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Tytuł:
Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis.
Autorzy:
Yoon TW; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
Kim YI; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
Cho H; Department of Orthopedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
Brand DD; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.; Veterans Affairs Medical Center-Memphis, Memphis, Tennessee, United States of America.
Rosloniec EF; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.; Veterans Affairs Medical Center-Memphis, Memphis, Tennessee, United States of America.
Myers LK; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
Postlethwaite AE; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.; Veterans Affairs Medical Center-Memphis, Memphis, Tennessee, United States of America.
Hasty KA; Department of Orthopedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.; Veterans Affairs Medical Center-Memphis, Memphis, Tennessee, United States of America.
Stuart JM; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.; Veterans Affairs Medical Center-Memphis, Memphis, Tennessee, United States of America.
Yi AK; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Dec 06; Vol. 14 (12), pp. e0226145. Date of Electronic Publication: 2019 Dec 06 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Arthritis, Experimental/*drug therapy
Carbazoles/*administration & dosage
Collagen Type II/*adverse effects
Synoviocytes/*enzymology
TRPP Cation Channels/*antagonists & inhibitors
Animals ; Arthritis, Experimental/enzymology ; Arthritis, Experimental/immunology ; Carbazoles/pharmacology ; Cells, Cultured ; Humans ; Mice ; Receptors, Interleukin-1/metabolism ; Synoviocytes/drug effects ; Synoviocytes/immunology ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sequential Annulations to Interesting Novel Pyrrolo[3,2- c ]carbazoles.
Autorzy:
Benzi A; Department of Chemistry and Industrial Chemistry, Università di Genova, Via Dodecaneso 31, I-16146 Genova, Italy. .
Bianchi L; Department of Chemistry and Industrial Chemistry, Università di Genova, Via Dodecaneso 31, I-16146 Genova, Italy. .
Maccagno M; Department of Chemistry and Industrial Chemistry, Università di Genova, Via Dodecaneso 31, I-16146 Genova, Italy. .
Pagano A; Department of Chemistry and Industrial Chemistry, Università di Genova, Via Dodecaneso 31, I-16146 Genova, Italy. angela_.
Petrillo G; Department of Chemistry and Industrial Chemistry, Università di Genova, Via Dodecaneso 31, I-16146 Genova, Italy. .
Tavani C; Department of Chemistry and Industrial Chemistry, Università di Genova, Via Dodecaneso 31, I-16146 Genova, Italy. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Oct 22; Vol. 24 (20). Date of Electronic Publication: 2019 Oct 22.
Typ publikacji:
Journal Article
MeSH Terms:
Carbazoles/*chemistry
Indoles/*chemistry
Pyrroles/*chemistry
Carbazoles/chemical synthesis ; Indoles/chemical synthesis ; Molecular Structure ; Pyrroles/chemical synthesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Overexpression of CD 133 and BCL-2 in non-small cell lung cancer with neuroendocrine differentiation after transformation in ALK rearrangement-positive adenocarcinoma.
Autorzy:
Koyama K; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Katsurada N; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Jimbo N; Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.
Tachihara M; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Tamura D; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Nakata K; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Nagano T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Yamamoto M; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kamiryo H; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kobayashi K; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Itoh T; Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.
Nishimura Y; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
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Źródło:
Pathology international [Pathol Int] 2019 May; Vol. 69 (5), pp. 294-299. Date of Electronic Publication: 2019 Mar 22.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/metabolism
Carcinoma, Non-Small-Cell Lung*/pathology
Carcinoma, Non-Small-Cell Lung*/secondary
Adenocarcinoma of Lung/*therapy
Anaplastic Lymphoma Kinase/*genetics
Carbazoles/*therapeutic use
Piperidines/*therapeutic use
Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Adult ; Anaplastic Lymphoma Kinase/metabolism ; Antigens, CD/metabolism ; Biomarkers, Tumor/metabolism ; Carbazoles/adverse effects ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Female ; Gene Rearrangement ; Humans ; Neoplasm Recurrence, Local ; Neoplastic Stem Cells/metabolism ; Piperidines/adverse effects ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Repressor Proteins/metabolism ; SOXB1 Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MnO 2 -Mediated Oxidative Cyclization of "Formal" Schiff's Bases: Easy Access to Diverse Naphthofuro-Annulated Triazines.
