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Wyświetlanie 1-20 z 2856
Tytuł:
12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-δ/PKD/ERK Signaling Pathway.
Autorzy:
Tsai JY; Graduate Institute of Natural Products, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Rédei D; Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Hohmann J; Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Wu CC; Graduate Institute of Natural Products, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 14; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 14.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Carcinogens/*pharmacology
Cell Proliferation/*drug effects
Phorbol Esters/*pharmacology
Signal Transduction/*drug effects
A549 Cells ; Carcinogens/chemistry ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Phorbol Esters/chemistry ; Protein Kinase C/metabolism ; Protein Kinase C-delta/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibitory effects of 4-hydroperoxy-2-decenoic acid ethyl ester on phorbol ester- and TGF-β1-induced MMPs expression.
Autorzy:
Kamiya T; Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
Tanaka M; Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
Hara H; Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
Yamaguchi E; Laboratory of Pharmaceutical Synthetic Chemistry, Gifu Pharmaceutical University, Gifu, Japan.
Itoh A; Laboratory of Pharmaceutical Synthetic Chemistry, Gifu Pharmaceutical University, Gifu, Japan.
Adachi T; Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
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Źródło:
Free radical research [Free Radic Res] 2019 Dec; Vol. 53 (11-12), pp. 1051-1059. Date of Electronic Publication: 2019 Oct 14.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Esters/*pharmacology
Fatty Acids/*pharmacology
Fatty Acids, Monounsaturated/*pharmacology
Matrix Metalloproteinases/*biosynthesis
Phorbol Esters/*pharmacology
Prostatic Neoplasms/*drug therapy
Transforming Growth Factor beta1/*antagonists & inhibitors
Antineoplastic Agents/chemistry ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Esters/chemistry ; Fatty Acids/chemistry ; Fatty Acids, Monounsaturated/chemistry ; Humans ; Male ; Matrix Metalloproteinases/genetics ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phorbol ester-type diterpenoids from the twigs and leaves of Croton tiglium.
Autorzy:
Jiang L; a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.; b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
Zhang YB; a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.; b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
Jiang SQ; a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.; b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
Zhou YD; a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.; b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
Luo D; a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.; b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
Niu QW; a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.; b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
Qian YR; a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.; b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
Li YL; a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.; b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
Wang GC; a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.; b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
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Źródło:
Journal of Asian natural products research [J Asian Nat Prod Res] 2017 Dec; Vol. 19 (12), pp. 1191-1197. Date of Electronic Publication: 2017 Apr 04.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic/*isolation & purification
Croton/*chemistry
Diterpenes/*isolation & purification
Phorbol Esters/*isolation & purification
Plant Components, Aerial/*chemistry
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Diterpenes/chemistry ; Diterpenes/pharmacology ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Phorbol Esters/economics ; Phorbol Esters/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae.
Autorzy:
Chen H; Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China. .; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, Yunnan, China. .
Zhang R; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China. .
Luo RH; Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China. .
Yang LM; Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China. .
Wang RR; Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China. .
Hao XJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China. .
Zheng YT; Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China. .; KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, Suzhou 215006, Jiangsu, China. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2017 Sep 08; Vol. 22 (9). Date of Electronic Publication: 2017 Sep 08.
Typ publikacji:
Journal Article
MeSH Terms:
Host-Pathogen Interactions*
Anti-HIV Agents/*pharmacology
Euphorbiaceae/*chemistry
HIV-1/*drug effects
Phorbol Esters/*pharmacology
Virion/*drug effects
Virus Replication/*drug effects
APOBEC-3G Deaminase/genetics ; APOBEC-3G Deaminase/metabolism ; Anti-HIV Agents/chemistry ; Anti-HIV Agents/isolation & purification ; Cell Line ; DNA, Viral/antagonists & inhibitors ; DNA, Viral/biosynthesis ; Gene Expression Regulation ; HIV-1/genetics ; HIV-1/metabolism ; HIV-2/drug effects ; HIV-2/genetics ; HIV-2/metabolism ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/virology ; Mutation ; Phorbol Esters/chemistry ; Phorbol Esters/isolation & purification ; Plant Extracts/chemistry ; Primary Cell Culture ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Signal Transduction ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism ; T-Lymphocytes/virology ; Virion/genetics ; Virion/metabolism ; vif Gene Products, Human Immunodeficiency Virus/deficiency ; vif Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hydroxy-octadecenoic acids instead of phorbol esters are responsible for the Jatropha curcas kernel cake's toxicity.
