- Tytuł:
-
High Glucose-Induced Oxidative Stress Mediates
Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells. - Autorzy:
- Źródło:
- Journal of diabetes research [J Diabetes Res] 2016; Vol. 2016, pp. 3765173. Date of Electronic Publication: 2016 Aug 22.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Apoptosis /*drug effects
Extracellular Matrix/*drug effects
Glucose/*pharmacology
Nucleus Pulposus/*drug effects
Oxidative Stress/*drug effects
RNA, Messenger/*drug effects
p38 Mitogen-Activated Protein Kinases/*drug effects
Acetylcysteine/pharmacology ; Aggrecans/drug effects ; Aggrecans/genetics ; Animals ; Blotting, Western ; Cell Survival/drug effects ; Cells, Cultured ; Collagen Type II/drug effects ; Collagen Type II/genetics ; Extracellular Matrix/metabolism ; Free Radical Scavengers/pharmacology ; Humans ; Hyperglycemia/genetics ; Hyperglycemia/metabolism ; Matrix Metalloproteinase 3/drug effects ; Matrix Metalloproteinase 3/genetics ; Nucleus Pulposus/cytology ; Nucleus Pulposus/metabolism ; RNA, Messenger/metabolism ; Rats ; Reactive Oxygen Species/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; SOX9 Transcription Factor/drug effects ; SOX9 Transcription Factor/genetics ; Tissue Inhibitor of Metalloproteinase-1/drug effects ; Tissue Inhibitor of Metalloproteinase-1/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe