Long-term depression in neurons involves temporal and ultra-structural dynamics of phosphatidylinositol-4,5-bisphosphate relying on PIP5K, PTEN and PLC.
Autorzy:
Hofbrucker-MacKenzie SA; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. Seemann E; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. Westermann M; Center for Electron Microscopy, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. Qualmann B; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. . KesselsMM; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. Michael.Kessels@med.uni-jena.de.
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Communications biology [Commun Biol] 2023 Apr 03; Vol. 6 (1), pp. 366. Date of Electronic Publication: 2023 Apr 03.
Poststroke dendritic arbor regrowth requires the actin nucleator Cobl.
Autorzy:
Ji Y; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany. Koch D; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany. González Delgado J; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany. Günther M; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany. Witte OW; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany. KesselsMM; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany. Frahm C; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany. Qualmann B; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany.
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PLoS biology [PLoS Biol] 2021 Dec 13; Vol. 19 (12), pp. e3001399. Date of Electronic Publication: 2021 Dec 13 (Print Publication: 2021).
The Role of Protein Arginine Methylation as Post-Translational Modification on Actin Cytoskeletal Components in Neuronal Structure and Function.
Autorzy:
Qualmann B; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany. KesselsMM; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany.
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Źródło:
Cells [Cells] 2021 May 01; Vol. 10 (5). Date of Electronic Publication: 2021 May 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis.
Autorzy:
Beer AJ; Institute of Biochemistry I, Jena University Hospital, Friedrich Schiller University Jena, 07743, Jena, Germany. Hertz D; Institute of Biochemistry I, Jena University Hospital, Friedrich Schiller University Jena, 07743, Jena, Germany.; Research Center Borstel, Leibniz Lung Center, Priority Area Infections, Parkallee 1-40, 23845, Borstel, Germany. Seemann E; Institute of Biochemistry I, Jena University Hospital, Friedrich Schiller University Jena, 07743, Jena, Germany. Beretta M; Center for Sepsis Control and Care and Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany.; Institute of Molecular Cell Biology, CMB-Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Straße 2, 07745, Jena, Germany.; School of Biotechnology and Biomolecular Sciences, University of New South Wales Sydney, Sydney, Australia. Westermann M; Electron Microscopy Center, Jena University Hospital, Friedrich Schiller University Jena, Ziegelmühlenweg 1, 07743, Jena, Germany. Bauer R; Institute of Molecular Cell Biology, CMB-Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Straße 2, 07745, Jena, Germany. Bauer M; Center for Sepsis Control and Care and Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany. KesselsMM; Institute of Biochemistry I, Jena University Hospital, Friedrich Schiller University Jena, 07743, Jena, Germany. Michael.Kessels@med.uni-jena.de. Qualmann B; Institute of Biochemistry I, Jena University Hospital, Friedrich Schiller University Jena, 07743, Jena, Germany. .
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Scientific reports [Sci Rep] 2020 Aug 04; Vol. 10 (1), pp. 13110. Date of Electronic Publication: 2020 Aug 04.
The actin nucleator Cobl organises the terminal web of enterocytes.
Autorzy:
Beer AJ; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. González Delgado J; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. Steiniger F; Centre of Electron Microscopy, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. Qualmann B; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. . KesselsMM; Institute of Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, 07743, Jena, Germany. Michael.Kessels@med.uni-jena.de.
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Scientific reports [Sci Rep] 2020 Jul 07; Vol. 10 (1), pp. 11156. Date of Electronic Publication: 2020 Jul 07.
Comparison of Multiscale Imaging Methods for Brain Research.
Autorzy:
Tröger J; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany. Hoischen C; Core Facility Imaging, Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany. Perner B; Core Facility Imaging, Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.; Molecular Genetics Lab, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany. Monajembashi S; Core Facility Imaging, Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany. Barbotin A; Department of Engineering Science, University of Oxford, Parks Road, Oxford OX13PJ, UK. Löschberger A; Advanced Development Light Microscopy, Carl Zeiss Microscopy GmbH, Carl-Zeiss-Promenade 10, 07745 Jena, Germany. Eggeling C; MRC Human Immunology Unit & Wolfson Imaging Center Oxford, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX39DS, UK.; Dep. Biophysical Imaging, Leibniz Institute of Photonic Technology, Albert-Einstein-Straße 9, 07745 Jena, and Institute for Applied Optics and Biophysics, Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Max-Wien-Platz 1, 07743 Jena, Germany. KesselsMM; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany. Qualmann B; Institute of Biochemistry I, Jena University Hospital-Friedrich Schiller University Jena, Nonnenplan 2-4, 07743 Jena, Germany. Hemmerich P; Core Facility Imaging, Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745 Jena, Germany.
