Temat: "DNA Topoisomerases" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Telling Your Right Hand from Your Left: The Effects of DNA Supercoil Handedness on the Actions of Type II Topoisomerases.
Autorzy:: Jian JY; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Osheroff N; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.; Department of Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, TN 37232, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 07; Vol. 24 (13). Date of Electronic Publication: 2023 Jul 07.
Typ publikacji:: Journal Article; Review
MeSH Terms:: DNA Topoisomerases, Type II*/metabolism
Functional Laterality*
Humans ; DNA ; Isomerases/genetics ; DNA Replication ; DNA Topoisomerases, Type I/metabolism

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Skocz do pozycji: 2.

Tytuł:: What's on the Other Side of the Gate: A Structural Perspective on DNA Gate Opening of Type IA and IIA DNA Topoisomerases.
Autorzy:: Vidmar V; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR 7104, Inserm U 1258, 67400 Illkirch, France.
Vayssières M; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR 7104, Inserm U 1258, 67400 Illkirch, France.
Lamour V; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR 7104, Inserm U 1258, 67400 Illkirch, France.; Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg, France.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 16; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:: Journal Article; Review
MeSH Terms:: DNA Topoisomerases*/metabolism
DNA*/chemistry
Isomerases/metabolism ; Catalytic Domain ; DNA Topoisomerases, Type I/metabolism ; DNA Topoisomerases, Type II/metabolism

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Skocz do pozycji: 3.

Tytuł:: Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life.
Autorzy:: Tan K; Structural Biology Center, X-ray Science Division, Advanced Photon Source, Argonne National Laboratory, 9700 S. Cass Avenue, Lemont, IL 60439, USA.
Tse-Dinh YC; Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA.; Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA.; Pokaż więcej
Źródło:: Cells [Cells] 2024 Mar 21; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:: Journal Article; Review
MeSH Terms:: DNA Topoisomerases, Type I*/chemistry
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
DNA*/metabolism
Humans ; DNA, Single-Stranded ; DNA Helicases/genetics ; RNA

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Skocz do pozycji: 4.

Tytuł:: Dual Topoisomerase I/II Inhibition-Induced Apoptosis and Necro-Apoptosis in Cancer Cells by a Novel Ciprofloxacin Derivative via RIPK1/RIPK3/MLKL Activation.
Autorzy:: Alaaeldin R; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt.
Abdel-Rahman IM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt.
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Bekhit AA; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Elhamadany EY; Innovative Research Center, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt.
Zhao QL; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Cui ZG; Department of Environmental Health, School of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Fathy M; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.; Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Nov 17; Vol. 27 (22). Date of Electronic Publication: 2022 Nov 17.
Typ publikacji:: Journal Article
MeSH Terms:: DNA Topoisomerases, Type I*/metabolism
Neoplasms*
Apoptosis ; Ciprofloxacin/pharmacology ; DNA Topoisomerases, Type II/metabolism ; Molecular Docking Simulation ; Protein Kinases/metabolism

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Skocz do pozycji: 5.