Autorzy:
Wang XH; Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, Yunnan, P. R. China.
Liu JQ; School of Biomedical Sciences, Huaqiao University, 362021, Quanzhou, P. R. China.
Chen S; Biocontrol Engineering Research Center of Plant Disease & Pest, Kunming, 650091, Yunnan, P. R. China.; Biocontrol Engineering Research Center of Crop Disease & Pest, Kunming, 650091, Yunnan, P. R. China.
Yin Y; Biomedical Research Center, Calmette Hospital of Kunming Medical University (Kunming First People's Hospital), Kunming, 650011, Yunnan, P. R. China.
Liu Y; Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, Yunnan, P. R. China.
Zhang C; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB)/Department of Biology and Environment, Universidade de Trás-os-Montes e Alto Douro (UTAD), Apartado 1013, 5001-801, Vila Real, Portugal. .; Instituto de Tecnologia Química e Biológica António Xavier (Green-it Unit), Universidade Nova de Lisboa, 2780-157, Oeiras, Portugal. .
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Źródło:
Communications biology [Commun Biol] 2020 May 08; Vol. 3 (1), pp. 228. Date of Electronic Publication: 2020 May 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Jatropha/*toxicity
Oleic Acids/*chemistry
Phorbol Esters/*chemistry
Seeds/*chemistry
Animals ; Carps ; Goldfish ; Guinea Pigs ; Humans ; Jatropha/chemistry ; MCF-7 Cells ; Mice ; Rats ; Rats, Sprague-Dawley ; Seeds/toxicity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Paper spray portable mass spectrometry for screening of phorbol ester contamination in glycerol-based medical products.
Autorzy:
Wickramasekara S; Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA. .
Kaushal R; Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
Li H; Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, Jiangsu, China.
Patwardhan D; Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2019 May; Vol. 411 (12), pp. 2707-2714. Date of Electronic Publication: 2019 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Contamination*
Paper*
Fluorescent Dyes/*chemistry
Glycerol/*chemistry
Mass Spectrometry/*methods
Phorbol Esters/*analysis
Animals ; Biocompatible Materials ; Ferric Compounds/chemistry ; Flowers/chemistry ; Humans ; Jatropha/chemistry ; Jatropha/embryology ; Limit of Detection ; Microscopy, Electron, Transmission ; Seeds/chemistry ; Spectrophotometry, Ultraviolet ; Spectrum Analysis/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reactive oxygen species are responsible for the cell aggregation and production of pro-inflammatory mediators in phorbol ester (PMA)-treated U937 cells on gelatin-coated dishes through upregulation of autophagy.
Autorzy:
Zhao YL; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Zhang X; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu WW; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Yang YT; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Gao ZK; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu XL; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Liu W; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Hayashi T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
Yamato M; b Institute of Advanced Biomedical Engineering and Science , Tokyo Women's Medical University , Tokyo , Japan.
Fujisaki H; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Hattori S; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Mizuno K; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Atsuzawa Y; c Nippi Research Institute of Biomatrix , Toride, Ibaraki , Japan.
Tashiro SI; d Department of Medical Education and Primary Care , Kyoto Prefectural University of Medicine , Kyoto , Japan.
Onodera S; e Department of Clinical and Pharmaceutical Sciences , Showa Pharmaceutical University , Tokyo , Japan.
Ikejima T; a China-Japan Research Institute of Medical and Pharmaceutical Sciences , Shenyang Pharmaceutical University , Shenyang , China.
