Skocz do pozycji: 1.

Tytuł:

Effects of structurally distinct human HDAC6 and HDAC6/HDAC8 inhibitors against S. mansoni larval and adult worm stages.

Autorzy:

Gimmelli R; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy.; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, Roma, Italy.
Papoff G; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy.
Saccoccia F; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy.
Lalli C; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy.
Gemma S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Campiani G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Ruberti G; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy.

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Źródło:

PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Feb 28; Vol. 18 (2), pp. e0011992. Date of Electronic Publication: 2024 Feb 28 (Print Publication: 2024).

Typ publikacji:

Journal Article

MeSH Terms:

Anthelmintics*/pharmacology
Anthelmintics*/therapeutic use
Quinolones*/pharmacology
Schistosomiasis*/drug therapy
Schistosomiasis mansoni*/drug therapy
Schistosomiasis mansoni*/parasitology
Histone Deacetylase Inhibitors*/chemistry
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Animals ; Humans ; Histone Deacetylase 6/antagonists & inhibitors ; Larva ; Praziquantel/pharmacology ; Praziquantel/therapeutic use ; Repressor Proteins ; Schistosoma mansoni

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 2.

Tytuł:

Discovery of Novel Metalloenzyme Inhibitors Based on Property Characterization: Strategy and Application for HDAC1 Inhibitors.

Autorzy:

Zhang L; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Department of Toxicology, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
Yang Y; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yang Y; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Xiao Z; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; State Key Laboratory of Digestive Health, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

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Źródło:

Molecules (Basel, Switzerland) [Molecules] 2024 Feb 29; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 29.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Metalloproteins*/chemistry
Humans ; Drug Discovery ; Zinc ; Histone Deacetylase 1

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 3.

Tytuł:

The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos.

Autorzy:

Shao R; Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan.
Suzuki T; SANKEN, Osaka University, 8-1 Mihogaoka, 567-0047, Ibaraki, Osaka, Japan.
Suyama M; Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan. .
Tsukada Y; Advanced Biological Information Research Division, INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, 819-0395, Fukuoka, Japan. .

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Źródło:

BMC genomics [BMC Genomics] 2024 Feb 05; Vol. 25 (1), pp. 143. Date of Electronic Publication: 2024 Feb 05.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Transcriptome*
Pregnancy ; Female ; Mice ; Animals ; Benzamides/pharmacology ; Pyrimidines/pharmacology

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 4.

Tytuł:

EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor.

Autorzy:

Sprinzen L; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Garcia F; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Mela A; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Lei L; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Upadhyayula P; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Mahajan A; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Humala N; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Manier L; Department of Chemistry, Vanderbilt School of Medicine, Nashville, TN 37240, USA.
Caprioli R; Department of Chemistry, Vanderbilt School of Medicine, Nashville, TN 37240, USA.
Quiñones-Hinojosa A; Department of Neurosurgery, Mayo Clinic, Jacksonville, FL 32224, USA.
Casaccia P; Neuroscience Initiative, Advanced Science Research Center, City University of New York, New York, NY 10031, USA.
Canoll P; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.

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Źródło:

Cells [Cells] 2024 Jan 25; Vol. 13 (3). Date of Electronic Publication: 2024 Jan 25.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Glioma*/drug therapy
Glioma*/genetics
Glioma*/pathology
Biphenyl Compounds*
Morpholines*
Pyridones*
Animals ; Mice ; Histones/genetics ; Benzamides

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 5.

Tytuł:

Histone Acetyltransferase and Deacetylase Inhibitors-New Aspects and Developments.

Autorzy:

Ibrahim HS; Department of Medicinal Chemistry, Institute of Pharmacy, Martin Luther University of Halle Wittenberg, 06120 Halle (Saale), Germany.
Sippl W; Department of Medicinal Chemistry, Institute of Pharmacy, Martin Luther University of Halle Wittenberg, 06120 Halle (Saale), Germany.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30.

Typ publikacji:

Editorial

MeSH Terms:

Histone Acetyltransferases*/metabolism
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Epigenesis, Genetic ; Cell Differentiation

Opinia redakcyjna

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 6.

Tytuł:

Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-Cells.

Autorzy:

Hali M; Biomedical Research Service, John D. Dingell VA Medical Center, Detroit, MI 48201, USA.
Pinto N; Biomedical Research Service, John D. Dingell VA Medical Center, Detroit, MI 48201, USA.
Gleason N; Biomedical Research Service, John D. Dingell VA Medical Center, Detroit, MI 48201, USA.; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Kowluru A; Biomedical Research Service, John D. Dingell VA Medical Center, Detroit, MI 48201, USA.; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2023 Nov 06; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 06.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Diabetes Mellitus*
Humans ; Histones/metabolism ; Hydroxamic Acids/pharmacology ; Caspase Activation and Recruitment Domain ; Vorinostat ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Stress, Physiological ; CARD Signaling Adaptor Proteins/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 7.

Tytuł:

EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer.

Autorzy:

Joseph R; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Dasari SK; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Umamaheswaran S; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mangala LS; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Bayraktar E; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rodriguez-Aguayo C; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Wu Y; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Nguyen N; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Powell RT; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Sobieski M; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Liu Y; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Kim MS; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Corvigno S; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Foster K; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hanjra P; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Vu TC; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Chowdhury MA; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Amero P; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Stephan C; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Lopez-Berestein G; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Westin SN; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sood AK; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2024 Jan 20; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 20.

Typ publikacji:

Journal Article

MeSH Terms:

Endometrial Neoplasms*/drug therapy
Endometrial Neoplasms*/genetics
Endometrial Neoplasms*/pathology
Histone Deacetylase Inhibitors*/therapeutic use
Receptor, EphA2*/antagonists & inhibitors
Animals ; Female ; Humans ; Mice ; Apoptosis ; Cell Line, Tumor ; Panobinostat/pharmacology ; Panobinostat/therapeutic use ; Phosphatidylinositol 3-Kinases ; Molecular Targeted Therapy

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 8.

Tytuł:

Efficacy and safety of an HDACi- and HMA-based protocol in adults with acute myeloid leukemia of intermediate- and adverse-risk categories: a retrospective study.

