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Wyszukujesz frazę ""DNA Breaks"" wg kryterium: Temat


Tytuł :
One end to rule them all: Non-homologous end-joining and homologous recombination at DNA double-strand breaks.
Autorzy :
Ensminger M; Radiation Biology and DNA Repair, Technical University of Darmstadt, 64287 Darmstadt, Germany.
Löbrich M; Radiation Biology and DNA Repair, Technical University of Darmstadt, 64287 Darmstadt, Germany.
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Źródło :
The British journal of radiology [Br J Radiol] 2020 Nov 01; Vol. 93 (1115), pp. 20191054. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA End-Joining Repair/*physiology
Gene Rearrangement/*physiology
Homologous Recombination/*physiology
DNA Breaks, Single-Stranded ; G1 Phase/genetics ; G2 Phase/genetics ; Humans
Czasopismo naukowe
Tytuł :
POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks.
Autorzy :
Davis L; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.
Khoo KJ; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA 98195.
Zhang Y; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.
Maizels N; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195; .; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA 98195.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 15; Vol. 117 (37), pp. 22900-22909. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Breaks, Double-Stranded*
Recombinational DNA Repair*
DNA-Directed DNA Polymerase/*metabolism
CRISPR-Cas Systems ; Cell Line, Tumor ; DNA Breaks, Single-Stranded ; DNA End-Joining Repair ; DNA Ligases/genetics ; DNA Ligases/metabolism ; DNA-Directed DNA Polymerase/genetics ; Heterozygote ; Humans ; Loss of Heterozygosity ; Mutation ; Recombination, Genetic
Czasopismo naukowe
Tytuł :
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
Autorzy :
Meng F; Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Shenzhen University Health Science Center, Shenzhen, China.; The Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Qian M; Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Shenzhen University Health Science Center, Shenzhen, China.; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.
Peng B; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.
Peng L; Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Shenzhen University Health Science Center, Shenzhen, China.; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.
Wang X; Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Shenzhen University Health Science Center, Shenzhen, China.; International Cancer Center, Shenzhen University Health Science Center, Shenzhen, China.
Zheng K; Anti-aging & Regenerative Medicine Research Institution, School of Life Sciences, Shandong University of Technology, Zibo, China.
Liu Z; Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Shenzhen University Health Science Center, Shenzhen, China.; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.
Tang X; Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Shenzhen University Health Science Center, Shenzhen, China.; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.
Zhang S; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.
Sun S; Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Shenzhen University Health Science Center, Shenzhen, China.; Anti-aging & Regenerative Medicine Research Institution, School of Life Sciences, Shandong University of Technology, Zibo, China.
Cao X; Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Shenzhen University Health Science Center, Shenzhen, China.; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.
Pang Q; Anti-aging & Regenerative Medicine Research Institution, School of Life Sciences, Shandong University of Technology, Zibo, China.
Zhao B; Anti-aging & Regenerative Medicine Research Institution, School of Life Sciences, Shandong University of Technology, Zibo, China.
Ma W; Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Songyang Z; Key Laboratory of Gene Engineering of the Ministry of Education and State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Xu B; The Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Zhu WG; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.; International Cancer Center, Shenzhen University Health Science Center, Shenzhen, China.
Xu X; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.; International Cancer Center, Shenzhen University Health Science Center, Shenzhen, China.
Liu B; Shenzhen Key Laboratory for Systemic Aging and Intervention, National Engineering Research Center for Biotechnology (Shenzhen), Shenzhen University Health Science Center, Shenzhen, China.; Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.; International Cancer Center, Shenzhen University Health Science Center, Shenzhen, China.; Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen, China.
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Źródło :
ELife [Elife] 2020 Jun 15; Vol. 9. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks*
DNA Damage*
DNA Repair*
Sirtuin 1/*physiology
Sirtuins/*physiology
Acetylation ; Animals ; DNA Breaks, Double-Stranded ; HEK293 Cells ; HeLa Cells ; Humans ; Immunoprecipitation ; Mice ; Mutagenesis, Site-Directed ; Sirtuin 1/metabolism ; Sirtuins/metabolism
Czasopismo naukowe
Tytuł :
A molecular Rosetta Stone to decipher the impact of chromatin features on the repair of Cas9-mediated DNA double-strand breaks.