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Źródło:
Connective tissue research [Connect Tissue Res] 2019 Jul; Vol. 60 (4), pp. 323-334. Date of Electronic Publication: 2018 Dec 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy/*drug effects
Gelatin/*chemistry
Inflammation Mediators/*metabolism
Phorbol Esters/*pharmacology
Reactive Oxygen Species/*metabolism
Up-Regulation/*drug effects
Animals ; Cell Aggregation/drug effects ; Cell Differentiation/drug effects ; Dinoprostone/metabolism ; Humans ; Interleukin-1beta/metabolism ; Models, Biological ; Signal Transduction/drug effects ; Swine ; Tumor Necrosis Factor-alpha/metabolism ; U937 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Convenient Oligonucleotide Conjugation via Tandem Staudinger Reaction and Amide Bond Formation at the Internucleotidic Phosphate Position.
Autorzy:
Klabenkova, Kristina V. (AUTHOR)
Zhdanova, Polina V. (AUTHOR)
Burakova, Ekaterina A. (AUTHOR)
Bizyaev, Sergei N. (AUTHOR)
Fokina, Alesya A. (AUTHOR)
Stetsenko, Dmitry A. (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 4, p2007. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bayesian Multi-Trait Analysis Reveals a Useful Tool to Increase Oil Concentration and to Decrease Toxicity in Jatropha curcas L.
Autorzy:
Silva Junqueira V; Animal Science Department, Federal University of Viçosa, Viçosa, Minas Gerais, zipcode: 36570-000, Brazil.
Azevedo Peixoto Ld; Biology Department, Federal University Viçosa, Viçosa, Minas Gerais, zipcode: 36570-000, Brazil.
Galvêas Laviola B; Empresa Brasileira de Pesquisa Agropecuária, Embrapa Agroenergia, Parque Estação Biológica-PqEB s/n, Asa Norte, zipcode: 70770901, Brasília, Brazil.
Lopes Bhering L; Biology Department, Federal University Viçosa, Viçosa, Minas Gerais, zipcode: 36570-000, Brazil.
Mendonça S; Empresa Brasileira de Pesquisa Agropecuária, Embrapa Agroenergia, Parque Estação Biológica-PqEB s/n, Asa Norte, zipcode: 70770901, Brasília, Brazil.
Agostini Costa Tda S; Empresa Brasileira de Pesquisa Agropecuária, Centro Nacional de Pesquisa de Recursos Genéticos e Biotecnologia, Parque Estação Biológica, PqEB, W5 Norte, Final PqEB, zipcode: 70770917, Brasília, Brazil.
Antoniassi R; Empresa Brasileira de Pesquisa Agropecuária, Centro Nacional de Pesquisa de Tecnologia Agroindustrial de Alimentos, Avenida das Americas 29501 Guaratiba, zipcode: 23020470, Rio de Janeiro, Brazil.
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Źródło:
PloS one [PLoS One] 2016 Jun 09; Vol. 11 (6), pp. e0157038. Date of Electronic Publication: 2016 Jun 09 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Quantitative Trait, Heritable*
Jatropha/*genetics
Phorbol Esters/*metabolism
Plant Oils/*chemistry
Seeds/*genetics
Bayes Theorem ; Genetic Variation ; Jatropha/growth & development ; Phenotype ; Phorbol Esters/toxicity ; Seeds/growth & development
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia.
Autorzy:
Pérez-Fernández A; Department of Biochemistry and Molecular Biology, University of Salamanca, Edificio Departamental, Lab 122, Plaza Doctores de la Reina, S/N, P.O. 37007, Salamanca, Spain.; IBSAL, Institute for Biomedical Research of Salamanca, Virgen de la Vega Hospital, 10th floor, Paseo de San Vicente, 58-182, P.O. 37007, Salamanca, Spain.
López-Ruano G; Department of Biochemistry and Molecular Biology, University of Salamanca, Edificio Departamental, Lab 122, Plaza Doctores de la Reina, S/N, P.O. 37007, Salamanca, Spain.; IBSAL, Institute for Biomedical Research of Salamanca, Virgen de la Vega Hospital, 10th floor, Paseo de San Vicente, 58-182, P.O. 37007, Salamanca, Spain.
