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Tytuł:
Direct knockdown of phospho-PTM targets mediated by TRIM21 can improve personalized treatment in breast cancer.
Autorzy:
Dey P; Molecular Functional Imaging Laboratory, KS232c, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Kharghar, Navi Mumbai, 410210, India.; Faculty of Life Sciences, Homi Bhabha National Institute, Mumbai, India.
Joshi M; Molecular Functional Imaging Laboratory, KS232c, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Kharghar, Navi Mumbai, 410210, India.; Faculty of Life Sciences, Homi Bhabha National Institute, Mumbai, India.
Mujawar A; Molecular Functional Imaging Laboratory, KS232c, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Kharghar, Navi Mumbai, 410210, India.; Faculty of Life Sciences, Homi Bhabha National Institute, Mumbai, India.
Malhotra R; Molecular Functional Imaging Laboratory, KS232c, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Kharghar, Navi Mumbai, 410210, India.
De A; Molecular Functional Imaging Laboratory, KS232c, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Sector 22, Kharghar, Navi Mumbai, 410210, India. .; Faculty of Life Sciences, Homi Bhabha National Institute, Mumbai, India. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2022 Oct; Vol. 45 (5), pp. 873-891. Date of Electronic Publication: 2022 Jul 14.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Breast Neoplasms*/metabolism
Humans ; Female ; Receptor, ErbB-2/metabolism ; STAT3 Transcription Factor/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Niclosamide/therapeutic use ; Precision Medicine ; Drug Resistance, Neoplasm ; Trastuzumab/pharmacology ; Trastuzumab/therapeutic use ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
VSIG4 Attenuates NLRP3 and Ameliorates Neuroinflammation via JAK2-STAT3-A20 Pathway after Intracerebral Hemorrhage in Mice.
Autorzy:
Ji N; Department of Anesthesia, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Wu L; Department of Neurology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China.
Shi H; Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China.
Li Q; Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China.
Yu A; Emergency Department of Emergency, Affiliated Hospital of Zunyi Medical University, Guizhou, 563003, China. .
Yang Z; Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2022 Feb; Vol. 40 (1), pp. 78-88. Date of Electronic Publication: 2022 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
NLR Family, Pyrin Domain-Containing 3 Protein*
Neuroinflammatory Diseases*
Animals ; Cerebral Hemorrhage/drug therapy ; Cerebral Hemorrhage/pathology ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Janus Kinase 2/metabolism ; Mice ; Mice, Inbred C57BL ; Receptors, Complement ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling.
Autorzy:
Pozios I; Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Seel NN; Department of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany.
Hering NA; Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Hartmann L; Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Liu V; Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.; Department of Minimal Invasive and Visceral Surgery, Vivantes Klinikum Neukölln, Berlin, Germany.
Camaj P; Department of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, Munich, Germany.; Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany.
Müller MH; Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.; Department of Minimal Invasive and Visceral Surgery, Vivantes Klinikum Neukölln, Berlin, Germany.
Lee LD; Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Bruns CJ; Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany.
Kreis ME; Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Seeliger H; Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2021 Feb; Vol. 44 (1), pp. 167-177. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji:
Journal Article
MeSH Terms:
Adenocarcinoma/*pathology
Cytokine Receptor gp130/*metabolism
Estrogen Receptor beta/*metabolism
Interleukin-6/*metabolism
Pancreatic Neoplasms/*metabolism
Pancreatic Neoplasms/*pathology
Raloxifene Hydrochloride/*pharmacology
STAT3 Transcription Factor/*metabolism
Adenocarcinoma/metabolism ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Male ; Mice, Nude ; Neoplasm Metastasis ; Signal Transduction/drug effects ; Time Factors ; Xenograft Model Antitumor Assays ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Long non-coding RNA SNHG3, induced by IL-6/STAT3 transactivation, promotes stem cell-like properties of gastric cancer cells by regulating the miR-3619-5p/ARL2 axis.
Autorzy:
Sun B; Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, 200032, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China.
Han Y; Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, 200032, Shanghai, China.; Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China.
Cai H; Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, 200032, Shanghai, China. .; Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China. .
Huang H; Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, 200032, Shanghai, China. .; Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China. .
Xuan Y; Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, 200032, Shanghai, China. .; Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2021 Feb; Vol. 44 (1), pp. 179-192. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
GTP-Binding Proteins/*metabolism
Interleukin-6/*metabolism
MicroRNAs/*metabolism
Neoplastic Stem Cells/*pathology
RNA, Long Noncoding/*metabolism
STAT3 Transcription Factor/*metabolism
Stomach Neoplasms/*genetics
Transcriptional Activation/*genetics
Base Sequence ; Cell Line, Tumor ; Cisplatin/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockdown Techniques ; Humans ; MicroRNAs/genetics ; Models, Biological ; Neoplastic Stem Cells/metabolism ; RNA, Long Noncoding/genetics ; Stomach Neoplasms/pathology ; Transcriptional Activation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Aberrantly expressed Bruton's tyrosine kinase preferentially drives metastatic and stem cell-like phenotypes in neuroblastoma cells.
Autorzy:
Pikatan NW; International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, 110, Taipei City, Taiwan.; Doctorate Program of Medical and Health Science, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, 55281, Yogyakarta, Indonesia.; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 110, Taipei City, Taiwan.
Liu YL; Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, 110, Taipei City, Taiwan.; Department of Pediatrics, Taipei Medical University Hospital, 110, Taipei City, Taiwan.; Taipei Cancer Center, Taipei Medical University, 110, Taipei City, Taiwan.
Bamodu OA; Department of Hematology and Oncology, Taipei Medical University-Shuang Ho Hospital, 235, New Taipei City, Taiwan.; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, 235, New Taipei City, Taiwan.
Hsiao M; Genomics Research Center, Academia Sinica, 11529, Taipei City, Taiwan.
Hsu WM; Department of Surgery, National Taiwan University Hospital, 100, Taipei City, Taiwan.
Haryana SM; Department of Histology and Cellular Biology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, 55281, Yogyakarta, Indonesia.
Sutaryo; Department of Pediatrics, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, 55281, Yogyakarta, Indonesia.
Chao TY; International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, 110, Taipei City, Taiwan. .; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 110, Taipei City, Taiwan. .; Taipei Cancer Center, Taipei Medical University, 110, Taipei City, Taiwan. .; Department of Hematology and Oncology, Taipei Medical University-Shuang Ho Hospital, 235, New Taipei City, Taiwan. .; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, 235, New Taipei City, Taiwan. .
Yeh CT; International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, 110, Taipei City, Taiwan. .; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 110, Taipei City, Taiwan. .; Department of Hematology and Oncology, Taipei Medical University-Shuang Ho Hospital, 235, New Taipei City, Taiwan. .; Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, 235, New Taipei City, Taiwan. .; Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 30015, Hsinchu City, Taiwan. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2020 Dec; Vol. 43 (6), pp. 1067-1084. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji:
Journal Article
MeSH Terms:
Agammaglobulinaemia Tyrosine Kinase/*metabolism
Neoplastic Stem Cells/*enzymology
Neoplastic Stem Cells/*pathology
Neuroblastoma/*enzymology
Neuroblastoma/*pathology
Agammaglobulinaemia Tyrosine Kinase/antagonists & inhibitors ; Agammaglobulinaemia Tyrosine Kinase/genetics ; Animals ; Antineoplastic Agents/pharmacology ; Benzamides/pharmacology ; Carcinogenesis/pathology ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cisplatin/pharmacology ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Ki-67 Antigen/metabolism ; Male ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Phenotype ; Prognosis ; Proto-Oncogene Proteins c-akt/metabolism ; Pyrazines/pharmacology ; STAT3 Transcription Factor/metabolism ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hispidulin Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia and Attenuates the Activation of Akt, NF-κB, and STAT3 Pathway.
Autorzy:
Yu CI; Department of Orthopedics, Chi Mei Medical Center, Liouying, Tainan, 73659, Taiwan.
Cheng CI; Department of Medical Imaging, Sin-Lau Medical Foundation the Presbyterian Church, Tainan, 70142, Taiwan.
Kang YF; School of Nursing, Fooyin University, 151 Jinxue Road, Daliao District, Kaohsiung, 83102, Taiwan.
Chang PC; Division of Thoracic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, 80708, Taiwan.; Weight Management Center, Kaohsiung Medical University Hospital, Kaohsiung, 80708, Taiwan.; College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Lin IP; Department of Pharmacology, Graduate Institute of Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Kuo YH; Department of Pharmacology, Graduate Institute of Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Jhou AJ; Department of Pharmacology, Graduate Institute of Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Lin MY; Community Health Promotion Center, Kaohsiung Municipal Ci-Jin Hospital, Kaohsiung, 80708, Taiwan.
Chen CY; Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung, 83102, Taiwan.
Lee CH; Department of Pharmacology, Graduate Institute of Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. .; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, 80708, Taiwan. .; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2020 Jun; Vol. 38 (1), pp. 163-174. Date of Electronic Publication: 2020 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents/*administration & dosage
Encephalitis/*metabolism
Encephalitis/*prevention & control
Flavones/*administration & dosage
Microglia/*drug effects
Microglia/*metabolism
Signal Transduction/*drug effects
Animals ; Apoptosis/drug effects ; Cells, Cultured ; Encephalitis/chemically induced ; Lipopolysaccharides/administration & dosage ; Mice ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
LncRNA PVT1 induces aggressive vasculogenic mimicry formation through activating the STAT3/Slug axis and epithelial-to-mesenchymal transition in gastric cancer.
Autorzy:
Zhao J; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.; Cancer Metastasis Institute, Fudan University, Shanghai, 200040, People's Republic of China.
Wu J; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.
Qin Y; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China.
Zhang W; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China. .
Huang G; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China. .
Qin L; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, People's Republic of China. .; Cancer Metastasis Institute, Fudan University, Shanghai, 200040, People's Republic of China. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2020 Oct; Vol. 43 (5), pp. 863-876. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Mimicry*/genetics
Epithelial-Mesenchymal Transition/*genetics
RNA, Long Noncoding/*metabolism
STAT3 Transcription Factor/*metabolism
Snail Family Transcription Factors/*metabolism
Stomach Neoplasms/*genetics
Stomach Neoplasms/*pathology
Animals ; Base Sequence ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Mice, Inbred NOD ; Mice, SCID ; Models, Biological ; Neoplasm Invasiveness ; Promoter Regions, Genetic/genetics ; RNA, Long Noncoding/genetics ; Snail Family Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RNAscope dual ISH-IHC technology to study angiogenesis in diffuse large B-cell lymphomas.
Autorzy:
Annese T; Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124, Bari, Italy.
Tamma R; Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124, Bari, Italy.
De Giorgis M; Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124, Bari, Italy.
Ruggieri S; Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124, Bari, Italy.
Maiorano E; Department of Emergency and Organ Transplantation, Operating Unit of Pathological Anatomy, Aldo Moro University, Bari, Italy.
Specchia G; Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari, Italy.
Ribatti D; Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124, Bari, Italy. .
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Źródło:
Histochemistry and cell biology [Histochem Cell Biol] 2020 Mar; Vol. 153 (3), pp. 185-192. Date of Electronic Publication: 2019 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Immunohistochemistry*
In Situ Hybridization, Fluorescence*
Lymphoma, Large B-Cell, Diffuse/*diagnosis
Neovascularization, Pathologic/*diagnosis
RNA, Messenger/*analysis
Humans ; Paraffin Embedding ; RNA, Messenger/genetics ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interleukin-6 contributes to initiation of neuronal regeneration program in the remote dorsal root ganglia neurons after sciatic nerve injury.
Autorzy:
Dubový P; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, 62500, Brno, Czech Republic.
Hradilová-Svíženská I; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, 62500, Brno, Czech Republic.
Klusáková I; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, 62500, Brno, Czech Republic.
Brázda V; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, 62500, Brno, Czech Republic.
Joukal M; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, 62500, Brno, Czech Republic. .
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Źródło:
Histochemistry and cell biology [Histochem Cell Biol] 2019 Aug; Vol. 152 (2), pp. 109-117. Date of Electronic Publication: 2019 Mar 29.
Typ publikacji:
Journal Article
MeSH Terms:
Nerve Regeneration*
Ganglia, Spinal/*cytology
Ganglia, Spinal/*metabolism
Interleukin-6/*metabolism
Neurons/*cytology
Neurons/*metabolism
Peripheral Nerve Injuries/*metabolism
Animals ; Blotting, Western ; Calcium-Binding Proteins ; Ganglia, Spinal/pathology ; Ganglia, Spinal/surgery ; Immunohistochemistry ; Interleukin-6/analysis ; Interleukin-6/deficiency ; Intracellular Signaling Peptides and Proteins/analysis ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons/chemistry ; Neurons/pathology ; Peripheral Nerve Injuries/pathology ; Peripheral Nerve Injuries/surgery ; STAT3 Transcription Factor/analysis ; Stathmin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dp44mT, an iron chelator, suppresses growth and induces apoptosis via RORA-mediated NDRG2-IL6/JAK2/STAT3 signaling in glioma.
Autorzy:
Zhou J; Department of Neurosurgery, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China.
Jiang Y; Department of Neurosurgery, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China.; Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhao J; Department of Neurosurgery, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China.
Zhang H; International Education College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Fu J; Department of Neurosurgery, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China.
Luo P; Department of Neurosurgery, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China.
Ma Y; Department of Oncology, Liaoning Province Tumor Hospital, Shenyang, Liaoning, China.
Zou D; The First Laboratory of Cancer Institute, the First Hospital of China Medical University, Shenyang, Liaoning, China.
Gao H; College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China.
Hu J; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang Y; The First Laboratory of Cancer Institute, the First Hospital of China Medical University, Shenyang, Liaoning, China.
Jing Z; Department of Neurosurgery, the First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2020 Jun; Vol. 43 (3), pp. 461-475. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Glioma/*pathology
Iron Chelating Agents/*pharmacology
Janus Kinase 2/*metabolism
Nuclear Receptor Subfamily 1, Group F, Member 1/*metabolism
STAT3 Transcription Factor/*metabolism
Thiosemicarbazones/*pharmacology
Tumor Suppressor Proteins/*metabolism
Animals ; Carcinogenesis/drug effects ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Humans ; Interleukin-6/metabolism ; Mice, Inbred BALB C ; Models, Biological ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Signal Transduction/drug effects ; Transcription, Genetic/drug effects ; Tumor Suppressor Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hypo-phosphorylated CD147 promotes migration and invasion of hepatocellular carcinoma cells and predicts a poor prognosis.
Autorzy:
Jin J; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
Wang SJ; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
Cui J; State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing, 210023, People's Republic of China.
Li L; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
Li JY; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
Liu FL; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
Sun XX; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.
Jiang JL; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China. .
Cui HY; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China. .
Chen ZN; Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2019 Aug; Vol. 42 (4), pp. 537-554. Date of Electronic Publication: 2019 Apr 23.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Movement*/drug effects
Basigin/*metabolism
Carcinoma, Hepatocellular/*metabolism
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*metabolism
Liver Neoplasms/*pathology
Amino Acid Sequence ; Basigin/chemistry ; Carcinoma, Hepatocellular/genetics ; Cell Line, Tumor ; Cyclophilin A/metabolism ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Liver Neoplasms/genetics ; Male ; NIMA-Related Kinases/metabolism ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Phosphorylation/drug effects ; Phosphoserine/metabolism ; Prognosis ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bilateral activation of STAT3 by phosphorylation at the tyrosine-705 (Y705) and serine-727 (S727) positions and its nuclear translocation in primary sensory neurons following unilateral sciatic nerve injury.
Autorzy:
Dubový P; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic. .
Hradilová-Svíženská I; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic.
Klusáková I; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic.
Kokošová V; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic.
Brázda V; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic.
Joukal M; Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, Brno, 62500, Czech Republic.
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Źródło:
Histochemistry and cell biology [Histochem Cell Biol] 2018 Jul; Vol. 150 (1), pp. 37-47. Date of Electronic Publication: 2018 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Nucleus/*metabolism
Phosphoserine/*metabolism
Phosphotyrosine/*metabolism
STAT3 Transcription Factor/*chemistry
STAT3 Transcription Factor/*metabolism
Sciatic Neuropathy/*metabolism
Sensory Receptor Cells/*metabolism
Active Transport, Cell Nucleus ; Animals ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/pathology ; Male ; Phosphorylation ; Rats ; Rats, Wistar ; Sciatic Neuropathy/pathology ; Sensory Receptor Cells/pathology
Czasopismo naukowe
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Tytuł:
Computational study on mechanism of G-quartet oligonucleotide T40214 selectively targeting Stat3.
Autorzy:
Zhu Q; Department of Medicine, Baylor College of Medicine, One Baylor Plaza, N1317.05, Houston, TX 77030, USA.
