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    Wyświetlanie 1-16 z 16
    Tytuł:
    The development and hepatotoxicity of acetaminophen: reviewing over a century of progress.
    Autorzy:
    McGill MR; Department of Environmental and Occupational Health, Fay W. Boozman College of Public Health, Little Rock, AR, USA.; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Hinson JA; Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
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    Źródło:
    Drug metabolism reviews [Drug Metab Rev] 2020 Nov; Vol. 52 (4), pp. 472-500. Date of Electronic Publication: 2020 Oct 14.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Acetaminophen/*toxicity
    Chemical and Drug Induced Liver Injury/*enzymology
    Liver/*drug effects
    Acetaminophen/metabolism ; Animals ; Chemical and Drug Induced Liver Injury/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; Humans ; Liver/enzymology ; Liver/metabolism ; Oxidative Stress
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration.
    Autorzy:
    Kutanzi KR; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
    Ewing LE; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Department of Biochemistry, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
    Skinner CM; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Department of Biochemistry, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
    Quick CM; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
    Kennon-McGill S; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
    McGill MR; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
    Walker LA; National Center for Natural Products Research, University of Mississippi, Oxford, MS 38677, USA.; ElSohly Laboratories, Inc. (ELI), Oxford, MS 38655, USA.
    ElSohly MA; National Center for Natural Products Research, University of Mississippi, Oxford, MS 38677, USA.; ElSohly Laboratories, Inc. (ELI), Oxford, MS 38655, USA.; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, Oxford, MS 38677, USA.
    Gurley BJ; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; National Center for Natural Products Research, University of Mississippi, Oxford, MS 38677, USA.
    Koturbash I; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2020 Oct 21; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 21.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Cannabidiol/*toxicity
    Plant Extracts/*toxicity
    Alkaline Phosphatase/blood ; Animals ; Cannabidiol/pharmacokinetics ; Cannabis/chemistry ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/pathology ; Cytochrome P-450 Enzyme System/metabolism ; Dietary Supplements/toxicity ; Glutamine/analogs & derivatives ; Glutamine/metabolism ; Herb-Drug Interactions ; Male ; Mice, Inbred C57BL ; Plant Extracts/chemistry ; Plant Extracts/pharmacokinetics ; Taurine/analogs & derivatives ; Taurine/metabolism ; Toxicity Tests
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms.
    Autorzy:
    Smith AK; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America.
    Ropella GEP; Tempus Dictum, Inc., Milwaukie, Oregon, United States of America.
    McGill MR; Department of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
    Krishnan P; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America.
    Dutta L; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America.
    Kennedy RC; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America.
    Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
    Hunt CA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2020 Jun 02; Vol. 16 (6), pp. e1007622. Date of Electronic Publication: 2020 Jun 02 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Necrosis*
    Alanine Transaminase/*blood
    Biomarkers/*blood
    Hepatocytes/*drug effects
    Acetaminophen/toxicity ; Animals ; Chemical and Drug Induced Liver Injury ; Computational Biology ; Computer Simulation ; Hepatocytes/enzymology ; Liver/drug effects ; Liver/enzymology ; Mice ; Monte Carlo Method ; Software
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways.
    Autorzy:
    Kennedy JL; a Division of Allergy and Immunology, Department of Pediatrics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.; b Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine , University of Arkansas for Medical Sciences , Little Rock , AR , USA.; c Arkansas Children's Hospital Research Institute , Little Rock , AR , USA.
    Kurten RC; a Division of Allergy and Immunology, Department of Pediatrics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.; c Arkansas Children's Hospital Research Institute , Little Rock , AR , USA.; d Department of Physiology and Biophysics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
    McCullough S; e Division of Clinical Pharmacology and Toxicology, Department of Pediatrics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
    Panettieri RA; f Department of Medicine , Rutgers, the State University of New Jersey , New Brunswick , NJ , USA.
    Koziol-White C; f Department of Medicine , Rutgers, the State University of New Jersey , New Brunswick , NJ , USA.