Autorzy:

Guo Z; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Guo D; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Kong D; Department of Hematology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Bian S; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.; Institute of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Lin L; Department of Hematology, Yantai Yuhuangding Hospital, Qingdao University Medical College, Yantai, People's Republic of China.
Fan S; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Li Q; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Zhao Y; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Jiang Y; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Yan J; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Wang Z; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Sun L; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Li Y; Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.

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Źródło:

Hematology (Amsterdam, Netherlands) [Hematology] 2023 Dec; Vol. 28 (1), pp. 2219930.

Typ publikacji:

Journal Article

MeSH Terms:

Antineoplastic Combined Chemotherapy Protocols*/adverse effects
Azacitidine*/adverse effects
Histone Deacetylase Inhibitors*/adverse effects
Leukemia, Myeloid, Acute*/metabolism
Antimetabolites, Antineoplastic*/adverse effects
Adult ; Humans ; Cytarabine/therapeutic use ; Decitabine/adverse effects ; Retrospective Studies

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 9.

Tytuł:

Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β -elemene scaffold.

Autorzy:

Gao Y; Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Duan J; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Dang X; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Yuan Y; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Wang Y; Research and Development, Dalian HolleyKingkong Pharmaceutical Co. Ltd, Liaoning, China.
He X; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Bai R; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Ye XY; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
Xie T; Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.

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Źródło:

Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2195991.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*
Antineoplastic Agents*/chemistry
Animals ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Histone Deacetylases/metabolism ; Drug Design ; Drug Screening Assays, Antitumor ; Histone Deacetylase 1/metabolism ; Histone Deacetylase 1/pharmacology ; Structure-Activity Relationship

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 10.

Tytuł:

Discovery of novel benzohydroxamate-based histone deacetylase 6 (HDAC6) inhibitors with the ability to potentiate anti-PD-L1 immunotherapy in melanoma.

Autorzy:

Peng X; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Yu Z; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Surineni G; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Deng B; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Zhang M; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Li C; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Sun Z; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Pan W; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Liu Y; Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai, China.
Liu S; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.
Yu B; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Chen J; College of Pharmacy, Gannan Medical University, Ganzhou, China.; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, China.

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Źródło:

Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2201408.

Typ publikacji:

Journal Article

MeSH Terms:

CD8-Positive T-Lymphocytes*/metabolism
Histone Deacetylase Inhibitors*/pharmacology
Melanoma*/drug therapy
Humans ; Cell Line, Tumor ; Cell Proliferation ; Histone Deacetylase 6/antagonists & inhibitors

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 11.

Tytuł:

Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory Disorders.

Autorzy:

Villoria-González A; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.
Zierfuss B; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.; Department of Neuroscience, Centre de Recherche du CHUM, Université de Montréal, Montréal, QC H2X 0A9, Canada.
Parzer P; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.
Heuböck E; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.
Zujovic V; Institut du Cerveau-Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital Pitié Salpétrière-University Hospital, Sorbonne University, DMU Neuroscience 6, 75013 Paris, France.
Waidhofer-Söllner P; Division of Immune Receptors and T Cell Activation, Institute of Immunology Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Ponleitner M; Department of Neurology, Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, 1090 Vienna, Austria.
Rommer P; Department of Neurology, Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, 1090 Vienna, Austria.
Göpfert J; Department of Pharma and Biotech, NMI Natural and Medical Sciences Institute, University of Tübingen, 72770 Reutlingen, Germany.
Forss-Petter S; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.
Berger J; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.
Weinhofer I; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.

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Źródło:

Biomolecules [Biomolecules] 2023 Nov 23; Vol. 13 (12). Date of Electronic Publication: 2023 Nov 23.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
ATP-Binding Cassette Transporters*/metabolism
Humans ; Neuroinflammatory Diseases ; Fatty Acids/metabolism ; ATP Binding Cassette Transporter, Subfamily D, Member 1 ; Fatty Acids, Nonesterified ; Macrophages/metabolism ; Immunity

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 12.

Tytuł:

Peripheral blood DNA methylation and neuroanatomical responses to HDACi treatment that rescues neurological deficits in a Kabuki syndrome mouse model.

Autorzy:

Goodman SJ; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada.
Luperchio TR; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
Ellegood J; Mouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, Canada.
Chater-Diehl E; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada.
Lerch JP; Mouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; Wellcome Centre for Integrative Neuroimaging, The University of Oxford, Oxford, UK.; Nuffield Department of Clinical Neuroscience, The University of Oxford, Oxford, UK.
Bjornsson HT; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, USA.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.; Landspitali University Hospital, Reykjavík, Iceland.
Weksberg R; Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada. .; Division of Clinical and Metabolic Genetics, Hospital for Sick Children, Toronto, Canada. .; Department of Molecular Genetics, University of Toronto, Toronto, Canada. .; Institute of Medical Science, University of Toronto, Toronto, Canada. .; Department of Paediatrics, University of Toronto, Toronto, ON, Canada. .

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Źródło:

Clinical epigenetics [Clin Epigenetics] 2023 Oct 27; Vol. 15 (1), pp. 172. Date of Electronic Publication: 2023 Oct 27.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

DNA Methylation*
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Humans ; Animals ; Mice ; Neuroanatomy ; Biomarkers

SCR Disease Name:

Kabuki syndrome

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 13.

Tytuł:

Dopaminergic cell protection and alleviation of neuropsychiatric disease symptoms by VMAT2 expression through the class I HDAC inhibitor TC-H 106.

Autorzy:

Lee H; New Drug Development Center, K-Medihub, Daegu, Korea.
Kim HJ; Department of Physiology, School of Medicine, Jeju National University, Jeju, Korea.
Choi DK; New Drug Development Center, K-Medihub, Daegu, Korea.
Ko EN; Department of Physiology, School of Medicine, Jeju National University, Jeju, Korea.
Choi JH; New Drug Development Center, K-Medihub, Daegu, Korea.
Seo Y; New Drug Development Center, K-Medihub, Daegu, Korea.
Lee S; New Drug Development Center, K-Medihub, Daegu, Korea.
Kim SH; New Drug Development Center, K-Medihub, Daegu, Korea.
Jung S; New Drug Development Center, K-Medihub, Daegu, Korea.
Kim M; New Drug Development Center, K-Medihub, Daegu, Korea.
Kang D; New Drug Development Center, K-Medihub, Daegu, Korea.
Im CY; New Drug Development Center, K-Medihub, Daegu, Korea.
Bae GH; New Drug Development Center, K-Medihub, Daegu, Korea.
Jung SC; Department of Physiology, School of Medicine, Jeju National University, Jeju, Korea.
Kwon OB; New Drug Development Center, K-Medihub, Daegu, Korea.

