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Tytuł:
Deletion of Slc9a1 in Cx3cr1 cells stimulated microglial subcluster CREB1 signaling and microglia-oligodendrocyte crosstalk.
Autorzy:
Song S; Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA. .; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA, USA. .; Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, 15213, USA. .
Oft H; Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA, USA.
Metwally S; Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA, USA.
Paruchuri S; Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA, USA.
Bielanin J; Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA, USA.
Fiesler V; Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA, USA.
Sneiderman C; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Kohanbash G; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Sun D; Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA, 15213, USA. .; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA, USA. .; Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, 15213, USA. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Mar 20; Vol. 21 (1), pp. 69. Date of Electronic Publication: 2024 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
Brain*/metabolism
Microglia*/metabolism
Sodium-Hydrogen Exchanger 1*/metabolism
Animals ; Mice ; CX3C Chemokine Receptor 1/metabolism ; Macrophages/metabolism ; Oligodendroglia/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł:
Structural dynamics of Na interactions with full-size mammalian NCX.
Autorzy:
Giladi M; Department of Physiology and Pharmacology, Faculty of Medicine, Tel-Aviv University, Tel Aviv, 69978, Israel. .; Tel-Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel. .
Fojtík L; Division BioCeV, Institute of Microbiology of the Czech Academy of Sciences, Prumyslova, 595, 252 50 Vestec, Prague, Czech Republic.; Department of Biochemistry, Faculty of Science, Charles University, 128 00, Prague, Czech Republic.
Strauss T; Department of Physiology and Pharmacology, Faculty of Medicine, Tel-Aviv University, Tel Aviv, 69978, Israel.
Da'adoosh B; Blavatnik Center for Drug Discovery, Tel Aviv University, Tel Aviv, 69978, Israel.
Hiller R; Department of Physiology and Pharmacology, Faculty of Medicine, Tel-Aviv University, Tel Aviv, 69978, Israel.
Man P; Division BioCeV, Institute of Microbiology of the Czech Academy of Sciences, Prumyslova, 595, 252 50 Vestec, Prague, Czech Republic. .; Department of Biochemistry, Faculty of Science, Charles University, 128 00, Prague, Czech Republic. .
Khananshvili D; Department of Physiology and Pharmacology, Faculty of Medicine, Tel-Aviv University, Tel Aviv, 69978, Israel. .
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Źródło:
Communications biology [Commun Biol] 2024 Apr 16; Vol. 7 (1), pp. 463. Date of Electronic Publication: 2024 Apr 16.
Typ publikacji:
Journal Article
MeSH Terms:
Mammals*
Sodium-Calcium Exchanger*/chemistry
Animals ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł:
Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke.
Autorzy:
Metwally SAH; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Paruchuri SS; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Yu L; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Capuk O; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Pennock N; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Sun D; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15213, USA.
Song S; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15213, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 27; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 27.
Typ publikacji:
Journal Article
MeSH Terms:
Ischemic Stroke*
Stroke*/drug therapy
White Matter*
Sodium-Hydrogen Exchanger 1*/antagonists & inhibitors
Animals ; Mice ; Anti-Arrhythmia Agents ; Inflammation ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł:
Inhibition of the Sodium-Calcium Exchanger Reverse Mode Activity Reduces Alcohol Consumption in Rats.
Autorzy:
Silva-Cardoso GK; Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.
N'Gouemo P; Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 08; Vol. 25 (7). Date of Electronic Publication: 2024 Apr 08.
Typ publikacji:
Journal Article
MeSH Terms:
Alcoholism*
Substance Withdrawal Syndrome*
Thiourea/*analogs & derivatives
Humans ; Adult ; Female ; Male ; Animals ; Rats ; Sodium-Calcium Exchanger ; Alcohol Drinking ; Ethanol ; Water
Czasopismo naukowe
Tytuł:
T-type voltage-gated channels, Na -exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration.