Autorzy:
Fatykhov RF; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.
Khalymbadzha IA; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskaya Str., 620990 Ekaterinburg, Russia.
Sharapov AD; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.
Potapova AP; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.
Mochulskaya NN; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.
Tsmokalyuk AN; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.
Ivoilova AV; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.
Mozharovskaia PN; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.
Santra S; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.
Chupakhin ON; Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskaya Str., 620990 Ekaterinburg, Russia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Oct 21; Vol. 27 (20). Date of Electronic Publication: 2022 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Schiff Bases*
Triazines*
Cyclization ; Manganese ; Manganese Compounds ; Oxides ; Carbazoles ; Phenols ; Oxidative Stress
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Carbazole Derivatives as Potential Antimicrobial Agents.
Autorzy:
Patil SA; Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA.
Patil SA; Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Ble-González EA; Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA.
Isbel SR; Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA.
Hampton SM; Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA.
Bugarin A; Department of Chemistry & Physics, Florida Gulf Coast University, 10501 FGCU Boulevard South, Fort Myers, FL 33965, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Oct 04; Vol. 27 (19). Date of Electronic Publication: 2022 Oct 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Anti-Infective Agents*/pharmacology
Antifungal Agents*/pharmacology
Anti-Bacterial Agents/pharmacology ; Carbazoles/pharmacology ; Microbial Sensitivity Tests ; Nitrogen ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
N-(3,4-dimethoxyphenethyl)-6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-amine inhibits bladder cancer progression by suppressing YAP1/TAZ.
Autorzy:
Shiraishi Y; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.; Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.
Maehama T; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Nishio M; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Otani J; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Hikasa H; Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
Mak TW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Department of Pathology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong.
Sasaki T; Department of Biochemical Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Honma T; RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Kondoh Y; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.
Osada H; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.; Department of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Yoshida M; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.; Department of Biotechnology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan.
Fujisawa M; Division of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.
Suzuki A; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2022 Oct; Vol. 27 (10), pp. 602-612. Date of Electronic Publication: 2022 Aug 22.
Typ publikacji:
Journal Article
MeSH Terms:
Urinary Bladder Neoplasms*/drug therapy
Animals ; Humans ; Male ; Mice ; Acyltransferases/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Amines ; Carbazoles ; Protein Serine-Threonine Kinases ; Signal Transduction/physiology ; Transcription Factors/metabolism ; YAP-Signaling Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CMIC: predicting DNA methylation inheritance of CpG islands with embedding vectors of variable-length k-mers.
Autorzy:
Maruyama O; Faculty of Design, Kyushu University, Fukuoka, Japan. .
Li Y; Graduate School of Design, Kyushu University, Fukuoka, Japan.
Narita H; School of Design, Kyushu University, Fukuoka, Japan.
Toh H; Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Au Yeung WK; Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. .
Sasaki H; Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2022 Sep 12; Vol. 23 (1), pp. 371. Date of Electronic Publication: 2022 Sep 12.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Methylation*
Databases, Genetic*
Animals ; Carbazoles ; CpG Islands ; Inheritance Patterns ; Mammals/genetics ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Development of Yellow-to-Orange Photoluminescence Molecules Based on Alterations in the Donor Units of Fluorinated Tolanes.
Autorzy:
Yamada S; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
Kobayashi K; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
Konno T; Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Sep 07; Vol. 27 (18). Date of Electronic Publication: 2022 Sep 07.
Typ publikacji:
Journal Article
MeSH Terms:
Citrus sinensis*
Amines ; Carbazoles ; Phenothiazines ; Piperidines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efficacy of lorlatinib after alectinib-induced interstitial lung disease in a patient with anaplastic lymphoma kinase-positive non-small cell lung cancer: a case report.
Autorzy:
Kashizaki F; Department of Respiratory Medicine, Yokohama Minami Kyosai Hospital, 1-21-1 Mutsuurahigashi, Kanazawa-ku, Yokohama, Kanagawa, 236-0037, Japan. .; Department of Respiratory Medicine, Isehara Kyodo Hospital, 345 Tanaka, Isehara, Kanagawa, 259-1187, Japan. .
