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Tytuł:
Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity.
Autorzy:
Rosenberg EM Jr; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
Jian X; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
Soubias O; Section of Macromolecular NMR, Center for Structural Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America.
Jackson RA; Section of Macromolecular NMR, Center for Structural Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America.
Gladu E; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
Andersen E; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
Esser L; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
Sodt AJ; Unit of Membrane Chemical Physics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States of America.
Xia D; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
Byrd RA; Section of Macromolecular NMR, Center for Structural Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States of America.
Randazzo PA; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Apr 04; Vol. 19 (4), pp. e0295103. Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
GTPase-Activating Proteins*/metabolism
Myristates*
Point Mutation ; Myristic Acid ; ADP-Ribosylation Factor 1/genetics ; ADP-Ribosylation Factor 1/metabolism ; ADP-Ribosylation Factors/genetics ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neurofibromin 1 mediates sleep depth in Drosophila.
Autorzy:
Brown EB; Department of Biology, Texas A&M University, College Station, Texas, United States of America.; Department of Biological Sciences, Florida State University, Tallahassee, Florida, United States of America.
Zhang J; Department of Biology, Texas A&M University, College Station, Texas, United States of America.
Lloyd E; Department of Biology, Texas A&M University, College Station, Texas, United States of America.
Lanzon E; Jupiter Life Science Initiative, Florida Atlantic University, Jupiter, Florida, United States of America.
Botero V; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America.
Tomchik S; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America.
Keene AC; Department of Biology, Texas A&M University, College Station, Texas, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2023 Dec 13; Vol. 19 (12), pp. e1011049. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Nerve Tissue Proteins*/genetics
Nerve Tissue Proteins*/metabolism
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
ras GTPase-Activating Proteins*/genetics
ras GTPase-Activating Proteins*/metabolism
Sleep ; Animals ; Drosophila melanogaster ; Sleep Duration ; Male ; Brain/metabolism ; Intestines/metabolism ; Diet
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.
Autorzy:
Lv M; Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China.
Li X; Department of Epidemiology, School of Public Health of China Medical University, Shenyang, China.
Yin Z; Department of Epidemiology, School of Public Health of China Medical University, Shenyang, China.
Yang H; Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China.
Zhou B; Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China.
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Źródło:
PloS one [PLoS One] 2024 Apr 02; Vol. 19 (4), pp. e0294227. Date of Electronic Publication: 2024 Apr 02 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/diagnosis
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Lung Neoplasms*/diagnosis
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Epstein-Barr Virus Infections*
Humans ; Herpesvirus 4, Human/metabolism ; Signal Transduction ; Neoplasm Proteins/genetics ; GTPase-Activating Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan.
Autorzy:
Meraş İ; Department of Anatomy and Cell Biology, McGill University, Montreal, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Canada.; Metabolic Disorders and Complications Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.
Chotard L; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Canada.; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Canada.
Liontis T; Metabolic Disorders and Complications Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.; Brain Repair and Integrative Neuroscience Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.
Ratemi Z; Metabolic Disorders and Complications Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.
Wiles B; Metabolic Disorders and Complications Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.
Seo JH; Metabolic Disorders and Complications Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.
Van Raamsdonk JM; Metabolic Disorders and Complications Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.; Brain Repair and Integrative Neuroscience Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.
Rocheleau CE; Department of Anatomy and Cell Biology, McGill University, Montreal, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Canada.; Metabolic Disorders and Complications Program, Centre for Translational Biology, Research Institute of the McGill University Health Centre, Montreal, Canada.; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Canada.
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Źródło:
PLoS genetics [PLoS Genet] 2022 Aug 01; Vol. 18 (8), pp. e1010328. Date of Electronic Publication: 2022 Aug 01 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Longevity*/genetics
Caenorhabditis elegans Proteins/*metabolism
Forkhead Transcription Factors/*metabolism
GTPase-Activating Proteins/*metabolism
Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Forkhead Transcription Factors/genetics ; GTPase-Activating Proteins/genetics ; Humans ; Insulin/metabolism ; Mutation ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gene regulation analysis of patient-derived iPSCs and its CRISPR-corrected control provides a new tool for studying perturbations of ELMOD3 c.512A>G mutation during the development of inherited hearing loss.
Autorzy:
Liu X; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China.
Wen J; Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.; Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China.
Liu X; Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United States of America.
Chen A; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China.
Li S; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China.
Liu J; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China.
Sun J; Department of Otolaryngology Head and Neck Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Futian District, Shenzhen, China.
Gong W; Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.; Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China.
Kang X; Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.; Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China.
Feng Z; Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.; Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China.
He C; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China.
Mei L; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China.
Ling J; Medical Functional Experiment Center, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Feng Y; Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.; Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China.
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Źródło:
PloS one [PLoS One] 2023 Sep 14; Vol. 18 (9), pp. e0288640. Date of Electronic Publication: 2023 Sep 14 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Induced Pluripotent Stem Cells*
Hearing Loss*/genetics
Deafness*
Humans ; Gene Expression Regulation ; Mutation ; GTPase-Activating Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains.
Autorzy:
Nano PR; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America.
Johnson TK; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America.
Kudo T; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America.
Mooney NA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America.
Ni J; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America.
Demeter J; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America.
Jackson PK; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America.
Chen JK; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America.; Department of Chemistry, Stanford University, Stanford, California, United States of America.
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Źródło:
PloS one [PLoS One] 2021 May 17; Vol. 16 (5), pp. e0251684. Date of Electronic Publication: 2021 May 17 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cilia*/chemistry
Cilia*/genetics
Cilia*/metabolism
GTPase-Activating Proteins*/biosynthesis
GTPase-Activating Proteins*/chemistry
GTPase-Activating Proteins*/genetics
Signal Transduction*
Animals ; HEK293 Cells ; Humans ; Mice ; NIH 3T3 Cells ; Protein Domains ; Protein Isoforms ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system.
Autorzy:
Herbette M; Laboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, École Normale Supérieure de Lyon, University of Lyon, Lyon, France.
Wei X; University of Rochester Medical Center, Department of Biomedical Genetics, Rochester, New York, United States of America.
Chang CH; University of Rochester Department of Biology, Rochester, New York, United States of America.
Larracuente AM; University of Rochester Department of Biology, Rochester, New York, United States of America.
Loppin B; Laboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, École Normale Supérieure de Lyon, University of Lyon, Lyon, France.
Dubruille R; Laboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, École Normale Supérieure de Lyon, University of Lyon, Lyon, France.
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Źródło:
PLoS genetics [PLoS Genet] 2021 Jul 06; Vol. 17 (7), pp. e1009662. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
DNA, Satellite/*genetics
Drosophila Proteins/*genetics
GTPase-Activating Proteins/*genetics
Spermatogenesis/*genetics
Animals ; Cell Nucleus/metabolism ; Chromatin/genetics ; Chromosome Mapping ; Chromosome Segregation ; Chromosomes/genetics ; DNA, Satellite/metabolism ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; GTPase-Activating Proteins/metabolism ; Genotype ; Male ; Meiosis ; Mutation ; Phenotype ; Spermatids/metabolism ; Spermatozoa/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence.
Autorzy:
Morimune T; Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.; Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.; Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Tano A; Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.; Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Tanaka Y; Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.; Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
Yukiue H; Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.
Yamamoto T; Central Research Laboratory, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.
Tooyama I; Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.
Maruo Y; Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.
Nishimura M; Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.
Mori M; Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga, Japan.; Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan.
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Źródło:
PloS one [PLoS One] 2021 Apr 22; Vol. 16 (4), pp. e0248517. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*metabolism
GTPase-Activating Proteins/*metabolism
Neurons/*metabolism
RNA, Long Noncoding/*metabolism
Animals ; Brain/cytology ; Cell Line ; Cells, Cultured ; GTPase-Activating Proteins/genetics ; Gene Expression Regulation ; Humans ; Mice, Inbred C57BL ; Neurons/cytology ; RNA, Long Noncoding/genetics ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The clinical features of familial focal epilepsy with variable foci and NPRL3 gene variant.
Autorzy:
Wang Y; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Yu P; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Zhu G; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Wu X; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Ding D; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Hong Z; Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
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Źródło:
PloS one [PLoS One] 2023 Apr 26; Vol. 18 (4), pp. e0284924. Date of Electronic Publication: 2023 Apr 26 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epilepsies, Partial*/genetics
Epileptic Syndromes*
Humans ; GTPase-Activating Proteins/genetics ; Electroencephalography ; RNA, Messenger/genetics
SCR Disease Name:
Epilepsy, Partial, with Variable Foci
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant.