Autorzy:
Yan J; Yunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming, 650021, China.; Cell Death Mechanism Group, Institute for Ophthalmic Research, University of Tübingen, Tübingen, 72076, Germany.; Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, 72076, Germany.
Wang L; Cell Death Mechanism Group, Institute for Ophthalmic Research, University of Tübingen, Tübingen, 72076, Germany.; Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, 72076, Germany.
Yang QL; The Third Affiliated Hospital of Kunming Medical University &Yunnan Cancer Hospital, Kunming, Yunnan, 650118, China.
Yang QX; The Third Affiliated Hospital of Kunming Medical University &Yunnan Cancer Hospital, Kunming, Yunnan, 650118, China.
He X; Graduate Training Centre of Neuroscience, University of Tübingen, Tübingen, 72076, Germany.; High-resolution Functional Imaging and Test Group, Institute for Ophthalmic Research, University of Tübingen, Tübingen, 72076, Germany.
Dong Y; Yunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming, 650021, China.
Hu Z; Yunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming, 650021, China.
Seeliger MW; Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, University of Tübingen, Tübingen, 72076, Germany.
Jiao K; Yunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming, 650021, China.
Paquet-Durand F; Cell Death Mechanism Group, Institute for Ophthalmic Research, University of Tübingen, Tübingen, 72076, Germany. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Feb 01; Vol. 22 (1), pp. 92. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Retinal Degeneration*/metabolism
Sirtuins*/metabolism
Egtazic Acid/*analogs & derivatives
Mice ; Animals ; Calpain/metabolism ; Sodium-Calcium Exchanger ; Photoreceptor Cells/metabolism ; Photoreceptor Cells/pathology ; Cell Death
Czasopismo naukowe
Tytuł:
Inhibition of Acid-Sensing Ion Channels by KB-R7943, a Reverse Na Exchanger Inhibitor.
Autorzy:
Sun HW; Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Chu XP; Department of Biomedical Sciences, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA.
Simon RP; Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Xiong ZG; Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
Leng TD; Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 Mar 10; Vol. 13 (3). Date of Electronic Publication: 2023 Mar 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Acid Sensing Ion Channels*
Sodium-Calcium Exchanger*/genetics
Cricetinae ; Mice ; Animals ; Cricetulus ; CHO Cells
Czasopismo naukowe
Tytuł:
Regulation of K -Exchangers (NCKX).
Autorzy:
Al-Khannaq M; Department of Biochemistry & Molecular Biology, Libin Cardiovascular Institute and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Lytton J; Department of Biochemistry & Molecular Biology, Libin Cardiovascular Institute and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 29; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Calcium*/metabolism
Sodium-Calcium Exchanger*/genetics
Sodium-Calcium Exchanger*/metabolism
Czasopismo naukowe
Tytuł:
Structure-Based Function and Regulation of NCX Variants: Updates and Challenges.
Autorzy:
Khananshvili D; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Medical School, Tel-Aviv University, Tel-Aviv 69978, Israel.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 21; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Eukaryotic Cells*/metabolism
Sodium-Calcium Exchanger*/genetics
Sodium-Calcium Exchanger*/metabolism
Animals ; Humans ; Scattering, Small Angle ; X-Ray Diffraction ; Protein Isoforms/metabolism ; Ion Transport/physiology ; Calcium/metabolism ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Genetic Deletion of AT 1a Receptor or Na Exchanger 3 Selectively in the Proximal Tubules of the Kidney Attenuates Two-Kidney, One-Clip Goldblatt Hypertension in Mice.
