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Tytuł:
Rethinking IL-1 Antagonism in Respiratory Viral Infections: A Role for IL-1 Signaling in the Development of Antiviral T Cell Immunity.
Autorzy:
Van Den Eeckhout B; HIV Cure and Research Center (HCRC), 9000 Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, 9820 Ghent, Belgium.
Ballegeer M; VIB Center for Medical Biotechnology, 9052 Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9000 Ghent, Belgium.
De Clercq J; HIV Cure and Research Center (HCRC), 9000 Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
Burg E; HIV Cure and Research Center (HCRC), 9000 Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
Saelens X; VIB Center for Medical Biotechnology, 9052 Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, 9000 Ghent, Belgium.
Vandekerckhove L; HIV Cure and Research Center (HCRC), 9000 Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
Gerlo S; HIV Cure and Research Center (HCRC), 9000 Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, 9820 Ghent, Belgium.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 30; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:
Journal Article
MeSH Terms:
CD8-Positive T-Lymphocytes*
Influenza, Human*
Humans ; Animals ; Mice ; Adaptive Immunity ; Interleukin-1 ; Antiviral Agents ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluating lncRNA Expression Patterns during HIV-1 Treatment Interruption.
Autorzy:
Schynkel T; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
van Snippenberg W; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Van Hecke C; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Trypsteen W; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 05; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/therapeutic use
HIV-1*
HIV Infections*/drug therapy
HIV Infections*/genetics
Humans ; Leukocytes, Mononuclear ; Anti-Retroviral Agents/therapeutic use ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bictegravir/emtricitabine/tenofovir alafenamide in older individuals with HIV: Results of a 96-week, phase 3b, open-label, switch trial in virologically suppressed people ≥65 years of age.
Autorzy:
Maggiolo F; Division of Infectious Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy.
Rizzardini G; Division of Infectious Diseases, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.; School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.
Molina JM; Department of Infectious Diseases, Saint Louis Hospital, University Paris Diderot, Paris, France.
Pulido F; Unidad VIH, Hospital Universitario 12 de Octubre, imas12, UCM, Madrid, Spain.
De Wit S; St Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Vandekerckhove L; University Hospital Ghent, Ghent, Belgium.
Berenguer J; Infectious Diseases, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain.
D'Antoni ML; Gilead Sciences, Foster City, California, USA.
Blair C; Gilead Sciences, Foster City, California, USA.
Chuck SK; Gilead Sciences, Foster City, California, USA.
Piontkowsky D; Gilead Sciences, Foster City, California, USA.
Martin H; Gilead Sciences, Foster City, California, USA.
Haubrich R; Gilead Sciences, Foster City, California, USA.
McNicholl IR; Gilead Sciences, Foster City, California, USA.
Gallant J; Gilead Sciences, Foster City, California, USA.
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Źródło:
HIV medicine [HIV Med] 2023 Jan; Vol. 24 (1), pp. 27-36. Date of Electronic Publication: 2022 May 08.
Typ publikacji:
Clinical Trial, Phase III; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections*/drug therapy
HIV-1*
Anti-HIV Agents*/adverse effects
Adult ; Humans ; Aged ; Emtricitabine/adverse effects ; Adenine/adverse effects ; Tenofovir/adverse effects ; Drug Combinations
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
People with HIV have higher percentages of circulating CCR5+ CD8+ T cells and lower percentages of CCR5+ regulatory T cells.
Autorzy:
van Eekeren LE; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. .; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. .; Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. .
Matzaraki V; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Zhang Z; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
van de Wijer L; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Blaauw MJT; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
de Jonge MI; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine, and Pediatrics, Ghent University & Ghent University Hospital, Ghent, Belgium.
Trypsteen W; HIV Cure Research Center, Department of Internal Medicine, and Pediatrics, Ghent University & Ghent University Hospital, Ghent, Belgium.
