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Wyświetlanie 1-20 z 88
Tytuł:
Matrine exerts anti‑breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF‑7 cells.
Autorzy:
Du J; Dongguan Scientific Research Center, Department of Pharmacology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China.
Li J; Dongguan Scientific Research Center, Department of Pharmacology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China.
Song D; Dongguan Scientific Research Center, Department of Pharmacology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China.
Li Q; Dongguan Scientific Research Center, Department of Pharmacology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China.
Li L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Li B; Dongguan Scientific Research Center, Department of Pharmacology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China.
Li L; Dongguan Scientific Research Center, Department of Pharmacology, Guangdong Medical University, Dongguan, Guangdong 523808, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2020 Nov; Vol. 22 (5), pp. 3659-3666. Date of Electronic Publication: 2020 Aug 20.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids/*pharmacology
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
Breast Neoplasms/*metabolism
Drugs, Chinese Herbal/*pharmacology
Phytotherapy/*methods
Proto-Oncogene Proteins c-akt/*metabolism
Quinolizines/*pharmacology
Signal Transduction/*drug effects
Sophora/*chemistry
TOR Serine-Threonine Kinases/*metabolism
Alkaloids/chemistry ; Antineoplastic Agents/chemistry ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Drugs, Chinese Herbal/chemistry ; Female ; Humans ; MCF-7 Cells ; Phosphorylation/drug effects ; Quinolizines/chemistry ; Matrines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
MicroRNA-211-5p promotes apoptosis and inhibits the migration of osteosarcoma cells by targeting proline-rich protein PRR11.
Autorzy:
Song D; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Yang K; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Wang W; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Tian R; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Wang H; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Wang K; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.; The first department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
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Źródło:
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2020 Apr; Vol. 98 (2), pp. 258-266. Date of Electronic Publication: 2019 May 10.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Cell Movement*
MicroRNAs/*metabolism
Osteosarcoma/*metabolism
Proteins/*metabolism
Animals ; Cell Line, Tumor ; Cell Survival ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasm Transplantation ; Osteoblasts/metabolism ; Osteosarcoma/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Reactive oxygen species, not Ca , mediates methotrexate-induced autophagy and apoptosis in spermatocyte cell line.
Autorzy:
Xiong S; Institute of Life Science and School of Life Sciences, Nanchang University, Nanchang, China.
Song D; Institute of Life Science and School of Life Sciences, Nanchang University, Nanchang, China.
Xiang Y; Institute of Life Science and School of Life Sciences, Nanchang University, Nanchang, China.
Li Y; Institute of Life Science and School of Life Sciences, Nanchang University, Nanchang, China.
Zhong Y; Institute of Life Science and School of Life Sciences, Nanchang University, Nanchang, China.
Li H; Institute of Life Science and School of Life Sciences, Nanchang University, Nanchang, China.
Zhang P; Institute of Life Science and School of Life Sciences, Nanchang University, Nanchang, China.
Zhou W; Medical School, Institute of Reproductive Medicine, Nantong University, Nantong, China.
Zeng X; Institute of Life Science and School of Life Sciences, Nanchang University, Nanchang, China.; Medical School, Institute of Reproductive Medicine, Nantong University, Nantong, China.
Zhang X; Institute of Life Science and School of Life Sciences, Nanchang University, Nanchang, China.; Medical School, Institute of Reproductive Medicine, Nantong University, Nantong, China.
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2020 Feb; Vol. 126 (2), pp. 144-152. Date of Electronic Publication: 2019 Sep 03.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Methotrexate/*toxicity
Reactive Oxygen Species/*metabolism
Spermatocytes/*drug effects
Animals ; Antimetabolites, Antineoplastic/toxicity ; Autophagy/drug effects ; Calcium/metabolism ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Signal Transduction/drug effects ; Spermatocytes/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Baicalin inhibits C2C12 myoblast apoptosis and prevents against skeletal muscle injury.
Autorzy:
Pan Y; Department of Emergency and Trauma Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China.
Song D; Zhongshan Hospital Clinical Science Institute, Fudan University, Shanghai 200032, P.R. China.
Zhou W; PET Center, Huashan Hospital, Fudan University, Shanghai 200235, P.R. China.
Lu X; PET Center, Huashan Hospital, Fudan University, Shanghai 200235, P.R. China.
Wang H; Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China.
Li Z; Department of Emergency and Trauma Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2019 Jul; Vol. 20 (1), pp. 709-718. Date of Electronic Publication: 2019 May 27.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
Apoptosis/*drug effects
Flavonoids/*therapeutic use
Muscle, Skeletal/*drug effects
Muscle, Skeletal/*injuries
Myoblasts/*drug effects
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Cell Line ; Female ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Mice, Inbred BALB C ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Myoblasts/metabolism ; Myoblasts/pathology ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Scutellaria baicalensis/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells.
Autorzy:
Liu L; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China.
Zhang N; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China.
Dou Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China.
Mao G; Zhejiang Provincial Key Laboratory of Geriatrics &Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou, Zhejiang 310013, China.
Bi C; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China.
Pang W; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China.
Liu X; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China.
Song D; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China.
Deng H; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China.
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Źródło:
Scientific reports [Sci Rep] 2017 Jan 31; Vol. 7, pp. 41862. Date of Electronic Publication: 2017 Jan 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Autophagy*
Antineoplastic Agents/*pharmacology
Lysosomes/*drug effects
Nitrogen Mustard Compounds/*pharmacology
Pancreatic Neoplasms/*metabolism
Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Cathepsins/metabolism ; Cell Line, Tumor ; Humans ; Lysosomes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2.
Autorzy:
Wang CX; Department of Medicine and Laboratory Medicine & Pathology, University of Alberta, Edmonton, Canada.
Song JH
Song DK
Yong VW
Shuaib A
Hao C
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Źródło:
Cell death and differentiation [Cell Death Differ] 2006 Jul; Vol. 13 (7), pp. 1203-12. Date of Electronic Publication: 2005 Nov 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*drug effects
Cyclin-Dependent Kinase 5/*metabolism
Extracellular Signal-Regulated MAP Kinases/*metabolism
Neurons/*drug effects
Proto-Oncogene Proteins c-bcl-2/*metabolism
Blotting, Western ; Brain-Derived Neurotrophic Factor/pharmacology ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cells, Cultured ; Flow Cytometry ; Humans ; Models, Biological ; Neurons/cytology ; Neurons/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation/drug effects ; Plasmids/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA, Small Interfering/genetics ; Signal Transduction/drug effects ; Transfection ; Tretinoin/pharmacology ; Up-Regulation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen.
Autorzy:
Hitsumoto Y; Department of Clinical Laboratory Medicine, Ehime University School of Medicine, Japan.
Song DS
Okada M
Hamada F
Saheki S
Takeuchi N
Pokaż więcej
Źródło:
Immunology [Immunology] 1996 Oct; Vol. 89 (2), pp. 200-4.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, CD*
Membrane Glycoproteins*
Antigens, Differentiation/*immunology
Apoptosis/*immunology
Receptor-CD3 Complex, Antigen, T-Cell/*immunology
T-Lymphocytes/*physiology
Animals ; Antibodies, Monoclonal/immunology ; Apoptosis/drug effects ; CD24 Antigen ; CD3 Complex/immunology ; Calcium/metabolism ; Cells, Cultured ; Cytosol/metabolism ; Glucocorticoids/pharmacology ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Tetradecanoylphorbol Acetate/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 88

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