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Źródło:

Pharmacology research & perspectives [Pharmacol Res Perspect] 2023 Oct; Vol. 11 (5), pp. e01135.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Neuroblastoma*
Humans ; Animals ; Mice ; Vesicular Monoamine Transport Proteins/genetics ; Cytoprotection ; Dopamine ; Oxidopamine

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 14.

Tytuł:

Biological Effects of HDAC Inhibitors Vary with Zinc Binding Group: Differential Effects on Zinc Bioavailability, ROS Production, and R175H p53 Mutant Protein Reactivation.

Autorzy:

Flores BM; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA.; Arizona College of Osteopathic Medicine, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA.
Uppalapati CK; Department of Microbiology & Immunology, College of Graduate Studies, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA.
Pascual AS; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA.
Vong A; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA.
Baatz MA; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA.
Harrison AM; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA.
Leyva KJ; Department of Microbiology & Immunology, College of Graduate Studies, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA.
Hull EE; Biomedical Sciences Program, College of Graduate Studies, Midwestern University, 19555 N 59th Avenue, Glendale, AZ 85308, USA.

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Źródło:

Biomolecules [Biomolecules] 2023 Oct 28; Vol. 13 (11). Date of Electronic Publication: 2023 Oct 28.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Zinc*/metabolism
Reactive Oxygen Species/metabolism ; Biological Availability ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 15.

Tytuł:

Epigenetic weapons in plant-herbivore interactions: Sulforaphane disrupts histone deacetylases, gene expression, and larval development in Spodoptera exigua while the specialist feeder Trichoplusia ni is largely resistant to these effects.

Autorzy:

Somers DJ; Department of Biology, Program in Biochemistry and Molecular Biology, Dickinson College, Carlisle, PA United States of America.
Kushner DB; Department of Biology, Program in Biochemistry and Molecular Biology, Dickinson College, Carlisle, PA United States of America.
McKinnis AR; Department of Biology, Program in Biochemistry and Molecular Biology, Dickinson College, Carlisle, PA United States of America.
Mehmedovic D; Department of Biology, Program in Biochemistry and Molecular Biology, Dickinson College, Carlisle, PA United States of America.
Flame RS; Department of Biology, Program in Biochemistry and Molecular Biology, Dickinson College, Carlisle, PA United States of America.
Arnold TM; Department of Biology, Program in Biochemistry and Molecular Biology, Dickinson College, Carlisle, PA United States of America.

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Źródło:

PloS one [PLoS One] 2023 Oct 19; Vol. 18 (10), pp. e0293075. Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2023).

Typ publikacji:

Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylases*/genetics
Histone Deacetylases*/metabolism
Humans ; Animals ; Spodoptera/genetics ; Spodoptera/metabolism ; Herbivory ; Isothiocyanates/pharmacology ; Sulfoxides ; Epigenesis, Genetic ; Gene Expression ; Mammals/genetics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 16.

Tytuł:

Histone deacetylase inhibitor sodium butyrate regulates the activation of toll-like receptor 4/interferon regulatory factor-3 signaling pathways in prostate cancer cells.

Autorzy:

Ozkan AD; Department of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
Eskiler GG; Department of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
Kazan N; Department of Medical Biology, Institute of Health Science, Sakarya University, Sakarya, Turkey.
Turna O; Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Istanbul-Cerrahpasa University, Istanbul, Turkey.

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Źródło:

Journal of cancer research and therapeutics [J Cancer Res Ther] 2023 Oct 01; Vol. 19 (7), pp. 1812-1817. Date of Electronic Publication: 2022 Mar 28.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Prostatic Neoplasms*/drug therapy
Prostatic Neoplasms*/genetics
Male ; Humans ; Butyric Acid/pharmacology ; Toll-Like Receptor 4/genetics ; Interferon Regulatory Factor-3/genetics ; NF-kappa B ; Signal Transduction

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 17.

Tytuł:

Inhibition of Notch Signaling Enhances Antitumor Activity of Histone Deacetylase Inhibitor LAQ824.

Autorzy:

Mei Q; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao Marine Science and Technology Center, Qingdao 266100, China.
Xu X; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao Marine Science and Technology Center, Qingdao 266100, China.
Gao D; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao Marine Science and Technology Center, Qingdao 266100, China.
Xu Y; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao Marine Science and Technology Center, Qingdao 266100, China.
Yang J; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao Marine Science and Technology Center, Qingdao 266100, China.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2023 Sep 04; Vol. 24 (17). Date of Electronic Publication: 2023 Sep 04.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Biological Assay*
Blotting, Western ; Cell Line, Tumor

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 18.

Tytuł:

Anticancer Study of a Novel Pan-HDAC Inhibitor MPT0G236 in Colorectal Cancer Cells.

Autorzy:

Tsai FL; School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Huang HL; TMU Research Center for Drug Discovery, Taipei Medical University, Taipei 110, Taiwan.; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
Lai MJ; TMU Research Center for Drug Discovery, Taipei Medical University, Taipei 110, Taiwan.
Liou JP; TMU Research Center for Drug Discovery, Taipei Medical University, Taipei 110, Taiwan.; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
Pan SL; TMU Research Center for Drug Discovery, Taipei Medical University, Taipei 110, Taiwan.; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City 235, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, New Taipei City 235, Taiwan.
Yang CR; School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2023 Aug 09; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 09.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Colorectal Neoplasms*/drug therapy
Humans ; Apoptosis ; Cell Proliferation ; Cell Cycle Proteins ; Histone Deacetylases ; Human Umbilical Vein Endothelial Cells

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 19.

Tytuł:

Histone deacetylase inhibitors inhibit lung adenocarcinoma metastasis via HDAC2/YY1 mediated downregulation of Cdh1.

Autorzy:

Wang D; Department of Gastrointestinal Surgery, The Affiliated Changzhou, No. 2 People's Hospital of Nanjing Medical University, Changzhou, 213004, Jiangsu, China.; Changzhou Medical Center of Nanjing Medical University, Changzhou, 213004, Jiangsu, China.
Yang Y; Institute of Burn Research, The First Affiliated Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Cao Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Meng M; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Wang X; Henan Provincial Chest Hospital, Zhengzhou, 450000, Henan, China.
Zhang Z; Henan Provincial Chest Hospital, Zhengzhou, 450000, Henan, China.
Fu W; Henan Provincial Chest Hospital, Zhengzhou, 450000, Henan, China.
Duan S; Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, 450003, Henan, China. .
Tang L; Department of Gastrointestinal Surgery, The Affiliated Changzhou, No. 2 People's Hospital of Nanjing Medical University, Changzhou, 213004, Jiangsu, China. .; Changzhou Medical Center of Nanjing Medical University, Changzhou, 213004, Jiangsu, China. .

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Źródło:

Scientific reports [Sci Rep] 2023 Jul 26; Vol. 13 (1), pp. 12069. Date of Electronic Publication: 2023 Jul 26.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Adenocarcinoma of Lung*/drug therapy
Adenocarcinoma of Lung*/enzymology
Adenocarcinoma of Lung*/metabolism
Adenocarcinoma of Lung*/pathology
Histone Deacetylase 2*/antagonists & inhibitors
Histone Deacetylase 2*/metabolism
YY1 Transcription Factor*/metabolism
Cadherins*/genetics
Cadherins*/metabolism
Antigens, CD*/metabolism
Neoplasm Metastasis*/drug therapy
Neoplasm Metastasis*/pathology
Neoplasm Metastasis*/prevention & control
Humans ; Animals ; Mice ; Female ; Cell Movement/drug effects ; Butyric Acid/pharmacology ; Butyric Acid/therapeutic use ; Transforming Growth Factor beta/metabolism ; Epithelial-Mesenchymal Transition/drug effects ; Protein Binding ; Transcription, Genetic ; Gene Expression Regulation, Neoplastic

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 20.

Tytuł:

SelSA-1, a novel HDAC inhibitor demonstrates enhanced chemotherapeutic potential by redox modulation.

Autorzy:

Garg A; Department of Biophysics, Panjab University, Chandigarh, 160014, India.
Desai D; Departments of Pharmacology, Pennsylvania State University College of Medicine, Hershey, USA.
Bhalla A; Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India.
Thakur S; Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh, 160014, India.
Rastogi P; Department of Hematology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Kaushal N; Department of Biophysics, Panjab University, Chandigarh, 160014, India. .

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Źródło:

Scientific reports [Sci Rep] 2023 Jun 08; Vol. 13 (1), pp. 9301. Date of Electronic Publication: 2023 Jun 08.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Epigenesis, Genetic*
Animals ; Mice ; NIH 3T3 Cells ; Hydroxamic Acids/pharmacology ; Apoptosis ; Oxidation-Reduction ; Cell Line, Tumor

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 21.

Tytuł:

Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway.

Autorzy:

Choi J; Department of Physiology, Chonnam National University Medical School, Hwasun-gun, Jellanamdo, 58128, Republic of Korea.
Hwang J; Department of Physiology, Chonnam National University Medical School, Hwasun-gun, Jellanamdo, 58128, Republic of Korea.
Ramalingam M; Department of Physiology, Chonnam National University Medical School, Hwasun-gun, Jellanamdo, 58128, Republic of Korea.
Jeong HS; Department of Physiology, Chonnam National University Medical School, Hwasun-gun, Jellanamdo, 58128, Republic of Korea. .
Jang S; Department of Physiology, Chonnam National University Medical School, Hwasun-gun, Jellanamdo, 58128, Republic of Korea. .

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Źródło:

BMC neuroscience [BMC Neurosci] 2023 May 01; Vol. 24 (1), pp. 28. Date of Electronic Publication: 2023 May 01.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Neuroblastoma*/metabolism
Humans ; Wnt Signaling Pathway ; Neurons/metabolism ; Valproic Acid ; Cell Differentiation ; Tretinoin/metabolism ; Cell Line, Tumor

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 22.

Tytuł:

Transcriptome analysis of Burkitt lymphoma cells treated with anti-convulsant drugs that are inhibitors of Epstein-Barr virus lytic reactivation.

Autorzy:

Gorres KL; Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, United States of America.
Reineke DM; Department of Mathematics and Statistics and Statistics Consulting Center, University of Wisconsin-La Crosse, La Crosse, Wisconsin, United States of America.
Miller G; Department of Pediatrics and Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, United States of America.

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Źródło:

PloS one [PLoS One] 2024 Apr 18; Vol. 19 (4), pp. e0299198. Date of Electronic Publication: 2024 Apr 18 (Print Publication: 2024).

Typ publikacji:

Journal Article

MeSH Terms:

Burkitt Lymphoma*/drug therapy
Burkitt Lymphoma*/genetics
Epstein-Barr Virus Infections*/drug therapy
Valproic Acid/*analogs & derivatives
Humans ; Herpesvirus 4, Human/physiology ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/metabolism ; Virus Activation ; Gene Expression Profiling ; Butyrates/pharmacology

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 23.

Tytuł:

Class I histone deacetylases inhibition reverses memory impairment induced by acute stress in mice.

Autorzy:

Martínez-Pacheco H; Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Juriquilla, Querétaro, México.
Zepeda RC; Centro de Investigaciones Biomédicas, Universidad Veracruzana, Xalapa, Veracruz, México.
Picazo O; Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México.
Quirarte GL; Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Juriquilla, Querétaro, México.
Roldán-Roldán G; Laboratorio de Neurobiología Conductual, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.

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Źródło:

PloS one [PLoS One] 2024 Apr 18; Vol. 19 (4), pp. e0302374. Date of Electronic Publication: 2024 Apr 18 (Print Publication: 2024).