Joosten LAB; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Netea MG; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
de Mast Q; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Koenen HJPM; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Li Y; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM) & TWINCORE, Joint Ventures Between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.
van der Ven AJAM; Department of General Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
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Źródło:
Scientific reports [Sci Rep] 2022 Jul 06; Vol. 12 (1), pp. 11425. Date of Electronic Publication: 2022 Jul 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD8-Positive T-Lymphocytes*/immunology
HIV Infections*/blood
HIV Infections*/immunology
HIV-1*/immunology
Receptors, CCR5*/immunology
T-Lymphocytes, Regulatory*/immunology
Cross-Sectional Studies ; Humans ; RNA/metabolism ; Receptors, HIV
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HCV reinfection after HCV therapy among HIV/HCV-coinfected individuals in Europe.
Autorzy:
Amele S; Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for Global Health, University College London, London, UK.
Sandri AK; CHIP, Rigshospitalet, Copenhagen, Denmark.
Rodger A; Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for Global Health, University College London, London, UK.
Vandekerckhove L; Ghent University Hospital, Ghent, Belgium.
Benfield T; Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Milinkovic A; Chelsea and Westminster Hospital, London, UK.
Duvivier C; AP-HP - Necker Enfants Malades Hospital, Infectious Diseases Department; Necker Pasteur Center for Infectious Diseases and Tropical Medicine; Université de Paris; IHU Imagine, Paris, France.
Stellbrink HJ; ICH Study Center, Hamburg, Germany.
Sambatakou H; Ippokration General Hospital, Athens, Greece.
Chkhartishvili N; Infectious Diseases, AIDS & Clinical Immunology Research Center, Tbilisi, Georgia.
Caldeira L; Santa Maria University Hospital, University of Lisbon, Lisbon, Portugal.
Laguno M; Infectious Diseases Service, Hospital Clinic, Barcelona, Spain.
Domingo P; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Wandeler G; Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
Gisinger M; Medical University of Innsbruck, Innsbruck, Austria.
Kuzovatova E; Nizhny Novgorod Scientific and Research Institute, Nizhny Novgorod, Russia.
Dragovic G; Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Belgrade, Serbia.
Knysz B; Wroclaw Medical University, Wroclaw, Poland.
Matulionyte R; Department of Infectious Diseases and Dermatovenerology, Faculty of Medicine, Vilnius University; Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Rockstroh JK; Universitäts Klinik Bonn, Bonn, Germany.
Lundgren JD; CHIP, Rigshospitalet, Copenhagen, Denmark.
Mocroft A; Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for Global Health, University College London, London, UK.; CHIP, Rigshospitalet, Copenhagen, Denmark.
Peters L; CHIP, Rigshospitalet, Copenhagen, Denmark.
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Corporate Authors:
EuroSIDA study group
Źródło:
HIV medicine [HIV Med] 2022 Jul; Vol. 23 (6), pp. 684-692. Date of Electronic Publication: 2021 Dec 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Coinfection*/complications
Coinfection*/drug therapy
HIV Infections*/complications
HIV Infections*/drug therapy
Hepatitis C, Chronic*/complications
Hepatitis C, Chronic*/drug therapy
Antiviral Agents/therapeutic use ; Europe/epidemiology ; Female ; Hepacivirus/genetics ; Humans ; Male ; Middle Aged ; Reinfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Distinct immune profiles of HIV-infected subjects are linked to specific lipid mediator signature.
Autorzy:
Sips M; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Gerlo S; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
De Clercq L; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Gomez EA; Lipid Mediator Unit, Centre for Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Colas RA; Lipid Mediator Unit, Centre for Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Dalli J; Lipid Mediator Unit, Centre for Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, UK.
Vandekerckhove L; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
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Źródło:
Immunity, inflammation and disease [Immun Inflamm Dis] 2022 Jun; Vol. 10 (6), pp. e629.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections*/drug therapy
Eicosanoids ; Flow Cytometry ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Patient-reported outcomes among people living with HIV on single- versus multi-tablet regimens: Data from a real-life setting.
Autorzy:
Degroote S; Department of General Internal Medicine, Ghent University Hospital, Ghent, Belgium.
Vandekerckhove L; Department of General Internal Medicine, Ghent University Hospital, Ghent, Belgium.; Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.
Vogelaers D; Department of General Internal Medicine, AZ Delta, Roeselare, Belgium.; Department of Physical Medicine and Rehabilitation, Ghent University Hospital, Ghent, Belgium.