Autorzy:
Robledo RF; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Ciciotte SL; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Graber JH; Mount Desert Island Biological Laboratory, Salisbury Cove, Maine, United States of America.
Zhao Y; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Lambert AJ; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Gwynn B; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Maki NJ; Mount Desert Island Biological Laboratory, Salisbury Cove, Maine, United States of America.
Brindley EC; Feinstein Institutes for Medical Research, Manhasset, New York, United States of America.
Hartman E; Feinstein Institutes for Medical Research, Manhasset, New York, United States of America.
Blanc L; Feinstein Institutes for Medical Research, Manhasset, New York, United States of America.
Peters LL; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2020 Dec 28; Vol. 16 (12), pp. e1008857. Date of Electronic Publication: 2020 Dec 28 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Genetic Background*
Hematopoiesis*
Mutation*
GTPase-Activating Proteins/*genetics
Pancytopenia/*genetics
Animals ; Cells, Cultured ; Female ; GTPase-Activating Proteins/metabolism ; Humans ; Male ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain.
Autorzy:
Liu D; Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Yang F; Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Liu Z; Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Wang J; Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Huang W; Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Meng W; Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Billadeau DD; Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America.
Sun Q; Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Mo X; Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Jia D; Department of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
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Źródło:
PLoS biology [PLoS Biol] 2020 May 26; Vol. 18 (5), pp. e3000746. Date of Electronic Publication: 2020 May 26 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoantigens/*metabolism
Brain/*embryology
GTPase-Activating Proteins/*metabolism
Golgi Matrix Proteins/*metabolism
Thiosulfate Sulfurtransferase/*metabolism
ADP-Ribosylation Factors/metabolism ; Animals ; Escherichia coli ; GTPase-Activating Proteins/chemistry ; GTPase-Activating Proteins/isolation & purification ; HEK293 Cells ; HeLa Cells ; Humans ; Membrane Proteins/metabolism ; Protein Conformation ; Protein Domains ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.
Autorzy:
Wang YY; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.
Ke CC; PhD Program in Nutrition & Food science, Fu Jen Catholic University, New Taipei City, Taiwan.; Department of Urology, En Chu Kong Hospital, New Taipei City, Taiwan.
Chen YL; Department of Pathology, Cardinal Tien Hospital, New Taipei City, Taiwan.; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Lin YH; Division of Urology, Department of Surgery, Cardinal Tien Hospital, New Taipei City, Taiwan.; Department of Chemistry, Fu Jen Catholic University, New Taipei City, Taiwan.
Yu IS; Laboratory Animal Center, College of Medicine, National Taiwan University, Taipei, Taiwan.
Ku WC; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
O'Bryan MK; School of Biological Sciences, Monash University, Melbourne, Victoria, Australia.
Lin YH; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan.
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Źródło:
PLoS genetics [PLoS Genet] 2020 Sep 25; Vol. 16 (9), pp. e1009020. Date of Electronic Publication: 2020 Sep 25 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
GTPase-Activating Proteins/*genetics
Infertility, Male/*genetics
Infertility, Male/*pathology
Microfilament Proteins/*genetics
Spermatozoa/*pathology
Spermatozoa/*physiology
Animals ; Asthenozoospermia/genetics ; Axoneme/genetics ; Axoneme/ultrastructure ; Flagella/genetics ; Flagella/pathology ; GTPase-Activating Proteins/metabolism ; Gene Expression ; Humans ; Male ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Microfilament Proteins/metabolism ; Mitochondria/genetics ; Mitochondria/pathology ; Mitochondrial Precursor Protein Import Complex Proteins ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Sperm Motility/genetics ; Sperm Tail/pathology ; Spermatozoa/ultrastructure ; Testis/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transition.
Autorzy:
Rinastiti P; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Ikeda K; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.
Rahardini EP; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Miyagawa K; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Tamada N; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kuribayashi Y; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.