Tanaka A; Department of Respiratory Medicine, Isehara Kyodo Hospital, 345 Tanaka, Isehara, Kanagawa, 259-1187, Japan.
Sekido Y; Department of Pathology, Isehara Kyodo Hospital, 345 Tanaka, Isehara, Kanagawa, 259-1187, Japan.
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Źródło:
Journal of medical case reports [J Med Case Rep] 2022 Aug 24; Vol. 16 (1), pp. 316. Date of Electronic Publication: 2022 Aug 24.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Antineoplastic Agents*/adverse effects
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/pathology
Kidney Diseases*
Lung Diseases, Interstitial*/chemically induced
Lung Diseases, Interstitial*/diagnostic imaging
Lung Diseases, Interstitial*/drug therapy
Lung Neoplasms*/pathology
Aminopyridines ; Anaplastic Lymphoma Kinase/genetics ; Carbazoles ; Humans ; Lactams ; Male ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Piperidines ; Protein Kinase Inhibitors/adverse effects ; Protein-Tyrosine Kinases ; Pyrazoles
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
N-thioalkylcarbazoles derivatives as new anti-proliferative agents: synthesis, characterisation and molecular mechanism evaluation.
Autorzy:
Sinicropi MS; a Department of Pharmacy, Health and Nutritional Sciences , University of Calabria , Arcavacata di Rende , Italy.
Iacopetta D; a Department of Pharmacy, Health and Nutritional Sciences , University of Calabria , Arcavacata di Rende , Italy.
Rosano C; b Biopolymers and Proteomics IRCCS Policlinico San Martino-IST , Genova , Italy.
Randino R; c Department of Pharmacy , University of Salerno , Fisciano , Italy.
Caruso A; a Department of Pharmacy, Health and Nutritional Sciences , University of Calabria , Arcavacata di Rende , Italy.
Saturnino C; d Department of Science , University of Basilicata , Potenza , Italy.
Muià N; a Department of Pharmacy, Health and Nutritional Sciences , University of Calabria , Arcavacata di Rende , Italy.
Ceramella J; a Department of Pharmacy, Health and Nutritional Sciences , University of Calabria , Arcavacata di Rende , Italy.
Puoci F; a Department of Pharmacy, Health and Nutritional Sciences , University of Calabria , Arcavacata di Rende , Italy.
Rodriquez M; c Department of Pharmacy , University of Salerno , Fisciano , Italy.
Longo P; e Department of Chemistry and Biology , University of Salerno , Fisciano , Italy.
Plutino MR; f Institute for the Study of Nanostructured Materials , ISMN-CNR, Palermo, c/o Department of ChiBioFarAm, University of Messina , Messina , Italy.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 434-444.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Carbazoles/*pharmacology
DNA Topoisomerases, Type II/*metabolism
Sulfhydryl Compounds/*pharmacology
Topoisomerase II Inhibitors/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbazoles/chemical synthesis ; Carbazoles/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship ; Sulfhydryl Compounds/chemical synthesis ; Sulfhydryl Compounds/chemistry ; Topoisomerase II Inhibitors/chemical synthesis ; Topoisomerase II Inhibitors/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Binding Study of the Fluorescent Carbazole Derivative with Human Telomeric G-Quadruplexes.
Autorzy:
Głuszyńska A; Laboratory of Bioanalytical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznań, Poland. .
Juskowiak B; Laboratory of Bioanalytical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznań, Poland. .
Rubiś B; Department of Clinical Chemistry and Molecular Diagnostics, University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2018 Nov 30; Vol. 23 (12). Date of Electronic Publication: 2018 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
G-Quadruplexes*
Carbazoles/*chemistry
Telomere/*metabolism
Carbazoles/chemical synthesis ; Carbazoles/pharmacology ; Cell Death/drug effects ; Cell Line, Tumor ; Circular Dichroism ; Humans ; Kinetics ; Ligands ; Nucleic Acid Denaturation ; Solvents ; Spectrometry, Fluorescence ; Telomerase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes.