Vanden Bulcke C; Department of General Internal Medicine, Ghent University Hospital, Ghent, Belgium.
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Źródło:
PloS one [PLoS One] 2022 Jan 13; Vol. 17 (1), pp. e0262533. Date of Electronic Publication: 2022 Jan 13 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-HIV Agents/*therapeutic use
Medication Adherence/*statistics & numerical data
Adult ; Antiviral Agents/therapeutic use ; Drug Combinations ; Drugs, Generic/therapeutic use ; Female ; HIV Infections/drug therapy ; Humans ; Longitudinal Studies ; Male ; Medication Adherence/psychology ; Middle Aged ; Patient Reported Outcome Measures ; Retrospective Studies ; Self Report ; Tablets/therapeutic use ; Treatment Outcome ; Viral Load/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising Human Alu Repeat Sequences.
Autorzy:
Malatinkova E; HIV Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, B-9000 Ghent, Belgium.
Thomas J; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7BE, UK.
De Spiegelaere W; Laboratory of Veterinary Morphology, Faculty of Veterinary Sciences, Ghent University, B-9820 Ghent, Belgium.
Rutsaert S; HIV Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, B-9000 Ghent, Belgium.
Geretti AM; Fondazione PTV and Faculty of Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.; School of Immunology & Microbial Sciences, King's College London, London WC2R 2LS, UK.
Pollakis G; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7BE, UK.
Paxton WA; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7BE, UK.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, B-9000 Ghent, Belgium.
Ruggiero A; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7BE, UK.; Department Neurosciences, Biomedicine and Movement Sciences, School of Medicine-University of Verona, 37129 Verona, Italy.
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Źródło:
Life (Basel, Switzerland) [Life (Basel)] 2021 Dec 16; Vol. 11 (12). Date of Electronic Publication: 2021 Dec 16.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.
Autorzy:
Zhang Z; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525HP, Nijmegen, the Netherlands.; Department of Genetics, University Medical Center Groningen, 9700RB, Groningen, the Netherlands.; Genomics Coordination Center, University Medical Center Groningen, 9700RB, Groningen, the Netherlands.; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine, CiiM, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
Trypsteen W; HIV Cure Research Center, Department of Internal Medicine, and Pediatrics, Ghent University and Ghent University Hospital, Ghent, Belgium.
Blaauw M; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525HP, Nijmegen, the Netherlands.
Chu X; Department of Genetics, University Medical Center Groningen, 9700RB, Groningen, the Netherlands.; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine, CiiM, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
Rutsaert S; HIV Cure Research Center, Department of Internal Medicine, and Pediatrics, Ghent University and Ghent University Hospital, Ghent, Belgium.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine, and Pediatrics, Ghent University and Ghent University Hospital, Ghent, Belgium.
van der Heijden W; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525HP, Nijmegen, the Netherlands.
Dos Santos JC; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525HP, Nijmegen, the Netherlands.
Xu CJ; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine, CiiM, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
Swertz MA; Department of Genetics, University Medical Center Groningen, 9700RB, Groningen, the Netherlands.; Genomics Coordination Center, University Medical Center Groningen, 9700RB, Groningen, the Netherlands.
van der Ven A; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525HP, Nijmegen, the Netherlands. .
Li Y; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525HP, Nijmegen, the Netherlands. .; Department of Genetics, University Medical Center Groningen, 9700RB, Groningen, the Netherlands. .; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine, CiiM, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany. .; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany. .
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Źródło:
BMC medicine [BMC Med] 2021 Nov 16; Vol. 19 (1), pp. 282. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections*/drug therapy
HIV Infections*/genetics
HIV-1*/genetics
Anti-Retroviral Agents/therapeutic use ; CD4-Positive T-Lymphocytes ; Carrier Proteins/therapeutic use ; DNA-Binding Proteins ; Genome-Wide Association Study ; Humans ; Transcription Factors ; Viral Load ; Virus Latency/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A rare but devastating cause of twin loss in a near-term pregnancy highlighting the features of severe SARS-CoV-2 placentitis.
