Temat: "Isocitrate dehydrogenase" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation.
Autorzy:: Kino S; Graduate School of Biomedical Engineering, Tohoku University, 6-6-05, Aza-Aoba, Aramaki, Aoba, Sendai City, 980-8579, Miyagi Prefecture, Japan.
Kanamori M; Department of Neurosurgery, Tohoku University Graduate School of Medicine, 980-8574 Seiryo 1-1, Aoba, Sendai City, Miyagi Prefecture, Japan.
Shimoda Y; Department of Neurosurgery, Tohoku University Graduate School of Medicine, 980-8574 Seiryo 1-1, Aoba, Sendai City, Miyagi Prefecture, Japan.
Niizuma K; Department of Neurosurgical Engineering and Translational Neuroscience, Graduate School of Biomedical Engineering, Tohoku University, Seiryo 2-1, Aoba, Sendai City, 980-8575, Miyagi Prefecture, Japan.; Department of Neurosurgical Engineering and Translational Neuroscience, Tohoku University Graduate School of Medicine, 980-8575 Seiryo 2-1, Aoba, Sendai City, Miyagi Prefecture, Japan.
Endo H; Department of Neurosurgery, Tohoku University Graduate School of Medicine, 980-8574 Seiryo 1-1, Aoba, Sendai City, Miyagi Prefecture, Japan.
Matsuura Y; Graduate School of Biomedical Engineering, Tohoku University, 6-6-05, Aza-Aoba, Aramaki, Aoba, Sendai City, 980-8579, Miyagi Prefecture, Japan. .; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2024 Feb 16; Vol. 24 (1), pp. 222. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:: Journal Article
MeSH Terms:: Brain Neoplasms*/diagnosis
Brain Neoplasms*/genetics
Brain Neoplasms*/pathology
Glioma*/diagnosis
Glioma*/genetics
Glioma*/metabolism
Isocitrate Dehydrogenase*/genetics
Isocitrate Dehydrogenase*/metabolism
Humans ; Ataxia Telangiectasia Mutated Proteins/genetics ; Blood Proteins/metabolism ; Mutation ; Protein Aggregates ; Spectroscopy, Fourier Transform Infrared ; Amyloid/metabolism

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Skocz do pozycji: 2.

Tytuł:: Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents.
Autorzy:: Khalil AF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
El-Moselhy TF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
El-Bastawissy EA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Abdelhady R; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.
Younis NS; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al Hofuf, Saudi Arabia.
El-Hamamsy MH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2157411.
Typ publikacji:: Journal Article
MeSH Terms:: Isocitrate Dehydrogenase*/genetics
Isocitrate Dehydrogenase*/metabolism
Antineoplastic Agents*/pharmacology
Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Mutation ; Triazines/pharmacology ; Triazines/chemistry

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Skocz do pozycji: 3.

Tytuł:: Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma.
Autorzy:: Silva FFVE; Department of Medicine and Dentistry, University of Santiago de Compostela, San Francisco Street, s/n, 15782 Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (FIDIS), Santiago de Compostela University Clinical Hospital, University of Santiago de Compostela, Choupana Street, s/n, 15706 Santiago de Compostela, Spain.; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via Abramo Lincoln, 5, 81100 Caserta, Italy.
Di Domenico M; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via Abramo Lincoln, 5, 81100 Caserta, Italy.
Caponio VCA; Department of Clinical and Experimental Medicine, University of Foggia, Via Napoli, 20, 71122 Foggia, Italy.
Pérez-Sayáns M; Department of Medicine and Dentistry, University of Santiago de Compostela, San Francisco Street, s/n, 15782 Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (FIDIS), Santiago de Compostela University Clinical Hospital, University of Santiago de Compostela, Choupana Street, s/n, 15706 Santiago de Compostela, Spain.
Camolesi GCV; Department of Medicine and Dentistry, University of Santiago de Compostela, San Francisco Street, s/n, 15782 Santiago de Compostela, Spain.
Rojo-Álvarez LI; Health Research Institute of Santiago de Compostela (FIDIS), Santiago de Compostela University Clinical Hospital, University of Santiago de Compostela, Choupana Street, s/n, 15706 Santiago de Compostela, Spain.
Ballini A; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via Abramo Lincoln, 5, 81100 Caserta, Italy.
García-García A; Department of Medicine and Dentistry, University of Santiago de Compostela, San Francisco Street, s/n, 15782 Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (FIDIS), Santiago de Compostela University Clinical Hospital, University of Santiago de Compostela, Choupana Street, s/n, 15706 Santiago de Compostela, Spain.
Padín-Iruegas ME; Health Research Institute of Santiago de Compostela (FIDIS), Santiago de Compostela University Clinical Hospital, University of Santiago de Compostela, Choupana Street, s/n, 15706 Santiago de Compostela, Spain.; Human Anatomy and Embryology Area, Department of Functional Biology and Health Sciences, University of Vigo, Lagoas-Marcosende, s/n, 36310 Vigo, Spain.
Suaréz-Peñaranda JM; Department of Medicine and Dentistry, University of Santiago de Compostela, San Francisco Street, s/n, 15782 Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (FIDIS), Santiago de Compostela University Clinical Hospital, University of Santiago de Compostela, Choupana Street, s/n, 15706 Santiago de Compostela, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 03; Vol. 25 (1). Date of Electronic Publication: 2024 Jan 03.
Typ publikacji:: Journal Article
MeSH Terms:: Glioblastoma*/genetics
Guanine*/analogs & derivatives
Isocitrate Dehydrogenase*/genetics
Humans ; DNA ; High-Throughput Nucleotide Sequencing ; Methylation ; O(6)-Methylguanine-DNA Methyltransferase/genetics ; Retrospective Studies

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Skocz do pozycji: 4.

Tytuł:: Isocitrate dehydrogenase 2 regulates the proliferation of triple-negative breast cancer through the ferroptosis pathway.
Autorzy:: Zhang, Chengwu (AUTHOR)
Zhou, Yuanhong (AUTHOR)
Chen, Tao (AUTHOR)
Bhushan, Sudhanshu (AUTHOR)
Sun, Shengrong (AUTHOR)
Zhang, Panshi (AUTHOR)
Yang, Yalong (AUTHOR); Pokaż więcej
Źródło:: Scientific Reports. 2/27/2024, Vol. 14 Issue 1, p1-12. 12p.

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Skocz do pozycji: 5.

Tytuł:: Nanomechanical Signatures in Glioma Cells Depend on CD44 Distribution in IDH1 Wild-Type but Not in IDH1R132H Mutant Early-Passage Cultures.
Autorzy:: Shmelev ME; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.
Farniev VM; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.
Shved NA; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia.
Kumeiko VV; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.; A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 17; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 17.
Typ publikacji:: Journal Article
MeSH Terms:: Glioma*/diagnosis
Glioma*/metabolism
Glioma*/pathology
Hyaluronan Receptors*/metabolism
Isocitrate Dehydrogenase*/genetics
Isocitrate Dehydrogenase*/metabolism
Humans ; Microscopy, Atomic Force ; Tumor Microenvironment ; Mutation

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Skocz do pozycji: 6.

Tytuł:: Pediatric-type high-grade gliomas with PDGFRA amplification in adult patients with Li-Fraumeni syndrome: clinical and molecular characterization of three cases.
Autorzy:: Kibe Y; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Ohka F; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. .
Aoki K; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Yamaguchi J; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Motomura K; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Ito E; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Takeuchi K; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Nagata Y; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Ito S; Department of Neurosurgery, Konan Kosei Hospital, 137 Oomatsubara, Takaya-cho, Konan, 483-8703, Japan.
Mizutani N; Department of Neurosurgery, Konan Kosei Hospital, 137 Oomatsubara, Takaya-cho, Konan, 483-8703, Japan.
Shiba Y; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Maeda S; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Nishikawa T; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Shimizu H; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Saito R; Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Apr 11; Vol. 12 (1), pp. 57. Date of Electronic Publication: 2024 Apr 11.
Typ publikacji:: Journal Article
MeSH Terms:: Glioblastoma*/genetics
Glioblastoma*/pathology
Li-Fraumeni Syndrome*/genetics
Brain Neoplasms*/genetics
Brain Neoplasms*/pathology
Glioma*/genetics
Glioma*/pathology
Cerebellar Neoplasms*/genetics
Adult ; Humans ; Child ; Genes, p53 ; Mutation/genetics ; Isocitrate Dehydrogenase/genetics

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Skocz do pozycji: 7.