Jing N
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Źródło:
Journal of computer-aided molecular design [J Comput Aided Mol Des] 2007 Oct-Nov; Vol. 21 (10-11), pp. 641-8. Date of Electronic Publication: 2007 Nov 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
G-Quadruplexes*
Oligonucleotides/*chemistry
Oligonucleotides/*pharmacology
STAT3 Transcription Factor/*antagonists & inhibitors
STAT3 Transcription Factor/*chemistry
Amino Acid Sequence ; Binding Sites ; Cell Line ; Computer Simulation ; Dimerization ; Humans ; Hydrogen Bonding ; Models, Molecular ; Molecular Sequence Data ; Nucleic Acid Conformation ; Protein Structure, Quaternary ; STAT3 Transcription Factor/genetics ; Sequence Homology, Amino Acid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Excess thyroid hormone inhibits embryonic neural stem/progenitor cells proliferation and maintenance through STAT3 signalling pathway.
Autorzy:
Chen C; Department of Occupational Health, Faculty of Preventive Medicine, Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China.
Zhou Z
Zhong M
Li M
Yang X
Zhang Y
Wang Y
Wei A
Qu M
Zhang L
Xu S
Chen S
Yu Z
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Źródło:
Neurotoxicity research [Neurotox Res] 2011 Jul; Vol. 20 (1), pp. 15-25. Date of Electronic Publication: 2010 Aug 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation/*drug effects
Cell Survival/*drug effects
Embryonic Stem Cells/*drug effects
STAT3 Transcription Factor/*metabolism
Signal Transduction/*drug effects
Triiodothyronine/*pharmacology
Animals ; Aptamers, Nucleotide/metabolism ; Cell Survival/physiology ; Cells, Cultured ; Embryonic Stem Cells/metabolism ; Embryonic Stem Cells/physiology ; Enzyme Inhibitors/pharmacology ; Female ; Hyperthyroidism/chemically induced ; Hyperthyroidism/metabolism ; Hyperthyroidism/physiopathology ; Janus Kinase 1/antagonists & inhibitors ; Janus Kinase 1/metabolism ; Janus Kinase 2/antagonists & inhibitors ; Janus Kinase 2/metabolism ; Mice ; Mice, Inbred BALB C ; Neocortex/drug effects ; Neocortex/metabolism ; Phosphorylation/drug effects ; STAT3 Transcription Factor/antagonists & inhibitors ; Signal Transduction/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Crosstalk between M2 macrophages and glioma stem cells.
Autorzy:
Nusblat LM; Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Carroll MJ; Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.; Department of Biomedical Engineering, University of Wisconsin, Madison, WI, 53706, USA.
Roth CM; Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. .; Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2017 Oct; Vol. 40 (5), pp. 471-482. Date of Electronic Publication: 2017 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Communication/*immunology
Macrophage Activation/*immunology
Macrophages/*immunology
Neoplastic Stem Cells/*immunology
Cell Line, Tumor ; Cell Movement/immunology ; Cell Survival/immunology ; Cells, Cultured ; Coculture Techniques ; Glioma/immunology ; Glioma/metabolism ; Glioma/pathology ; Humans ; Macrophages/classification ; Macrophages/metabolism ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; RNA Interference ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/immunology ; STAT3 Transcription Factor/metabolism ; Transforming Growth Factor beta1/immunology ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Upregulation of Vesicular Glutamate Transporter 2 and STAT3 Activation in the Spinal Cord of Mice Receiving 3,3'-Iminodipropionitrile.
Autorzy:
Ohgomori T; Department of Anatomy and Neuroscience, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yamasaki R; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Kira JI; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Jinno S; Department of Anatomy and Neuroscience, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2018 May; Vol. 33 (4), pp. 768-780. Date of Electronic Publication: 2017 Sep 30.
Typ publikacji:
Journal Article
MeSH Terms:
Nitriles/*toxicity
STAT3 Transcription Factor/*metabolism
Spinal Cord/*drug effects
Up-Regulation/*drug effects
Vesicular Glutamate Transport Protein 2/*metabolism
Animals ; Benzoxazoles/metabolism ; Choline O-Acetyltransferase/metabolism ; Excitatory Amino Acid Transporter 2/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Neurons/drug effects ; Motor Neurons/metabolism ; Motor Neurons/pathology ; Nerve Tissue Proteins/metabolism ; Presynaptic Terminals/drug effects ; Presynaptic Terminals/metabolism ; Quinolinium Compounds/metabolism ; Spinal Cord/pathology ; Spinal Nerve Roots/metabolism ; Spinal Nerve Roots/pathology ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism ; Synaptophysin/metabolism ; Up-Regulation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 698

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