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylases*/metabolism
Corticosterone*/metabolism
Mice ; Animals ; Learning ; Memory Disorders/drug therapy ; Memory Disorders/etiology ; Memory Disorders/metabolism ; Memory, Long-Term ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylase Inhibitors/metabolism ; Hippocampus/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 24.

Tytuł:

Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors.

Autorzy:

Cheng Y; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China.
Dai Y; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tang H; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China.
Lu X; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China.
Xie J; Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xie W; Department of Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang Q; National Research Center for Translational Medicine (Shanghai), State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Y; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China.
Lin S; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China.
Yao H; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China.
Shang H; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China.
Yang K; Department of Neurosurgery, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Liu H; Department of Neurosurgery, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Wu X; Center for Immune-Related DiseasesShanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang J; National Research Center for Translational Medicine (Shanghai), State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang X; Neuroendocrine Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Xue L; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China. .
Wu ZB; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China. .; Department of Neurosurgery, Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. .

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Źródło:

Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Apr 18; Vol. 12 (1), pp. 61. Date of Electronic Publication: 2024 Apr 18.

Typ publikacji:

Journal Article

MeSH Terms:

Neuroendocrine Tumors*/drug therapy
Pituitary Neoplasms*
Humans ; Panobinostat/pharmacology ; Panobinostat/therapeutic use ; NF-E2-Related Factor 2/genetics ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Signal Transduction

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 25.

Tytuł:

Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss.

Autorzy:

Peng X; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China.
Wang T; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China.; Department of Orthopedics, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, 214000, Jiangsu, China.
Wang Q; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China.
Zhao Y; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China.
Xu H; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China.
Yang H; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China.
Gu Y; Department of Orthopedics, Changshu First People's Hospital Affiliated to Soochow University, Changshu, 215500, Jiangsu, China.
Tao Y; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China. .
Yan B; Department of Orthopedics, Huishan Second People's Hospital, Wuxi, 214174, China. .
Xu Y; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China. .
Geng D; Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China. .

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Źródło:

Cell communication and signaling : CCS [Cell Commun Signal] 2024 Mar 04; Vol. 22 (1), pp. 160. Date of Electronic Publication: 2024 Mar 04.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Bone Resorption*/drug therapy
Osteoporosis*/drug therapy
Osteoporosis*/etiology
Female ; Animals ; Mice ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Vorinostat/pharmacology ; Vorinostat/therapeutic use ; Molecular Docking Simulation ; Signal Transduction ; Estrogens

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 26.

Tytuł:

Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma.

Autorzy:

Sasagawa, Satoru (AUTHOR)
Kumai, Jun (AUTHOR)
Wakamatsu, Toru (AUTHOR)
Yui, Yoshihiro (AUTHOR)

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Źródło:

Cancer Innovation. Apr2024, Vol. 3 Issue 2, p1-16. 16p.

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 27.

Tytuł:

Alterations in Proteostasis Mechanisms in Niemann–Pick Type C Disease.

Autorzy:

Servín Muñoz, Iris Valeria (AUTHOR)
Ortuño-Sahagún, Daniel (AUTHOR)
Griñán-Ferré, Christian (AUTHOR)
Pallàs, Mercè (AUTHOR)
González-Castillo, Celia (AUTHOR)

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Źródło:

International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 7, p3806. 17p.

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 28.

Tytuł:

High-content analysis identified synergistic drug interactions between INK128, an mTOR inhibitor, and HDAC inhibitors in a non-small cell lung cancer cell line.

Autorzy:

Wang, Sijiao (AUTHOR)
Oliveira-Silveira, Juliano (AUTHOR)
Fang, Gang (AUTHOR)
Kang, Jungseog (AUTHOR)

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Źródło:

BMC Cancer. 3/12/2024, Vol. 24 Issue 1, p1-16. 16p.

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 29.

Tytuł:

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents.

Autorzy:

Mohapatra, Tapas Kumar (AUTHOR)
Nayak, Reena Rani (AUTHOR)
Ganeshpurkar, Ankit (AUTHOR)
Tiwari, Prashant (AUTHOR)
Kumar, Dileep (AUTHOR)

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Źródło:

Drugs & Drug Candidates. Mar2024, Vol. 3 Issue 1, p70-101. 32p.

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 30.

Tytuł:

Synergistic integration of histone deacetylase inhibitors apparently enhances the cytokine‐induced killer cell efficiency in multiple myeloma via the NKG2D pathway.

Autorzy:

Pu, Jingjing
Sharma, Amit
Liu, Ting
Hou, Jian
Schmidt‐Wolf, Ingo GH

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Źródło:

Clinical & Translational Immunology. 2024, Vol. 13 Issue 3, p1-13. 13p.

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 31.

Tytuł:

Development of an UPLC-MS/MS method for quantitative analysis of abexinostat levels in rat plasma and application of pharmacokinetics.

Autorzy:

Yu, Yige (AUTHOR)
Hu, Jinyu (AUTHOR)
Chen, Xiaohai (AUTHOR)
Wu, Hua-lu (AUTHOR)
Wang, Anzhou (AUTHOR)
Tang, Congrong (AUTHOR)

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Źródło:

BMC Chemistry. 2/20/2024, Vol. 18 Issue 1, p1-7. 7p.

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 32.

Tytuł:

The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities.

Autorzy:

Psilopatis I; Department of Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece.
Vrettou K; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece.
Fleckenstein FN; Department of Diagnostic and Interventional Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.; BIH Charité Clinician Scientist Program, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, 10117 Berlin, Germany.
Theocharis S; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece.

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Źródło:

Cells [Cells] 2023 Apr 23; Vol. 12 (9). Date of Electronic Publication: 2023 Apr 23.

Typ publikacji:

Journal Article; Review

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Endometriosis*/drug therapy
Humans ; Female ; Histone Code ; Histone Deacetylase 1/metabolism ; Histone Deacetylases/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 33.

Tytuł:

Exploring the Potential of Phytocompounds for Targeting Epigenetic Mechanisms in Rheumatoid Arthritis: An In Silico Study Using Similarity Indexing.