Tytuł:: Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML.
Autorzy:: Katebi A; Department of Bioengineering, Northeastern University, Boston, MA, USA.; Center for Theoretical Biological Physics, Northeastern University, Boston, MA, USA.
Chen X; Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Ramirez D; Department of Bioengineering, Northeastern University, Boston, MA, USA.; Center for Theoretical Biological Physics, Northeastern University, Boston, MA, USA.
Li S; Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. .; Department of Computer Science & Engineering, University of Connecticut, Storrs, CT, USA. .; The Jackson Laboratory Cancer Center, Bar Harbor, ME, USA. .
Lu M; Department of Bioengineering, Northeastern University, Boston, MA, USA. .; Center for Theoretical Biological Physics, Northeastern University, Boston, MA, USA. .; Pokaż więcej
Źródło:: NPJ systems biology and applications [NPJ Syst Biol Appl] 2024 Apr 09; Vol. 10 (1), pp. 38. Date of Electronic Publication: 2024 Apr 09.
Typ publikacji:: Journal Article
MeSH Terms:: Nucleophosmin*
Leukemia, Myeloid, Acute*/genetics
Humans ; Gene Regulatory Networks/genetics ; Isocitrate Dehydrogenase/genetics ; Carcinogenesis

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Skocz do pozycji: 8.

Tytuł:: Relaxation Along a Fictitious Field, continuous wave T1rho, adiabatic T1rho and adiabatic T2rho imaging of human gliomas at 3T: A feasibility study.
Autorzy:: Jambor I; Department of Radiology, University of Turku, Turku, Finland.; Enterprise Service Group-Radiology, Mass General Brigham, Boston, MA, United States of America.
Steiner A; Department of Radiology, University of Turku, Turku, Finland.; Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland.
Pesola M; Department of Radiology, University of Turku, Turku, Finland.
Gardberg M; Tyks Laboratories, Pathology, Turku University Hospital and Institute of Biomedicine, University of Turku Turku, Finland.
Frantzén J; Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital and University of Turku, Turku, Finland.
Jokinen P; Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital and University of Turku, Turku, Finland.
Liimatainen T; Department of Radiology, University of Oulu, Oulu, Finland.; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Minn H; Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland.; Turku PET Centre, Turku University and Turku University Hospital, Turku, Finland, Finland.
Aronen H; Department of Radiology, University of Turku, Turku, Finland.; Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland.
Merisaari H; Department of Radiology, University of Turku, Turku, Finland.; Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2024 Apr 01; Vol. 19 (4), pp. e0296958. Date of Electronic Publication: 2024 Apr 01 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Brain Neoplasms*/diagnostic imaging
Brain Neoplasms*/pathology
Glioma*/diagnostic imaging
Glioma*/pathology
Humans ; Feasibility Studies ; Prospective Studies ; Magnetic Resonance Imaging/methods ; Mutation ; Chromosome Aberrations ; Isocitrate Dehydrogenase/genetics ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 19

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Skocz do pozycji: 9.

Tytuł:: Rational Computational Approaches in Drug Discovery: Potential Inhibitors for Allosteric Regulation of Mutant Isocitrate Dehydrogenase-1 Enzyme in Cancers.
Autorzy:: Thamim M; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.
Agrahari AK; Translational Health Science and Technology Institute, Faridabad 121001, Haryana, India.
Gupta P; Department of Pharmaceutical Chemistry, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, Maharashtra, India.
Thirumoorthy K; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Mar 02; Vol. 28 (5). Date of Electronic Publication: 2023 Mar 02.
Typ publikacji:: Journal Article
MeSH Terms:: Isocitrate Dehydrogenase*/genetics
Neoplasms*
Humans ; Allosteric Regulation ; Glutarates/chemistry ; Mutation ; Drug Discovery ; Enzyme Inhibitors/pharmacology

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Skocz do pozycji: 10.

