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    Wyświetlanie 1-9 z 9
    Tytuł:
    Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma.
    Autorzy:
    Tateishi K; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan. .; Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan. .; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan. .
    Miyake Y; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.
    Nakamura T; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.
    Iwashita H; Department of Pathology, Yokohama City University Hospital, Yokohama, Japan.; Department of Diagnostic Pathology, Yokohama City University Hospital, Yokohama, Japan.
    Hayashi T; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.
    Oshima A; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.
    Honma H; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.
    Hayashi H; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.; Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
    Sugino K; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.; Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.
    Kato M; Laboratory of Biopharmaceutical and Regenerative Science, Graduate School of Medical Science, Yokohama City University, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan.
    Satomi K; Department of Pathology, Kyorin University School of Medicine, Tokyo, Japan.
    Fujii S; Department of Diagnostic Pathology, Yokohama City University Hospital, Yokohama, Japan.; Department of Molecular Pathology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
    Komori T; Department of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
    Yamamoto T; Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.
    Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.; Translational-Neurooncology Laboratory, Brain Tumor Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
    Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.; Translational-Neurooncology Laboratory, Brain Tumor Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
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    Źródło:
    Acta neuropathologica communications [Acta Neuropathol Commun] 2023 Nov 27; Vol. 11 (1), pp. 186. Date of Electronic Publication: 2023 Nov 27.
    Typ publikacji:
    Case Reports; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Astrocytoma*/genetics
    Astrocytoma*/pathology
    Brain Neoplasms*/genetics
    Brain Neoplasms*/pathology
    Receptor, Platelet-Derived Growth Factor alpha*/genetics
    Retinoblastoma Protein*/genetics
    Animals ; Humans ; Mice ; Homozygote ; Isocitrate Dehydrogenase/genetics ; Mutation ; Sequence Deletion ; Signal Transduction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.
    Autorzy:
    Karz A; Department of Pathology, NYU Grossman School of Medicine, New York, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, USA.
    Dimitrova M; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, USA.; Department of Medicine, NYU Grossman School of Medicine, New York, USA.
    Kleffman K; Department of Pathology, NYU Grossman School of Medicine, New York, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, USA.
    Alvarez-Breckenridge C; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Atkins MB; Georgetown-Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University Medical Center, Washington, District of Columbia, USA.
    Boire A; Human Oncology and Pathogenesis Program, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, USA.
    Bosenberg M; Laboratory of Cancer Biology and Genetics, Center for Cancer Research NCI, NIH, USA.
    Brastianos P; MGH Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    Chen Q; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
    Ferguson S; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Forsyth P; Department of Neuro-Oncology and Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
    Glitza Oliva IC; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Goldberg SB; Department of Medicine (Medical Oncology), Yale School of Medicine, New Haven, Connecticut, USA.
    Holmen SL; Huntsman Cancer Institute and Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
    Knisely JPS; Meyer Cancer Center and Department of Radiation Oncology, Weill Cornell Medicine, New York, New York, USA.
    Merlino G; Laboratory of Cancer Biology and Genetics, Center for Cancer Research NCI, NIH, USA.
    Nguyen DX; Department of Pathology, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA.
    Pacold ME; Department of Radiation Oncology, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
    Perez-Guijarro E; Laboratory of Cancer Biology and Genetics, Center for Cancer Research NCI, NIH, USA.
    Smalley KSM; Department of Tumor Biology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
    Tawbi HA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Wen PY; Center for Neuro-Oncology, Dana-Farber Cancer Institute, United States, Boston, Massachusetts, USA.
    Davies MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Kluger HM; Department of Medicine (Medical Oncology), Yale School of Medicine, New Haven, Connecticut, USA.
    Mehnert JM; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, USA.; Department of Medicine, NYU Grossman School of Medicine, New York, USA.
    Hernando E; Department of Pathology, NYU Grossman School of Medicine, New York, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, USA.
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    Źródło:
    Pigment cell & melanoma research [Pigment Cell Melanoma Res] 2022 Nov; Vol. 35 (6), pp. 554-572. Date of Electronic Publication: 2022 Sep 01.
    Typ publikacji:
    Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural; Research Support, N.I.H., Extramural
    MeSH Terms:
    Melanoma*/pathology
    Brain Neoplasms*/therapy
    Brain Neoplasms*/secondary
    Neoplasms, Second Primary*/pathology
    Humans ; Ecosystem ; Immunotherapy/methods ; Brain ; Tumor Microenvironment
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    An integrated RF-receive/B 0 -shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T.
    Autorzy:
    Esmaeili M; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Diagnostic Imaging, Akershus University Hospital, Lørenskog, Norway.