Autorzy:
Nakagawa T; a Chugai Pharmaceutical Co. Ltd ., Gotemba , Japan.
Fowler S; b Non-Clinical Drug Safety, F. Hoffmann-La Roche Ltd. , Basel , Switzerland.
Takanashi K; a Chugai Pharmaceutical Co. Ltd ., Gotemba , Japan.
Youdim K; b Non-Clinical Drug Safety, F. Hoffmann-La Roche Ltd. , Basel , Switzerland.
Yamauchi T; a Chugai Pharmaceutical Co. Ltd ., Gotemba , Japan.
Kawashima K; a Chugai Pharmaceutical Co. Ltd ., Gotemba , Japan.
Sato-Nakai M; a Chugai Pharmaceutical Co. Ltd ., Gotemba , Japan.
Yu L; c Roche Innovation Center , New York , NY , USA.
Ishigai M; a Chugai Pharmaceutical Co. Ltd ., Gotemba , Japan.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2018 Jun; Vol. 48 (6), pp. 546-554. Date of Electronic Publication: 2017 Jul 21.
Typ publikacji:
Journal Article
MeSH Terms:
Carbazoles*/pharmacokinetics
Carbazoles*/pharmacology
Piperidines*/pharmacokinetics
Piperidines*/pharmacology
Cytochrome P-450 CYP3A/*metabolism
Hepatocytes/*enzymology
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
Anaplastic Lymphoma Kinase ; Cells, Cultured ; Hepatocytes/cytology ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Upgrading of dissolution and anti-hypertensive effect of Carvedilol via two combined approaches: self-emulsification and liquisolid techniques.
Autorzy:
Ibrahim TM; a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Zagazig University , Zagazig , Egypt.
Abdallah MH; a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Zagazig University , Zagazig , Egypt.; b Department of Pharmaceutics, College of Pharmacy , Hail University , Hail , Kingdom of Saudi Arabia.
El-Megrab NA; a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Zagazig University , Zagazig , Egypt.
El-Nahas HM; a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Zagazig University , Zagazig , Egypt.
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Źródło:
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2018 Jun; Vol. 44 (6), pp. 873-885. Date of Electronic Publication: 2017 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Antihypertensive Agents/*administration & dosage
Carbazoles/*pharmacology
Emulsions/*chemistry
Ethylene Glycols/*administration & dosage
Polymers/*chemistry
Polysorbates/*chemistry
Propanolamines/*pharmacology
Propylene Glycols/*chemistry
Surface-Active Agents/*chemistry
Animals ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/pharmacology ; Carbazoles/administration & dosage ; Carbazoles/chemistry ; Carvedilol ; Chemistry, Pharmaceutical ; Drug Delivery Systems ; Ethylene Glycols/chemistry ; Ethylene Glycols/pharmacology ; Excipients ; Propanolamines/administration & dosage ; Propanolamines/chemistry ; Rats ; Solubility ; Tablets
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Triphenylamine, Carbazole or Tetraphenylethylene-Functionalized Benzothiadiazole Derivatives: Aggregation-Induced Emission (AIE), Solvatochromic and Different Mechanoresponsive Fluorescence Characteristics.
Autorzy:
Yang Y; Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China.
Deng D; Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China.
Deng X; Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China.
Chen Z; Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China.
Pu S; Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China.; Department of Ecology and Environment, Yuzhang Normal University, Nanchang 330103, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jul 25; Vol. 27 (15). Date of Electronic Publication: 2022 Jul 25.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorescent Dyes*
Stilbenes*
Amines ; Carbazoles ; Thiadiazoles
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effects of Carbazole Derivatives on Neurite Outgrowth and Hydrogen Peroxide-Induced Cytotoxicity in Neuro2a Cells.
Autorzy:
Furukawa Y; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. .
Sawamoto A; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. .
Yamaoka M; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. .
Nakaya M; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. .
Hieda Y; Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 1 Sanzo, Gakuen-cho, Fukuyama, Hiroshima 729-0292, Japan. .
Choshi T; Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 1 Sanzo, Gakuen-cho, Fukuyama, Hiroshima 729-0292, Japan. .