Tytuł:: IDH2 mutation in angioimmunoblastic T-cell lymphoma: A retrospective multicenter case series.
Autorzy:: Riva M; Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy.
Tisi MC; Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy.
Bertorelle R; Department of Surgery, Oncology and Gastroenterology, University of Padova, Istituto Oncologico Veneto, Padova, Italy.
Famengo B; Pathology Department, San Bortolo Hospital, Vicenza, Italy.
D'Amore ESG; Pathology Department, San Bortolo Hospital, Vicenza, Italy.
Pizzi M; General Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padova, Padova, Italy.
Parisi A; Unit of Pathology, Department of Diagnostics and Public Health, G.B. Rossi University Hospital, Verona, Italy.
Boscato E; Department of Pathology and Molecular Genetics, Treviso General Hospital, Treviso, Italy.
Mazzucco M; Hematology Unit, Ospedale dell'Angelo and Ospedale S. Giovanni e Paolo, Mestre Venezia, Italy.
Semenzato G; Department of Medicine, Hematology and Clinical Immunology Unit, Padova, Italy.
Krampera M; Department of Medicine, Section of Hematology, University of Verona, Verona, Italy.
Gherlinzoni F; Hematology Unit, Department of Medicine, Treviso General Hospital, Treviso, Italy.
Trentin L; Department of Medicine, Hematology and Clinical Immunology Unit, Padova, Italy.
Ruggeri M; Cell Therapy and Hematology, San Bortolo Hospital, Vicenza, Italy.
Visco C; Department of Medicine, Section of Hematology, University of Verona, Verona, Italy.
Stefani PM; Hematology Unit, Department of Medicine, Treviso General Hospital, Treviso, Italy.
Piazza F; Department of Medicine, Hematology and Clinical Immunology Unit, Padova, Italy.; Pokaż więcej
Źródło:: European journal of haematology [Eur J Haematol] 2023 Feb; Vol. 110 (2), pp. 217-220. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:: Multicenter Study; Letter
MeSH Terms:: Immunoblastic Lymphadenopathy*/diagnosis
Immunoblastic Lymphadenopathy*/genetics
Isocitrate Dehydrogenase*/genetics
Lymphoma, T-Cell*/diagnosis
Lymphoma, T-Cell*/genetics
Humans ; Mutation ; Retrospective Studies

Raport

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Skocz do pozycji: 11.

Tytuł:: Isocitrate Dehydrogenase Alpha-1 Modulates Lifespan and Oxidative Stress Tolerance in Caenorhabditis elegans .
Autorzy:: Lin ZH; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.; Institute of Chemistry, Academia Sinica, Taipei 115201, Taiwan.; Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 115201, Taiwan.; Institute of Biochemical Sciences, National Taiwan University, Taipei 106319, Taiwan.
Chang SY; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.
Shen WC; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.
Lin YH; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.
Shen CL; Department of Life Science, National Tsing Hua University, Hsinchu 300044, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 10002, Taiwan.
Liao SB; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.
Liu YC; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.
Chen CS; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Ching TT; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Wang HD; Institute of Biotechnology, National Tsing Hua University, Hsinchu 300044, Taiwan.; Department of Life Science, National Tsing Hua University, Hsinchu 300044, Taiwan.; Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu 300044, Taiwan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 29; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 29.
Typ publikacji:: Journal Article
MeSH Terms:: Caenorhabditis elegans*/enzymology
Caenorhabditis elegans*/genetics
Caenorhabditis elegans Proteins*/genetics
Caenorhabditis elegans Proteins*/metabolism
Isocitrate Dehydrogenase*/genetics
Isocitrate Dehydrogenase*/metabolism
Longevity*/genetics
Oxidative Stress*
Animals

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Skocz do pozycji: 12.