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Źródło:
Cells [Cells] 2020 Jun 01; Vol. 9 (6). Date of Electronic Publication: 2020 Jun 01.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Nonlinear Structured Illumination Using a Fluorescent Protein Activating at the Readout Wavelength.
Autorzy:
Lu-Walther HW; Leibniz Institute of Photonic Technology, Jena, Germany. Hou W; Institute of Biochemistry I, Jena University Hospital/Friedrich Schiller University Jena, Jena, Germany. Kielhorn M; Leibniz Institute of Photonic Technology, Jena, Germany. Arai Y; The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan. Nagai T; The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan. KesselsMM; Institute of Biochemistry I, Jena University Hospital/Friedrich Schiller University Jena, Jena, Germany. Qualmann B; Institute of Biochemistry I, Jena University Hospital/Friedrich Schiller University Jena, Jena, Germany. Heintzmann R; Leibniz Institute of Photonic Technology, Jena, Germany.; Institute of Physical Chemistry, Abbe Center of Photonics, Friedrich-Schiller-University Jena, Jena, Germany.
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Źródło:
PloS one [PLoS One] 2016 Oct 26; Vol. 11 (10), pp. e0165148. Date of Electronic Publication: 2016 Oct 26 (Print Publication: 2016).
The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
Autorzy:
Hou W; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany. Izadi M; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany. Nemitz S; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany. Haag N; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany. KesselsMM; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany. Qualmann B; Institute of Biochemistry I, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany.
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Źródło:
PLoS biology [PLoS Biol] 2015 Sep 03; Vol. 13 (9), pp. e1002233. Date of Electronic Publication: 2015 Sep 03 (Print Publication: 2015).
In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11.
Autorzy:
Varga RE; Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany; Institute of Clinical Chemistry, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Khundadze M; Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Damme M; Biochemical Institute, University of Kiel, Kiel, Germany. Nietzsche S; Electron Microscopy Center, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Hoffmann B; Biomolecular Photonics Group, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Stauber T; Leibniz-Institut für Molekulare Pharmakologie (FMP) und Max-Delbrück Centrum für Molekulare Medizin (MDC), Berlin, Germany. Koch N; Institute of Biochemistry I, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Hennings JC; Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Franzka P; Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Huebner AK; Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. KesselsMM; Institute of Biochemistry I, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Biskup C; Biomolecular Photonics Group, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Jentsch TJ; Leibniz-Institut für Molekulare Pharmakologie (FMP) und Max-Delbrück Centrum für Molekulare Medizin (MDC), Berlin, Germany. Qualmann B; Institute of Biochemistry I, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Braulke T; Department of Biochemistry, Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Kurth I; Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Beetz C; Institute of Clinical Chemistry, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany. Hübner CA; Institute of Human Genetics, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
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PLoS genetics [PLoS Genet] 2015 Aug 18; Vol. 11 (8), pp. e1005454. Date of Electronic Publication: 2015 Aug 18 (Print Publication: 2015).
Terminal axonal arborization and synaptic bouton formation critically rely on abp1 and the arp2/3 complex.
Autorzy:
Koch N; Institute for Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany; Research Group Membrane Trafficking and Cytoskeleton, Department of Neurochemistry & Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany. Kobler O; Research Group Functional Genetics of the Synapse, Department of Neurochemistry & Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany. Thomas U; Research Group Functional Genetics of the Synapse, Department of Neurochemistry & Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany. Qualmann B; Institute for Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany. KesselsMM; Institute for Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany; Research Group Membrane Trafficking and Cytoskeleton, Department of Neurochemistry & Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany.
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Źródło:
PloS one [PLoS One] 2014 May 19; Vol. 9 (5), pp. e97692. Date of Electronic Publication: 2014 May 19 (Print Publication: 2014).
Ultrastructural freeze-fracture immunolabeling identifies plasma membrane-localized syndapin II as a crucial factor in shaping caveolae.
Autorzy:
Koch D; Institute for Biochemistry I, Jena University Hospital - Friedrich Schiller University Jena, 07743 Jena, Germany. Westermann M KesselsMM Qualmann B
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Źródło:
Histochemistry and cell biology [Histochem Cell Biol] 2012 Aug; Vol. 138 (2), pp. 215-30. Date of Electronic Publication: 2012 Jun 21.
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