Hatae N; School of Pharmaceutical Sciences, Health Science University of Hokkaido, Ishikari, Tobetsu, Hokkaido 061-0293, Japan. .
Okuyama S; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. .
Nakajima M; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. .
Hibino S; Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 1 Sanzo, Gakuen-cho, Fukuyama, Hiroshima 729-0292, Japan. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Apr 07; Vol. 24 (7). Date of Electronic Publication: 2019 Apr 07.
Typ publikacji:
Journal Article
MeSH Terms:
Carbazoles/*pharmacology
Hydrogen Peroxide/*pharmacology
Neuronal Outgrowth/*drug effects
Neurons/*drug effects
Neurons/*physiology
Animals ; Carbazoles/chemistry ; Cell Differentiation/drug effects ; Cell Survival/drug effects ; Molecular Structure ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Murrayanine Attenuates Lipopolysaccharide-induced Inflammation and Protects Mice from Sepsis-associated Organ Failure.
Autorzy:
Gupta S; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicines, Jammu Tawi, Jammu and Kashmir, India.; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, Jammu Tawi, Jammu and Kashmir, India.
Khajuria V; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicines, Jammu Tawi, Jammu and Kashmir, India.; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, Jammu Tawi, Jammu and Kashmir, India.
Wani A; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicines, Jammu Tawi, Jammu and Kashmir, India.; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, Jammu Tawi, Jammu and Kashmir, India.
Nalli Y; Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu Tawi, Jammu and Kashmir, India.
Bhagat A; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, Jammu Tawi, Jammu and Kashmir, India.
Ali A; Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu Tawi, Jammu and Kashmir, India.
Ahmed Z; Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, Jammu Tawi, Jammu and Kashmir, India.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2019 Apr; Vol. 124 (4), pp. 351-359. Date of Electronic Publication: 2019 Jan 22.
Typ publikacji:
Journal Article
MeSH Terms:
Carbazoles/*pharmacology
Inflammation/*prevention & control
Multiple Organ Failure/*prevention & control
Sepsis/*drug therapy
Animals ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Carbazoles/isolation & purification ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Immunosuppressive Agents/isolation & purification ; Immunosuppressive Agents/pharmacology ; Lipopolysaccharides/toxicity ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/pathology ; Mice ; Mice, Inbred BALB C ; Multiple Organ Failure/etiology ; Murraya/chemistry ; NF-kappa B/metabolism ; RAW 264.7 Cells ; Sepsis/complications
Czasopismo naukowe
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Tytuł:
Base-Promoted S N Ar Reactions of Fluoro- and Chloroarenes as a Route to N -Aryl Indoles and Carbazoles.
Autorzy:
Iqbal MA; Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China. .
Mehmood H; Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China. .
Lv J; Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China. .
Hua R; Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Mar 22; Vol. 24 (6). Date of Electronic Publication: 2019 Mar 22.
Typ publikacji:
Journal Article
MeSH Terms:
Carbazoles/*chemistry
Indoles/*chemistry
Carbazoles/chemical synthesis ; Carbon/chemistry ; Indoles/chemical synthesis ; Molecular Structure ; Nitrogen/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison of F-FET PET in high grade glioma: a double-tracer pilot study.
Autorzy:
Unterrainer M; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Fleischmann DF; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Diekmann C; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Vomacka L; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Lindner S; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Vettermann F; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Brendel M; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Wenter V; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Ertl-Wagner B; Institute of Clinical Radiology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Herms J; Department of Neuropathology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Wetzel C; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Rupprecht R; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Tonn JC; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurosurgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Belka C; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Bartenstein P; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Niyazi M; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Albert NL; Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany. .; German Cancer Consortium (DKTK), Partner Site Munich; and German Cancer Research Center (DKFZ), Heidelberg, Germany. .