Autorzy :
Caron P; Laboratory of Epigenome Integrity, Epigenetics & Cell Fate Centre, UMR 7216 CNRS - University of Paris, 35 rue Hélène Brion, 75205 Paris Cedex 13, France.
Pobega E; Laboratory of Epigenome Integrity, Epigenetics & Cell Fate Centre, UMR 7216 CNRS - University of Paris, 35 rue Hélène Brion, 75205 Paris Cedex 13, France.
Polo SE; Laboratory of Epigenome Integrity, Epigenetics & Cell Fate Centre, UMR 7216 CNRS - University of Paris, 35 rue Hélène Brion, 75205 Paris Cedex 13, France. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 May 20; Vol. 81 (10), pp. 2059-2060.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Chromatin*/genetics
DNA Breaks, Double-Stranded*
CRISPR-Cas Systems ; DNA ; DNA Repair ; Humans
Czasopismo naukowe
Tytuł :
Boon and Bane of DNA Double-Strand Breaks.
Autorzy :
Schubert I; Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, D-06466 Seeland, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 13; Vol. 22 (10). Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Chromatin*
DNA Breaks, Double-Stranded*
DNA Repair*
Meiosis*
Animals ; Gene Editing ; Humans
Czasopismo naukowe
Tytuł :
The Protective Effects of EMF-LTE against DNA Double-Strand Break Damage In Vitro and In Vivo.
Autorzy :
Jin H; College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Kim K; College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Park GY; College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Kim M; College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Lee HJ; Division of Basic Radiation Bioscience, Korea Institute of Radiological & Medical Sciences, Seoul 03760, Korea.
Jeon S; Radio & Satellite Research Division, Electronics and Telecommunications Research Institute, Daejeon 34129, Korea.
Kim JH; Department of Pharmacology, College of Medicine, Dankook University, Chungnam 31116, Korea.
Kim HR; Department of Pharmacology, College of Medicine, Dankook University, Chungnam 31116, Korea.
Lim KM; College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Lee YS; College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 12; Vol. 22 (10). Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Breaks, Double-Stranded*
Electromagnetic Fields*
Protective Agents*
Radiation, Ionizing*
Radio Waves*
Keratinocytes/*radiation effects
Melanoma/*prevention & control
Animals ; Apoptosis ; Cell Survival ; DNA Repair ; Humans ; In Vitro Techniques ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Male ; Melanoma/etiology ; Melanoma/pathology ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
Structural parameters of palindromic repeats determine the specificity of nuclease attack of secondary structures.
Autorzy :
Ait Saada A; School of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GE 30332, USA.
Costa AB; School of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GE 30332, USA.
Sheng Z; School of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GE 30332, USA.
Guo W; School of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GE 30332, USA.
Haber JE; Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Waltham, MA 02454-9110, USA.
Lobachev KS; School of Biological Sciences and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GE 30332, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Apr 19; Vol. 49 (7), pp. 3932-3947.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Replication*
Inverted Repeat Sequences*
DNA, Fungal/*metabolism
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*chemistry
Nucleic Acid Conformation ; Protein Structural Elements ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide.
Autorzy :
Jamsen JA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Sassa A; Laboratory of Chromatin Metabolism and Epigenetics, Graduate School of Science, Chiba University, Chiba, Japan.
Shock DD; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Beard WA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Wilson SH; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 06; Vol. 12 (1), pp. 2059. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
DNA-Directed DNA Polymerase/*metabolism
Mutagenesis/*genetics
Nucleotides/*metabolism
Adenine/metabolism ; Base Pairing ; Biocatalysis ; Catalytic Domain ; Cytosine/metabolism ; Deoxyguanine Nucleotides/metabolism ; Humans ; Models, Molecular ; Mutagenesis, Insertional/genetics ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity.
Autorzy :
Burgess JT; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Cheong CM; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Suraweera A; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Sobanski T; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Beard S; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Dave K; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Rose M; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Boucher D; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Croft LV; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Adams MN; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
O'Byrne K; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.; Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane, Queensland 4102, Australia.