Tytuł:: Tumor growth-arrest effect of tetrahydroquinazoline-derivative human topoisomerase II-alpha inhibitor in HPV-negative head and neck squamous cell carcinoma.
Autorzy:: Sarogni P; Center for Nanotechnology Innovation@ NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12, 56126, Pisa, Italy.; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genoa, Italy.
Brindani N; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genoa, Italy.
Zamborlin A; Center for Nanotechnology Innovation@ NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12, 56126, Pisa, Italy.; NEST - Scuola Normale Superiore, Piazza San Silvestro, 12, 56126, Pisa, Italy.; Ghent Research Group on Nanomedicines, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000, Ghent, Belgium.
Gonnelli A; Center for Nanotechnology Innovation@ NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12, 56126, Pisa, Italy.; Department of Translational Medicine, University of Pisa, 56126, Pisa, Italy.
Menicagli M; Fondazione Pisana per la Scienza ONLUS, via Ferruccio Giovannini, 13, 56017, S. Giuliano Terme, Italy.
Mapanao AK; Center for Radiopharmaceutical Sciences, Paul Scherrer Institute (PSI), 5232, Villigen, Switzerland.
Munafò F; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genoa, Italy.
De Vivo M; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genoa, Italy. .
Voliani V; Center for Nanotechnology Innovation@ NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12, 56126, Pisa, Italy. .; Department of Pharmacy, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Apr 21; Vol. 14 (1), pp. 9150. Date of Electronic Publication: 2024 Apr 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: DNA Topoisomerases, Type II*/metabolism
Topoisomerase II Inhibitors*/pharmacology
Topoisomerase II Inhibitors*/therapeutic use
Squamous Cell Carcinoma of Head and Neck*/drug therapy
Squamous Cell Carcinoma of Head and Neck*/pathology
Humans ; Cell Line, Tumor ; Animals ; Quinazolines/pharmacology ; Quinazolines/therapeutic use ; Cell Proliferation/drug effects ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/pathology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Chick Embryo

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Skocz do pozycji: 6.

Tytuł:: Molecular Dynamics Investigations of Human DNA-Topoisomerase I Interacting with Novel Dewar Valence Photo-Adducts: Insights into Inhibitory Activity.
Autorzy:: Di Martino J; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.
Arcieri M; Department of Health Technology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
Madeddu F; Department of Computer Science, 'Sapienza' University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy.
Pieroni M; Department of Computer Science, 'Sapienza' University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy.
Carotenuto G; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.
Bottoni P; Department of Computer Science, 'Sapienza' University of Rome, P.le Aldo Moro, 5, 00185 Rome, Italy.
Botta L; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.
Castrignanò T; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.
Gabellone S; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.; Preclinic and Osteoncology Unit, Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', 47014 Meldola, Italy.
Saladino R; Department of Ecological and Biological Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 23; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 23.
Typ publikacji:: Journal Article
MeSH Terms:: Molecular Dynamics Simulation*
DNA Topoisomerases, Type I*
Humans ; Biomimetics ; DNA Adducts ; Data Interpretation, Statistical ; Pyrimidine Dimers

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Skocz do pozycji: 7.

Tytuł:: Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme.
Autorzy:: Swedan HK; Central Administration of Research and Health Development, Ministry of Health, and Population (MoHP), Cairo, Egypt.
Kassab AE; Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Cairo University, Cairo, Egypt.
Gedawy EM; Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Cairo University, Cairo, Egypt.; Faculty of Pharmacy and Pharmaceutical Industries, Department of Pharmaceutical Chemistry, Badr University in Cairo (BUC), Badr City, Egypt.
Elmeligie SE; Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Cairo University, Cairo, Egypt.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 118-137.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/chemistry
DNA Topoisomerases, Type II*/metabolism
Cell Line, Tumor ; Cell Proliferation ; Ciprofloxacin/pharmacology ; Ciprofloxacin/chemistry ; Dose-Response Relationship, Drug ; Doxorubicin/pharmacology ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship

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Skocz do pozycji: 8.

Tytuł:: Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae .
Autorzy:: García-López M; Unidad de Genética Bacteriana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Hernández P; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
Megias D; Unidad de Microscopía Confocal, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Ferrándiz MJ; Unidad de Genética Bacteriana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Campa AG; Unidad de Genética Bacteriana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.; Presidencia, Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 31; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:: Journal Article
MeSH Terms:: Transcriptome*
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Streptococcus pneumoniae/genetics ; DNA Gyrase/genetics ; DNA Gyrase/metabolism ; Anti-Bacterial Agents/pharmacology

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Skocz do pozycji: 9.

