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    Wyświetlanie 1-16 z 16
    Tytuł:
    Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease.
    Autorzy:
    Chen S; Department of Neuroscience, College of Medicine, Ohio State University, Columbus, OH, 43210, USA.; Biomedical Sciences Graduate Program, Ohio State University, Columbus, OH, 43210, USA.
    Chang Y; Biomedical Sciences Graduate Program, Ohio State University, Columbus, OH, 43210, USA.; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, 43210, USA.
    Li L; Department of Neuroscience, College of Medicine, Ohio State University, Columbus, OH, 43210, USA.
    Acosta D; Department of Neuroscience, College of Medicine, Ohio State University, Columbus, OH, 43210, USA.
    Li Y; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, 43210, USA.
    Guo Q; Biomedical Sciences Graduate Program, Ohio State University, Columbus, OH, 43210, USA.; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, 43210, USA.
    Wang C; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, 43210, USA.
    Turkes E; UK Dementia Research Institute, UCL Queen Square Institute of Neurology, London, UK.
    Morrison C; Department of Neuroscience, College of Medicine, Ohio State University, Columbus, OH, 43210, USA.
    Julian D; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43205, USA.
    Hester ME; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43205, USA.
    Scharre DW; Department of Neurology, Center for Cognitive and Memory Disorders, Center for Neuromodulation, Ohio State University, Columbus, OH, 43210, USA.
    Santiskulvong C; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
    Song SX; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
    Plummer JT; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
    Serrano GE; Banner Sun Health Research Institute, Sun City, AZ, 85351, USA.
    Beach TG; Banner Sun Health Research Institute, Sun City, AZ, 85351, USA.
    Duff KE; UK Dementia Research Institute, UCL Queen Square Institute of Neurology, London, UK.
    Ma Q; Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, 43210, USA. .
    Fu H; Department of Neuroscience, College of Medicine, Ohio State University, Columbus, OH, 43210, USA. .
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    Źródło:
    Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Dec 21; Vol. 10 (1), pp. 188. Date of Electronic Publication: 2022 Dec 21.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Alzheimer Disease*/genetics
    Alzheimer Disease*/pathology
    Temporal Lobe*/metabolism
    Transcriptome*
    Humans ; Amyloid beta-Peptides/metabolism ; In Situ Hybridization, Fluorescence ; Kinesins/genetics ; Kinesins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    P62 accumulates through neuroanatomical circuits in response to tauopathy propagation.
    Autorzy:
    Blaudin de Thé FX; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, 630 W 168th St, NY, 10032, New York, USA.; Neuroscience and Immunoinflammation Therapeutic Area, Institut de Recherche Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.
    Lassus B; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, 630 W 168th St, NY, 10032, New York, USA.; HiFiBiO Therapeutics Pépinière Paris Santé Cochin, 29 Rue du Faubourg Saint-Jacques, 75014, Paris, France.
    Schaler AW; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, 630 W 168th St, NY, 10032, New York, USA.; UCLA - Physiology Department, 10833 Le Conte Ave, CHS76200, CA, 90095, Los Angeles, USA.
    Fowler SL; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, 630 W 168th St, NY, 10032, New York, USA.; UK Dementia Research Institute at UCL, University College London, 90 Gower St, W1T 7NF, London, UK.
    Goulbourne CN; Nathan Kline Institute: Center for Dementia Research, 140 Old Orangeburg Road, NY, 10962, Orangeburg, USA.
    Jeggo R; Neuroscience and Immunoinflammation Therapeutic Area, Institut de Recherche Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.
    Mannoury la Cour C; Neuroscience and Immunoinflammation Therapeutic Area, Institut de Recherche Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.
    Millan MJ; Neuroscience and Immunoinflammation Therapeutic Area, Institut de Recherche Servier, 125 Chemin de Ronde, 78290, Croissy-sur-Seine, France.; Institute of Neuroscience and Psychology, College of Medicine, Vet and Life Science, Glasgow University, Glasgow, G12 8QQ, United Kingdom.
    Duff KE; Taub Institute for Research On Alzheimer's Disease and the Aging Brain, 630 W 168th St, NY, 10032, New York, USA. k.duff@ucl.ac.uk.; UK Dementia Research Institute at UCL, University College London, 90 Gower St, W1T 7NF, London, UK. k.duff@ucl.ac.uk.
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    Źródło:
    Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Nov 02; Vol. 9 (1), pp. 177. Date of Electronic Publication: 2021 Nov 02.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Brain/*pathology
    Neurons/*pathology
    Sequestosome-1 Protein/*metabolism
    Tauopathies/*pathology
    Animals ; Brain/metabolism ; Disease Progression ; Humans ; Mice ; Neurons/metabolism ; Tauopathies/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus.
    Autorzy:
    Rodriguez GA; Taub Institute for Research on Alzheimer's disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America.
    Barrett GM; Taub Institute for Research on Alzheimer's disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America.