Autorzy:

Deshpande SH; Department of Biotechnology, KLE Technological University, Hubballi 580031, India.
Bagewadi ZK; Department of Biotechnology, KLE Technological University, Hubballi 580031, India.
Khan TMY; Department of Mechanical Engineering, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia.
Mahnashi MH; Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran 66462, Saudi Arabia.
Shaikh IA; Department of Pharmacology, College of Pharmacy, Najran University, Najran 66462, Saudi Arabia.
Alshehery S; Department of Mechanical Engineering, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia.
Khan AA; Department of General Science, Ibn Sina National College for Medical Studies, Jeddah 22421, Saudi Arabia.
Patil VS; ICMR-National Institute of Traditional Medicine, Belagavi 590010, India.
Roy S; ICMR-National Institute of Traditional Medicine, Belagavi 590010, India.

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Źródło:

Molecules (Basel, Switzerland) [Molecules] 2023 Mar 07; Vol. 28 (6). Date of Electronic Publication: 2023 Mar 07.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/chemistry
Arthritis, Rheumatoid*/drug therapy
Arthritis, Rheumatoid*/genetics
Humans ; Amides ; Molecular Dynamics Simulation ; Epigenesis, Genetic ; Molecular Docking Simulation ; Histone Deacetylases/genetics ; Repressor Proteins

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 34.

Tytuł:

Selective Targeting of Class I HDAC Reduces Microglial Inflammation in the Entorhinal Cortex of Young APP/PS1 Mice.

Autorzy:

Wang C; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Shen D; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Hu Y; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Chen J; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Liu J; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Huang Y; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Yu X; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Chu H; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Zhang C; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Yin L; Department of Oncology, Dalian Municipal Central Hospital, Dalian 116089, China.
Liu Y; Department of Neurology, Dalian Municipal Central Hospital, Dalian 116089, China.
Ma H; Department of Histology and Embryology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2023 Mar 02; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 02.

Typ publikacji:

Journal Article

MeSH Terms:

Alzheimer Disease*/drug therapy
Amyloid beta-Protein Precursor*/metabolism
Entorhinal Cortex*/metabolism
Inflammation*/metabolism
Microglia*/metabolism
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Animals ; Mice ; Amyloid beta-Peptides/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Disease Models, Animal ; Hippocampus/metabolism ; Mice, Transgenic ; NF-kappa B/metabolism ; Presenilin-1/genetics

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 35.

Tytuł:

Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells.

Autorzy:

Ptacek J; Institute of Biotechnology CAS, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Snajdr I; Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Schimer J; Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Kutil Z; Institute of Biotechnology CAS, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Mikesova J; Institute of Biotechnology CAS, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Baranova P; Institute of Biotechnology CAS, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Havlinova B; Institute of Biotechnology CAS, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.
Tueckmantel W; StarWise Therapeutics LLC, University Research Park, Inc., Madison, WI 53719, USA.
Majer P; Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Flemingovo n. 2, 166 10 Prague 6, Czech Republic.
Kozikowski A; StarWise Therapeutics LLC, University Research Park, Inc., Madison, WI 53719, USA.; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Barinka C; Institute of Biotechnology CAS, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2023 Mar 01; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 01.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase 6*/antagonists & inhibitors
Histone Deacetylase Inhibitors*/chemistry
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylases*/metabolism
Hydroxamic Acids*/chemistry
Hydroxamic Acids*/pharmacology
Oxadiazoles*/chemistry
Oxadiazoles*/pharmacology
Humans ; Protein Processing, Post-Translational ; Acetylation ; Cell Line, Tumor

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 36.

Tytuł:

The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors.

Autorzy:

Tien Anh D; Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 10000, Vietnam.
Hai Nam N; Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 10000, Vietnam.
Kircher B; Immunobiology and Stem Cell Laboratory, Department of Internal Medicine V (Hematology and Oncology), Medical University Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.; Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria.
Baecker D; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Straße 17, 17489 Greifswald, Germany.

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Źródło:

Molecules (Basel, Switzerland) [Molecules] 2023 Feb 19; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 19.

Typ publikacji:

Journal Article; Review

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Fluorine*
Halogenation ; Histone Deacetylases/metabolism ; Hydroxamic Acids/chemistry ; Protein Isoforms/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 37.

Tytuł:

Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone.

Autorzy:

Fukuda M; Department of Anatomy and Developmental Biology, School of Medicine, Shimane University, 89-1, Enya-cho, Izumo-shi 693-8501, Japan.
Fujita Y; Department of Anatomy and Developmental Biology, School of Medicine, Shimane University, 89-1, Enya-cho, Izumo-shi 693-8501, Japan.
Hino Y; Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Nakao M; Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
Shirahige K; Laboratory of Genome Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.; Department of Cell and Molecular Biology, Karolinska Institutet, Biomedicum, Quarter A6, 171 77 Stockholm, Sweden.
Yamashita T; Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita 565-0871, Japan.; WPI Immunology Frontier Research Center, Osaka University, 3-1, Yamadaoka, Suita 565-0871, Japan.; Graduate School of Frontier Biosciences, Osaka University, 1-3, Yamadaoka, Suita 565-0871, Japan.; Department of Neuro-Medical Science, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita 565-0871, Japan.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2024 Feb 22; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 22.

Typ publikacji:

Journal Article

MeSH Terms:

Percutaneous Coronary Intervention*
Neural Stem Cells*
Adult Stem Cells*
Animals ; Mice ; Lateral Ventricles ; Histone Deacetylase Inhibitors ; Cell Proliferation ; Mammals

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 38.

Tytuł:

Drug-induced loss of imprinting revealed using bioluminescent reporters of Cdkn1c.

Autorzy:

Dimond A; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK. .
Van de Pette M; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.; MRC Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge, CB2 1QR, UK.
Taylor-Bateman V; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Brown K; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Sardini A; Whole Animal Physiology and Imaging, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Whilding C; Microscopy Facility, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Feytout A; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Prinjha RK; Immunology and Epigenetics Research Unit, Research, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, Herts, UK.
Merkenschlager M; Lymphocyte Development Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Fisher AG; Epigenetic Memory Group, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK. .