Tytuł:: Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation.
Autorzy:: Frese-Schaper M; Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Berlin, Germany.
Voll RE; Department of Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg, Germany.
Frese S; Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Berlin, Germany. .; Department of Thoracic Surgery, AMEOS Klinikum Schönebeck, Köthener Str. 13, D-39218, Schönebeck, Germany. .; Pokaż więcej
Źródło:: BMC research notes [BMC Res Notes] 2023 Oct 28; Vol. 16 (1), pp. 298. Date of Electronic Publication: 2023 Oct 28.
Typ publikacji:: Journal Article
MeSH Terms:: DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Lupus Erythematosus, Systemic*
Animals ; Mice ; Oligonucleotides ; Antibodies, Antinuclear/metabolism ; DNA/genetics

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Skocz do pozycji: 10.

Tytuł:: To Break or Not to Break: The Role of TOP2B in Transcription.
Autorzy:: Cowell IG; Biosciences Institute, The Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Casement JW; Bioinformatics Support Unit, The Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Austin CA; Biosciences Institute, The Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 30; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 30.
Typ publikacji:: Journal Article; Review
MeSH Terms:: DNA Topoisomerases, Type II*/genetics
DNA Topoisomerases, Type II*/metabolism
Transcription, Genetic*
Animals ; DNA ; DNA Replication ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; Mammals/metabolism ; Humans

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Skocz do pozycji: 11.

Tytuł:: Effects of In Vitro Digestion of Polyphenols from Coffee on Binding Parameters to Human Topoisomerase II α.
Autorzy:: Grzelczyk J; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-537 Lodz, Poland.
Pérez-Sánchez H; Structural Bioinformatics and High-Performance Computing Research Group (BIO-HPC), Computer Engineering Department, UCAM Universidad Católica de Murcia, Guadalupe, 30107 Murcia, Spain.
Carmena-Bargueño M; Structural Bioinformatics and High-Performance Computing Research Group (BIO-HPC), Computer Engineering Department, UCAM Universidad Católica de Murcia, Guadalupe, 30107 Murcia, Spain.
Oracz J; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-537 Lodz, Poland.
Budryn G; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-537 Lodz, Poland.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Aug 10; Vol. 28 (16). Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:: Journal Article
MeSH Terms:: Polyphenols*/pharmacology
DNA Topoisomerases, Type II*
Humans ; Molecular Docking Simulation ; Chlorogenic Acid/pharmacology ; Digestion

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Skocz do pozycji: 12.

Tytuł:: MSN8C: A Promising Candidate for Antitumor Applications as a Novel Catalytic Inhibitor of Topoisomerase II.
Autorzy:: Ou JB; Department of Pharmacy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Huang WH; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Liu XZ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Dai GY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Wang L; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Huang ZS; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou 510120, China.
Huang SL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou 510120, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Jul 24; Vol. 28 (14). Date of Electronic Publication: 2023 Jul 24.
Typ publikacji:: Journal Article
MeSH Terms:: DNA Topoisomerases, Type II*/metabolism
Antineoplastic Agents*/pharmacology
Humans ; Topoisomerase II Inhibitors/pharmacology ; Etoposide/pharmacology ; Cell Line, Tumor ; HL-60 Cells

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Skocz do pozycji: 13.

Tytuł:: StaR Is a Positive Regulator of Topoisomerase I Activity Involved in Supercoiling Maintenance in Streptococcus pneumoniae .
Autorzy:: de Vasconcelos Junior AA; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Tirado-Vélez JM; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Martín-Galiano AJ; Unidades Centrales Científico-Técnicas, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Megias D; Unidad de Microscopía Confocal, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Ferrándiz MJ; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
Hernández P; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
Amblar M; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.
de la Campa AG; Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain.; Presidencia, Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 22; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 22.
Typ publikacji:: Journal Article
MeSH Terms:: DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Streptococcus pneumoniae*/genetics
Streptococcus pneumoniae*/metabolism
Humans ; Novobiocin/pharmacology ; DNA, Bacterial/genetics ; DNA Gyrase/genetics ; DNA Gyrase/metabolism

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Skocz do pozycji: 14.