Autorzy:
Li XC; Tulane Hypertension and Renal Center of Excellence, 1430 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Hassan R; Tulane Hypertension and Renal Center of Excellence, 1430 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Leite APO; Tulane Hypertension and Renal Center of Excellence, 1430 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Katsurada A; Tulane Hypertension and Renal Center of Excellence, 1430 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Dugas C; Tulane Hypertension and Renal Center of Excellence, 1430 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Sato R; Tulane Hypertension and Renal Center of Excellence, 1430 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Zhuo JL; Tulane Hypertension and Renal Center of Excellence, 1430 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Physiology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 13; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Hypertension*/metabolism
Hypertension, Renovascular*/genetics
Receptor, Angiotensin, Type 1*/genetics
Receptor, Angiotensin, Type 1*/metabolism
Sodium-Hydrogen Exchanger 3*/genetics
Sodium-Hydrogen Exchanger 3*/metabolism
Animals ; Male ; Mice ; Angiotensin II/metabolism ; Blood Pressure ; Kidney/metabolism ; Kidney Tubules, Proximal/metabolism ; Gene Deletion ; Mice, Knockout
Czasopismo naukowe
Tytuł:
Antiarrhythmic and Inotropic Effects of Selective Na Exchanger Inhibition: What Can We Learn from the Pharmacological Studies?
Autorzy:
Nagy N; ELKH-SZTE Research Group of Cardiovascular Pharmacology, 6720 Szeged, Hungary.; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, 6720 Szeged, Hungary.
Tóth N; ELKH-SZTE Research Group of Cardiovascular Pharmacology, 6720 Szeged, Hungary.
Nánási PP; Department of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Department of Dental Physiology and Pharmacology, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 24; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 24.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Sodium-Calcium Exchanger*/metabolism
Anti-Arrhythmia Agents*/pharmacology
Humans ; Ion Channels/metabolism ; Arrhythmias, Cardiac/drug therapy ; Biological Transport/physiology ; Calcium/metabolism
Czasopismo naukowe
Tytuł:
Inhibition of Voltage-Gated Na Exchanging Process.
Autorzy:
Wu SN; Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.; Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan 70101, Taiwan.; Department of Post-Baccalaureate Medicine, National Sun Yat-sen University Medical College, Kaohsiung 80708, Taiwan.
Yu MC; Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 16; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 16.
Typ publikacji:
Journal Article
MeSH Terms:
Thiourea*/pharmacology
Sodium-Calcium Exchanger*
Czasopismo naukowe
Tytuł:
The reverse mode of the Na exchanger contributes to the pacemaker mechanism in rabbit sinus node cells.
Autorzy:
Tóth N; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, Szeged, 6720, Hungary.
Loewe A; Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Szlovák J; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, Szeged, 6720, Hungary.
Kohajda Z; ELKH-SZTE Research Group of Cardiovascular Pharmacology, Szeged, Hungary.
Bitay G; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, Szeged, 6720, Hungary.
Levijoki J; Orion Pharma, Espoo, Finland.
Papp JG; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, Szeged, 6720, Hungary.; ELKH-SZTE Research Group of Cardiovascular Pharmacology, Szeged, Hungary.
Varró A; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, Szeged, 6720, Hungary.; ELKH-SZTE Research Group of Cardiovascular Pharmacology, Szeged, Hungary.
Nagy N; Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, Szeged, 6720, Hungary. .; ELKH-SZTE Research Group of Cardiovascular Pharmacology, Szeged, Hungary. .
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Źródło:
Scientific reports [Sci Rep] 2022 Dec 17; Vol. 12 (1), pp. 21830. Date of Electronic Publication: 2022 Dec 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sodium-Calcium Exchanger*
Sinoatrial Node*/metabolism
Animals ; Rabbits ; Sodium Chloride ; Myocytes, Cardiac/metabolism ; Calcium/metabolism
Czasopismo naukowe
Tytuł:
Real time monitoring of cold Ca dependent transcription and its modulation by NCX inhibitors.