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Źródło:

Scientific reports [Sci Rep] 2023 Apr 06; Vol. 13 (1), pp. 5626. Date of Electronic Publication: 2023 Apr 06.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

DNA Methylation*
Histone Deacetylase Inhibitors*
Animals ; Mice ; Genomic Imprinting ; Epigenesis, Genetic ; Chromatin ; Cyclin-Dependent Kinase Inhibitor p57/genetics ; Cyclin-Dependent Kinase Inhibitor p57/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 39.

Tytuł:

Valproic acid inhibits cell growth in both MCF-7 and MDA-MB231 cells by triggering different responses in a cell type-specific manner.

Autorzy:

Giordano F; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy. .
Paolì A; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Forastiero M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Marsico S; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
De Amicis F; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Marrelli M; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Naimo GD; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Mauro L; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Panno ML; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy. .

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Źródło:

Journal of translational medicine [J Transl Med] 2023 Mar 02; Vol. 21 (1), pp. 165. Date of Electronic Publication: 2023 Mar 02.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Valproic Acid*/pharmacology
Histone Deacetylase Inhibitors*/pharmacology
Female ; Humans ; MCF-7 Cells ; Reactive Oxygen Species ; Cell Cycle ; Cell Proliferation

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 40.

Tytuł:

Identification of Novel Natural Dual HDAC and Hsp90 Inhibitors for Metastatic TNBC Using e-Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Studies.

Autorzy:

AbdElmoniem N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
H Abdallah M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
M Mukhtar R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Moutasim F; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Rafie Ahmed A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Edris A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Ibraheem W; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
Makki AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.
M Elshamly E; Department of Molecular Biotechnology, Hochschule Anhalt, 06846 Dessau-Roßlau, Germany.
Elhag R; Department of Biology, College of Science and Technology, Florida A & M University, Tallahassee, FL 32307, USA.
Osman W; Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Khartoum 11114, Sudan.
A Mothana R; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alzain AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani 21111, Sudan.

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Źródło:

Molecules (Basel, Switzerland) [Molecules] 2023 Feb 13; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 13.

Typ publikacji:

Journal Article

MeSH Terms:

Antineoplastic Agents*/pharmacology
Triple Negative Breast Neoplasms*/drug therapy
HSP90 Heat-Shock Proteins*/antagonists & inhibitors
Histone Deacetylase Inhibitors*/pharmacology
Female ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pharmacophore

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 41.

Tytuł:

Immunomodulation of HDAC Inhibitor Entinostat Potentiates the Anticancer Effects of Radiation and PD-1 Blockade in the Murine Lewis Lung Carcinoma Model.

Autorzy:

Kim Y; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Park K; Samsung Genome Institute, Samsung Medical Center, Seoul 06351, Republic of Korea.
Kim YJ; Samsung Genome Institute, Samsung Medical Center, Seoul 06351, Republic of Korea.
Shin SW; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Kim YJ; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Choi C; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.
Noh JM; Department of Radiation Oncology, Samsung Medical Center, Seoul 06351, Republic of Korea.; Department of Radiation Oncology, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2022 Dec 08; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 08.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Carcinoma, Lewis Lung*/drug therapy
Animals ; Mice ; CD8-Positive T-Lymphocytes ; Immunomodulation ; Immunity ; Interferon-gamma/pharmacology ; Cell Line, Tumor ; Tumor Microenvironment

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 42.

Tytuł:

Discovery and SAR analysis of 5-chloro-4-((substituted phenyl)amino)pyrimidine bearing histone deacetylase inhibitors.

Autorzy:

Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Chen Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Li F; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Zhang L; School of Stomatology, Weifang Medical University, Weifang, China.
Feng J; Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of sciences), Jinan, China.
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.

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Źródło:

Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1918-1927.

Typ publikacji:

Journal Article

MeSH Terms:

Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Histone Deacetylase Inhibitors*/chemistry
Histone Deacetylase Inhibitors*/pharmacology
Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Histone Deacetylase 1 ; Histone Deacetylase 6/metabolism ; Histone Deacetylases/metabolism ; Pyrimidines/pharmacology ; Structure-Activity Relationship

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknieSzczegóły

Skocz do pozycji: 43.

Tytuł:

Small-Molecule Fluorescent Probes for Detecting HDAC Activity.

Autorzy:

Tan S; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, P. R. China.
Li X; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, P. R. China.

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Źródło:

Chemistry, an Asian journal [Chem Asian J] 2022 Nov 16; Vol. 17 (22), pp. e202200835. Date of Electronic Publication: 2022 Sep 27.

Typ publikacji:

Journal Article; Review

MeSH Terms:

Fluorescent Dyes*/chemistry
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/chemistry
Histone Deacetylases/chemistry ; Histone Deacetylases/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 44.

Tytuł:

The Novel Class IIa Selective Histone Deacetylase Inhibitor YAK540 Is Synergistic with Bortezomib in Leukemia Cell Lines.

Autorzy:

Bollmann LM; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Skerhut AJ; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Asfaha Y; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Horstick N; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Hanenberg H; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, 40225 Duesseldorf, Germany.
Hamacher A; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Kurz T; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Kassack MU; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2022 Nov 02; Vol. 23 (21). Date of Electronic Publication: 2022 Nov 02.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Leukemia, Myeloid, Acute*/genetics
Humans ; Bortezomib/pharmacology ; Bortezomib/therapeutic use ; HEK293 Cells ; Proteasome Inhibitors/pharmacology ; Apoptosis ; Cell Line, Tumor ; Drug Synergism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 45.

Tytuł:

The Roles and Regulatory Mechanisms of Tight Junction Protein Cingulin and Transcription Factor Forkhead Box Protein O1 in Human Lung Adenocarcinoma A549 Cells and Normal Lung Epithelial Cells.

Autorzy:

Ishii D; Department of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.; Department of Cell Science, Institute of Cancer Research, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Shindo Y; Department of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.; Department of Cell Science, Institute of Cancer Research, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Arai W; Department of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Konno T; Department of Cell Science, Institute of Cancer Research, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Kohno T; Department of Cell Science, Institute of Cancer Research, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Honda K; Department of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.; Department of Cell Science, Institute of Cancer Research, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Miyajima M; Department of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Watanabe A; Department of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.
Kojima T; Department of Cell Science, Institute of Cancer Research, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2024 Jan 24; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 24.