Hirata KI; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Emoto N; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
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Źródło:
PloS one [PLoS One] 2020 Feb 13; Vol. 15 (2), pp. e0226049. Date of Electronic Publication: 2020 Feb 13 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*
Endothelial Cells/*pathology
GTPase-Activating Proteins/*metabolism
Hypertension, Pulmonary/*pathology
Pulmonary Artery/*pathology
Animals ; Cell Line ; Disease Models, Animal ; GTPase-Activating Proteins/genetics ; Humans ; Lung/blood supply ; Male ; Mice ; Mice, Knockout ; Pulmonary Artery/cytology ; Signal Transduction ; Vascular Remodeling ; beta Catenin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
In vivo glucoregulation and tissue-specific glucose uptake in female Akt substrate 160 kDa knockout rats.
Autorzy:
Zheng X; Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America.
Arias EB; Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America.
Qi NR; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States of America.
Saunders TL; Transgenic Animal Model Core, University of Michigan Medical School, Ann Arbor, MI, United States of America.
Cartee GD; Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America.; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States of America.; Division of Genetic Medicine Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, United States of America.; Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Feb 13; Vol. 15 (2), pp. e0223340. Date of Electronic Publication: 2020 Feb 13 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
GTPase-Activating Proteins/*deficiency
Gluconeogenesis/*genetics
Glucose/*metabolism
Insulin Resistance/*genetics
Muscle, Skeletal/*metabolism
AMP-Activated Protein Kinases/metabolism ; Animals ; Disease Models, Animal ; Female ; GTPase-Activating Proteins/genetics ; Glucose Clamp Technique ; Glucose Tolerance Test ; Glucose Transport Proteins, Facilitative/metabolism ; Humans ; Liver/metabolism ; Physical Conditioning, Animal ; Rats ; Rats, Transgenic ; Rats, Wistar ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
ACAP1 assembles into an unusual protein lattice for membrane deformation through multiple stages.
Autorzy:
Chan C; Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong, China.
Pang X; National Laboratory of Biomacromolecules, CAS Center for excellence in biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Zhang Y; National Laboratory of Biomacromolecules, CAS Center for excellence in biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Niu T; National Laboratory of Biomacromolecules, CAS Center for excellence in biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yang S; School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Zhao D; School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Li J; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Lu L; School of Biological Sciences, Nanyang Technological University, Singapore.
Hsu VW; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Zhou J; School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, China.
Sun F; National Laboratory of Biomacromolecules, CAS Center for excellence in biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Fan J; Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong, China.; City University of Hong Kong Shenzhen Research Institute, Shenzhen, China.; Center for Advanced Nuclear Safety and Sustainable Development, City University of Hong Kong, Hong Kong, China.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2019 Jul 10; Vol. 15 (7), pp. e1007081. Date of Electronic Publication: 2019 Jul 10 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
GTPase-Activating Proteins/*metabolism
Membrane Proteins/*metabolism
Cell Membrane/metabolism ; Dimerization ; GTPase-Activating Proteins/chemistry ; Humans ; Pleckstrin Homology Domains ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development.
Autorzy:
Dent LG; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
Manning SA; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Department of Anatomy and Developmental Biology, and Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Kroeger B; Department of Anatomy and Developmental Biology, and Biomedicine Discovery Institute, Monash University, Clayton, Australia.
Williams AM; Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, United States of America.
Saiful Hilmi AJ; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Crea L; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Kondo S; Laboratory of Invertebrate Genetics, National Institute of Genetics, Yata, Mishima, Shizuoka, Japan.
Horne-Badovinac S; Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, United States of America.
Harvey KF; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Department of Anatomy and Developmental Biology, and Biomedicine Discovery Institute, Monash University, Clayton, Australia.
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Źródło:
PLoS genetics [PLoS Genet] 2019 May 22; Vol. 15 (5), pp. e1008083. Date of Electronic Publication: 2019 May 22 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
ATP-Binding Cassette Transporters/*genetics
Drosophila Proteins/*genetics
Drosophila melanogaster/*genetics
GTPase-Activating Proteins/*genetics
Morphogenesis/*genetics
Myosins/*genetics
ATP-Binding Cassette Transporters/metabolism ; Animals ; Cell Movement ; Drosophila Proteins/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Female ; Focal Adhesions/metabolism ; Focal Adhesions/ultrastructure ; GTPase-Activating Proteins/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Mechanotransduction, Cellular ; Myosins/metabolism ; Zygote/cytology ; Zygote/growth & development ; Zygote/metabolism ; p21-Activated Kinases/genetics ; p21-Activated Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells.