Richard DJ; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
Bolderson E; Queensland University of Technology (QUT), Cancer & Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Brisbane, Australia.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Apr 06; Vol. 49 (6), pp. 3294-3307.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
DNA-Activated Protein Kinase/*metabolism
DNA-Binding Proteins/*metabolism
Cell Line ; HEK293 Cells ; Homologous Recombination ; Humans
Czasopismo naukowe
Tytuł :
DNA-driven condensation assembles the meiotic DNA break machinery.
Autorzy :
Claeys Bouuaert C; Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Howard Hughes Medical Institute, New York, New York, USA. .; Louvain Institute of Biomolecular Science and Technology, Université Catholique de Louvain, Louvain-La-Neuve, Belgium. .
Pu S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Howard Hughes Medical Institute, New York, New York, USA.
Wang J; Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Oger C; Louvain Institute of Biomolecular Science and Technology, Université Catholique de Louvain, Louvain-La-Neuve, Belgium.
Daccache D; Louvain Institute of Biomolecular Science and Technology, Université Catholique de Louvain, Louvain-La-Neuve, Belgium.
Xie W; Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Patel DJ; Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Keeney S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center and Howard Hughes Medical Institute, New York, New York, USA. .
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Źródło :
Nature [Nature] 2021 Apr; Vol. 592 (7852), pp. 144-149. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
Meiosis*
Saccharomyces cerevisiae*/cytology
Saccharomyces cerevisiae*/genetics
DNA, Fungal/*metabolism
Nuclear Proteins/*metabolism
Nucleoproteins/*metabolism
Recombinases/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
DNA, Fungal/chemistry ; Endodeoxyribonucleases/metabolism ; Homologous Recombination ; Nuclear Proteins/chemistry ; Nucleoproteins/chemistry ; Protein Binding ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Recombinases/chemistry ; Saccharomyces cerevisiae Proteins/chemistry
Czasopismo naukowe
Tytuł :
ATM: Translating the DNA Damage Response to Adaptive Immunity.
Autorzy :
Weitering TJ; Department of Pediatrics, Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, The Netherlands.
Takada S; Department of Pediatrics, Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, The Netherlands.
Weemaes CMR; Department of Pediatrics, Radboudumc Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.
van Schouwenburg PA; Department of Pediatrics, Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, The Netherlands.
van der Burg M; Department of Pediatrics, Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: .
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Źródło :
Trends in immunology [Trends Immunol] 2021 Apr; Vol. 42 (4), pp. 350-365. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
Adaptive Immunity ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; DNA Damage ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Immunoglobulin Class Switching
Czasopismo naukowe
Tytuł :
Profiling of the assembly of RecA nucleofilaments implies a potential target for environmental factors to disturb DNA repair.
Autorzy :
Yuan Z; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yu F; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang D; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wang H; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute of Environment and Health, Jianghan University, Wuhan 430056, China; Institute of Environment and Health, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 430056, China. Electronic address: .
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Źródło :
Journal of environmental sciences (China) [J Environ Sci (China)] 2021 Apr; Vol. 102, pp. 283-290. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
DNA Damage
Czasopismo naukowe
Tytuł :
Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair.
Autorzy :
Zahn KE; Department of Microbiology and Molecular Genetics, University of Vermont, 89 Beaumont Ave., Burlington, VT 05405, USA; Department of Therapeutic Radiology, Yale University, New Haven, CT 06510, USA.
Jensen RB; Department of Therapeutic Radiology, Yale University, New Haven, CT 06510, USA.
Wood RD; Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 78957, USA. Electronic address: .
Doublié S; Department of Microbiology and Molecular Genetics, University of Vermont, 89 Beaumont Ave., Burlington, VT 05405, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1534-1547.e4. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
DNA/*metabolism
DNA-Directed DNA Polymerase/*metabolism
Endonucleases/*metabolism
Metals/*metabolism
Cell Line ; DNA/genetics ; DNA-Directed DNA Polymerase/genetics ; Endonucleases/genetics ; Humans
Czasopismo naukowe
Tytuł :
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.
