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Wyświetlanie 1-20 z 768
Tytuł:
HTRA1 promotes EMT through the HDAC6/Ac-α-tubulin pathway in human GBM cells.
Autorzy:
Zhao W; Department of Neurosurgery, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Qilu Hospital, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
Wu Y; Department of Neurosurgery, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Qilu Hospital, Shandong University, Jinan, China.
Wang S; University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
Zhao F; Department of Neurosurgery, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Qilu Hospital, Shandong University, Jinan, China.
Liu W; Department of Neurosurgery, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Qilu Hospital, Shandong University, Jinan, China.
Xue Z; Department of Neurosurgery, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Qilu Hospital, Shandong University, Jinan, China.
Zhang L; Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, China.
Wang J; Department of Neurosurgery, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Qilu Hospital, Shandong University, Jinan, China.; Department of Biomedicine, University of Bergen, Bergen, Norway.
Han M; Department of Neurosurgery, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Qilu Hospital, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
Li X; Department of Neurosurgery, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Qilu Hospital, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
Huang B; Department of Neurosurgery, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Qilu Hospital, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14605.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glioma*/genetics
Tubulin*/metabolism
Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Histone Deacetylase 6/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage.
Autorzy:
Peng C; Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.; Department of Neurology, Hunan Provincial Rehabilitation Hospital, Hunan University of Medicine, Changsha, Hunan, China.
Wang Y; Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hu Z; Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen C; Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Mar; Vol. 30 (3), pp. e14429. Date of Electronic Publication: 2023 Sep 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood-Brain Barrier*/metabolism
Tubulin*/metabolism
Animals ; Humans ; Rats ; Brain/metabolism ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/drug therapy ; Cerebral Hemorrhage/genetics ; Disease Models, Animal ; Endothelial Cells/metabolism ; Histone Deacetylase 6/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis, antiproliferative activity, and molecular docking studies of 4-chlorothiocolchicine analogues.
Autorzy:
Klejborowska G; Department of Bioorganic Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Moshari M; Department of Chemistry, University of Alberta, Edmonton, AB, Canada.
Maj E; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Majcher U; Department of Bioorganic Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Preto J; Department of Oncology, University of Alberta, Edmonton, AB, Canada.
Wietrzyk J; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Tuszynski JA; Department of Oncology, University of Alberta, Edmonton, AB, Canada.; DIMEAS, Politecnico di Torino, Turin, Italy.
Huczyński A; Department of Bioorganic Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2020 Jan; Vol. 95 (1), pp. 182-191. Date of Electronic Publication: 2019 Sep 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tubulin Modulators*/chemical synthesis
Tubulin Modulators*/pharmacology
Antineoplastic Agents/*chemical synthesis
Colchicine/*analogs & derivatives
Animals ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Colchicine/chemical synthesis ; Colchicine/pharmacology ; Doxorubicin/pharmacology ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Molecular Docking Simulation ; Protein Conformation ; Thermodynamics ; Tubulin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis and biological evaluation of benz-fused five-membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities.
Autorzy:
Komuraiah B; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Ren Y; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Xue M; Tianjin Tiancheng Chemical Co., Ltd, Tianjin, China.
Cheng B; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Liu J; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Liu Y; Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai, China.
Chen J; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2021 May; Vol. 97 (5), pp. 1109-1116. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Design*
Antineoplastic Agents/*chemical synthesis
Benzene/*chemistry
Heterocyclic Compounds/*chemistry
Tubulin Modulators/*chemistry
Animals ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Colchicine/chemistry ; Colchicine/metabolism ; Drug Screening Assays, Antitumor ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Mice ; Structure-Activity Relationship ; Tubulin/chemistry ; Tubulin/metabolism ; Tubulin Modulators/metabolism ; Tubulin Modulators/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Acetylated α-tubulin alleviates injury to the dendritic spines after ischemic stroke in mice.
Autorzy:
Yang C; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Chen X; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Zhang C; Department of Neurosurgery, the 904th Hospital of PLA, School of Medicine of Anhui Medical University, Wuxi, Jiangsu Province, 214044, China.