Autorzy:
Libbrecht S; Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Van Cleemput J; Department of Internal Medicine and Paediatrics, HIV Cure Research Centre, Ghent University, Ghent, Belgium.
Vandekerckhove L; Department of Internal Medicine and Paediatrics, HIV Cure Research Centre, Ghent University, Ghent, Belgium.; Department of General Internal Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium.
Colman S; Department of Medical Microbiology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Padalko E; Department of Medical Microbiology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Verhasselt B; Department of Medical Microbiology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Van de Vijver K; Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Dendooven A; Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Dehaene I; Department of Gynaecology and Obstetrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
Van Dorpe J; Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.
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Źródło:
Histopathology [Histopathology] 2021 Oct; Vol. 79 (4), pp. 674-676. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
COVID-19/*diagnosis
Coronavirus Nucleocapsid Proteins/*metabolism
Placenta Diseases/*pathology
Pregnancy Complications, Infectious/*virology
SARS-CoV-2/*genetics
Adult ; COVID-19/pathology ; COVID-19/virology ; Female ; Humans ; Immunohistochemistry ; Maternal Death ; Necrosis ; Phosphoproteins/metabolism ; Placenta/pathology ; Placenta/virology ; Placenta Diseases/virology ; Pregnancy ; Pregnancy Complications, Infectious/pathology ; Pregnancy Trimester, Third ; Pregnancy, Twin ; Risk ; Trophoblasts/pathology ; Trophoblasts/virology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across clinical conditions.
Autorzy:
Vergauwen G; Department of Human Structure and Repair Laboratory of Experimental Cancer Research Ghent University Ghent Belgium.; Cancer Research Institute Ghent Ghent Belgium.; Department of Gynecology Ghent University Hospital Ghent Belgium.
Tulkens J; Department of Human Structure and Repair Laboratory of Experimental Cancer Research Ghent University Ghent Belgium.; Cancer Research Institute Ghent Ghent Belgium.
Pinheiro C; Department of Human Structure and Repair Laboratory of Experimental Cancer Research Ghent University Ghent Belgium.; Cancer Research Institute Ghent Ghent Belgium.
Avila Cobos F; Cancer Research Institute Ghent Ghent Belgium.; Department of Biomolecular Medicine OncoRNALab Ghent University Ghent Belgium.
Dedeyne S; Department of Human Structure and Repair Laboratory of Experimental Cancer Research Ghent University Ghent Belgium.; Cancer Research Institute Ghent Ghent Belgium.
De Scheerder MA; Department of Internal Medicine and Pediatrics HIV Cure Research Center Ghent University Hospital Ghent Belgium.
Vandekerckhove L; Department of Internal Medicine and Pediatrics HIV Cure Research Center Ghent University Hospital Ghent Belgium.
Impens F; VIB Center for Medical Biotechnology Ghent Belgium.; Department of Biomolecular Medicine Ghent University Ghent Belgium.; VIB Proteomics Core Ghent Belgium.
Miinalainen I; Biocenter Oulu University of Oulu Oulu Finland.
Braems G; Cancer Research Institute Ghent Ghent Belgium.; Department of Gynecology Ghent University Hospital Ghent Belgium.
Gevaert K; VIB Center for Medical Biotechnology Ghent Belgium.; Department of Biomolecular Medicine Ghent University Ghent Belgium.
Mestdagh P; Cancer Research Institute Ghent Ghent Belgium.; Department of Biomolecular Medicine OncoRNALab Ghent University Ghent Belgium.
Vandesompele J; Cancer Research Institute Ghent Ghent Belgium.; Department of Biomolecular Medicine OncoRNALab Ghent University Ghent Belgium.
Denys H; Cancer Research Institute Ghent Ghent Belgium.; Department of Medical Oncology Ghent University Hospital Ghent Belgium.
De Wever O; Department of Human Structure and Repair Laboratory of Experimental Cancer Research Ghent University Ghent Belgium.; Cancer Research Institute Ghent Ghent Belgium.