Prieto-Bermejo R; Department of Biochemistry and Molecular Biology, University of Salamanca, Edificio Departamental, Lab 122, Plaza Doctores de la Reina, S/N, P.O. 37007, Salamanca, Spain.; IBSAL, Institute for Biomedical Research of Salamanca, Virgen de la Vega Hospital, 10th floor, Paseo de San Vicente, 58-182, P.O. 37007, Salamanca, Spain.
Ijurko C; Department of Biochemistry and Molecular Biology, University of Salamanca, Edificio Departamental, Lab 122, Plaza Doctores de la Reina, S/N, P.O. 37007, Salamanca, Spain.; IBSAL, Institute for Biomedical Research of Salamanca, Virgen de la Vega Hospital, 10th floor, Paseo de San Vicente, 58-182, P.O. 37007, Salamanca, Spain.
Díez-Campelo M; IBSAL, Institute for Biomedical Research of Salamanca, Virgen de la Vega Hospital, 10th floor, Paseo de San Vicente, 58-182, P.O. 37007, Salamanca, Spain.; Hematology Department, University Hospital of Salamanca, Paseo de San Vicente, 139, P.O. 37007, Salamanca, Spain.
Sánchez-Guijo F; IBSAL, Institute for Biomedical Research of Salamanca, Virgen de la Vega Hospital, 10th floor, Paseo de San Vicente, 58-182, P.O. 37007, Salamanca, Spain.; Hematology Department, University Hospital of Salamanca, Paseo de San Vicente, 139, P.O. 37007, Salamanca, Spain.
Hernández-Hernández Á; Department of Biochemistry and Molecular Biology, University of Salamanca, Edificio Departamental, Lab 122, Plaza Doctores de la Reina, S/N, P.O. 37007, Salamanca, Spain. .; IBSAL, Institute for Biomedical Research of Salamanca, Virgen de la Vega Hospital, 10th floor, Paseo de San Vicente, 58-182, P.O. 37007, Salamanca, Spain. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Feb 14; Vol. 38 (1), pp. 80. Date of Electronic Publication: 2019 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation/*drug effects
Leukemia, Myeloid, Acute/*pathology
Phorbol Esters/*pharmacology
Protein Tyrosine Phosphatase, Non-Receptor Type 11/*metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 6/*metabolism
Animals ; Female ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Male ; Mice, Inbred NOD ; Mice, SCID ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes.
Autorzy:
Cooke M; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Casado-Medrano V; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ann J; Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Lee J; Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Blumberg PM; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, Bethesda, MD, 20892, USA.
Abba MC; Centro de Investigaciones Inmunológicas Básicas y Aplicadas, Universidad Nacional de La Plata, CP1900, La Plata, Argentina. .
Kazanietz MG; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Apr 15; Vol. 9 (1), pp. 6041. Date of Electronic Publication: 2019 Apr 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Enzyme Activation/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Lactones/*pharmacology
Lung Neoplasms/*genetics
Phorbol Esters/*pharmacology
Protein Kinase C/*metabolism
A549 Cells ; Diglycerides/pharmacology ; Drug Discovery ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Ligands ; Lung Neoplasms/drug therapy ; Lung Neoplasms/enzymology ; Lung Neoplasms/metabolism ; Protein Kinase C/genetics ; Transcriptome/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Reactivation of latent HIV-1 in vitro using an ethanolic extract from Euphorbia umbellata (Euphorbiaceae) latex.
Autorzy:
Valadão ALC; Laboratório de Virologia Molecular, Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Pezzuto P; Laboratório de Virologia Molecular, Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Silva VAO; Centro de Pesquisa em Oncologia Molecular, Hospital de Câncer de Barretos, Barretos, Brazil.
Gonçalves BS; Departamento de Microbiologia e Parasitologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Rossi ÁD; Laboratório de Virologia Molecular, Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
da Cunha RD; Laboratório de Virologia Molecular, Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Siani AC; Departamento de Produtos Naturais, Instituto de Tecnologia em Fármacos, Fundação Oswaldo Cruz, Rio de Janeiro Brazil.
Tostes JBF; Departamento de Produtos Naturais, Instituto de Tecnologia em Fármacos, Fundação Oswaldo Cruz, Rio de Janeiro Brazil.