    Jones SM; a Division of Allergy and Immunology, Department of Pediatrics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.; c Arkansas Children's Hospital Research Institute , Little Rock , AR , USA.; d Department of Physiology and Biophysics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
    Caid K; g Department of Pediatrics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
    Gill PS; c Arkansas Children's Hospital Research Institute , Little Rock , AR , USA.; g Department of Pediatrics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
    Roberts D; e Division of Clinical Pharmacology and Toxicology, Department of Pediatrics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
    Jaeschke H; h Department of Pharmacology, Toxicology, and Therapeutics , University of Kansas Medical Center , Kansas City , KS , USA.
    McGill MR; i Department of Environmental and Occupational Health, Fay W. Boozman College of Public Health , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
    James L; e Division of Clinical Pharmacology and Toxicology, Department of Pediatrics , University of Arkansas for Medical Sciences , Little Rock , AR , USA.
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    Źródło:
    Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Sep; Vol. 49 (9), pp. 1106-1115. Date of Electronic Publication: 2019 Jan 30.
    Typ publikacji:
    Journal Article; Video-Audio Media
    MeSH Terms:
    Acetaminophen/*pharmacology
    Bronchoconstriction/*drug effects
    Bronchodilator Agents/*pharmacology
    Lung/*drug effects
    Acetaminophen/administration & dosage ; Acetaminophen/adverse effects ; Albuterol/pharmacology ; Animals ; Asthma/physiopathology ; Bronchodilator Agents/adverse effects ; Carbachol/pharmacology ; Chemical and Drug Induced Liver Injury/etiology ; Dose-Response Relationship, Drug ; Humans ; Lung/physiology ; Male ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Middle Aged ; Organ Culture Techniques ; Oxidative Stress/drug effects ; Respiratory Hypersensitivity/chemically induced
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration.
    Autorzy:
    Ewing LE; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    McGill MR; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Yee EU; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Quick CM; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Skinner CM; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Kennon-McGill S; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Clemens M; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Vazquez JH; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    McCullough SS; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Williams DK; Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Kutanzi KR; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Walker LA; National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA. .; ElSohly Laboratories, Inc. (ELI), Oxford, MS 38677, USA. .
    ElSohly MA; National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA. .; ElSohly Laboratories, Inc. (ELI), Oxford, MS 38677, USA. .; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA. .
    James LP; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Gurley BJ; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Koturbash I; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2019 Jun 17; Vol. 24 (12). Date of Electronic Publication: 2019 Jun 17.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Acetaminophen/*adverse effects
    Cannabidiol/*adverse effects
    Hepatic Veno-Occlusive Disease/*diagnosis
    Hepatic Veno-Occlusive Disease/*etiology
    Animals ; Biomarkers ; Cannabidiol/chemistry ; Cannabis/chemistry ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Synergism ; Female ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Mice ; Mice, Inbred Strains ; Phytochemicals/adverse effects ; Phytochemicals/chemistry ; Plant Extracts/adverse effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model.
    Autorzy:
    Ewing LE; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Skinner CM; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Quick CM; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Kennon-McGill S; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    McGill MR; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
    Walker LA; National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA. .; ElSohly Laboratories, Inc. (ELI), Oxford, MS 38655, USA. .
    ElSohly MA; National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA. .; ElSohly Laboratories, Inc. (ELI), Oxford, MS 38655, USA. .; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA. .
    Gurley BJ; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72223, USA. .
    Koturbash I; Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2019 Apr 30; Vol. 24 (9). Date of Electronic Publication: 2019 Apr 30.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Cannabidiol/*chemistry
    Cannabidiol/*pharmacology
    Cannabis/*chemistry
    Hepatocytes/*drug effects
    Plant Extracts/*chemistry
    Plant Extracts/*pharmacology
    Animals ; Biomarkers ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Disease Models, Animal ; Gene Expression Profiling ; Hepatocytes/metabolism ; Liver Function Tests ; Mice ; Transcriptome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis.