Hendrix A; Department of Human Structure and Repair Laboratory of Experimental Cancer Research Ghent University Ghent Belgium.; Cancer Research Institute Ghent Ghent Belgium.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2021 Aug; Vol. 10 (10), pp. e12122. Date of Electronic Publication: 2021 Aug 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proteome*
Centrifugation, Density Gradient/*methods
Chemical Fractionation/*methods
Extracellular Vesicles/*chemistry
Lipoproteins/*analysis
Plasma/*chemistry
Biomarkers/analysis ; Breast Neoplasms/blood ; Breast Neoplasms/chemistry ; Chromatography, Gel ; Female ; HIV Infections/blood ; Humans ; Ovarian Neoplasms/blood ; Ovarian Neoplasms/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed People with HIV Aged ≥ 65 Years: Week 48 Results of a Phase 3b, Open-Label Trial.
Autorzy:
Maggiolo F; Division of Infectious Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy.
Rizzardini G; Division of Infectious Diseases, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.; School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.
Molina JM; Department of Infectious Diseases, Saint Louis Hospital, University Paris Diderot, Paris, France.
Pulido F; Unidad VIH, Hospital Universitario 12 de Octubre, imas12, UCM, Madrid, Spain.
De Wit S; St Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Vandekerckhove L; University Hospital Ghent, Ghent, Belgium.
Berenguer J; Infectious Diseases, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain.
D'Antoni ML; Gilead Sciences, Foster City, CA, USA.
Blair C; Gilead Sciences, Foster City, CA, USA.
Chuck SK; Gilead Sciences, Foster City, CA, USA.
Piontkowsky D; Gilead Sciences, Foster City, CA, USA.
Martin H; Gilead Sciences, Foster City, CA, USA.
Haubrich R; Gilead Sciences, Foster City, CA, USA.
McNicholl IR; Gilead Sciences, Foster City, CA, USA.
Gallant J; Gilead Sciences, Foster City, CA, USA. .
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Źródło:
Infectious diseases and therapy [Infect Dis Ther] 2021 Jun; Vol. 10 (2), pp. 775-788. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
On the whereabouts of SARS-CoV-2 in the human body: A systematic review.
Autorzy:
Trypsteen W; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University & Ghent University Hospital, Ghent, Belgium.
Van Cleemput J; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University & Ghent University Hospital, Ghent, Belgium.
Snippenberg WV; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University & Ghent University Hospital, Ghent, Belgium.
Gerlo S; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University & Ghent University Hospital, Ghent, Belgium.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University & Ghent University Hospital, Ghent, Belgium.
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Źródło:
PLoS pathogens [PLoS Pathog] 2020 Oct 30; Vol. 16 (10), pp. e1009037. Date of Electronic Publication: 2020 Oct 30 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms:
Antiviral Agents/*pharmacology
Betacoronavirus/*drug effects
Coronavirus Infections/*drug therapy
Lung/*virology
Pneumonia, Viral/*drug therapy
Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/virology ; Female ; Humans ; Lung/metabolism ; Male ; Pandemics ; Peptidyl-Dipeptidase A/drug effects ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/virology ; Receptors, Virus/drug effects ; Receptors, Virus/metabolism ; SARS-CoV-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interferon-Mediated Long Non-Coding RNA Response in Macrophages in the Context of HIV.
Autorzy:
Schynkel T; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Szaniawski MA; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Spivak AM; Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Bosque A; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA.
Planelles V; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Trypsteen W; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 19; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 19.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1/*physiology
Interferons/*metabolism
Macrophages/*metabolism
Macrophages/*virology
RNA, Long Noncoding/*metabolism
Gene Expression Regulation ; Gene Ontology ; Gene Regulatory Networks ; HIV Infections/genetics ; HIV Infections/virology ; Humans ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcriptome/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on-going viral transcription.
Autorzy:
Pannus P; Departments of Clinical and Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Rutsaert S; Department of General Internal Medicine, HIV Cure Research Centre, Ghent University Hospital and Ghent University, Ghent, Belgium.
De Wit S; Saint Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Allard SD; HIV Reference Centre, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Vanham G; Departments of Clinical and Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Cole B; Department of General Internal Medicine, HIV Cure Research Centre, Ghent University Hospital and Ghent University, Ghent, Belgium.