Autorzy:
Haley R; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, United States of America.
Wang Y; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, United States of America.
Zhou Z; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2018 Aug 23; Vol. 14 (8), pp. e1007558. Date of Electronic Publication: 2018 Aug 23 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Apoptosis*
Genome, Helminth*
Caenorhabditis elegans/*genetics
Caenorhabditis elegans Proteins/*metabolism
GTPase-Activating Proteins/*metabolism
rab GTP-Binding Proteins/*metabolism
Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Endosomes/genetics ; Endosomes/metabolism ; GTPase-Activating Proteins/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Phagosomes/genetics ; Phagosomes/metabolism ; Phosphatidylinositols/metabolism ; Protein Transport ; RNA Interference ; rab GTP-Binding Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3.
Autorzy:
Li K; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, United States of America.; Department of Bioengineering, University of Pennsylvania, Pennsylvania, United States of America.
Wada S; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, United States of America.
Gosis BS; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, United States of America.
Thorsheim C; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, United States of America.
Loose P; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, United States of America.
Arany Z; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2022 Mar 31; Vol. 20 (3), pp. e3001594. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Lysosomes*/metabolism
TOR Serine-Threonine Kinases*/metabolism
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; GTPase-Activating Proteins/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A positive feedback loop involving the Spa2 SHD domain contributes to focal polarization.
Autorzy:
Lawson MJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States of America.
Drawert B; Department of Computer Science, University of North Carolina Asheville, Asheville, NC, United States of America.
Petzold L; Department of Computer Science, University of California, Santa Barbara, Santa Barbara, CA, United States of America.
Yi TM; Molecular, Cellular, and Developmental Biology, 3131 Biological Sciences II, University of California, Santa Barbara, Santa Barbara, CA, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Feb 08; Vol. 17 (2), pp. e0263347. Date of Electronic Publication: 2022 Feb 08 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Cell Communication/*physiology
Cell Polarity/*physiology
Cytoskeletal Proteins/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Actins/metabolism ; Cell Polarity/genetics ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/physiology ; Feedback ; GTPase-Activating Proteins/metabolism ; Microfilament Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.
Autorzy:
Kroken AR; School of Optometry, University of California, Berkeley, Berkeley, California, United States of America.; Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, United States of America.
Gajenthra Kumar N; School of Optometry, University of California, Berkeley, Berkeley, California, United States of America.
Yahr TL; Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.
Smith BE; Vision Science Program, University of California, Berkeley, Berkeley, California, United States of America.
Nieto V; School of Optometry, University of California, Berkeley, Berkeley, California, United States of America.
Horneman H; School of Optometry, University of California, Berkeley, Berkeley, California, United States of America.
Evans DJ; School of Optometry, University of California, Berkeley, Berkeley, California, United States of America.; College of Pharmacy, Touro University California, Vallejo, California, United States of America.
Fleiszig SMJ; School of Optometry, University of California, Berkeley, Berkeley, California, United States of America.; Vision Science Program, University of California, Berkeley, Berkeley, California, United States of America.; Graduate Groups in Microbiology, and Infectious Diseases & Immunity, University of California, Berkeley, Berkeley, California, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Feb 07; Vol. 18 (2), pp. e1010306. Date of Electronic Publication: 2022 Feb 07 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Membrane Permeability*
ADP Ribose Transferases/*metabolism
Exotoxins/*metabolism
Pseudomonas Infections/*microbiology
Pseudomonas aeruginosa/*metabolism
Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/metabolism ; Bacterial Toxins/metabolism ; Cell Death ; Epithelial Cells/metabolism ; Epithelial Cells/microbiology ; GTPase-Activating Proteins/metabolism ; HeLa Cells ; Host-Pathogen Interactions ; Humans ; Mutation ; Pseudomonas aeruginosa/drug effects ; Type III Secretion Systems/metabolism ; Vacuoles/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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