    Autorzy:
    Weemhoff JL; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
    Woolbright BL; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
    Jenkins RE; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
    McGill MR; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
    Sharpe MR; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
    Olson JC; Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
    Antoine DJ; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
    Curry SC; Department of Medical Toxicology, Banner -University Medical Center Phoenix, Phoenix, AZ, USA.; Department of Medicine, and the Center for Toxicology and Pharmacology Education and Research, University of Arizona College of Medicine, Phoenix, AZ, USA.
    Jaeschke H; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
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    Źródło:
    Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2017 Mar; Vol. 37 (3), pp. 377-384. Date of Electronic Publication: 2016 Aug 06.
    Typ publikacji:
    Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Hepatitis/*blood
    Hypoxia/*blood
    Ischemia/*blood
    Liver/*physiopathology
    Acetaminophen/toxicity ; Adolescent ; Adult ; Alanine Transaminase/blood ; Apoptosis ; Biomarkers/blood ; DNA Fragmentation ; DNA, Mitochondrial/blood ; Female ; HMGB1 Protein/blood ; Humans ; Ischemia/etiology ; Keratin-18/blood ; Linear Models ; Liver/blood supply ; Male ; MicroRNAs/blood ; Middle Aged ; Mitochondria/pathology ; Necrosis/etiology ; United States ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study.
    Autorzy:
    McGill MR; a Department of Pharmacology , Toxicology and Therapeutics and.
    Kennon-McGill S; b Department of Otolaryngology - Head and Neck Surgery , University of Kansas Medical Center , Kansas City , KS , USA.
    Durham D; b Department of Otolaryngology - Head and Neck Surgery , University of Kansas Medical Center , Kansas City , KS , USA.
    Jaeschke H; a Department of Pharmacology , Toxicology and Therapeutics and.
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    Źródło:
    Toxicology mechanisms and methods [Toxicol Mech Methods] 2016 Feb; Vol. 26 (2), pp. 104-11. Date of Electronic Publication: 2016 Mar 16.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Chemical and Drug Induced Liver Injury*/metabolism
    Chemical and Drug Induced Liver Injury*/physiopathology
    Drug Overdose*/metabolism
    Drug Overdose*/physiopathology
    Acetaminophen/*toxicity
    Cochlea/*drug effects
    Hearing/*drug effects
    Oxidative Stress/*drug effects
    Acetaminophen/administration & dosage ; Acetaminophen/metabolism ; Alanine Transaminase/blood ; Animals ; Cochlea/metabolism ; Glutathione Disulfide/blood ; Male ; Mice, Inbred C57BL ; Protein Binding
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes.
    Autorzy:
    Woolbright BL; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
    McGill MR; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
    Yan H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
    Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
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    Źródło:
    Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2016 Feb; Vol. 118 (2), pp. 160-7. Date of Electronic Publication: 2015 Aug 13.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Glycochenodeoxycholic Acid*/metabolism
    Glycochenodeoxycholic Acid*/toxicity
    Hepatocytes*/drug effects
    Hepatocytes*/metabolism
    Taurocholic Acid*/metabolism
    Taurocholic Acid*/toxicity
    Amino Acid Chloromethyl Ketones/*pharmacology
    Apoptosis/*drug effects
    Cholestasis/*metabolism
    Animals ; Bile Acids and Salts/metabolism ; Bile Acids and Salts/toxicity ; Hep G2 Cells ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Protective Agents/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Connexin32: a mediator of acetaminophen-induced liver injury?
    Autorzy:
    Maes M; a Department of In Vitro Toxicology and Dermato-Cosmetology , Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel , Brussels , Belgium .
    McGill MR; b Department of Pharmacology , Toxicology and Therapeutics, University of Kansas Medical Center , Kansas City , KS , USA .
    da Silva TC; c Department of Pathology , School of Veterinary Medicine and Animal Science, University of São Paulo , São Paulo , Brazil , and.