Nescoi C; Saint Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Aerts J; Vrije Universiteit Brussel, Brussels, Belgium.
De Spiegelaere W; Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Tsoumanis A; Departments of Clinical and Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Couttenye MM; Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.
Herssens N; Departments of Clinical and Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
De Scheerder MA; Department of General Internal Medicine, HIV Cure Research Centre, Ghent University Hospital and Ghent University, Ghent, Belgium.
Vandekerckhove L; Department of General Internal Medicine, HIV Cure Research Centre, Ghent University Hospital and Ghent University, Ghent, Belgium.
Florence E; Departments of Clinical and Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
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Źródło:
Journal of the International AIDS Society [J Int AIDS Soc] 2020 Feb; Vol. 23 (2), pp. e25453.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections/*virology
HIV-1/*physiology
Adult ; CD4-Positive T-Lymphocytes/virology ; DNA, Viral ; Female ; HIV Infections/drug therapy ; HIV-1/genetics ; Humans ; Leukocytes, Mononuclear/virology ; Male ; Middle Aged ; Remission Induction ; Transcription, Genetic ; Viral Load ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence.
Autorzy:
Lambrechts L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.; BioBix, Department of Data Analysis and Mathematical Modelling, Faculty of Bioscience Engineering, Ghent University, 9000 Ghent, Belgium.
Cole B; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
Rutsaert S; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
Trypsteen W; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium.
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Źródło:
Viruses [Viruses] 2020 Jan 28; Vol. 12 (2). Date of Electronic Publication: 2020 Jan 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Virus Latency*
HIV Infections/*virology
HIV-1/*genetics
Polymerase Chain Reaction/*methods
Animals ; Genome, Viral ; HIV Seropositivity ; Humans ; Simian Immunodeficiency Virus/genetics ; Viral Load/methods ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Long non-coding RNAs and latent HIV - A search for novel targets for latency reversal.
Autorzy:
Trypsteen W; HIV Cure Research Center, Department of Internal Medicine, Ghent University and Ghent University Hospital, Ghent, Belgium.
White CH; Faculty of Medicine, University of Southampton, Southampton, Hants, United Kingdom.
Mukim A; San Diego VA Medical Center and Veterans Medical Research Foundation, San Diego, CA, United States of America.
Spina CA; San Diego VA Medical Center and Veterans Medical Research Foundation, San Diego, CA, United States of America.; Department of Pathology, University of California San Diego, La Jolla, CA, United States of America.
De Spiegelaere W; Department of Morphology, Faculty of Veterinary Sciences, Ghent University, Ghent, Belgium.
Lefever S; Center for Medical Genetics, Ghent University, Ghent, Belgium.
Planelles V; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States of America.
Bosque A; Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, United States of America.
Woelk CH; Faculty of Medicine, University of Southampton, Southampton, Hants, United Kingdom.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine, Ghent University and Ghent University Hospital, Ghent, Belgium.
Beliakova-Bethell N; San Diego VA Medical Center and Veterans Medical Research Foundation, San Diego, CA, United States of America.; Department of Medicine, University of California San Diego, La Jolla, CA, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Nov 11; Vol. 14 (11), pp. e0224879. Date of Electronic Publication: 2019 Nov 11 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
HIV-1/*genetics
RNA, Long Noncoding/*genetics
Virus Latency/*genetics
Depsipeptides/pharmacology ; Down-Regulation/drug effects ; HIV-1/drug effects ; Humans ; Immunologic Memory ; RNA, Long Noncoding/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reproducibility of Results ; Signal Transduction/drug effects ; Signal Transduction/genetics ; T-Lymphocytes/immunology ; Virus Latency/drug effects ; Vorinostat/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predictors of virological failure in HIV-1-infected patients switching to dolutegravir maintenance monotherapy.
Autorzy:
Wijting I; Department of Internal Medicine, Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
Rutsaert SL; Department of Internal Medicine, HIV Cure Research Center, Ghent University, Ghent, Belgium.
Rokx C; Department of Internal Medicine, Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
Burger DM; Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.
