/*therapeutic use
Lung Neoplasms/*drug therapy
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Autophagy-Related Protein 5 ; Cell Line, Tumor ; Docetaxel ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Ganoderma ; Humans ; Male ; Medicine, Chinese Traditional ; Mice ; Mice, Inbred NOD ; Microtubule-Associated Proteins/genetics ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; RNA Interference ; RNA, Small Interfering ; Ribosomal Protein S6 Kinases, 70-kDa/antagonists & inhibitors ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Taxoids/therapeutic use ; Thapsigargin/therapeutic use ; Tunicamycin/therapeutic use ; Vincristine/therapeutic use ; Xenograft Model Antitumor Assays

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 5.

Tytuł:: Anthraquinone G503 induces apoptosis in gastric cancer cells through the mitochondrial pathway.
Autorzy:: Huang L; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Zhang T; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Li S; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Duan J; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Ye F; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Li H; Key Laboratory of Functional Molecules from Marine Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou, Guangdong Province, China.
She Z; Key Laboratory of Functional Molecules from Marine Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou, Guangdong Province, China.
Gao G; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China; China Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong Province, China.
Yang X; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China; Key Laboratory of Functional Molecules from Marine Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou, Guangdong Province, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 Sep 30; Vol. 9 (9), pp. e108286. Date of Electronic Publication: 2014 Sep 30 (Print Publication: 2014).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anthraquinones/*pharmacology
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Epithelial Cells/*drug effects
Mitochondria/*drug effects
Amino Acid Chloromethyl Ketones/pharmacology ; Anthraquinones/isolation & purification ; Antineoplastic Agents/isolation & purification ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 8/genetics ; Caspase 8/metabolism ; Caspase 9/genetics ; Caspase 9/metabolism ; Caspase Inhibitors/pharmacology ; Caspases, Initiator/genetics ; Caspases, Initiator/metabolism ; Cell Line, Tumor ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Gastric Mucosa/drug effects ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Gene Expression Regulation, Neoplastic ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Mitochondria/metabolism ; Oligopeptides/pharmacology ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Saccharomycetales/chemistry ; Signal Transduction ; bcl-2-Associated X Protein/agonists ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 6.

Tytuł:: Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells.
Autorzy:: Lee HS; Department of Food Science and Nutrition, Dongseo University, 47 Jurye-ro, Sasang-gu, Busan 617-716, Korea. .
Cho HJ; Department of Food and Nutrition, Hallym University, Chuncheon 200-702, Korea. .
Yu R; Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, Korea. .
Lee KW; Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Gyonggi-do 443-270, Korea. .
Chun HS; Food Science and Technology, Chung-Ang University, An-Sung 456-756, Korea. .
Park JH; Department of Food and Nutrition, Hallym University, Chuncheon 200-702, Korea. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2014 Feb 17; Vol. 15 (2), pp. 2722-37. Date of Electronic Publication: 2014 Feb 17.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*toxicity
Apoptosis/*drug effects
Kaempferols/*toxicity
Amino Acid Chloromethyl Ketones/pharmacology ; Caspase 3/chemistry ; Caspase 3/metabolism ; Caspase 7/chemistry ; Caspase 7/metabolism ; Caspase 8/chemistry ; Caspase 8/metabolism ; Caspase 9/chemistry ; Caspase 9/metabolism ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Cytochromes c/metabolism ; DNA Fragmentation/drug effects ; HT29 Cells ; Humans ; Mitochondria/metabolism ; Poly(ADP-ribose) Polymerases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; bcl-X Protein/metabolism

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 7.

Tytuł:: The tricyclodecan-9-yl-xanthogenate D609 triggers ceramide increase and enhances FasL-induced caspase-dependent and -independent cell death in T lymphocytes.
Autorzy:: Milhas D; Team 4, Cancer Research Center of Toulouse, INSERM UMR1037, BP84225, 31432 Toulouse Cedex 4, France.
Andrieu-Abadie N; Team 4, Cancer Research Center of Toulouse, INSERM UMR1037, BP84225, 31432 Toulouse Cedex 4, France.
Levade T; Team 4, Cancer Research Center of Toulouse, INSERM UMR1037, BP84225, 31432 Toulouse Cedex 4, France.
Benoist H; Team 4, Cancer Research Center of Toulouse, INSERM UMR1037, BP84225, 31432 Toulouse Cedex 4, France.; Department of Cell Biology, Hematology and Immunology, Faculty of Pharmaceutical Sciences, Paul Sabatier University (Toulouse III), 31062 Toulouse, France.
Ségui B; Team 4, Cancer Research Center of Toulouse, INSERM UMR1037, BP84225, 31432 Toulouse Cedex 4, France.; Department of Cell Biology, Hematology and Immunology, Faculty of Pharmaceutical Sciences, Paul Sabatier University (Toulouse III), 31062 Toulouse, France.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2012; Vol. 13 (7), pp. 8834-8852. Date of Electronic Publication: 2012 Jul 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Bridged-Ring Compounds/*pharmacology
Caspase 8/*metabolism
Ceramides/*metabolism
Fas Ligand Protein/*metabolism
T-Lymphocytes/*metabolism
Thiones/*pharmacology
Amino Acid Chloromethyl Ketones/pharmacology ; Caspase Inhibitors/metabolism ; Caspase Inhibitors/pharmacology ; Cell Death/drug effects ; Fas Ligand Protein/pharmacology ; Humans ; Jurkat Cells ; Mitochondria/metabolism ; Norbornanes ; Signal Transduction/drug effects ; T-Lymphocytes/cytology ; Thiocarbamates ; bcl-X Protein