- Tytuł:
-
Activation of Sirt1 by resveratrol inhibits TNF-α induced
inflammation in fibroblasts. - Autorzy:
- Źródło:
- PloS one [PLoS One] 2011; Vol. 6 (11), pp. e27081. Date of Electronic Publication: 2011 Nov 01.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Antineoplastic Agents, Phytogenic/*pharmacology
Fibroblasts/*drug effects
Fibroblasts/*metabolismInflammation /*drug therapy
Sirtuin 1/*metabolism
Stilbenes/*pharmacology
Tumor Necrosis Factor-alpha/*toxicity
Animals ; Anti-Inflammatory Agents ; Apoptosis ; Blotting, Western ; Cell Line ; Cell Proliferation ; Fibroblasts/cytology ;Inflammation /chemically induced ;Inflammation /metabolism ;Inflammation Mediators ; Interleukin-1beta/genetics ; Interleukin-1beta/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Mice ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Real-Time Polymerase Chain Reaction ; Resveratrol ; Sirtuin 1/antagonists & inhibitors ; Sirtuin 1/genetics ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Transcription Factor RelA/genetics ; Transcription Factor RelA/metabolism
Czasopismo naukowe