- Tytuł:
- A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer.
- Autorzy:
- Źródło:
- Scientific reports [Sci Rep] 2019 Jan 24; Vol. 9 (1), pp. 648. Date of Electronic Publication: 2019 Jan 24.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Carcinoma, Non-Small-Cell Lung/*pathology
Drug Resistance, Neoplasm/*genetics
Lung Neoplasms/*pathology
Proto-Oncogene Proteins p21(ras)/*genetics
Thiazolidines/*pharmacology
ras Proteins/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; ErbB Receptors/antagonists & inhibitors ; Erlotinib Hydrochloride/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; HEK293 Cells ; Humans ; MAP Kinase Signaling System/drug effects ; Mice ; Protein Kinase Inhibitors/pharmacology ; Protein Stability/drug effects ; beta Catenin/metabolism
Czasopismo naukowe