Autor: "Salukhe IA" - OpacWWW

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Tytuł:: High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity.
Autorzy:: Choi R; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.
Zhou M; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
Shek R; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
Wilson JW; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
Tillery L; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
Craig JK; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
Salukhe IA; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.
Hickson SE; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.
Kumar N; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
James RM; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
Buchko GW; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.; School of Molecular Bioscience, Washington State University, Pullman, WA, United States of America.
Wu R; Bioenergy and Biome Sciences, Los Alamos National Laboratory (LANL), Los Alamos, NM, United States of America.
Huff S; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.
Nguyen TT; Calibr, a division of The Scripps Research Institute, La Jolla, CA, United States of America.
Hurst BL; Institute for Antiviral Research, Utah State University, Logan, UT, United States of America.
Cherry S; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Barrett LK; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
Hyde JL; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.
Van Voorhis WC; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.; Department of Global Health, University of Washington, Seattle, WA, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2021 Apr 22; Vol. 16 (4), pp. e0250019. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Drug Repositioning*/methods
COVID-19 Drug Treatment*
Antiviral Agents/*pharmacology
Endoribonucleases/*antagonists & inhibitors
SARS-CoV-2/*drug effects
Small Molecule Libraries/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Animals ; Antiviral Agents/chemistry ; COVID-19/virology ; Caco-2 Cells ; Chlorocebus aethiops ; Endoribonucleases/metabolism ; High-Throughput Screening Assays/methods ; Humans ; Molecular Docking Simulation ; SARS-CoV-2/metabolism ; Small Molecule Libraries/chemistry ; Vero Cells ; Viral Nonstructural Proteins/metabolism

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