Tytuł:: Unraveling topoisomerase IA gate dynamics in presence of PPEF and its preclinical evaluation against multidrug-resistant pathogens.
Autorzy:: Maurya V; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Singh R; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Singh RK; Department of Chemistry, IIT Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Pandey S; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Yadav P; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Parashar P; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Gaind R; Vardhaman Medical College Hospital, Safdarjung Hospital, New Delhi, 110029, India.
Dubey KD; Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Gautam Buddha Nagar, Uttar Pradesh, 201314, India.
Naresh Patwari G; Department of Chemistry, IIT Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Tandon V; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2023 Feb 18; Vol. 6 (1), pp. 195. Date of Electronic Publication: 2023 Feb 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Escherichia coli*/genetics
DNA Topoisomerases, Type I*/chemistry
DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Animals ; Mice ; Bisbenzimidazole ; DNA ; DNA, Single-Stranded

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Skocz do pozycji: 15.

Tytuł:: Design, synthesis and in vitro anticancer activity of some new lomefloxacin derivatives.
Autorzy:: Adly ME; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini Street, Cairo, 11562, Egypt. .
Gedawy EM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini Street, Cairo, 11562, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University in Cairo, Cairo, 11829, Egypt.
El-Malah AA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini Street, Cairo, 11562, Egypt.
Khalil OM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini Street, Cairo, 11562, Egypt.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Mar 14; Vol. 14 (1), pp. 6175. Date of Electronic Publication: 2024 Mar 14.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Fluoroquinolones*
Humans ; Molecular Structure ; Structure-Activity Relationship ; Cell Line, Tumor ; DNA Topoisomerases, Type II/metabolism ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Dose-Response Relationship, Drug

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Skocz do pozycji: 16.

Tytuł:: Anthracyclines induce cardiotoxicity through a shared gene expression response signature.
Autorzy:: Matthews ER; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Johnson OD; Biochemistry, Cellular and Molecular Biology Graduate Program, University of Texas Medical Branch, Galveston, Texas, United States of America.
Horn KJ; John Sealy School of Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.
Gutiérrez JA; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Powell SR; Neuroscience Graduate Program, University of Texas Medical Branch, Galveston, Texas, United States of America.
Ward MC; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2024 Feb 28; Vol. 20 (2), pp. e1011164. Date of Electronic Publication: 2024 Feb 28 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Anthracyclines*/adverse effects
Anthracyclines*/metabolism
Cardiotoxicity*/genetics
Cardiotoxicity*/metabolism
Humans ; Female ; Antibiotics, Antineoplastic/adverse effects ; Antibiotics, Antineoplastic/metabolism ; Topoisomerase II Inhibitors/metabolism ; Topoisomerase II Inhibitors/pharmacology ; Doxorubicin/adverse effects ; Doxorubicin/metabolism ; Mitoxantrone/adverse effects ; Mitoxantrone/metabolism ; Myocytes, Cardiac/metabolism ; Daunorubicin/metabolism ; Daunorubicin/pharmacology ; Epirubicin/metabolism ; Epirubicin/pharmacology ; DNA Topoisomerases, Type II/genetics ; Gene Expression

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Skocz do pozycji: 17.

Tytuł:: Interaction of Camptothecin Anticancer Drugs with Ribosomal Proteins L15 and L11: A Molecular Docking Study.
Autorzy:: Bailly C; Institut de Chimie Pharmaceutique Albert Lespagnol (ICPAL), Faculté de Pharmacie, University of Lille, 3 rue du Professeur Laguesse, BP-83, F-59006 Lille, France.; CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, University of Lille, F-59000 Lille, France.; OncoWitan, Consulting Scientific Office, Wasquehal, F-59290 Lille, France.
Vergoten G; Institut de Chimie Pharmaceutique Albert Lespagnol (ICPAL), Faculté de Pharmacie, University of Lille, 3 rue du Professeur Laguesse, BP-83, F-59006 Lille, France.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 15; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:: Journal Article
MeSH Terms:: DNA Topoisomerases, Type I*/metabolism
Antineoplastic Agents*/pharmacology
Humans ; Molecular Docking Simulation ; Camptothecin ; Ribosomal Proteins/metabolism ; Topotecan/pharmacology ; DNA ; Topoisomerase I Inhibitors

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Skocz do pozycji: 18.