Tytuł:: Single-center, observational study of AML/MDS-EB with IDH1/2 mutations: genetic profile, immunophenotypes, mutational kinetics and outcomes.
Autorzy:: Papadopoulou V; Service and Laboratory of Hematology, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.
Schoumans J; Service and Laboratory of Hematology, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.
Basset V; Service and Laboratory of Hematology, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.
Solly F; Service and Laboratory of Hematology, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.
Pasquier J; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
Blum S; Service and Laboratory of Hematology, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.
Spertini O; Service and Laboratory of Hematology, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.; Pokaż więcej
Źródło:: Hematology (Amsterdam, Netherlands) [Hematology] 2023 Dec; Vol. 28 (1), pp. 2180704.
Typ publikacji:: Observational Study; Journal Article
MeSH Terms:: Leukemia, Myeloid, Acute*/genetics
Myelodysplastic Syndromes*
Humans ; Nuclear Proteins/genetics ; Nucleophosmin ; Genetic Profile ; Retrospective Studies ; Mutation ; Prognosis ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/therapeutic use

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Skocz do pozycji: 13.

Tytuł:: IDH1 mutation increases radiotherapy efficacy and a 4-gene radiotherapy-related signature of WHO grade 4 gliomas.
Autorzy:: Han X; Department of Radiotherapy, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, 050000, Hebei, China.
Zhou H; Department of Radiotherapy, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, 050000, Hebei, China.; Department of Central Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.; Center of Metabolic Diseases and Cancer Research (CMCR), Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Sun W; Department of Radiotherapy, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, 050000, Hebei, China.
Hou L; Department of Radiotherapy, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, 050000, Hebei, China.; Department of Central Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Wang Y; Department of Radiotherapy, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, 050000, Hebei, China.
Wang H; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Lv Z; Department of Neurosurgery, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, 050000, Hebei, China. .
Xue X; Department of Radiotherapy, The Second Hospital of Hebei Medical University, No. 215, Heping West Road, Xinhua District, Shijiazhuang, 050000, Hebei, China. .; Center of Metabolic Diseases and Cancer Research (CMCR), Hebei Medical University, Shijiazhuang, 050017, Hebei, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Nov 11; Vol. 13 (1), pp. 19659. Date of Electronic Publication: 2023 Nov 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain Neoplasms*/genetics
Brain Neoplasms*/radiotherapy
Glioma*/genetics
Glioma*/radiotherapy
Glioblastoma*
Humans ; Sincalide/genetics ; Sincalide/metabolism ; Mutation ; Prognosis ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; World Health Organization ; Calmodulin-Binding Proteins/genetics

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Skocz do pozycji: 14.

Tytuł:: Gene expression changes of isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 affect carcinogenesis and survival probability.
Autorzy:: ATALAY, Esra BULUT; Pokaż więcej
Alternatywny tytuł:: İzositrat dehidrojenaz 1 ve izositrat dehidrojenaz 2 genlerinin gen ekspresyon değişiklikleri karsinojenezi ve hayatta kalma olasılığını etkiler.
Źródło:: Gümüshane Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2024, Vol. 14 Issue 1, p370-378. 9p.

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Skocz do pozycji: 15.

Tytuł:: Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function.
Autorzy:: Notarangelo G; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Spinelli JB; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Perez EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Baker GJ; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.
Kurmi K; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Elia I; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Stopka SA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Baquer G; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Electronic Engineering, Rovira i Virgili University, Tarragona, Spain.
Lin JR; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
Golby AJ; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Joshi S; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Baron HF; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Psychiatry and Neurology, Harvard Medical School, Boston, MA, USA.
Drijvers JM; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Georgiev P; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Ringel AE; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Zaganjor E; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
McBrayer SK; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sorger PK; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
Sharpe AH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Wucherpfennig KW; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Santagata S; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Agar NYR; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Suvà ML; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Haigis MC; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2022 Sep 30; Vol. 377 (6614), pp. 1519-1529. Date of Electronic Publication: 2022 Sep 29.
Typ publikacji:: Journal Article
MeSH Terms:: CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/metabolism
Carcinogenesis*/genetics
Carcinogenesis*/metabolism
Glutarates*/metabolism
Isocitrate Dehydrogenase*/genetics
Isocitrate Dehydrogenase*/metabolism
Neoplasms*/genetics
Neoplasms*/immunology
Neoplasms*/metabolism
Animals ; Gain of Function Mutation ; Humans ; Interferon-gamma/metabolism ; L-Lactate Dehydrogenase/antagonists & inhibitors ; L-Lactate Dehydrogenase/metabolism ; Mice

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Skocz do pozycji: 16.

