- Tytuł:
- FGFR3b Extracellular Loop Mutation Lacks Tumorigenicity In Vivo but Collaborates with p53/pRB Deficiency to Induce High-grade Papillary Urothelial Carcinoma.
- Autorzy:
- Źródło:
- Scientific reports [Sci Rep] 2016 May 09; Vol. 6, pp. 25596. Date of Electronic Publication: 2016 May 09.
- Typ publikacji:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
- MeSH Terms:
-
Carcinogenesis/*genetics
Carcinoma, Papillary/*genetics
Mutation/*genetics
Receptor, Fibroblast Growth Factor, Type 3/*chemistry
Receptor, Fibroblast Growth Factor, Type 3/*genetics
Retinoblastoma Protein/*deficiency
Tumor Suppressor Protein p53/*metabolism
Urinary Bladder Neoplasms/*genetics
Animals ; Carcinogenesis/pathology ; Carcinoma, Papillary/pathology ; Cell Cycle ; Cell Proliferation ; Humans ; Mice ; Mice, Transgenic ; Neoplasm Grading ; Organ Specificity ; Phosphorylation ; Protein Structure, Secondary ; Signal Transduction ; Urinary Bladder Neoplasms/pathology ; Urothelium/pathology
Czasopismo naukowe