Tytuł:: Study of Genotoxicity, Activities on Caspase 8 and on the Stabilization of the Topoisomerase Complex of Isoeleutherin and Analogues.
Autorzy:: Albuquerque KCO; Postgraduate Program in Biodiversity and Biotechnology (BIONORTE), Federal University of Pará, Belém 66075-110, Brazil.
Galucio NCDR; Postgraduate Program in Genetics and Molecular Biology, Federal University of Pará, Belém 66075-110, Brazil.
Ferreira GG; Laboratory of Pharmacology of Neglected Diseases, Health Sciences Institute, Federal University of Pará, Belém 66075-110, Brazil.
Quaresma ACS; Postgraduate Program in Pharmaceutical Sciences, Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Vale VV; Postgraduate Program in Pharmaceutical Innovation, Federal University of Pará, Belém 66075-110, Brazil.
Bahia MO; Postgraduate Program in Neuroscience and Cell Biology, Federal University of Pará, Belém 66075-110, Brazil.
Burbano RMR; Postgraduate Program in Genetics and Molecular Biology, Federal University of Pará, Belém 66075-110, Brazil.; Postgraduate Program in Neuroscience and Cell Biology, Federal University of Pará, Belém 66075-110, Brazil.
Molfetta FA; Laboratory of Molecular Modeling, Institute of Exact and Natural Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Percario S; Postgraduate Program in Biodiversity and Biotechnology (BIONORTE), Federal University of Pará, Belém 66075-110, Brazil.
Dolabela MF; Postgraduate Program in Biodiversity and Biotechnology (BIONORTE), Federal University of Pará, Belém 66075-110, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Postgraduate Program in Pharmaceutical Innovation, Federal University of Pará, Belém 66075-110, Brazil.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 08; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 08.
Typ publikacji:: Journal Article
MeSH Terms:: DNA Damage*
DNA Topoisomerases, Type II*
Humans ; Molecular Docking Simulation ; Caspase 8

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Skocz do pozycji: 19.

Tytuł:: Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B.
Autorzy:: Ottaviani A; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.; Department of Onco-Hematology, Gene and Cell Therapy, Bambino Gesù Children's Hospital-IRCCS, 00146 Rome, Italy.
Iacovelli F; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
Welsch J; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Morozzo Della Rocca B; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
Desideri A; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
Falconi M; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.
Calcul L; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Baker BJ; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Fiorani P; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.; Institute of Translational Pharmacology, National Research Council, CNR, 00133 Rome, Italy.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Nov 03; Vol. 11 (21). Date of Electronic Publication: 2022 Nov 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: DNA Topoisomerases, Type I*/genetics
DNA Topoisomerases, Type I*/metabolism
Camptothecin*/pharmacology
Humans ; Molecular Docking Simulation ; DNA/metabolism

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Skocz do pozycji: 20.

Tytuł:: EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A.
Autorzy:: Wang K; Department of digestive surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; Department of General Surgery, Central Theater Command General Hospital of the Chinese People's Liberation Army, Wuhan, 430064, China.; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China.
Jiang X; Department of digestive surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China.
Jiang Y; Department of Hepatobiliary Surgery, XI'AN DAXING hospital, Xi'an, 710032, China.
Liu J; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China.
Du Y; Department of digestive surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China.
Zhang Z; Department of digestive surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China.
Li Y; Department of digestive surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Zhao X; Department of Thyroid and Breast Surgery, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, 710018, China.
Li J; Department of digestive surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. .; Department of Experimental Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. .
Zhang R; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, China. .; State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, 710032, China. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Nov 27; Vol. 42 (1), pp. 320. Date of Electronic Publication: 2023 Nov 27.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
Animals ; Humans ; Mice ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cellular Senescence/genetics ; DNA Topoisomerases, Type II/genetics ; DNA Topoisomerases, Type II/metabolism ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Histones/metabolism ; Mice, Nude

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