Tytuł:: GlioPredictor: a deep learning model for identification of high-risk adult IDH-mutant glioma towards adjuvant treatment planning.
Autorzy:: Zheng S; Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. .
Rammohan N; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Sita T; Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Teo PT; Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Wu Y; Department of Mathematics, DigiPen Institute of Technology, Redmond, WA, USA.
Lesniak M; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sachdev S; Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Thomas TO; Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. .; Department of Radiation Oncology, Northwestern Medical Group, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 25; Vol. 14 (1), pp. 2126. Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:: Journal Article
MeSH Terms:: Deep Learning*
Glioma*/genetics
Glioma*/therapy
Adult ; Humans ; Isocitrate Dehydrogenase/genetics ; DNA Copy Number Variations ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Cyclin-Dependent Kinase Inhibitor Proteins ; ErbB Receptors/genetics

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Skocz do pozycji: 17.

Tytuł:: The genomic alterations in glioblastoma influence the levels of CSF metabolites.
Autorzy:: Wang DH; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 2130 W. Holcombe Blvd., Suite 910, Houston, TX, 77030, USA.
Fujita Y; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, 6400 Fannin St., Suite 2800, Houston, TX, 77030, USA.
Dono A; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, 6400 Fannin St., Suite 2800, Houston, TX, 77030, USA.
Rodriguez Armendariz AG; Escuela de Medicina y Ciencias de la Salud, Tecnológico de Monterrey, Av. Ignacio Morones Prieto 3000, Sertoma, Monterrey, N.L, 64710, Mexico.
Shah M; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 2130 W. Holcombe Blvd., Suite 910, Houston, TX, 77030, USA.
Putluri N; Advanced Technology Core, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.; Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Pichardo-Rojas PS; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, 6400 Fannin St., Suite 2800, Houston, TX, 77030, USA.
Patel CB; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1002, BSRB S5.8116b, Houston, TX, 77030, USA.
Zhu JJ; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, 6400 Fannin St., Suite 2800, Houston, TX, 77030, USA.; Memorial Hermann Hospital-Texas Medical Center, Houston, TX, 77030, USA.
Huse JT; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 2130 W. Holcombe Blvd., Suite 910, Houston, TX, 77030, USA.; Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Parker Kerrigan BC; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd., Room FC7.2000, Unit 442, Houston, TX, 77030, USA.
Lang FF; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd., Room FC7.2000, Unit 442, Houston, TX, 77030, USA.
Esquenazi Y; Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, 6400 Fannin St., Suite 2800, Houston, TX, 77030, USA.; Memorial Hermann Hospital-Texas Medical Center, Houston, TX, 77030, USA.; Center for Precision Health, McGovern Medical School, The University of Texas Health Science Center at Houston, 7000 Fannin St., Suite 600, Houston, TX, 77030, USA.
Ballester LY; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 2130 W. Holcombe Blvd., Suite 910, Houston, TX, 77030, USA. .; Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. .; Neuropathology and Molecular Genetic Pathology, Department of Pathology, Department of Translational Molecular Pathology, 1515 Holcombe Blvd, Unit 85, Houston, TX, 77030, USA. .; Pokaż więcej
Źródło:: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Jan 19; Vol. 12 (1), pp. 13. Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:: Journal Article
MeSH Terms:: Glioblastoma*/genetics
Brain Neoplasms*/pathology
Glioma*/genetics
Humans ; Mutation/genetics ; Genomics ; Biomarkers, Tumor/genetics ; Isocitrate Dehydrogenase/genetics

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Skocz do pozycji: 18.