    Duff KE; Taub Institute for Research on Alzheimer's disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America.; UK Dementia Research Institute at University College London, London, United Kingdom.
    Hussaini SA; Taub Institute for Research on Alzheimer's disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America.
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    Źródło:
    PLoS biology [PLoS Biol] 2020 Aug 21; Vol. 18 (8), pp. e3000851. Date of Electronic Publication: 2020 Aug 21 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Alzheimer Disease/*genetics
    Amyloid beta-Protein Precursor/*genetics
    Entorhinal Cortex/*metabolism
    Tauopathies/*genetics
    tau Proteins/*genetics
    Action Potentials/physiology ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/therapy ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Dependovirus/genetics ; Dependovirus/metabolism ; Disease Models, Animal ; Electrodes, Implanted ; Entorhinal Cortex/pathology ; Female ; Gene Expression Regulation ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Hippocampus/metabolism ; Hippocampus/pathology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Neurons/pathology ; Protein Aggregates ; Stereotaxic Techniques ; Tauopathies/metabolism ; Tauopathies/pathology ; Tauopathies/therapy ; Theta Rhythm/physiology ; Transduction, Genetic ; Transgenes ; tau Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice.
    Autorzy:
    Area-Gomez E; Department of Neurology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.; Institute of Human Nutrition, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.
    Larrea D; Department of Neurology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.
    Pera M; Department of Neurology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.; Department of Basic Sciences, Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya (UIC), 08195, Sant Cugat del Vallés, Spain.
    Agrawal RR; Institute of Human Nutrition, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.
    Guilfoyle DN; Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute, Orangeburg, NY, 10962, USA.
    Pirhaji L; Department of Biological Engineering, Massachusetts Institute of Technology, 350 Brookline Street, Cambridge, MA, 02139, USA.
    Shannon K; Animal Facility, Nathan S. Kline Institute, Orangeburg, NY, 10962, USA.
    Arain HA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.; Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.
    Ashok A; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.; Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.
    Chen Q; Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA.
    Dillman AA; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, 20892, USA.
    Figueroa HY; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.; Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.
    Cookson MR; Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, 20892, USA.
    Gross SS; Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA.
    Fraenkel E; Department of Biological Engineering, Massachusetts Institute of Technology, 350 Brookline Street, Cambridge, MA, 02139, USA.; Broad Institute, 415 Main Street, Cambridge, MA 02142, Cambridge, Massachusetts, 02139, USA.
    Duff KE; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.; Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.; UK Dementia Research Institute, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.
    Nuriel T; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 West 168th Street, New York, NY, 10032, USA. .; Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA. .
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    Źródło:
    Scientific reports [Sci Rep] 2020 Mar 09; Vol. 10 (1), pp. 4277. Date of Electronic Publication: 2020 Mar 09.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Metabolome*
    Transcriptome*
    Apolipoprotein E4/*genetics
    Brain/*metabolism
    Energy Metabolism/*genetics
    Mitochondria/*pathology
    Animals ; Male ; Mice ; Mitochondria/genetics ; Mitochondria/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice.
    Autorzy:
    Fu H; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America.
    Hussaini SA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America.
    Wegmann S; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America.
    Profaci C; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America.
    Daniels JD; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America.
    Herman M; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America.
    Emrani S; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America.
    Figueroa HY; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America.
    Hyman BT; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America.
    Davies P; Litwin-Zucker Center for Research in Alzheimer's Disease, Feinstein Institute for Medical Research, North Shore/LIJ Health System, Manhasset, New York, United States of America.
    Duff KE; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America.
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    Źródło:
    PloS one [PLoS One] 2016 Jul 28; Vol. 11 (7), pp. e0159463. Date of Electronic Publication: 2016 Jul 28 (Print Publication: 2016).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Memory Disorders/*metabolism
    Neurons/*metabolism
    tau Proteins/*metabolism
    Animals ; Gliosis/metabolism ; Humans ; Mice ; Mice, Transgenic ; tau Proteins/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.
    Autorzy:
    Fá M; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Puzzo D; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.; Department of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Catania, 95125 Italy.
    Piacentini R; Institute of Human Physiology, Università Cattolica del Sacro Cuore, Rome, 00168 Italy.
    Staniszewski A; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Zhang H; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Baltrons MA; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.; Department of Biochemistry and Molecular Biology, Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain.
    Li Puma DD; Institute of Human Physiology, Università Cattolica del Sacro Cuore, Rome, 00168 Italy.
    Chatterjee I; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.; Oligomerix, Inc., Oligomerix, Inc., 7 Legion Drive, Suite 101, Valhalla, NY 10595, USA.
    Li J; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.; Department of Neurology, Third Military Medical University, Chongqing, 400042, China.
    Saeed F; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Berman HL; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Ripoli C; Institute of Human Physiology, Università Cattolica del Sacro Cuore, Rome, 00168 Italy.