Lei X; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Lu Y; Clinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Wang Y; Department of Neurosurgery, the 904th Hospital of PLA, School of Medicine of Anhui Medical University, Wuxi, Jiangsu Province, 214044, China.
Feng H; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Chen T; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Yang Y; Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.; Department of Neurosurgery, the 904th Hospital of PLA, School of Medicine of Anhui Medical University, Wuxi, Jiangsu Province, 214044, China.
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Źródło:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2023 Aug; Vol. 29 (8), pp. 2327-2338. Date of Electronic Publication: 2023 Mar 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ischemic Stroke*/metabolism
Stroke*/metabolism
Mice ; Animals ; Dendritic Spines/metabolism ; Tubulin/metabolism ; Pyramidal Cells/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis, and biological evaluation of tetrahydroisoquinoline stilbene derivatives as potential antitumor candidates.
Autorzy:
Li B; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Wang J; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Yuan M; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Miao Y; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Zhang H; Department of Chemistry, Bengbu Medical College, Bengbu, China.
Zhang J; Department of Chemistry, Bengbu Medical College, Bengbu, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2023 Feb; Vol. 101 (2), pp. 364-379. Date of Electronic Publication: 2022 Sep 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Stilbenes*/pharmacology
Antineoplastic Agents*/pharmacology
Tetrahydroisoquinolines*/pharmacology
Humans ; Cell Line, Tumor ; Tubulin/metabolism ; Tubulin Modulators/pharmacology ; Apoptosis ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis, biological evaluation, and 3D-QSAR analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents.
Autorzy:
Wang ZZ; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Sun WX; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Wang X; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Zhang YH; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Qiu HY; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Qi JL; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Pang YJ; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.
Lu GH; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Wang XM; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Yu FG; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.
Yang YH; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2017 Aug; Vol. 90 (2), pp. 236-243. Date of Electronic Publication: 2017 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Neoplasms/*drug therapy
Podophyllotoxin/*chemistry
Podophyllotoxin/*pharmacology
Tubulin Modulators/*chemistry
Tubulin Modulators/*pharmacology
Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Neoplasms/metabolism ; Oxadiazoles/chemical synthesis ; Oxadiazoles/chemistry ; Oxadiazoles/pharmacology ; Podophyllotoxin/chemical synthesis ; Quantitative Structure-Activity Relationship ; Tubulin/metabolism ; Tubulin Modulators/chemical synthesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure-based approaches for the design of benzimidazole-2-carbamate derivatives as tubulin polymerization inhibitors.
Autorzy:
Aguayo-Ortiz R; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, CDMX, México, Mexico.; Facultad de Química, Departamento de Fisicoquímica, Universidad Nacional Autónoma de México, CDMX, México, Mexico.
Cano-González L; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, CDMX, México, Mexico.
Castillo R; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, CDMX, México, Mexico.
Hernández-Campos A; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, CDMX, México, Mexico.
Dominguez L; Facultad de Química, Departamento de Fisicoquímica, Universidad Nacional Autónoma de México, CDMX, México, Mexico.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2017 Jul; Vol. 90 (1), pp. 40-51. Date of Electronic Publication: 2017 Jan 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzimidazoles/*chemistry
Carbamates/*chemistry
Tubulin Modulators/*chemistry
Amino Acid Sequence ; Animals ; Binding Sites ; Carbamates/metabolism ; Humans ; Hydrogen Bonding ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Sequence Data ; Protein Structure, Tertiary ; Sequence Alignment ; Thermodynamics ; Tubulin/chemistry ; Tubulin/metabolism ; Tubulin Modulators/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis, and biological evaluation of 2,3-diphenyl-cycloalkyl pyrazole derivatives as potential tubulin polymerization inhibitors.
Autorzy:
Xia LY; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Yang R; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Zhang YL; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Chu YC; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Qi YL; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Man RJ; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Guangxi Biological Polysaccharide Separation, Purification and Modification Research Platform, Guangxi University for Nationalities, Nanning, China.