    Lebofsky M; b Department of Pharmacology , Toxicology and Therapeutics, University of Kansas Medical Center , Kansas City , KS , USA .
    Maria Monteiro de Araújo C; c Department of Pathology , School of Veterinary Medicine and Animal Science, University of São Paulo , São Paulo , Brazil , and.
    Tiburcio T; c Department of Pathology , School of Veterinary Medicine and Animal Science, University of São Paulo , São Paulo , Brazil , and.
    Veloso Alves Pereira I; c Department of Pathology , School of Veterinary Medicine and Animal Science, University of São Paulo , São Paulo , Brazil , and.
    Willebrords J; a Department of In Vitro Toxicology and Dermato-Cosmetology , Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel , Brussels , Belgium .
    Crespo Yanguas S; a Department of In Vitro Toxicology and Dermato-Cosmetology , Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel , Brussels , Belgium .
    Farhood A; d Department of Pathology , St. David's North Austin Medical Center , Austin , TX , USA.
    Zaidan Dagli ML; c Department of Pathology , School of Veterinary Medicine and Animal Science, University of São Paulo , São Paulo , Brazil , and.
    Jaeschke H; b Department of Pharmacology , Toxicology and Therapeutics, University of Kansas Medical Center , Kansas City , KS , USA .
    Cogliati B; c Department of Pathology , School of Veterinary Medicine and Animal Science, University of São Paulo , São Paulo , Brazil , and.
    Vinken M; a Department of In Vitro Toxicology and Dermato-Cosmetology , Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel , Brussels , Belgium .
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    Źródło:
    Toxicology mechanisms and methods [Toxicol Mech Methods] 2016 Feb; Vol. 26 (2), pp. 88-96. Date of Electronic Publication: 2016 Jan 07.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Acetaminophen/*toxicity
    Chemical and Drug Induced Liver Injury/*metabolism
    Connexins/*metabolism
    Liver/*drug effects
    Acetaminophen/administration & dosage ; Acetaminophen/metabolism ; Alanine Transaminase/blood ; Animals ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/pathology ; Connexins/genetics ; Cytokines/blood ; Glutathione Disulfide/metabolism ; Liver/immunology ; Liver/metabolism ; Liver/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Proliferating Cell Nuclear Antigen/metabolism ; Protein Binding ; Gap Junction beta-1 Protein
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.
    Autorzy:
    McGill MR; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center , Kansas City, KS , USA.
    Du K
    Xie Y
    Bajt ML
    Ding WX
    Jaeschke H
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    Źródło:
    Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2015 May; Vol. 45 (5), pp. 442-9. Date of Electronic Publication: 2014 Nov 25.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Chemical and Drug Induced Liver Injury/*enzymology
    Furosemide/*adverse effects
    JNK Mitogen-Activated Protein Kinases/*metabolism
    Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
    Animals ; Anthracenes/pharmacology ; Anthracenes/therapeutic use ; Cell Line ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/pathology ; DNA Damage ; Enzyme Activation/drug effects ; Glutathione Disulfide/metabolism ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Time Factors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.
    Autorzy:
    Xie Y; a Department of Pharmacology, Toxicology, and Therapeutics , University of Kansas Medical Center , Kansas City , KS , USA .
    McGill MR
    Cook SF
    Sharpe MR
    Winefield RD
    Wilkins DG
    Rollins DE
    Jaeschke H
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    Źródło:
    Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2015; Vol. 45 (10), pp. 921-9. Date of Electronic Publication: 2015 Apr 14.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Acetaminophen/*blood
    Acetaminophen/*metabolism
    Blood Proteins/*metabolism
    Drug Overdose/*blood
    Liver/*cytology
    Adolescent ; Adult ; Analgesics, Non-Narcotic/blood ; Analgesics, Non-Narcotic/metabolism ; Cell Line/drug effects ; Cell Line/metabolism ; Female ; Humans ; Liver/drug effects ; Male ; Middle Aged ; Time Factors ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimide.