Trovó M; Departamento de Botânica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Damasco P; Departamento de Microbiologia e Parasitologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Gonçalves G; Laboratório de Virologia Molecular, Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Reis RM; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Aguiar RS; Laboratório de Virologia Molecular, Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Bento CAM; Departamento de Microbiologia e Parasitologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Tanuri A; Laboratório de Virologia Molecular, Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
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Źródło:
PloS one [PLoS One] 2018 Nov 27; Vol. 13 (11), pp. e0207664. Date of Electronic Publication: 2018 Nov 27 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Euphorbia/*chemistry
HIV-1/*drug effects
Latex/*chemistry
Phorbol Esters/*pharmacology
Plant Extracts/*pharmacology
Virus Activation/*drug effects
Cell Survival/drug effects ; Cells, Cultured ; Cytokines/metabolism ; Ethanol/chemistry ; HIV-1/physiology ; Host-Pathogen Interactions/drug effects ; Humans ; Jurkat Cells ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/virology ; Virus Latency/drug effects ; Virus Latency/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-dose PMA with RANKL and MCSF induces THP‑1 cell differentiation into human functional osteoclasts in vitro.
Autorzy:
Li ZH; Department of Otolaryngology Head and Neck Surgery, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China.
Si Y; Department of Otolaryngology Head and Neck Surgery, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China.
Xu G; Department of Otolaryngology Head and Neck Surgery, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China.
Chen XM; Department of Otolaryngology Head and Neck Surgery, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China.
Xiong H; Department of Otolaryngology Head and Neck Surgery, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China.
Lai L; Department of Otolaryngology Head and Neck Surgery, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China.
Zheng YQ; Department of Otolaryngology Head and Neck Surgery, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China.
Zhang ZG; Department of Otolaryngology Head and Neck Surgery, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 Dec; Vol. 16 (6), pp. 8380-8384. Date of Electronic Publication: 2017 Sep 26.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation/*drug effects
Macrophage Colony-Stimulating Factor/*pharmacology
Osteoclasts/*cytology
Phorbol Esters/*pharmacology
RANK Ligand/*pharmacology
Bone Resorption/metabolism ; Bone Resorption/pathology ; Cells, Cultured ; Humans ; Macrophages/cytology ; Macrophages/metabolism ; THP-1 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Detoxification of toxic phorbol esters from Malaysian Jatropha curcas Linn. kernel by Trichoderma spp. and endophytic fungi.
Autorzy:
Najjar A; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. .
Abdullah N; Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. .
Saad WZ; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. .
Ahmad S; Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. .
Oskoueian E; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. .
Abas F; Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. faridah_.
Gherbawy Y; Department of Biology, Faculty of Science, Taif University, P.O. Box: 888-Taif, Taif 21974, Saudi Arabia. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2014 Feb 05; Vol. 15 (2), pp. 2274-88. Date of Electronic Publication: 2014 Feb 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biotransformation*
Endophytes/*metabolism
Jatropha/*chemistry
Phorbol Esters/*chemistry
Trichoderma/*metabolism
Animal Feed ; Animals ; Carbon/metabolism ; Cell Line ; Cell Survival/drug effects ; Chemical Fractionation ; Culture Media ; Fermentation ; Humans ; Phorbol Esters/toxicity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Control of ADAM17 activity by regulation of its cellular localisation.
Autorzy:
Lorenzen I; Institute of Biochemistry, Kiel University, Olshausenstr 40, 24098 Kiel, Germany.
Lokau J; Institute of Biochemistry, Kiel University, Olshausenstr 40, 24098 Kiel, Germany.
Korpys Y; Institute of Biochemistry, Kiel University, Olshausenstr 40, 24098 Kiel, Germany.
Oldefest M; Institute of Biochemistry, Kiel University, Olshausenstr 40, 24098 Kiel, Germany.
Flynn CM; Institute of Biochemistry, Kiel University, Olshausenstr 40, 24098 Kiel, Germany.
Künzel U; Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.
Garbers C; Institute of Biochemistry, Kiel University, Olshausenstr 40, 24098 Kiel, Germany.
Freeman M; Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.
Grötzinger J; Institute of Biochemistry, Kiel University, Olshausenstr 40, 24098 Kiel, Germany.