Wang ZC; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Wang BZ; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Zhu HL; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2019 Sep; Vol. 94 (5), pp. 1894-1904. Date of Electronic Publication: 2019 Aug 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*chemical synthesis
Hydrocarbons, Cyclic/*chemical synthesis
Hydrocarbons, Cyclic/*metabolism
Pyrazoles/*chemical synthesis
Tubulin/*metabolism
Tubulin Modulators/*chemical synthesis
Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Hydrocarbons, Cyclic/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Protein Conformation ; Pyrazoles/pharmacology ; Quantitative Structure-Activity Relationship ; Reactive Oxygen Species/metabolism ; Tubulin Modulators/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer.
Autorzy:
Singh A; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.
Fatima K; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.
Srivastava A; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.
Khwaja S; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.
Priya D; CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu, Jammu and Kashmir, India.
Singh A; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.
Mahajan G; CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu, Jammu and Kashmir, India.
Alam S; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.
Saxena AK; Amity University, Lucknow, Uttar Pradesh, India.
Mondhe DM; CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Jammu, Jammu and Kashmir, India.
Luqman S; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.
Chanda D; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.
Khan F; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India.
Negi AS; CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, Uttar Pradesh, India. .
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2016 Nov; Vol. 88 (5), pp. 625-634. Date of Electronic Publication: 2016 Aug 06.
Typ publikacji:
Editorial; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*chemistry
Gallic Acid/*chemistry
Indans/*chemistry
Tubulin Modulators/*chemistry
Animals ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/toxicity ; Apoptosis/drug effects ; Benzylidene Compounds/chemistry ; Binding Sites ; Biomarkers, Tumor/blood ; Carcinoma, Ehrlich Tumor/drug therapy ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Indans/chemical synthesis ; Indans/toxicity ; M Phase Cell Cycle Checkpoints/drug effects ; Mice ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Tubulin/chemistry ; Tubulin/metabolism ; Tubulin Modulators/therapeutic use ; Tubulin Modulators/toxicity
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives.
Autorzy:
Hussaini SM; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500607, India.
Yedla P; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500607, India.
Babu KS; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500607, India.
Shaik TB; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500607, India.
Chityal GK; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500607, India.
Kamal A; Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500607, India.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2016 Jul; Vol. 88 (1), pp. 97-109. Date of Electronic Publication: 2016 Mar 24.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Drug Design*
Models, Molecular*
Antineoplastic Agents/*pharmacology
Chalcones/*pharmacology
Pyrazoles/*pharmacology
Triazoles/*pharmacology
Tubulin Modulators/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Chalcones/chemical synthesis ; Chalcones/chemistry ; Female ; G2 Phase/drug effects ; Humans ; Male ; Membrane Potential, Mitochondrial/drug effects ; Molecular Structure ; Neoplasms/drug therapy ; Neoplasms/pathology ; Polymerization/drug effects ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Tubulin/chemistry ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, Synthesis and Molecular Docking Studies of Novel Indole-Pyrimidine Hybrids as Tubulin Polymerization Inhibitors.
Autorzy:
Hu MJ; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
Zhang B; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
Yang HK; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
Liu Y; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
Chen YR; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
Ma TZ; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
Lu L; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
You WW; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
Zhao PL; Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2015 Dec; Vol. 86 (6), pp. 1491-500. Date of Electronic Publication: 2015 Aug 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tubulin Modulators/*chemical synthesis
Tubulin Modulators/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Design ; Drug Screening Assays, Antitumor ; HT29 Cells ; Humans ; In Vitro Techniques ; Indoles/chemical synthesis ; Indoles/chemistry ; Indoles/pharmacology ; MCF-7 Cells ; Molecular Docking Simulation ; Protein Multimerization/drug effects ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Structure-Activity Relationship ; Swine ; Tubulin/chemistry ; Tubulin/drug effects ; Tubulin Modulators/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Newly Designed and Synthesized Curcumin Analogs with in vitro Cytotoxicity and Tubulin Polymerization Activity.