    Autorzy:
    Mcgill MR; a Department of Pharmacology , Toxicology and Therapeutics, University of Kansas Medical Center , Kansas City , KS , USA.
    Jaeschke H; a Department of Pharmacology , Toxicology and Therapeutics, University of Kansas Medical Center , Kansas City , KS , USA.
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    Źródło:
    Toxicology mechanisms and methods [Toxicol Mech Methods] 2015; Vol. 25 (8), pp. 589-95. Date of Electronic Publication: 2015 Oct 13.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Enzyme Inhibitors/*pharmacology
    Ethylmaleimide/*pharmacology
    Glutathione/*analysis
    Glutathione Reductase/*antagonists & inhibitors
    Pyridines/*pharmacology
    Sulfhydryl Reagents/*pharmacology
    Analytic Sample Preparation Methods ; Animals ; Biomarkers/analysis ; Biomarkers/metabolism ; Glutathione/metabolism ; Glutathione Reductase/metabolism ; Kidney/chemistry ; Kidney/drug effects ; Kidney/metabolism ; Kinetics ; Liver/chemistry ; Liver/drug effects ; Liver/metabolism ; Lung/chemistry ; Lung/drug effects ; Lung/metabolism ; Mice, Inbred C57BL ; Oxidation-Reduction ; Protein Stability/drug effects ; Reproducibility of Results ; Solid Phase Extraction
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans.
    Autorzy:
    McGill MR; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center , Kansas City, KS , USA .
    Cao M
    Svetlov A
    Sharpe MR
    Williams CD
    Curry SC
    Farhood A
    Jaeschke H
    Svetlov SI
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    Źródło:
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2014 May; Vol. 19 (3), pp. 222-30. Date of Electronic Publication: 2014 Mar 06.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Acetaminophen/*poisoning
    Argininosuccinate Synthase/*blood
    Drug Overdose/*blood
    Animals ; Humans ; Mice ; Mice, Inbred C57BL
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.
    Autorzy:
    Woolbright BL; Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
    Ramachandran A
    McGill MR
    Yan HM
    Bajt ML
    Sharpe MR
    Lemasters JJ
    Jaeschke H
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    Źródło:
    Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2012 Dec; Vol. 111 (6), pp. 417-25. Date of Electronic Publication: 2012 Sep 25.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Acetaminophen/*toxicity
    Cathepsin B/*metabolism
    Chemical and Drug Induced Liver Injury/*physiopathology
    Hepatocytes/*drug effects
    Lysosomes/*pathology
    Adult ; Animals ; Cathepsin B/antagonists & inhibitors ; Cysteine Proteinase Inhibitors/pharmacology ; Dipeptides/pharmacology ; Dose-Response Relationship, Drug ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Ketones/pharmacology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Lysosomes/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Prospective Studies
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
    Autorzy:
    Jaeschke H; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, 66160, USA. />McGill MR
    Ramachandran A
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    Źródło:
    Drug metabolism reviews [Drug Metab Rev] 2012 Feb; Vol. 44 (1), pp. 88-106. Date of Electronic Publication: 2012 Jan 10.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Acetaminophen/*adverse effects
    Acetaminophen/*pharmacology
    Cell Death/*drug effects
    Chemical and Drug Induced Liver Injury/*physiopathology
    Mitochondria/*drug effects
    Oxidative Stress/*drug effects
    Analgesics, Non-Narcotic/adverse effects ; Analgesics, Non-Narcotic/pharmacology ; Antioxidants/metabolism ; Apoptosis/drug effects ; DNA Fragmentation ; Humans ; Inflammation/chemically induced ; Liver/drug effects ; Liver/metabolism ; Mitochondria/metabolism ; Necrosis/chemically induced ; Oxidants/adverse effects ; Oxidants/pharmacology ; Peroxynitrous Acid/metabolism ; Reactive Oxygen Species/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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