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Wyświetlanie 1-9 z 9
Tytuł:
Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
Autorzy:
Sundberg JP; The Jackson Laboratory, Bar Harbor, ME, United States of America.
Pratt CH; The Jackson Laboratory, Bar Harbor, ME, United States of America.
Goodwin LP; The Jackson Laboratory, Bar Harbor, ME, United States of America.
Silva KA; The Jackson Laboratory, Bar Harbor, ME, United States of America.
Kennedy VE; The Jackson Laboratory, Bar Harbor, ME, United States of America.
Potter CS; The Jackson Laboratory, Bar Harbor, ME, United States of America.
Dunham A; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States of America.
Sundberg BA; The Jackson Laboratory, Bar Harbor, ME, United States of America.
HogenEsch H; The Jackson Laboratory, Bar Harbor, ME, United States of America.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Jul 20; Vol. 15 (7), pp. e0235295. Date of Electronic Publication: 2020 Jul 20 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Dermatitis, Atopic/*genetics
Inflammation/*genetics
Keratin-14/*genetics
Nerve Tissue Proteins/*genetics
S100 Calcium-Binding Protein A4/*genetics
Animals ; Apoptosis/genetics ; Arthritis/genetics ; Arthritis/pathology ; Dermatitis, Atopic/pathology ; Disease Models, Animal ; Gene Expression Regulation/genetics ; Humans ; Immunoglobulin E/genetics ; Inflammation/pathology ; Integrases/genetics ; Interleukin-18/genetics ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Mice ; NF-kappa B/genetics ; Phenotype ; Signal Transduction
Czasopismo naukowe
Tytuł:
2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata.
Autorzy:
Sundberg JP; The Jackson Laboratory, Bar Harbor, Maine, USA.
Silva KA; The Jackson Laboratory, Bar Harbor, Maine, USA.
Kennedy VE; The Jackson Laboratory, Bar Harbor, Maine, USA.
Wilson JJ; The Jackson Laboratory, Bar Harbor, Maine, USA.
Gott NE; The Jackson Laboratory, Bar Harbor, Maine, USA.
Sundberg BA; The Jackson Laboratory, Bar Harbor, Maine, USA.
Roopenian DC; The Jackson Laboratory, Bar Harbor, Maine, USA.
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Źródło:
Experimental dermatology [Exp Dermatol] 2019 Sep; Vol. 28 (9), pp. 1091-1093. Date of Electronic Publication: 2019 Aug 19.
Typ publikacji:
Letter; Research Support, N.I.H., Extramural
MeSH Terms:
Alopecia Areata/*drug therapy
Deoxyglucose/*therapeutic use
Animals ; Deoxyglucose/administration & dosage ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Female ; Hair Follicle/drug effects ; Mice ; Mice, Inbred C3H ; Skin Transplantation ; Treatment Failure
Raport
Tytuł:
Nail abnormalities identified in an ageing study of 30 inbred mouse strains.
Autorzy:
Linn SC; The Ohio State University College of Veterinary Medicine, Columbus, Ohio.
Mustonen AM; Purdue University College of Veterinary Medicine, West Lafayette, Indiana.
Silva KA; The Jackson Laboratory, Bar Harbor, Maine.
Kennedy VE; The Jackson Laboratory, Bar Harbor, Maine.
Sundberg BA; The Jackson Laboratory, Bar Harbor, Maine.
Bechtold LS; The Jackson Laboratory, Bar Harbor, Maine.
Alghamdi S; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Hoehndorf R; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Schofield PN; The Jackson Laboratory, Bar Harbor, Maine.; Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK.
Sundberg JP; The Jackson Laboratory, Bar Harbor, Maine.
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Źródło:
Experimental dermatology [Exp Dermatol] 2019 Apr; Vol. 28 (4), pp. 383-390. Date of Electronic Publication: 2018 Sep 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aging/*pathology
Nails, Malformed/*pathology
Toe Phalanges/*pathology
Animals ; Bone Remodeling ; Cross-Sectional Studies ; Epidermal Cyst/complications ; Female ; Inflammation/etiology ; Keratin-1/metabolism ; Keratin-10/metabolism ; Keratosis/etiology ; Longitudinal Studies ; Male ; Metaplasia/pathology ; Mice ; Mice, Inbred Strains ; Nails, Malformed/etiology ; Nails, Malformed/metabolism
Czasopismo naukowe
Tytuł:
Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia.
Autorzy:
Sundberg JP; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Shen T; West Coast Metabolomics Center, University of California, Davis, California, United States of America.
Fiehn O; West Coast Metabolomics Center, University of California, Davis, California, United States of America.; Biochemistry Department, King Abdulaziz University, Jeddah, Saudi-Arabia.
Rice RH; Department of Environmental Toxicology, University of California, Davis, California, United States of America.
Silva KA; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Kennedy VE; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Gott NE; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Dionne LA; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Bechtold LS; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Murray SA; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Kuiper R; Department of Laboratory Medicine, The Karolinska Institute, Stockholm, Sweden.
Pratt CH; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
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Źródło:
PloS one [PLoS One] 2018 Oct 29; Vol. 13 (10), pp. e0205775. Date of Electronic Publication: 2018 Oct 29 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aldehyde Oxidoreductases/*genetics
Alopecia/*genetics
Cicatrix/*genetics
Hair Follicle/*pathology
Sebaceous Glands/*pathology
Alopecia/pathology ; Animals ; Cicatrix/pathology ; Disease Models, Animal ; Female ; Humans ; Lipid Metabolism/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Sebaceous Glands/cytology
Czasopismo naukowe
Tytuł:
Loss of FAS/FASL signalling does not reduce apoptosis in Sharpin null mice.