Verbon A; Department of Internal Medicine, Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
van Kampen J; Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Boucher C; Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
Rijnders B; Department of Internal Medicine, Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
Vandekerckhove L; Department of Internal Medicine, HIV Cure Research Center, Ghent University, Ghent, Belgium.
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Źródło:
HIV medicine [HIV Med] 2019 Jan; Vol. 20 (1), pp. 63-68. Date of Electronic Publication: 2018 Sep 30.
Typ publikacji:
Equivalence Trial; Journal Article; Randomized Controlled Trial
MeSH Terms:
HIV Infections/*drug therapy
HIV Integrase Inhibitors/*therapeutic use
HIV-1/*drug effects
Heterocyclic Compounds, 3-Ring/*therapeutic use
Adult ; CD4 Lymphocyte Count ; Female ; HIV Infections/immunology ; HIV Infections/virology ; HIV Integrase Inhibitors/pharmacology ; HIV-1/physiology ; Heterocyclic Compounds, 3-Ring/pharmacology ; Humans ; Maintenance Chemotherapy ; Male ; Middle Aged ; Oxazines ; Piperazines ; Pyridones ; Treatment Failure ; Viral Load/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluation of bisulfite kits for DNA methylation profiling in terms of DNA fragmentation and DNA recovery using digital PCR.
Autorzy:
Kint S; Department of Data Analysis and Mathematical Modelling, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.; HIV Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, Ghent, Belgium.
De Spiegelaere W; Department of Morphology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
De Kesel J; Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, Ghent, Belgium.
Van Criekinge W; Department of Data Analysis and Mathematical Modelling, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
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Źródło:
PloS one [PLoS One] 2018 Jun 14; Vol. 13 (6), pp. e0199091. Date of Electronic Publication: 2018 Jun 14 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA/*genetics
DNA Fragmentation/*drug effects
DNA Methylation/*drug effects
Polymerase Chain Reaction/*methods
Sulfites/*pharmacology
Temperature ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Abacavir usage patterns and hypersensitivity reactions in the EuroSIDA cohort.
Autorzy:
Roen A; University College London, London, UK.
Laut K; University of Copenhagen, Copenhagen, Denmark.
Pelchen-Matthews A; University College London, London, UK.
Borodulina E; Samara State Medical University, Samara, Russia.
Caldeira L; Hospital Santa Maria, Lisbon, Portugal.
Clarke A; Royal Sussex County Hospital, Brighton, UK.
Clotet B; Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
d'Arminio Monforte A; Ospedale San Paulo, Milan, Italy.
Fätkenheuer G; University Hospital Cologne, Cologne, Germany.
Gatell Artigas JM; Hospital Clinic, Barcelona, Spain.
Karpov I; Belarus State Medical University, Minsk, Belarus.
Kuznetsova A; Kharkov State Medical University, Khrakov, Ukraine.
Kyselyova G; Crimean Republican AIDS Centre, Simferopol, Ukraine.
Mozer-Lisewska I; Poznan University of Medical Sciences, Poznań, Poland.
Mulcahy F; St James' Hospital, Dublin, Ireland.
Ragone L; ViiV Healthcare, Research Triangle Park, NC, USA.
Scherrer A; University Hospital Zürich, Zürich, Switzerland.
Uzdaviniene V; Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
Vandekerckhove L; Ghent University Hospital, Gent, Belgium.
Vannappagari V; ViiV Healthcare, Research Triangle Park, NC, USA.
Ostergaard L; Aarhus University Hospital, Skejby, Denmark.
Mocroft A; University College London, London, UK.
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Corporate Authors:
EuroSIDA study
Źródło:
HIV medicine [HIV Med] 2018 Apr; Vol. 19 (4), pp. 252-260. Date of Electronic Publication: 2017 Dec 22.
Typ publikacji:
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-HIV Agents/*adverse effects
Dideoxynucleosides/*adverse effects
Drug Hypersensitivity/*epidemiology
HIV Infections/*drug therapy
Adult ; Cohort Studies ; Drug Hypersensitivity/etiology ; Drug Utilization ; Europe/epidemiology ; Female ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Poisson Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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