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2019 Mar; Vol. 46 (3), pp. 580-590. Date of Electronic Publication: 2018 Sep 22.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Carbazoles*/metabolism
Glioma/*diagnostic imaging
Glioma/*pathology
Positron-Emission Tomography/*methods
Tyrosine/*analogs & derivatives
Adult ; Aged ; Biological Transport ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Female ; Glioma/genetics ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Grading ; Pilot Projects ; Polymorphism, Genetic ; Radioactive Tracers ; Receptors, GABA/genetics ; Tumor Burden ; Tyrosine/metabolism
Czasopismo naukowe
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Tytuł:
Macrophage Migration Inhibitory Factor Acts as the Potential Target of a Newly Synthesized Compound, 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline.
Autorzy:
Ko PH; Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Shen YC; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Murugan K; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Huang CW; Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Sivakumar G; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Pal P; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Liao CC; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Luo KS; Department of Ophthalmology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan.
Chuang EY; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.; Bioinformatics and Biostatistics Core, Center of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan.
Tsai MH; Bioinformatics and Biostatistics Core, Center of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan.; Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
Lai LC; Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan. .; Bioinformatics and Biostatistics Core, Center of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan. .
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Źródło:
Scientific reports [Sci Rep] 2019 Feb 14; Vol. 9 (1), pp. 2147. Date of Electronic Publication: 2019 Feb 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Carbazoles/*pharmacology
Carbolines/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Intramolecular Oxidoreductases/*antagonists & inhibitors
Macrophage Migration-Inhibitory Factors/*antagonists & inhibitors
Antineoplastic Agents/chemistry ; Apoptosis ; Biomarkers, Tumor ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carbazoles/chemistry ; Carbolines/chemistry ; Cell Cycle ; Cell Proliferation ; Female ; Gene Expression Profiling ; Humans ; Intramolecular Oxidoreductases/metabolism ; Macrophage Migration-Inhibitory Factors/metabolism ; Phosphorylation ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
From Quinoxaline, Pyrido[2,3- b ]pyrazine and Pyrido[3,4- b ]pyrazine to Pyrazino-Fused Carbazoles and Carbolines.
Autorzy:
Lassagne F; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Langlais T; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Caytan E; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Limanton E; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Paquin L; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Boullard M; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Courtel C; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Curbet I; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Gédéon C; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Lebreton J; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Picot L; Laboratoire Littoral Environnement et Sociétés, UMRi CNRS 7266, Université de La Rochelle, 17042 La Rochelle, France. .
Thiéry V; Laboratoire Littoral Environnement et Sociétés, UMRi CNRS 7266, Université de La Rochelle, 17042 La Rochelle, France. .
Souab M; Sorbonne Universités, UPMC Univ Paris 06, CNRS USR3151, 'Protein Phosphorylation and Human Disease' Unit, Plateforme de criblage KISSf, Station Biologique de Roscoff, Place Georges Teissier, 29688 Roscoff, France. .
Baratte B; Sorbonne Universités, UPMC Univ Paris 06, CNRS USR3151, 'Protein Phosphorylation and Human Disease' Unit, Plateforme de criblage KISSf, Station Biologique de Roscoff, Place Georges Teissier, 29688 Roscoff, France. .
Ruchaud S; Sorbonne Universités, UPMC Univ Paris 06, CNRS USR3151, 'Protein Phosphorylation and Human Disease' Unit, Plateforme de criblage KISSf, Station Biologique de Roscoff, Place Georges Teissier, 29688 Roscoff, France. .
Bach S; Sorbonne Universités, UPMC Univ Paris 06, CNRS USR3151, 'Protein Phosphorylation and Human Disease' Unit, Plateforme de criblage KISSf, Station Biologique de Roscoff, Place Georges Teissier, 29688 Roscoff, France. .
Roisnel T; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
Mongin F; Univ Rennes, CNRS, Institut des Sciences Chimiques de Rennes (ISCR)-UMR 6226, F-35000 Rennes, France. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2018 Nov 13; Vol. 23 (11). Date of Electronic Publication: 2018 Nov 13.
Typ publikacji:
Journal Article
MeSH Terms:
Carbazoles/*chemistry
Carbolines/*chemistry
Pyrazines/*chemistry
Quinoxalines/*chemistry
Carbazoles/pharmacology ; Carbolines/pharmacology ; Molecular Structure ; Oxidative Coupling ; Palladium/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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