Autorzy:
Potter CS; The Jackson Laboratory, Bar Harbor, ME, USA.
Silva KA; The Jackson Laboratory, Bar Harbor, ME, USA.
Kennedy VE; The Jackson Laboratory, Bar Harbor, ME, USA.
Stearns TM; The Jackson Laboratory, Bar Harbor, ME, USA.
HogenEsch H; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Sundberg JP; The Jackson Laboratory, Bar Harbor, ME, USA.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
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Źródło:
Experimental dermatology [Exp Dermatol] 2017 Sep; Vol. 26 (9), pp. 820-822. Date of Electronic Publication: 2017 May 03.
Typ publikacji:
Letter
MeSH Terms:
Carrier Proteins/*physiology
Fas Ligand Protein/*metabolism
Keratinocytes/*physiology
Skin Diseases/*etiology
fas Receptor/*metabolism
Animals ; Apoptosis ; Fas Ligand Protein/genetics ; Intracellular Signaling Peptides and Proteins ; Mice ; Tumor Necrosis Factor-alpha/metabolism ; fas Receptor/genetics
Opinia redakcyjna
Tytuł:
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Autorzy:
Sundberg JP; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Dadras SS; Departments of Dermatology and Pathology, University of Connecticut, Farmington, Connecticut, United States of America.
Silva KA; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Kennedy VE; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Garland G; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Murray SA; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Sundberg BA; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Schofield PN; The Jackson Laboratory, Bar Harbor, Maine, United States of America.; Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Pratt CH; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Jul 10; Vol. 12 (7), pp. e0180682. Date of Electronic Publication: 2017 Jul 10 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Hair/*abnormalities
Nails, Malformed/*genetics
Skin Abnormalities/*genetics
Animals ; Mice, Inbred C57BL ; Mice, Knockout ; Sebaceous Glands/pathology ; Skin/pathology ; Vibrissae/pathology
Czasopismo naukowe
Tytuł:
Defining the complex phenotype of severe systemic loxoscelism using a large electronic health record cohort.
Autorzy:
Robinson JR; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America.; Department of General Surgery, Vanderbilt University Medical Center, Nashville, TN, United States of America.
Kennedy VE; Department of Internal Medicine, Stanford University, Stanford, CA, United States of America.
Doss Y; Yale University, New Haven, CT, United States of America.
Bastarache L; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America.
Denny J; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America.
Warner JL; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States of America.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Apr 19; Vol. 12 (4), pp. e0174941. Date of Electronic Publication: 2017 Apr 19 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Brown Recluse Spider/*pathogenicity
Disseminated Intravascular Coagulation/*diagnosis
Spider Bites/*diagnosis
Spider Venoms/*toxicity
Adolescent ; Animals ; Bilirubin/blood ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Disseminated Intravascular Coagulation/blood ; Disseminated Intravascular Coagulation/mortality ; Disseminated Intravascular Coagulation/physiopathology ; Electronic Health Records/statistics & numerical data ; Female ; Hemoglobins/metabolism ; Hemolysis/drug effects ; Humans ; L-Lactate Dehydrogenase/blood ; Male ; Phenotype ; Retrospective Studies ; Spider Bites/blood ; Spider Bites/mortality ; Spider Bites/physiopathology ; Survival Analysis ; Young Adult
Czasopismo naukowe
Tytuł:
Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.
Autorzy:
Li Q; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, 233 South 10th Street BLSB Building, Suite 431, Philadelphia, PA, 19107, USA. .
Berndt A; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA.
Sundberg BA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Silva KA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Kennedy VE; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Cario CL; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Richardson MA; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Chase TH; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Schofield PN; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Uitto J; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, 233 South 10th Street BLSB Building, Suite 431, Philadelphia, PA, 19107, USA.
Sundberg JP; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
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Źródło:
Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2016 Jun; Vol. 27 (5-6), pp. 179-90. Date of Electronic Publication: 2016 Apr 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Genome-Wide Association Study*
Aging/*genetics
Fibrosis/*genetics
Heart/*physiopathology
Aging/pathology ; Animals ; Calcinosis/genetics ; Calcinosis/physiopathology ; Chromosome Mapping/methods ; Chromosomes/genetics ; Crosses, Genetic ; Fibrosis/physiopathology ; Genetic Predisposition to Disease ; Genotype ; Humans ; Mice ; Phenotype ; Quantitative Trait Loci/genetics
Czasopismo naukowe
Tytuł:
Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling.
Autorzy:
Potter CS; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Wang Z; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States of America.
Silva KA; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Kennedy VE; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Stearns TM; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Burzenski L; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Shultz LD; The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Hogenesch H; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States of America.
Sundberg JP; The Jackson Laboratory, Bar Harbor, Maine, United States of America ; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Jan 21; Vol. 9 (1), pp. e85666. Date of Electronic Publication: 2014 Jan 21 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoimmunity*
Dermatitis/*pathology
Keratinocytes/*pathology
Skin/*pathology
Animals ; B-Lymphocytes/immunology ; Carrier Proteins/genetics ; Carrier Proteins/immunology ; Crosses, Genetic ; Dermatitis/genetics ; Dermatitis/immunology ; Female ; Gene Deletion ; Gene Expression Regulation ; Homeodomain Proteins/genetics ; Homeodomain Proteins/immunology ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Interleukin-13/immunology ; Interleukin-4/immunology ; Intracellular Signaling Peptides and Proteins ; Keratinocytes/immunology ; Lymphocyte Depletion ; Male ; Mice ; Mice, Knockout ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/immunology ; Signal Transduction ; Skin/immunology ; T-Lymphocytes/immunology
Czasopismo naukowe
    Wyświetlanie 1-9 z 9

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