Autorzy :
Lee JH; The University of Texas at Austin, Department of Molecular Biosciences, Austin, TX 78712, USA.
Ryu SW; The University of Texas at Austin, Department of Molecular Biosciences, Austin, TX 78712, USA.
Ender NA; The University of Texas at Austin, Department of Molecular Biosciences, Austin, TX 78712, USA.
Paull TT; The University of Texas at Austin, Department of Molecular Biosciences, Austin, TX 78712, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1515-1533.e5. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Breaks, Single-Stranded*
Poly ADP Ribosylation*
Proteostasis*
Ataxia Telangiectasia Mutated Proteins/*deficiency
MRE11 Homologue Protein/*deficiency
Neocortex/*metabolism
Spinocerebellar Ataxias/*metabolism
Adult ; Cell Line, Tumor ; Female ; Humans ; Male ; Neocortex/pathology ; Spinocerebellar Ataxias/genetics ; Spinocerebellar Ataxias/pathology
Czasopismo naukowe
Tytuł :
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ.
Autorzy :
Black SJ; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Ozdemir AY; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Kashkina E; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Kent T; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Rusanov T; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Ristic D; Department of Molecular Genetics and Department of Radiation Oncology, Erasmus University Medical Center, 3000 CA, Rotterdam, The Netherlands.
Shin Y; Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA, 16802, USA.
Suma A; Institute for Computational Molecular Science, Temple University, Philadelphia, PA, USA.
Hoang T; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Chandramouly G; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Siddique LA; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Borisonnik N; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Sullivan-Reed K; Fels Institute for Cancer Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Mallon JS; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Skorski T; Fels Institute for Cancer Research, Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
Carnevale V; Institute for Computational Molecular Science, Temple University, Philadelphia, PA, USA.
Murakami KS; Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA, 16802, USA.
Wyman C; Department of Molecular Genetics and Department of Radiation Oncology, Erasmus University Medical Center, 3000 CA, Rotterdam, The Netherlands.
Pomerantz RT; Fels Institute for Cancer Research, Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA. .
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Źródło :
Nature communications [Nat Commun] 2019 Sep 27; Vol. 10 (1), pp. 4423. Date of Electronic Publication: 2019 Sep 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA End-Joining Repair/*physiology
DNA Helicases/*metabolism
DNA, Single-Stranded/*metabolism
DNA-Directed DNA Polymerase/*chemistry
DNA-Directed DNA Polymerase/*metabolism
Catalytic Domain ; DNA Breaks ; DNA-Binding Proteins/metabolism ; DNA-Directed DNA Polymerase/genetics ; Humans ; Models, Molecular ; Mutagenesis, Site-Directed
Czasopismo naukowe
Tytuł :
Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice.
Autorzy :
Dereli I; Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden, Fiedlerstrasse 42, 01307 Dresden, Germany.
Stanzione M; Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden, Fiedlerstrasse 42, 01307 Dresden, Germany.
Olmeda F; Max Planck Institute for the Physics of Complex Systems, Noethnitzer Strasse 38, 01187 Dresden, Germany.
Papanikos F; Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden, Fiedlerstrasse 42, 01307 Dresden, Germany.
Baumann M; Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden, Fiedlerstrasse 42, 01307 Dresden, Germany.
Demir S; Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden, Fiedlerstrasse 42, 01307 Dresden, Germany.
Carofiglio F; Department of Developmental Biology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands.
Lange J; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
de Massy B; Institute of Human Genetics, UMR 9002, CNRS, Université de Montpellier, 34396 Montpellier cedex 5, France.
Baarends WM; Department of Developmental Biology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands.
Turner J; Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Rulands S; Max Planck Institute for the Physics of Complex Systems, Noethnitzer Strasse 38, 01187 Dresden, Germany.; Center for Systems Biology Dresden (CSBD), Pfotenhauer Strasse 108, 01307 Dresden, Germany.
