- Tytuł:
-
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of
progeria . - Autorzy:
- Źródło:
- Science (New York, N.Y.) [Science] 2006 Mar 17; Vol. 311 (5767), pp. 1621-3. Date of Electronic Publication: 2006 Feb 16.
- Typ publikacji:
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Journal Article; Research Support, N.I.
H ., Extramural; Research Support, Non-U.S. Gov't - MeSH Terms:
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Enzyme Inhibitors/*therapeutic use
Farnesyltranstransferase/*antagonists & inhibitors
Imidazoles/*therapeutic useProgeria /*drug therapy
Animals ; Body Weight/drug effects ; Disease Models, Animal ; Enzyme Inhibitors/pharmacology ; Female ; Hand Strength ; Imidazoles/pharmacology ; Lamin Type A ; Male ; Membrane Proteins/deficiency ; Membrane Proteins/genetics ; Metalloendopeptidases/deficiency ; Metalloendopeptidases/genetics ; Mice ; Nuclear Proteins/metabolism ;Progeria /physiopathology ; Protein Precursors/metabolism ; Protein Prenylation/drug effects ; Rib Fractures/prevention & control ; Survival Rate
Czasopismo naukowe