Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Na v 1.2 expression.
Autorzy:
Eaton M; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Zhang J; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Ma Z; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Park AC; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Lietzke E; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Romero CM; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Liu Y; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Coleman ER; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Chen X; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Xiao T; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Que Z; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Lai S; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Wu J; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Lee JH; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Palant S; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Nguyen HP; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. Huang Z; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China. SkarnesWC; Department of Cellular Engineering, The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA. Koss WA; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA.; Office of the Executive Vice President for Research and Partnerships, Purdue University, West Lafayette, Indiana, USA. Yang Y; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA.
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Źródło:
Genes, brain, and behavior [Genes Brain Behav] 2021 Apr; Vol. 20 (4), pp. e12725. Date of Electronic Publication: 2021 Jan 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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