Autorzy:
Wang HT; Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.; Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.; Department of Biological Science, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Miyairi S; Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.; Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
Kitamura M; Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.; Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
Iizuka K; Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.; Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
Asano Y; Department of Biological Science, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Yoshimura T; Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.; Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
Kon N; Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. .; Laboratory of Animal Integrative Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. .; Suntory Rising Stars Encouragement Program in Life Sciences (SunRiSE), 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto, 619-0284, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2022 Oct 15; Vol. 12 (1), pp. 17325. Date of Electronic Publication: 2022 Oct 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcium*/metabolism
Sodium-Calcium Exchanger*/genetics
Sodium-Calcium Exchanger*/metabolism
Animals ; Mammals/metabolism ; Rats
Czasopismo naukowe
Tytuł:
Effect of an NHE3 inhibitor in combination with an NPT2b inhibitor on gastrointestinal phosphate absorption in Rodent models.
Autorzy:
Wang X; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Yu X; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Gavardinas K; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Dey A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Zhang HY; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Porter G; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Porras L; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Yu L; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Guo H; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Reidy CA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Haas JV; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Xu Y; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Kowala MC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Jadhav PK; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
Wetterau JR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Jan 26; Vol. 19 (1), pp. e0292091. Date of Electronic Publication: 2024 Jan 26 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Phosphates*/metabolism
Renal Insufficiency, Chronic*/metabolism
Rats ; Mice ; Animals ; Sodium-Hydrogen Exchanger 3 ; Rodentia ; Intestinal Absorption ; Sodium-Hydrogen Exchangers/metabolism
Czasopismo naukowe
Tytuł:
Studies with Human-Induced Pluripotent Stem Cells Reveal That CTNS Mutations Can Alter Renal Proximal Tubule Differentiation.
Autorzy:
Thiyagarajan R; Division of Geriatric Medicine, University of Kansas Medical Center, University of Kansas, Kansas City, KS 66160, USA.
Taub M; Biochemistry Department, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Cystinosis*/genetics
Induced Pluripotent Stem Cells*/metabolism
Amino Acid Transport Systems, Neutral*/metabolism
Humans ; Cystine/metabolism ; Sodium-Hydrogen Exchanger 3/genetics ; Mutation ; Lysosomes/metabolism
SCR Disease Name:
Cystinosis, Infantile Nephropathic
Czasopismo naukowe
Tytuł:
Long-term safety and decrease of pill burden by tenapanor therapy: a phase 3 open-label study in hemodialysis patients with hyperphosphatemia.
Autorzy:
Koiwa F; Division of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-Ku, Yokohama, 227-8501, Japan. .
Sato Y; R&D Division, Kyowa Kirin Co., Ltd., Tokyo, Japan.
Ohara M; R&D Division, Kyowa Kirin Co., Ltd., Tokyo, Japan.
Nakanishi K; R&D Division, Kyowa Kirin Co., Ltd., Tokyo, Japan.
Fukagawa M; Division of Nephrology, Endocrinology, and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Akizawa T; Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 04; Vol. 13 (1), pp. 19100. Date of Electronic Publication: 2023 Nov 04.
Typ publikacji:
Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Hyperphosphatemia*/drug therapy
Renal Dialysis*
Humans ; Phosphates ; Phosphorus/metabolism ; Sodium-Hydrogen Exchanger 3
Czasopismo naukowe
Tytuł:
Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage?
Autorzy:
Ballarini E; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Malacrida A; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Rodriguez-Menendez V; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Pozzi E; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Canta A; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Chiorazzi A; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Monza L; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Semperboni S; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Meregalli C; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Carozzi VA; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Hashemi M; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Nicolini G; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Scuteri A; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Housley SN; Integrated Cancer Research Center, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Cavaletti G; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
Alberti P; School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.; NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 02; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 02.
Typ publikacji:
Journal Article
MeSH Terms:
Neurotoxicity Syndromes*/etiology
Neurotoxicity Syndromes*/metabolism
Sodium-Calcium Exchanger*/metabolism
Animals ; Axons/metabolism ; Mice ; Oxaliplatin/adverse effects ; Pilot Projects ; Rats
Czasopismo naukowe

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