    Stockmann J; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Strasser B; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Arango N; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
    Thapa B; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Wang Z; Siemens Medical Solutions, USA, Charlestown, MA, USA.
    van der Kouwe A; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Dietrich J; Division of Neuro-Oncology, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Batchelor TT; Department Neurology, Brigham's and Women Hospital, Harvard Medical School, Boston, MA, USA.
    White J; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
    Adalsteinsson E; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
    Wald L; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Andronesi OC; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. .; Athinoula A. Martinos Center for Biomedical Imaging, Building 149, Room 2301 13th Street, Charlestown, MA, 02129, USA. .
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    Źródło:
    Scientific reports [Sci Rep] 2020 Sep 14; Vol. 10 (1), pp. 15029. Date of Electronic Publication: 2020 Sep 14.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Brain Neoplasms/*diagnostic imaging
    Glioma/*diagnostic imaging
    Magnetic Resonance Spectroscopy/*instrumentation
    Adult ; Brain/diagnostic imaging ; Brain/metabolism ; Brain Neoplasms/metabolism ; Female ; Glioma/metabolism ; Glutarates/metabolism ; Humans ; Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Spectroscopy/standards ; Male ; Sensitivity and Specificity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma.
    Autorzy:
    Tanaka S; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Boston, USA.; Department of Neurosurgery, Boston, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA, 02114, USA.; The University of Tokyo Hospital, Tokyo, Japan.
    Batchelor TT; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Boston, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA, 02114, USA.; Present Address: Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Present Address: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
    Iafrate AJ; Translational Research Laboratory, Cancer Center, Boston, USA.; Department of Pathology, Boston, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA, 02114, USA.
    Dias-Santagata D; Translational Research Laboratory, Cancer Center, Boston, USA.; Department of Pathology, Boston, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA, 02114, USA.
    Borger DR; Translational Research Laboratory, Cancer Center, Boston, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA, 02114, USA.
    Ellisen LW; Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA, 02114, USA.
    Yang D; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Boston, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA, 02114, USA.
    Louis DN; Department of Pathology, Boston, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA, 02114, USA.
    Cahill DP; Department of Neurosurgery, Boston, USA. cahill@mgh.harvard.edu.; Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Yawkey 9E, Boston, MA, 02114, USA. cahill@mgh.harvard.edu.
    Chi AS; Perlmutter Cancer Center, New York University Langone Health and School of Medicine, New York, USA. .; Present Address: Neon Therapeutics, 40 Erie Street, Suite 110, Cambridge, MA, USA. .
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    Źródło:
    Acta neuropathologica communications [Acta Neuropathol Commun] 2019 Apr 29; Vol. 7 (1), pp. 66. Date of Electronic Publication: 2019 Apr 29.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Brain Neoplasms/*genetics
    Class I Phosphatidylinositol 3-Kinases/*genetics
    Glioblastoma/*genetics
    Adult ; Aged ; Aged, 80 and over ; Brain/pathology ; Brain Neoplasms/complications ; Brain Neoplasms/pathology ; DNA Methylation ; Female ; Glioblastoma/complications ; Glioblastoma/pathology ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local/complications ; Neoplasm Recurrence, Local/genetics ; Retrospective Studies ; Survival Analysis ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    TERT promoter wild-type glioblastomas show distinct clinical features and frequent PI3K pathway mutations.
    Autorzy:
    Williams EA; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit street, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Miller JJ; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit street, Boston, MA, USA.; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
    Tummala SS; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit street, Boston, MA, USA.
    Penson T; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit street, Boston, MA, USA.
    Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Juratli TA; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit street, Boston, MA, USA.
    Cahill DP; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit street, Boston, MA, USA. cahill@mgh.harvard.edu.
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    Źródło:
    Acta neuropathologica communications [Acta Neuropathol Commun] 2018 Oct 17; Vol. 6 (1), pp. 106. Date of Electronic Publication: 2018 Oct 17.
    Typ publikacji:
    Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Brain Neoplasms/*genetics
    Glioblastoma/*genetics
    Mutation/*genetics
    Phosphatidylinositol 3-Kinases/*genetics
    Promoter Regions, Genetic/*genetics
    Telomerase/*genetics
    Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/metabolism ; Cohort Studies ; DNA Modification Methylases/metabolism ; DNA Repair Enzymes/metabolism ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Glioblastoma/metabolism ; Humans ; Isocitrate Dehydrogenase/genetics ; Male ; Middle Aged ; Signal Transduction/genetics ; Tumor Suppressor Proteins/metabolism ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq.
    Autorzy:
    Venteicher AS; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Tirosh I; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. .
    Hebert C; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Yizhak K; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Neftel C; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Institute of Pathology, Faculty of Biology and Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
    Filbin MG; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Cancer Center, Boston, MA 02215, USA.
    Hovestadt V; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Escalante LE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Shaw ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Rodman C; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Gillespie SM; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Dionne D; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Luo CC; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Ravichandran H; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Mylvaganam R; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Mount C; Departments of Neurology, Neurosurgery, Pediatrics and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
    Onozato ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Nahed BV; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Curry WT; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Iafrate AJ; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Rivera MN; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Frosch MP; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Golub TR; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Cancer Center, Boston, MA 02215, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
    Brastianos PK; Departments of Medicine and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Getz G; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Patel AP; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Monje M; Departments of Neurology, Neurosurgery, Pediatrics and Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
    Cahill DP; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Rozenblatt-Rosen O; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Louis DN; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Bernstein BE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
    Regev A; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Koch Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
    Suvà ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. .; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2017 Mar 31; Vol. 355 (6332).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Tumor Microenvironment*
    Brain Neoplasms/*genetics
    Brain Neoplasms/*pathology
    Glioma/*genetics
    Glioma/*pathology
    Isocitrate Dehydrogenase/*genetics
    Brain Neoplasms/classification ; Cell Lineage ; Glioma/classification ; Humans ; Macrophages ; Microglia/metabolism ; Microglia/pathology ; Neoplasm Grading ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Principal Component Analysis ; Sequence Analysis, RNA ; Single-Cell Analysis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
    Autorzy:
    Patel AP; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA.
    Tirosh I; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA.
    Trombetta JJ; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA.
    Shalek AK; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA.
    Gillespie SM; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA.
    Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Cahill DP; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Nahed BV; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Curry WT; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Martuza RL; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Louis DN; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
    Rozenblatt-Rosen O; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA.
    Suvà ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. .
    Regev A; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA. Department of Biology, MIT, Cambridge, MA 02139, USA. .
    Bernstein BE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA. .
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    Źródło:
    Science (New York, N.Y.) [Science] 2014 Jun 20; Vol. 344 (6190), pp. 1396-401. Date of Electronic Publication: 2014 Jun 12.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Variation*
    Brain Neoplasms/*genetics
    Glioblastoma/*genetics
    RNA, Messenger/*genetics
    Brain Neoplasms/classification ; Brain Neoplasms/drug therapy ; Gene Expression Profiling ; Glioblastoma/classification ; Glioblastoma/drug therapy ; Humans ; Prognosis ; Sequence Analysis, RNA/methods ; Single-Cell Analysis/methods
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Mutations in CIC and FUBP1 contribute to human oligodendroglioma.
    Autorzy:
    Bettegowda C; Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.
    Agrawal N
    Jiao Y
    Sausen M
    Wood LD
    Hruban RH
    Rodriguez FJ
    Cahill DP
    McLendon R
    Riggins G
    Velculescu VE
    Oba-Shinjo SM
    Marie SK
    Vogelstein B
    Bigner D
    Yan H
    Papadopoulos N
    Kinzler KW
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    Źródło:
    Science (New York, N.Y.) [Science] 2011 Sep 09; Vol. 333 (6048), pp. 1453-5. Date of Electronic Publication: 2011 Aug 04.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Mutation*
    Brain Neoplasms/*genetics
    DNA Helicases/*genetics
    DNA-Binding Proteins/*genetics
    Oligodendroglioma/*genetics
    Repressor Proteins/*genetics
    Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 19/genetics ; DNA Helicases/chemistry ; DNA Helicases/metabolism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Exons ; Female ; Genes, Tumor Suppressor ; Genetic Predisposition to Disease ; Humans ; Loss of Heterozygosity ; Male ; Mutation, Missense ; RNA-Binding Proteins ; Receptor, Notch2/genetics ; Repressor Proteins/chemistry ; Repressor Proteins/metabolism ; Sequence Analysis, DNA
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A comprehensive genomic study of 390 H3F3A-mutant pediatric and adult diffuse high-grade gliomas, CNS WHO grade 4
    Autorzy:
    Williams, Erik A.Aff1, Aff2
    Brastianos, Priscilla K.
    Wakimoto, Hiroaki
    Zolal, Amir
    Filbin, Mariella G.Aff6, Aff7
    Cahill, Daniel P.
    Santagata, SandroAff8, Aff9, Aff10
    Juratli, Tareq A.Aff4, Aff5, Aff11, IDs00401023026096_cor8
    Pokaż więcej
    Źródło:
    Acta Neuropathologica: Pathology and Mechanisms of Neurological Disease. 146(3):515-525
    Czasopismo naukowe
    Szczegóły
      Wyświetlanie 1-9 z 9

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