Düsterhöft S; Institute of Biochemistry, Kiel University, Olshausenstr 40, 24098 Kiel, Germany.; Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK.
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Źródło:
Scientific reports [Sci Rep] 2016 Oct 12; Vol. 6, pp. 35067. Date of Electronic Publication: 2016 Oct 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
ADAM17 Protein/*metabolism
Cell Membrane/*metabolism
Clathrin-Coated Vesicles/*metabolism
Phorbol Esters/*pharmacology
Down-Regulation ; Enzyme Activation/drug effects ; HEK293 Cells ; HeLa Cells ; Humans ; Protein Kinase C/metabolism ; Proteolysis/drug effects ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Phorbol esters from Jatropha meal triggered apoptosis, activated PKC-δ, caspase-3 proteins and down-regulated the proto-oncogenes in MCF-7 and HeLa cancer cell lines.
Autorzy:
Oskoueian E; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Abdullah N
Ahmad S
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2012 Sep 10; Vol. 17 (9), pp. 10816-30. Date of Electronic Publication: 2012 Sep 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Caspase 3/*metabolism
Jatropha/*chemistry
Phorbol Esters/*pharmacology
Protein Kinase C-delta/*metabolism
Proto-Oncogenes/*drug effects
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Proliferation/drug effects ; Down-Regulation ; Enzyme Activation ; HeLa Cells ; Humans ; MCF-7 Cells ; Phorbol Esters/chemistry ; Phorbol Esters/isolation & purification ; Proto-Oncogene Proteins c-fos/metabolism ; Proto-Oncogene Proteins c-jun/metabolism ; Proto-Oncogene Proteins c-myc/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Potential treatments to reduce phorbol esters levels in jatropha seed cake for improving the value added product.
Autorzy:
Sadubthummarak U; Environmental Toxicology, Technology and Management Program, Chulabhorn Research Institute, Bangkok, Thailand. />Parkpian P
Ruchirawat M
Kongchum M
Delaune RD
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Źródło:
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes [J Environ Sci Health B] 2013; Vol. 48 (11), pp. 974-82.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nutritive Value*
Animal Feed/*toxicity
Jatropha/*chemistry
Phorbol Esters/*toxicity
Adsorption ; Animal Feed/analysis ; Bentonite/chemistry ; Cell Line ; Hot Temperature ; Humans ; Nanoparticles/chemistry ; Phorbol Esters/analysis ; Seeds/chemistry ; Sodium Bicarbonate/chemistry ; Zinc Oxide/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phorbol esters isolated from Jatropha meal induced apoptosis-mediated inhibition in proliferation of chang and Vero cell lines.
Autorzy:
Oskoueian E; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. .
Abdullah N
Ahmad S
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2012 Oct 24; Vol. 13 (11), pp. 13816-29. Date of Electronic Publication: 2012 Oct 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Jatropha/*chemistry
Phorbol Esters/*pharmacology
Plant Extracts/*pharmacology
Animals ; Caspase 3/metabolism ; Cell Proliferation/drug effects ; Chlorocebus aethiops ; DNA Fragmentation/drug effects ; Dose-Response Relationship, Drug ; Flow Cytometry ; Humans ; Phorbol Esters/isolation & purification ; Plant Extracts/isolation & purification ; Protein Kinase C/metabolism ; Vero Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Toxic compound, anti-nutritional factors and functional properties of protein isolated from detoxified Jatropha curcas seed cake.
Autorzy:
Saetae D; Department of Microbiology, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand; E-Mail: .
Suntornsuk W
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2010 Dec 28; Vol. 12 (1), pp. 66-77. Date of Electronic Publication: 2010 Dec 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Jatropha/*chemistry
Phorbol Esters/*chemistry
Toxins, Biological/*chemistry
Biofuels ; Lectins/analysis ; Nutritive Value ; Phorbol Esters/analysis ; Phytic Acid/analysis ; Plant Proteins/analysis ; Plant Proteins/isolation & purification ; Saponins/analysis ; Toxins, Biological/analysis ; Trypsin Inhibitors/analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 2856

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