Autorzy:
Fawzy IM; Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University, Cairo, 12311, Egypt.
Youssef KM; Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University, Cairo, 12311, Egypt.
Ismail NS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Gullbo J; Division of Clinical Pharmacology, Department of Medical Sciences, Uppsala University Hospital, SE-751 85, Uppsala, Sweden.
Abouzid KA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2015 Jul; Vol. 86 (1), pp. 80-90. Date of Electronic Publication: 2014 Nov 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Curcumin*/analogs & derivatives
Curcumin*/chemical synthesis
Curcumin*/chemistry
Curcumin*/pharmacology
Cytotoxins*/chemical synthesis
Cytotoxins*/chemistry
Cytotoxins*/pharmacology
Tubulin Modulators*/chemical synthesis
Tubulin Modulators*/chemistry
Tubulin Modulators*/pharmacology
Microtubules/*metabolism
Tubulin/*metabolism
Humans ; U937 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthesis and biological evaluation of quinoxaline derivatives as tubulin polymerization inhibitors that elevate intracellular ROS and triggers apoptosis via mitochondrial pathway.
Autorzy:
Qi J; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Huang J; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Zhou X; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Luo W; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Xie J; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Niu L; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Yan Z; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Luo Y; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Men Y; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Chen Y; Institute of Behavior and Psychology, Henan University Jimming Campus, Kaifeng, Henan, China.
Zhang Y; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
Wang J; Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University Jinming Campus, Kaifeng, Henan, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2019 Apr; Vol. 93 (4), pp. 617-627. Date of Electronic Publication: 2019 Jan 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Mitochondria/*metabolism
Quinoxalines/*chemistry
Reactive Oxygen Species/*metabolism
Tubulin/*chemistry
Tubulin Modulators/*chemical synthesis
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Binding Sites ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Dose-Response Relationship, Drug ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Quinoxalines/metabolism ; Quinoxalines/pharmacology ; Structure-Activity Relationship ; Tubulin/metabolism ; Tubulin Modulators/metabolism ; Tubulin Modulators/pharmacology ; Up-Regulation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification and molecular characterization of the tubulin-podophyllotoxin-type lignans binding site on Giardia lamblia.
Autorzy:
Gutiérrez-Gutiérrez F; Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, México.
Romo-Mancillas A; Laboratorio de Diseño Asistido por Computadora y Síntesis de Fármacos, Facultad de Química, Universidad Autónoma de Querétaro, Santiago de Querétaro, México.
Puebla-Pérez AM; Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, México.
Hernández-Hernández JM; Departamento de Biología Celular, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México.
Castillo-Romero A; Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2019 Dec; Vol. 94 (6), pp. 2031-2040. Date of Electronic Publication: 2019 Sep 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Giardia lamblia/*metabolism
Lignans/*metabolism
Podophyllotoxin/*chemistry
Protozoan Proteins/*metabolism
Tubulin/*metabolism
Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/metabolism ; Binding Sites ; Giardia lamblia/growth & development ; Lignans/chemistry ; Molecular Docking Simulation ; Protein Binding ; Protozoan Proteins/chemistry ; Trophozoites/metabolism ; Tubulin/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The effect of colchicine on the echocardiographic constrictive physiology after coronary artery bypass graft surgery.
Autorzy:
Shojaeifard M; Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Pakbaz M; Department of Cardiovascular Disease, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran.
Beheshti R; Department of Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Noohi Bezanjani F; Department of Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Ahangar H; Department of Cardiology, Mousavi Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Gohari S; School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Dehghani Mohammad Abadi H; Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Erami S; School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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Źródło:
Echocardiography (Mount Kisco, N.Y.) [Echocardiography] 2020 Mar; Vol. 37 (3), pp. 399-403. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Colchicine*/therapeutic use
Coronary Artery Bypass*
Pericarditis, Constrictive*/diagnostic imaging
Pericarditis, Constrictive*/drug therapy
Tubulin Modulators*/therapeutic use
Double-Blind Method ; Echocardiography ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments.