Tytuł:: Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel.
Autorzy:: Brooks AM; Integrative Bioinformatics Support Group, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.
Vornoli A; Comparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
Kovi RC; Comparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.; Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, United States of America.
Ton TVT; Comparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.
Xu M; Comparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.
Mashal A; Comparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.
Tibaldi E; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
Gnudi F; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
Li JL; Integrative Bioinformatics Support Group, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.
Sills RC; Comparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.
Bucher JR; Comparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.
Mandrioli D; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
Belpoggi F; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy.
Pandiri AR; Comparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2024 Jan 17; Vol. 19 (1), pp. e0296699. Date of Electronic Publication: 2024 Jan 17 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: Glioma*/genetics
Glioma*/pathology
Neurilemmoma*/genetics
Radiation Exposure*
Brain Neoplasms*/pathology
Humans ; Rats ; Animals ; Rats, Sprague-Dawley ; Mutation ; High-Throughput Nucleotide Sequencing/methods ; Isocitrate Dehydrogenase/genetics

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Skocz do pozycji: 19.

Tytuł:: IDH1 mutation is detectable in plasma cell-free DNA and is associated with survival outcome in glioma patients.
Autorzy:: Crucitta S; Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Pasqualetti F; Radiation Oncology, Department of Medicine and Oncology, University of Pisa, Pisa, Italy.; Department of Oncology, University of Oxford, Oxford, UK.
Gonnelli A; Radiation Oncology, Department of Medicine and Oncology, University of Pisa, Pisa, Italy.
Ruglioni M; Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Luculli GI; Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Cantarella M; Radiation Oncology, Department of Medicine and Oncology, University of Pisa, Pisa, Italy.
Ortenzi V; Division of Pathology, Department of Translational Research & New Technologies in Medicine & Surgery, University of Pisa, Pisa, Italy.
Scatena C; Division of Pathology, Department of Translational Research & New Technologies in Medicine & Surgery, University of Pisa, Pisa, Italy.
Paiar F; Radiation Oncology, Department of Medicine and Oncology, University of Pisa, Pisa, Italy.
Naccarato AG; Division of Pathology, Department of Translational Research & New Technologies in Medicine & Surgery, University of Pisa, Pisa, Italy.
Danesi R; Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. .; Department of Oncology and Hemato-Oncology, University of Milano, Via Festa del Perdono, 7, Milano, 20122, Italy. .
Del Re M; Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.; Pokaż więcej
Źródło:: BMC cancer [BMC Cancer] 2024 Jan 03; Vol. 24 (1), pp. 31. Date of Electronic Publication: 2024 Jan 03.
Typ publikacji:: Journal Article
MeSH Terms:: Glioma*/pathology
Brain Neoplasms*/pathology
Cell-Free Nucleic Acids*/genetics
Humans ; Mutation ; Polymerase Chain Reaction ; Isocitrate Dehydrogenase/genetics

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Skocz do pozycji: 20.

Tytuł:: Cognitive functioning is prognostic in patients with IDH1-wild type and MGMT-unmethylated high-grade gliomas.
Autorzy:: Smrdel U; Uroš Smrdel, Institute of Oncology Ljubljana, Zaloška 2, 1000 Ljubljana, Slovenia, .
Škufca Smrdel AC
Podlesek A
Skoblar Vidmar M
Kos G
Markovic J
Jereb J
Knific J
Rus T; Pokaż więcej
Źródło:: Croatian medical journal [Croat Med J] 2023 Dec 31; Vol. 64 (6), pp. 383-390.
Typ publikacji:: Journal Article
MeSH Terms:: Brain Neoplasms*/genetics
Glioma*/genetics
Glioma*/surgery
Humans ; Prognosis ; DNA Methylation ; Isocitrate Dehydrogenase/genetics ; Biomarkers, Tumor ; Mutation ; Cognition ; Retrospective Studies ; DNA Modification Methylases/genetics ; Tumor Suppressor Proteins/genetics ; DNA Repair Enzymes/genetics

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