Tóth A; Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden, Fiedlerstrasse 42, 01307 Dresden, Germany.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2609-2628.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
Meiosis/*genetics
ATPases Associated with Diverse Cellular Activities/physiology ; Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Cycle Proteins/physiology ; Chromosome Pairing ; Feedback, Physiological ; Gametogenesis ; Mice ; Pachytene Stage ; Sex Chromosomes ; Signal Transduction
Czasopismo naukowe
Tytuł :
The CD44high Subpopulation of Multifraction Irradiation-Surviving NSCLC Cells Exhibits Partial EMT-Program Activation and DNA Damage Response Depending on Their p53 Status.
Autorzy :
Pustovalova M; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.
Alhaddad L; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.
Blokhina T; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098 Moscow, Russia.; Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russia.
Smetanina N; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098 Moscow, Russia.
Chigasova A; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; Emanuel Institute for Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia.
Chuprov-Netochin R; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.
Eremin P; FSBI 'National Medical Research Center for Rehabilitation and Balneology', Ministry of Health of Russia, 121099 Moscow, Russia.
Gilmutdinova I; FSBI 'National Medical Research Center for Rehabilitation and Balneology', Ministry of Health of Russia, 121099 Moscow, Russia.
Osipov AN; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098 Moscow, Russia.; Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russia.
Leonov S; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russia.; Institute of Cell Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 27; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 27.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
DNA Breaks, Double-Stranded*
Radiation Tolerance*
Recombinational DNA Repair*
Carcinoma, Non-Small-Cell Lung/*radiotherapy
Lung Neoplasms/*radiotherapy
Tumor Suppressor Protein p53/*metabolism
A549 Cells ; Autophagy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/physiopathology ; Cell Line, Tumor ; Cell Movement ; DNA/metabolism ; DNA End-Joining Repair ; Epithelial-Mesenchymal Transition ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/physiopathology ; Rad51 Recombinase/metabolism ; X-Rays
Czasopismo naukowe
Tytuł :
A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage.
Autorzy :
Dong C; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong S.A.R.
An L; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong S.A.R.
Yu CH; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong S.A.R.
Huen MSY; School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong S.A.R.; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, 5 Sassoon Road, Pokfulam, Hong Kong S.A.R.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 22; Vol. 49 (3), pp. 1485-1496.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA, Ribosomal*
Gene Silencing*
Transcription, Genetic*
Protein-Serine-Threonine Kinases/*metabolism
Protein-Tyrosine Kinases/*metabolism
Cell Line ; Cell Nucleolus/genetics ; DNA Repair ; Poly(ADP-ribose) Polymerases/metabolism ; Protein-Serine-Threonine Kinases/physiology ; Protein-Tyrosine Kinases/physiology ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł :
To skip or not to skip: choosing repriming to tolerate DNA damage.
Autorzy :
Quinet A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Tirman S; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Cybulla E; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA.
Meroni A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Vindigni A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 18; Vol. 81 (4), pp. 649-658. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
DNA Breaks, Single-Stranded*
DNA Repair*
DNA Replication*
Genomic Instability*
DNA, Single-Stranded/*metabolism
Animals ; DNA, Single-Stranded/genetics ; Humans
Czasopismo naukowe
Tytuł :
CARM1 regulates replication fork speed and stress response by stimulating PARP1.
Autorzy :
Genois MM; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
Gagné JP; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City, QC G1V 0A6, Canada; CHU de Québec Research Center, CHUL Pavilion, Oncology Axis, Québec City, Québec G1V 4G2, Canada.
Yasuhara T; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
Jackson J; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Saxena S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
Langelier MF; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Ahel I; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Bedford MT; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.
Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Vindigni A; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Poirier GG; Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City, QC G1V 0A6, Canada; CHU de Québec Research Center, CHUL Pavilion, Oncology Axis, Québec City, Québec G1V 4G2, Canada.
Zou L; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 18; Vol. 81 (4), pp. 784-800.e8. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Single-Stranded*
DNA Replication*
Poly (ADP-Ribose) Polymerase-1/*metabolism
Protein-Arginine N-Methyltransferases/*metabolism
Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line, Tumor ; HEK293 Cells ; Humans ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Poly (ADP-Ribose) Polymerase-1/genetics ; Protein-Arginine N-Methyltransferases/genetics ; RecQ Helicases/genetics ; RecQ Helicases/metabolism
Czasopismo naukowe

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