Typ publikacji:

Journal Article

MeSH Terms:

Adenocarcinoma of Lung*/metabolism
Adenocarcinoma of Lung*/pathology
Carcinoma, Non-Small-Cell Lung*/metabolism
Carcinoma, Non-Small-Cell Lung*/pathology
Forkhead Box Protein O1*/genetics
Forkhead Box Protein O1*/metabolism
Hydroxamic Acids*
Lung Neoplasms*/metabolism
Tight Junction Proteins*/metabolism
Humans ; A549 Cells ; Epithelial Cells/metabolism ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/metabolism ; Lung/pathology ; Transcription Factors/metabolism

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 46.

Tytuł:

Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.

Autorzy:

Baselious F; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle (Saale), Germany.
Hilscher S; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle (Saale), Germany.
Robaa D; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle (Saale), Germany.
Barinka C; Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, 252 50 Vestec, Czech Republic.
Schutkowski M; Charles Tanford Protein Center, Department of Enzymology, Institute of Biochemistry and Biotechnology, Martin-Luther-University of Halle-Wittenberg, 06120 Halle (Saale), Germany.
Sippl W; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle (Saale), Germany.

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Źródło:

International journal of molecular sciences [Int J Mol Sci] 2024 Jan 22; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 22.

Typ publikacji:

Journal Article

MeSH Terms:

Molecular Dynamics Simulation*
Models, Chemical*
Molecular Docking Simulation ; Catalytic Domain ; Drug Design ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/chemistry

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 47.

Tytuł:

Histone deacetylase inhibitors VPA and WT161 ameliorate the pathological features and cognitive impairments of the APP/PS1 Alzheimer's disease mouse model by regulating the expression of APP secretases.

Autorzy:

Zhang M; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.; Prenatal Diagnostic Center, Yiwu Maternity and Children Hospital, Yiwu, 322000, China.
Wang W; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Ye Q; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Fu Y; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.; College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, 350000, China.
Li X; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Yang K; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Gao F; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Zhou A; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Wei Y; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Tian S; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Li S; Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, 300222, China.
Wei F; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Shi W; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. .
Li WD; Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. .

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Źródło:

Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Jan 20; Vol. 16 (1), pp. 15. Date of Electronic Publication: 2024 Jan 20.

Typ publikacji:

Journal Article; Research Support, Non-U.S. Gov't

MeSH Terms:

Alzheimer Disease*/genetics
Cognitive Dysfunction*
Hydroxamic Acids*
Terphenyl Compounds*
Mice ; Animals ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/metabolism ; Chromatography, Liquid ; Aspartic Acid Endopeptidases/metabolism ; Tandem Mass Spectrometry ; Mice, Transgenic ; Disease Models, Animal ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Presenilin-1/genetics ; Presenilin-1/metabolism

Czasopismo naukowe

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Skocz do pozycji: 48.

Tytuł:

Discovery of novel polysubstituted N -alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy.

Autorzy:

Wang Z; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Zhao L; Institute of Drug Discovery Technology, Ningbo University, Ningbo, People's Republic of China.
Zhang B; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Feng J; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Wang Y; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Zhang B; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Jin H; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Ding L; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.
Wang N; Institute of Drug Discovery Technology, Ningbo University, Ningbo, People's Republic of China.
He S; Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, People's Republic of China.; Ningbo Institute of Marine Medicine, Peking University, Ningbo, People's Republic of China.

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Źródło:

Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2206581.

Typ publikacji:

Journal Article

MeSH Terms:

Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Neoplasms*
Humans ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/chemistry ; Molecular Structure ; Structure-Activity Relationship ; Cell Line, Tumor ; Molecular Docking Simulation ; Histone Deacetylases/metabolism ; Protein Isoforms/metabolism ; Cell Proliferation ; Histone Deacetylase 1/metabolism ; Histone Deacetylase 1/pharmacology ; Repressor Proteins/metabolism ; Repressor Proteins/pharmacology

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 49.

Tytuł:

Balancing the interplay of histone deacetylases and non-coding genomes: a step closer to understand the landscape of cancer treatment.

Autorzy:

Pu J; Department of Integrated Oncology, Center for Integrated Oncology (CIO) Bonn, University Hospital Bonn, Bonn, Germany.
Liu T; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
Sharma A; Department of Integrated Oncology, Center for Integrated Oncology (CIO) Bonn, University Hospital Bonn, Bonn, Germany.
Schmidt-Wolf IGH; Department of Integrated Oncology, Center for Integrated Oncology (CIO) Bonn, University Hospital Bonn, Bonn, Germany. .

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Źródło:

BMC medical genomics [BMC Med Genomics] 2023 Nov 17; Vol. 16 (1), pp. 295. Date of Electronic Publication: 2023 Nov 17.

Typ publikacji:

Letter; Research Support, Non-U.S. Gov't

MeSH Terms:

MicroRNAs*/genetics
Multiple Myeloma*/drug therapy
Multiple Myeloma*/genetics
Humans ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Histone Deacetylase 6 ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use

Raport

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Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły

Skocz do pozycji: 50.

Tytuł:

Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors.

Autorzy:

Bachmann LM; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany.
Hanl M; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Feller F; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Sinatra L; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany.
Schöler A; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany.
Pietzsch J; Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.; Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, Mommsenstraße 4, 01062 Dresden, Germany.
Laube M; Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany.
Hansen FK; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

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Źródło:

Molecules (Basel, Switzerland) [Molecules] 2023 Jan 20; Vol. 28 (3). Date of Electronic Publication: 2023 Jan 20.

Typ publikacji:

Journal Article

MeSH Terms:

Histone Deacetylase Inhibitors*/pharmacology
Antineoplastic Agents*/pharmacology
Cyclooxygenase 2 ; Cell Proliferation ; Histone Deacetylases ; Cyclooxygenase Inhibitors/pharmacology ; Cell Line, Tumor ; Drug Screening Assays, Antitumor

Czasopismo naukowe

• na półce

Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły