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Wyświetlanie 1-8 z 8
Tytuł:
Nrf2 plays a critical role in the metabolic response during and after spaceflight.
Autorzy:
Uruno A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Saigusa D; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Suzuki T; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yumoto A; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Nakamura T; Department of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Matsukawa N; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Yamazaki T; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Saito R; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Taguchi K; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, Japan.
Suzuki M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan.
Suzuki N; Division of Oxygen Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Otsuki A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Katsuoka F; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, Japan.
Hishinuma E; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, Japan.
Okada R; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Koshiba S; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, Japan.
Tomioka Y; Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Shimizu R; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Kensler TW; Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan. shiba.dai@jaxa.jp.
Yamamoto M; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. .; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan. .
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Źródło:
Communications biology [Commun Biol] 2021 Dec 09; Vol. 4 (1), pp. 1381. Date of Electronic Publication: 2021 Dec 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Space Flight*
Adipose Tissue, White/*metabolism
Epididymis/*metabolism
NF-E2-Related Factor 2/*genetics
Animals ; Male ; Metabolome ; Mice ; Mice, Knockout ; NF-E2-Related Factor 2/deficiency ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Tytuł:
Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight.
Autorzy:
Hayashi T; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Kudo T; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. .
Fujita R; Divsion of Regenerative Medicine, Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Fujita SI; Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.; Department of Genome Biology, Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Tsubouchi H; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Fuseya S; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Suzuki R; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, Ibaraki, Japan.
Hamada M; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Okada R; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, Japan.
Muratani M; Department of Genome Biology, Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, Japan.
Suzuki T; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Warabi E; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. .
Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takahashi S; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan. .
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Źródło:
Communications biology [Commun Biol] 2021 Jun 24; Vol. 4 (1), pp. 787. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Space Flight*
Muscle Fibers, Skeletal/*pathology
Muscle, Skeletal/*pathology
Muscular Atrophy/*etiology
NF-E2-Related Factor 2/*physiology
Animals ; Gene Expression Profiling ; Glycolysis ; Male ; Mice ; Mice, Inbred C57BL ; NF-E2-Related Factor 2/deficiency
Czasopismo naukowe
Tytuł:
Nrf2 contributes to the weight gain of mice during space travel.
Autorzy:
Suzuki T; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Uruno A; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Yumoto A; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Taguchi K; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Suzuki M; Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan.
Harada N; Institute for Animal Experimentation, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ryoke R; Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Naganuma E; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Osanai N; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Goto A; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Suda H; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Browne R; Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
Otsuki A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Katsuoka F; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Zorzi M; Department of Molecular Biotechnology and Health Sciences, University of Turin, 10125, Torino, Italy.
Yamazaki T; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Saigusa D; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Koshiba S; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Nakamura T; Division of Molecular Pharmacology & Cell Biophysics, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Fukumoto S; Division of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Ikehata H; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
Nishikawa K; Immunology Frontier Research Center, Osaka University, Suita, Japan.
Suzuki N; Division of Oxygen Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hirano I; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shimizu R; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Department of Molecular Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Oishi T; Division of Oxygen Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Motohashi H; Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Tsubouchi H; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Okada R; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Kudo T; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shimomura M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Kensler TW; Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Mizuno H; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan.
Takahashi S; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Japan. shiba.dai@jaxa.jp.
Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan. .; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. .; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan. .
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Źródło:
Communications biology [Commun Biol] 2020 Sep 08; Vol. 3 (1), pp. 496. Date of Electronic Publication: 2020 Sep 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Space Flight*
Weight Gain*/genetics
NF-E2-Related Factor 2/*metabolism
Abdominal Fat/pathology ; Adipose Tissue, White/pathology ; Aging/blood ; Aging/metabolism ; Animals ; Bone and Bones/pathology ; Gene Expression Regulation ; Homeostasis ; Metabolome ; Mice, Knockout ; Muscles/pathology ; NF-E2-Related Factor 2/deficiency ; NF-E2-Related Factor 2/genetics ; Sequence Analysis, RNA ; Stress, Physiological
Czasopismo naukowe
Tytuł:
Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight.
Autorzy:
Horie K; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Kato T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Kudo T; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Sasanuma H; Laboratory of Developmental Genetics, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Miyauchi M; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Akiyama N; Laboratory for Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Miyao T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Seki T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Ishikawa T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Takakura Y; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, 305-8505, Japan.
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Ibaraki, 305-8505, Japan.
Hamada M; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Jeon H; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Yoshida N; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Laboratory of Developmental Genetics, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Inoue JI; Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Muratani M; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.; Transborder Medical Research Center, and Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
Takahashi S; Laboratory Animal Resource Center in Transborder Medical Research Center, and Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan.
Ohno H; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .
Akiyama T; Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. .; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Ibaraki, 305-8505, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2019 Dec 27; Vol. 9 (1), pp. 19866. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gravity, Altered*
Space Flight*
Thymus Gland/*metabolism
Animals ; Base Sequence ; Enzyme-Linked Immunosorbent Assay ; Male ; Mice ; Mice, Inbred C57BL ; Principal Component Analysis ; RNA-Seq
Czasopismo naukowe
Tytuł:
Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis.
Autorzy:
Mao XW; Department of Basic Sciences, Division of Biomedical Engineering Sciences (BMES), Loma Linda University School of Medicine and Medical Center, Loma Linda, CA 92350, USA. .
Byrum S; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.. .; Arkansas Children's Research Institute, Little Rock, AR 72202, USA. .
Nishiyama NC; Department of Basic Sciences, Division of Biomedical Engineering Sciences (BMES), Loma Linda University School of Medicine and Medical Center, Loma Linda, CA 92350, USA. .
Pecaut MJ; Department of Basic Sciences, Division of Biomedical Engineering Sciences (BMES), Loma Linda University School of Medicine and Medical Center, Loma Linda, CA 92350, USA. .
Sridharan V; Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
Boerma M; Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. .
Tackett AJ; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.. .; Arkansas Children's Research Institute, Little Rock, AR 72202, USA. .
Shiba D; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba 305-8505, Japan. shiba.dai@jaxa.jp.
Shirakawa M; JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba 305-8505, Japan. .
Takahashi S; Department of Anatomy and Embryology, University of Tsukuba, Tsukuba 305-8575, Japan. .
Delp MD; Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Aug 28; Vol. 19 (9). Date of Electronic Publication: 2018 Aug 28.
Typ publikacji:
Journal Article
MeSH Terms:
Gravity, Altered*
Space Flight*
Weightlessness*
Retina/*physiology
Animals ; Apoptosis ; Endothelial Cells/metabolism ; Male ; Mice ; Oxidative Stress ; Proteome ; Proteomics ; Reactive Oxygen Species/metabolism ; Retinal Pigment Epithelium/cytology ; Retinal Pigment Epithelium/metabolism
Czasopismo naukowe
Tytuł:
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration.
Autorzy:
Afshinnekoo, Ebrahim (AUTHOR)
Scott, Ryan T. (AUTHOR)
MacKay, Matthew J. (AUTHOR)
Pariset, Eloise (AUTHOR)
Cekanaviciute, Egle (AUTHOR)
Barker, Richard (AUTHOR)
Gilroy, Simon (AUTHOR)
Hassane, Duane (AUTHOR)
Smith, Scott M. (AUTHOR)
Zwart, Sara R. (AUTHOR)
Nelman-Gonzalez, Mayra (AUTHOR)
Crucian, Brian E. (AUTHOR)
Ponomarev, Sergey A. (AUTHOR)
Orlov, Oleg I. (AUTHOR)
Shiba, Dai (AUTHOR)
Muratani, Masafumi (AUTHOR)
Yamamoto, Masayuki (AUTHOR)
Richards, Stephanie E. (AUTHOR)
Vaishampayan, Parag A. (AUTHOR)
Meydan, Cem (AUTHOR)
Pokaż więcej
Temat:
SPACE flight
Źródło:
Cell. Nov2021, Vol. 184 Issue 24, p6002-6002. 1p.
Czasopismo naukowe
    Wyświetlanie 1-8 z 8

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