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    Wyświetlanie 1-7 z 7
    Tytuł:
    Respirable aerosol exposures of nicotine dry powder formulations to in vitro , ex vivo , and in vivo pre-clinical models demonstrate consistency of pharmacokinetic profiles.
    Autorzy:
    Sciuscio D; PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Hoeng J; PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Peitsch MC; PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Vanscheeuwijck P; PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
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    Źródło:
    Inhalation toxicology [Inhal Toxicol] 2019 May; Vol. 31 (6), pp. 248-257. Date of Electronic Publication: 2019 Sep 09.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Nicotine/*administration & dosage
    Nicotine/*pharmacokinetics
    Administration, Inhalation ; Aerosols ; Animals ; Lung/metabolism ; Male ; Nicotine/blood ; Powders ; Rats, Sprague-Dawley
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols.
    Autorzy:
    Lee KM; a Altria Client Services LLC , Richmond , VA , USA.
    Hoeng J; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Harbo S; c Battelle , Columbus , OH , USA.
    Kogel U; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Gardner W; a Altria Client Services LLC , Richmond , VA , USA.
    Oldham M; a Altria Client Services LLC , Richmond , VA , USA.
    Benson E; c Battelle , Columbus , OH , USA.
    Talikka M; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Kondylis A; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Martin F; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Titz B; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Ansari S; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Trivedi K; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Guedj E; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Elamin A; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Ivanov NV; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Vanscheeuwijck P; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    Peitsch MC; b PMI R&D, Philip Morris Products S.A , Neuchâtel , Switzerland.
    McKinney WJ Jr; a Altria Client Services LLC , Richmond , VA , USA.
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    Źródło:
    Inhalation toxicology [Inhal Toxicol] 2018 Nov - Dec; Vol. 30 (13-14), pp. 553-567. Date of Electronic Publication: 2019 Mar 08.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Electronic Nicotine Delivery Systems*
    Respiratory System/*drug effects
    Smoke/*adverse effects
    Tobacco Products/*adverse effects
    Administration, Inhalation ; Aerosols ; Animals ; Bronchoalveolar Lavage Fluid/chemistry ; Bronchoalveolar Lavage Fluid/cytology ; Carboxyhemoglobin/analysis ; Female ; Gene Expression Profiling ; Mice, Inbred C57BL ; Respiratory Function Tests ; Respiratory Physiological Phenomena/drug effects ; Respiratory System/metabolism ; Respiratory System/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A framework for in vitro systems toxicology assessment of e-liquids.
    Autorzy:
    Iskandar AR; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Gonzalez-Suarez I; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Majeed S; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Marescotti D; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Sewer A; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Xiang Y; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Leroy P; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Guedj E; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Mathis C; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Schaller JP; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Vanscheeuwijck P; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Frentzel S; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Martin F; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Ivanov NV; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Peitsch MC; a Philip Morris International R&D , Neuchâtel , Switzerland.
    Hoeng J; a Philip Morris International R&D , Neuchâtel , Switzerland.
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    Źródło:
    Toxicology mechanisms and methods [Toxicol Mech Methods] 2016 Jul; Vol. 26 (6), pp. 389-413. Date of Electronic Publication: 2016 Apr 26.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Air Pollutants/*toxicity
    Electronic Nicotine Delivery Systems/*adverse effects
    Toxicity Tests/*instrumentation
    Toxicity Tests/*methods
    Aerosols ; Cell Culture Techniques ; Cell Survival/drug effects ; Cells, Cultured ; Equipment Design ; High-Throughput Screening Assays ; Humans ; Systems Biology ; Volatilization
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe -/- mice--a systems toxicology analysis.
    Autorzy:
    Lo Sasso G; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Titz B; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Nury C; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Boué S; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Phillips B; b Philip Morris International Research Laboratories , Singapore , Singapore , and.
    Belcastro V; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Schneider T; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Dijon S; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Baumer K; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Peric D; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Dulize R; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Elamin A; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Guedj E; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Buettner A; c Histovia GmbH , Overath , Germany.
    Leroy P; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Kleinhans S; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Vuillaume G; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Veljkovic E; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Ivanov NV; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Martin F; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Vanscheeuwijck P; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Peitsch MC; a Philip Morris International Research and Development , Neuchatel , Switzerland .
    Hoeng J; a Philip Morris International Research and Development , Neuchatel , Switzerland .
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    Źródło:
    Inhalation toxicology [Inhal Toxicol] 2016 Apr; Vol. 28 (5), pp. 226-40. Date of Electronic Publication: 2016 Mar 30.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Smoke*
    Liver/*drug effects
    Nicotiana/*toxicity
    Tobacco Products/*toxicity
    Animals ; Apolipoproteins E/genetics ; Female ; Lipid Metabolism/drug effects ; Liver/metabolism ; Mice, Knockout ; Proteomics ; Risk ; Smoking Cessation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague-Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology.
    Autorzy:
    Phillips B; a Philip Morris International Research Laboratories Pte Ltd , Science Park II , Singapore and.
    Esposito M
    Verbeeck J
    Boué S
    Iskandar A
    Vuillaume G
    Leroy P
    Krishnan S
    Kogel U
    Utan A
    Schlage WK
    Bera M
    Veljkovic E
    Hoeng J
    Peitsch MC
    Vanscheeuwijck P
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    Źródło:
    Inhalation toxicology [Inhal Toxicol] 2015; Vol. 27 (9), pp. 405-31. Date of Electronic Publication: 2015 Aug 20.
    Typ publikacji:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antioxidants/*toxicity
    Nicotine/*toxicity
    Nicotinic Agonists/*toxicity
    Pyruvic Acid/*toxicity
    Tobacco Use Cessation Devices/*adverse effects
    Administration, Inhalation ; Aerosols ; Animals ; Biomarkers/blood ; Biomarkers/metabolism ; Dose-Response Relationship, Drug ; Drug Combinations ; Female ; Gene Expression Regulation/drug effects ; Lipid Metabolism/drug effects ; Liver/cytology ; Liver/drug effects ; Liver/metabolism ; Male ; Organ Size/drug effects ; Random Allocation ; Rats, Sprague-Dawley ; Specific Pathogen-Free Organisms ; Toxicity Tests, Subchronic ; Weight Gain/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Lung inflammation in rats following subchronic exposure to cigarette mainstream smoke.
    Autorzy:
    Friedrichs B; Philip Morris Research Laboratories GmbH, Cologne, Germany. />Miert Ev
    Vanscheeuwijck P
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    Źródło:
    Experimental lung research [Exp Lung Res] 2006 May; Vol. 32 (5), pp. 151-79.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Pneumonia/*pathology
    Smoke/*adverse effects
    Smoke Inhalation Injury/*physiopathology
    Animals ; Bronchoalveolar Lavage ; Cell Differentiation ; Epithelial Cells/pathology ; Female ; Inflammation ; Larynx/pathology ; Lymph Nodes/pathology ; Lymphocytes/pathology ; Neutrophils/pathology ; Nose/pathology ; Pneumonia/immunology ; Rats ; Rats, Sprague-Dawley ; Smoke Inhalation Injury/immunology ; Nicotiana
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-7 z 7

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