    Gulisano W; Department of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Catania, 95125 Italy.
    Gonzalez J; Translational Technology Core Laboratory, Rockefeller University, New York, NY 10065, USA.
    Tian H; Department of Chemical Engineering, ASU, Tempe, AZ 85281, USA.
    Costa JA; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Lopez P; Oligomerix, Inc., Oligomerix, Inc., 7 Legion Drive, Suite 101, Valhalla, NY 10595, USA.
    Davidowitz E; Oligomerix, Inc., Oligomerix, Inc., 7 Legion Drive, Suite 101, Valhalla, NY 10595, USA.
    Yu WH; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Haroutunian V; Department of Psychiatry, The Mount Sinai School of Medicine, JJ-Peters VA Medical Center, Bronx, NY 10468, USA.
    Brown LM; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
    Palmeri A; Department of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Catania, 95125 Italy.
    Sigurdsson EM; Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA.
    Duff KE; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Teich AF; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Honig LS; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
    Sierks M; Translational Technology Core Laboratory, Rockefeller University, New York, NY 10065, USA.
    Moe JG; Oligomerix, Inc., Oligomerix, Inc., 7 Legion Drive, Suite 101, Valhalla, NY 10595, USA.
    D'Adamio L; Department of Microbiology and Immunology, Einstein College of Medicine, Bronx, NY 10461, USA.
    Grassi C; Institute of Human Physiology, Università Cattolica del Sacro Cuore, Rome, 00168 Italy.; San Raffaele Pisana Scientific Institute for Research, Hospitalization and Health Care, Rome, 00163, Italy.
    Kanaan NM; Department of Translational Science and Molecular Medicine, College of Human Medicine, MSU, Grand Rapids, MI, 49503, USA.
    Fraser PE; Tanz Centre for Research in Neurodegenerative Diseases and Department of Medical Biophysics, University of Toronto, 60 Leonard Avenue, Toronto, Ontario M5T 2S8 Toronto, Canada.
    Arancio O; Department of Pathology and Cell Biology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St. New York, NY 10032 USA.
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    Źródło:
    Scientific reports [Sci Rep] 2016 Jan 20; Vol. 6, pp. 19393. Date of Electronic Publication: 2016 Jan 20.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Long-Term Potentiation*
    Memory*
    Protein Aggregates*
    Protein Aggregation, Pathological*
    Protein Multimerization*
    tau Proteins/*metabolism
    Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/psychology ; Amyloid beta-Peptides/metabolism ; Animals ; Disease Models, Animal ; Extracellular Space/metabolism ; Hippocampus/metabolism ; Hippocampus/pathology ; Mice ; Neurons/metabolism ; tau Proteins/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.
    Autorzy:
    Khan UA; 1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, USA. [2] Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA. [3] Program in Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
    Liu L; 1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, USA. [2] Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
    Provenzano FA; 1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, USA. [2] Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
    Berman DE; 1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, USA. [2] Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
    Profaci CP; 1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, USA. [2] Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
    Sloan R; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.
    Mayeux R; 1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, USA. [2] Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
    Duff KE; 1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, USA. [2] Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
    Small SA; 1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, USA. [2] Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA. [3] Department of Radiology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
    Pokaż więcej
    Źródło:
    Nature neuroscience [Nat Neurosci] 2014 Feb; Vol. 17 (2), pp. 304-11. Date of Electronic Publication: 2013 Dec 22.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Brain Mapping*
    Alzheimer Disease/*genetics
    Alzheimer Disease/*pathology
    Cortical Spreading Depression/*physiology
    Entorhinal Cortex/*physiopathology
    Functional Laterality/*physiology
    Age Factors ; Aged ; Aged, 80 and over ; Alzheimer Disease/complications ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Analysis of Variance ; Animals ; Cognition Disorders/etiology ; Cognition Disorders/genetics ; Cortical Spreading Depression/genetics ; Disease Progression ; Entorhinal Cortex/blood supply ; Entorhinal Cortex/pathology ; Female ; Gene Expression/genetics ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Mice ; Mice, Transgenic ; Mutation/genetics ; Nerve Tissue Proteins/metabolism ; Oxygen/blood ; tau Proteins/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.
    Autorzy:
    O'Leary JC 3rd; Department of Molecular Medicine, Byrd Alzheimer's Research Institute, University of South Florida, Tampa, FL 33613, USA. .
    Li Q
    Marinec P
    Blair LJ
    Congdon EE
    Johnson AG
    Jinwal UK
    Koren J 3rd
    Jones JR
    Kraft C
    Peters M
    Abisambra JF
    Duff KE
    Weeber EJ
    Gestwicki JE
    Dickey CA
    Pokaż więcej
    Źródło:
    Molecular neurodegeneration [Mol Neurodegener] 2010 Nov 01; Vol. 5, pp. 45. Date of Electronic Publication: 2010 Nov 01.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-16 z 16

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