Autorzy:
Churchill CD; Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, AB, T6G 2G2, Canada.
Klobukowski M; Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, AB, T6G 2G2, Canada.
Tuszynski JA; Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB, T6G 1Z2, Canada.; Department of Physics, University of Alberta, 4-181 CCIS, Edmonton, AB, T6G 2E1, Canada.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2015 Aug; Vol. 86 (2), pp. 190-9. Date of Electronic Publication: 2014 Nov 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Macrolides/*chemistry
Microtubules/*chemistry
Tubulin/*chemistry
Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Binding Sites ; Drug Discovery/methods ; Macrolides/metabolism ; Macrolides/pharmacology ; Microtubules/drug effects ; Microtubules/metabolism ; Molecular Dynamics Simulation ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Structure-Activity Relationship ; Thermodynamics ; Tubulin/metabolism ; Tubulin Modulators/chemistry ; Tubulin Modulators/metabolism ; Tubulin Modulators/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular modeling study on the tubulin-binding modes of epothilone derivatives: Insight into the structural basis for epothilones activity.
Autorzy:
Jiménez VA; Departamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andres Bello Sede Concepción, Talcahuano, Chile.
Alderete JB; Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción, Chile.
Navarrete KR; Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Concepción, Chile.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2017 Dec; Vol. 90 (6), pp. 1247-1259. Date of Electronic Publication: 2017 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Epothilones/*chemistry
Tubulin/*metabolism
Tubulin Modulators/*metabolism
Binding Sites ; Crystallography, X-Ray ; Dimerization ; Epothilones/metabolism ; Ligands ; Molecular Conformation ; Molecular Dynamics Simulation ; Protein Binding ; Protein Structure, Tertiary ; Thermodynamics ; Tubulin/chemistry ; Tubulin Modulators/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors.
Autorzy:
Wang YT; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Cai XC; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Shi TQ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Zhang YL; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Wang ZC; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Liu CH; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Zhu HL; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2017 Jul; Vol. 90 (1), pp. 112-118. Date of Electronic Publication: 2017 Feb 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzimidazoles/*chemistry
Tubulin/*metabolism
Tubulin Modulators/*chemical synthesis
A549 Cells ; Animals ; Benzimidazoles/chemical synthesis ; Benzimidazoles/pharmacology ; Binding Sites ; Cell Cycle Checkpoints/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Colchicine/chemistry ; Colchicine/metabolism ; Colchicine/pharmacology ; Crystallography, X-Ray ; HeLa Cells ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Mice ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Quantitative Structure-Activity Relationship ; Tubulin/chemistry ; Tubulin Modulators/chemistry ; Tubulin Modulators/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors.
Autorzy:
Mangiatordi GF; Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari 'Aldo Moro', Bari, Italy.
Trisciuzzi D; Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari 'Aldo Moro', Bari, Italy.
Iacobazzi R; Istituto Tumori IRCCS Giovanni Paolo II, Bari, Italy.
Denora N; Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari 'Aldo Moro', Bari, Italy.
Pisani L; Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari 'Aldo Moro', Bari, Italy.
Catto M; Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari 'Aldo Moro', Bari, Italy.
Leonetti F; Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari 'Aldo Moro', Bari, Italy.
Alberga D; Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari 'Aldo Moro', Bari, Italy.
Nicolotti O; Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari 'Aldo Moro', Bari, Italy.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2018 Jul; Vol. 92 (1), pp. 1161-1170. Date of Electronic Publication: 2018 Apr 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Tubulin Modulators/*chemistry
Benzopyrans/chemistry ; Benzopyrans/pharmacology ; Binding Sites ; Cell Proliferation/drug effects ; Colchicine/chemistry ; Colchicine/metabolism ; Humans ; Hydrogen Bonding ; MCF-7 Cells ; Molecular Docking Simulation ; Protein Structure, Tertiary ; Tubulin Modulators/metabolism ; Tubulin Modulators/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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